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Öğe Adrenal androgens, cytokines, and thyroid autoantibodies and their relationship with quality of life, anxiety, depression in fibromyalgia syndrome(Bmj Publishing Group, 2006) Gur, A.; Basboga, L.; Sarac, A. J.; Nas, K.; Cevik, R.[Abstract Not Available]Öğe Can the patient-reported outcome instruments determine disease activity in rheumatoid arthritis?(Aepress Sro, 2011) Durmus, B.; Altay, Z.; Baysal, O.; Ersoy, Y.; Erdal, A.; Cevik, R.; Ardicoglu, O.Objectives: The aim of this study was to investigate the indicative value of the patient-reported outcome instruments (PROs) on disease activity in rheumatoid arthritis (RA). Methods: Three hundred sixty eight patients with RA were included in this cross-sectional study. Disease activity was evaluated using both the Disease Activity Score 28 (DAS 28) and the Clinical Disease Activity Index (CDAI). Patients who had DAS 28 score <3.60 points and CDAI score <10.00 points were allocated into the low disease activity group and those who had DAS 28 score >= 3.60 points and CDAI score >= 10.00 points into the moderate or high disease activity group. The Health Assessment Questionnaire (HAQ), Nottingham Health Profile (NHP), Rheumatoid Arthritis Quality of Life (RAQoL), and Short Form 36 (SF 36) were used as PROs. Logistic regression analysis was used to find variables, which had an indicative value for disease activity. Results: HAQ, pain and emotional reaction subscales of NHP, and bodily pain, general health and social functioning subscales of SF 36 had independent indicative values, when DAS 28 was used as dependent variable. On the other hand, HAQ, pain and emotional reaction subscales of NHP, and general health and emotional role limitation subscales of SF 36 had indicative values when CDAI was used as dependent variable. DAS 28 and CDAI both showed HAQ as the parameter with the highest odds ratio (OR). But RAQoL had shown no independent indicative value for projecting disease activity. Conclusion: It was concluded that HAQ could determine disease activity in RA better than other PROs included in this study (Tab. 4, Ref. 36). Full Text in free PDF www.bmj.sk.Öğe COMPARISON OF CLINICAL FEATURES IN PATIENTS WITH PSORIATIC AND NON-PSORIATIC SPONDYLITIS(Clinical & Exper Rheumatology, 2016) Ozgocmen, S.; Cengiz, G.; Erol, K.; Gok, K.; Dagli, A. Z.; Cevik, R.; Nas, K.[Abstract Not Available]Öğe THE DIFFERENCES AND SIMILARITIES BETWEEN PATIENTS AND PHYSICIAN GLOBAL ASSESSMENT IN PATIENTS WITH PSORIATIC ARTHRITIS(Bmj Publishing Group, 2017) Nas, K.; Kilic, E.; Cevik, R.; Dagli, A. Z.; Kilic, G.; Sag, S.; Kamanli, A.[Abstract Not Available]Öğe EFFICACY OF PULSED AND CONTINUOUS THERAPEUTIC ULTRASOUND IN MYOFASCIAL PAIN SYNDROME: A RANDOMISED CONTROLLED STUDY(Bmj Publishing Group, 2014) Ilter, L.; Dilek, B.; Batmaz, I.; Ulu, M. A.; Sariyildiz, M. A.; Nas, K.; Cevik, R.[Abstract Not Available]Öğe GENDER SPECIFIC DIFFERENCES IN PATIENTS WITH PSORIATIC ARTHRITIS(Bmj Publishing Group, 2015) Nas, K.; Capkin, E.; Dagli, A. Z.; Cevik, R.; Kilic, E.; Kilic, G.; Karkucak, M.[Abstract Not Available]Öğe IL-17-22-23 PATHWAYS IN PSORIATIC ARTHRITIS AND PSORIASIS(Bmj Publishing Group, 2017) Nas, K.; Cevik, R.; Yildiz, I.; Rech, J.; Schett, G.[Abstract Not Available]Öğe Immunologic and psychosocial status in chronic fatigue syndrome(Comenius Univ, 2011) Nas, K.; Cevik, R.; Batum, S.; Sarac, A. J.; Acar, S.; Kalkanli, S.Objective: The aim of the study was to investigate the immunologic functions and psychosocial status in patients with chronic fatigue syndrome (CFS). Methods: Twenty-five patients with CFS diagnosed by the international CFS definition criteria and 20 age- and gender-matched healthy controls were recruited. Depression was assessed by Beck Depression Inventory (BDI) and health status was assessed by Nottingham Health Profile (NHP).Monoclonal antibodies (MAbs) were measured to identify the following NK cell subsets: CD3, CD4, CD8 and CD56 and cytokine measurements were performed for IL2r, IL6 and IL8 in both patients and control subjects. Results:The BDI and NHP scores of CFS group were found to be significantly higher than in the control group. The absolute numbers of CD56 cell were also significantly decreased in the patients with CFS compared with the healthy controls. There were no other significant differences of NK cell activity (CD3, CD4 and CD8) and there were significant differences in IL6 and IL2r levels between patients and controls. There were significant correlations between serum IL-6 level and sleep, social isolation and physical ability NHP subscores, and betweenCD56 NK cell activity and emotional reaction NHP sub score in CFS patients. Conclusion: Significantly higher ratios of psychological and physical disturbances were found in patients with CFS. Decreased CD56 NK cell activity and increased IL2r levels seem to be important immunopathologic changes in CFS. IL-6 and CD 56 NK cell activity may play an important role in sleep, physical, social, and physicological manifestations of CFS (Tab. 3, Fig. 1, Ref. 36). Full Text in free PDF www.bmj.sk.Öğe THE IMPACT OF ANKYLOSING SPONDYLITIS ON FEMALE SEXUAL FUNCTIONS(Wiley-Blackwell, 2014) Bozkurt, M.; Sariyildiz, M. A.; Batmaz, I; Karakoc, M.; Cevik, R.; Bozkurt, Y.; Penbegul, N.[Abstract Not Available]Öğe IMPACT OF DISEASE ACTIVITY ON PHYSICAL FUNCTION AND HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH PSORIATIC ARTHRITIS(Bmj Publishing Group, 2017) Nas, K.; Kilic, G.; Cevik, R.; Dagli, A. Z.; Kilic, E.; Sag, S.; Erkorkmaz, U.[Abstract Not Available]Öğe LEVELS PENTRAXIN 3 AND C1Q IN SYSTEMIC SCLEROSIS: ASSOCIATION WITH PULMONARY ARTERIAL HYPERTENSION AND CLINICAL FINDINGS(Bmj Publishing Group, 2017) Cevik, R.; Nas, K.; Bozan, T.; Ekinci, A.; Kamanli, A.; Tekeoglu, I.; Ayyildiz, M. O.[Abstract Not Available]Öğe Low dose of tramadol in the treatment of fibromyalgia syndrome: A controlled clinical trial versus placebo(B M J Publishing Group, 2006) Gur, A.; Calgan, N.; Nas, K.; Cevik, R.; Sarac, A. J.[Abstract Not Available]Öğe THE PREVALENCE OF RHEUMATOLOGICAL DISEASES AND PSORIASIS IN THE FIRST-DEGREE RELATIVES OF PsA PATIENTS(Clinical & Exper Rheumatology, 2018) Nas, K.; Cevik, R.; Dagli, A. Z.; Tekeoglu, I; Kamanli, A.; Sag, S.[Abstract Not Available]Öğe A prospective randomised placebo controlled clinical trial comparing the tolerability and efficacy of different molecular weight hyaluronan solutions in the treatment of knee osteoarthritis(B M J Publishing Group, 2006) Gur, A.; Bahadir, P.; Sarac, A. J.; Cevik, R.; Nas, K.[Abstract Not Available]Öğe Relation of asymmetric dimethylarginine and cardiac involvement in systemic sclerosis(Publisaude-Edicoes Medicas Lda, 2014) Dag, Sevin; Budulgan, M.; Dilek, B.; Batmaz, I; Ariturk, Z.; Nas, K.; Cevik, R.Objectives: The heart is a commonly involved organ in systemic sclerosis (SSc) and pulmonary hypertension is a commonly observed complication that is associated with poor prognosis in this disease. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthases. In this study, we aimed to contribute to an early diagnosis of cardiac involvement by evaluating ADMA and tissue Doppler echocardiographic findings in patients with SSc. Methods: 30 SSc patients without clinical cardiac symptoms and 30 controls were included. Plasma ADMA levels were measured and tissue Doppler echocardiography examination was carried out for all participants. Systolic and diastolic functions were assessed; pulmonary arterial systolic pressure and mean pulmonary arterial pressure were measured. Results: The patient and control groups demonstrated a significant difference with regard to right ventricular free wall tissue Doppler late diastolic wave, pulmonary arterial systolic pressure, right ventricular ejection fraction, and right ventricular diastolic dysfunction values. ADMA levels were significantly higher in SSc patients and also in active patients compared to inactive patients. No significant relationship between ADMA and echocardiographic parameters was found. Conclusion: Tissue Doppler echocardiography is capable of revealing impaired right ventricular functions and increased pulmonary arterial systolic pressure before the occurrence of any cardiac clinical symptoms in patients with SSc. Serum ADMA levels were increased in SSc and in patients with active disease.Öğe Serum GDF-15 level in rheumatoid arthritis: relationship with disease activity and subclinical atherosclerosis(Publisaude-Edicoes Medicas Lda, 2017) Tanrikulu, O.; Sariyildiz, M. A.; Batmaz, I; Yazmalar, L.; Polat, N.; Kaplan, I; Cevik, R.Objectives: Growth differentiation factor (GDF)-15 was originally identified as a factor secreted by activa ted macrophages, and plays an important role in cell growth and differentiation. GDF-15 plays an important role in cell growth, signal transduction, and apoptosis regulation. The aim of this study was to evaluate the serum GDF-15 levels and their relationship with di sease- related characteristics in patients with rheumatoid arthritis (RA). Materials and methods: Forty-six patients diagnosed with RA and 36 demographically matched healthy control subjects participated in this study. GDF-15 levels were measured in blood samples from patients and controls. The disease activity score-28 (DAS28) was used to evaluate the disease activity of RA. The quality of life was evaluated using the disease-specific rheumatoid arthritis quality of life (RAQoL) scale. The health assessment questionnaire (HAQ) was used to evaluate the functional status. The degree of joint damage was assessed according to Larsen's method. Atherosclerosis was assessed by a cardiologist with the help of echocardiography according to the carotid intima media thickness (CIMT) method; vascular stiffness was assessed by using the flow mediated dilatation (FMD) method. Results: Serum GDF-15 levels were significantly hi gher in RA patients when compared to the control sub jects (p< 0.05). RA patients were divided into two groups according to the disease activity; while 26 subjects (57%) were in the active group, 20 patients were in the non-active group (43%). Serum GDF-15 levels were significantly higher in the group that was considered to have an active disease. According to Pearson's correlation, serum GDF-15 levels were positively correlated with erythrocyte sedimentation rate (ESR) le vels, morning stiffness, DAS28 score, tender joint count, and CIMT (p<0.05). Conclusion: GDF-15 may play a role in the pathway of disease activity, joint involvement, and atherosclerosis in patients with rheumatoid arthritis.Öğe Ultrasonographic Measurement of the Femoral Cartilage Thickness in Patients with Behcet's Disease(Univ West Indies Faculty Medical Sciences, 2014) Batmaz, I.; Kara, M.; Tiftik, T.; Yildiz, M.; Cevik, R.; Ozcakar, L.Objective: To evaluate femoral cartilage thickness in patients with Behcet's disease (BD) by using ultrasonography. Methods: Thirty-one patients with BD (18 M, 13 F; mean age: 32.87 +/- 8.5 years) and 31 age-, gender- and body mass index-matched healthy subjects were enrolled. Demographic features and medications of the patients were recorded. The femoral cartilage thicknesses of both knees were measured with a 7-12 MHz linear probe while subjects' knees were held in maximum flexion. Three mid-point measurements were taken from both knees: lateral femoral condyle (LFC), intercondylar area (ICA) and medial femoral condyle (MFC). Results: Cartilage measurements of BD patients were significantly thinner at the ICA (p = 0.009) and LFC (p = 0.007) on the left knee, and at the MFC on both sides (both p < 0.05). Left knee cartilage thickness value at MFC (p = 0.005) was decreased in BD patients with arthritis compared to the healthy control group. Conclusion: These preliminary findings of decreased femoral cartilage thickness in BD patients with arthritis should be complemented with future studies. However, the possibility of early knee joint degeneration and eventual osteoarthritis in BD should also be kept in mind.Öğe VALIDITY OF ASDAS AND BASDAI AS A MEASURE OF DISEASE ACTIVITY IN AXIAL PSORIATIC ARTHRITIS(Clinical & Exper Rheumatology, 2014) Kilic, G.; Kilic, E.; Nas, K.; Karkucak, M.; Capkin, E.; Dagli, A. Z.; Cevik, R.[Abstract Not Available]Öğe WOMEN WITH PSORIATIC ARTHRITIS WHO ARE HOMEMAKERS OR OFFICE WORKERS DECLARE SIMILAR DIFFICULTIES DURING WORKING(Bmj Publishing Group, 2016) Kilic, E.; Kilic, G.; Nas, K.; Cevik, R.; Capkin, E.; Dagli, A. Z.; Karkucak, M.[Abstract Not Available]
