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Yazar "Celik, Yusuf" seçeneğine göre listele

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    18F-FDG PET-CT and USG/CT in benign and malignant ovarian tumors with postoperative histopathological correlation
    (Studio K, 2011) Kuyumcuoglu, Umur; Irfan, Guzel Ali; Celik, Yusuf; Erdemoglu, Mahmut; Komek, Halil
    Objectives: The role of F-18-FDG (F-18 fluorodeoxyglucose) PET/CT** (Positron emission tomography) in the diagnosis, treatment and follow up of benign and malignant ovarian tumors had been investigated previously. The objective of the following study was to evaluate the predictive value of PET/CT in benign and malignant ovarian tumors and compare with computerized tomography and post-operative pathology. Materials and methods: In this retrospective study a total of sixty nine cases with benign or malignant pelvic masses underwent laparotomy at our clinic. Postoperative pathology of the patients was recorded and PET/CT results were compared with ultrasonography, computerized tomography and postoperative pathology. Results: The ROCs and AUCs values four predictors were shown in Figure 1. The AUCs (95 % CI) values calculated for CA 125, ultrasonography (USG), PET/CT and CT were as follows: 0.855(0.752-0.958), 0.703(0.540-0.866), 0.681(0.514-0.848) and 0.631(0.463-0.799) respectively. CA 125 has the highest AUC value in order to predict the malignant potential of the patient. USG has the highest AUC value between the imaging techniques, following PET/CT and CT. Conclusion: According to this study among four modalities that distinguish malignant potential preoperatively; CA 125 is the best parameter. USG and PET provide similar benefits in detecting malignant ovarian masses preoperatively. Both of these parameters are superior to CT. Combination of CA 125, USG and PET/CT may be useful in detecting malignant ovarian masses preoperatively, resulting in less invasive surgeries. **F-18-FDG (F-18 fluorodeoxyglucose) PET/CT will be used as the PET/CT, later in this article.
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    Analysis of thrombophilic genetic mutations in patients with Sheehan's syndrome: is thrombophilia responsible for the pathogenesis of Sheehan's syndrome?
    (Springer, 2011) Gokalp, Deniz; Tuzcu, Alpaslan; Bahceci, Mithat; Ayyildiz, Orhan; Yurt, Murat; Celik, Yusuf; Alpagat, Gulistan
    The gene mutations of Factor V R506Q (FV-Leiden), prothrombin (FII G20210A), methylene tetrahydrofolate reductase (MTHFR) C677T and A1298C and PAI-1 4G/5G are well-established risk factors for thrombosis. We aimed to investigate the prevalence of these gene mutations and their possible impact on the development of pathogenesis in patients with Sheehan's syndrome (SS). 40 female patients with SS compared to a control group of 45 healthy women. The presence of FV-Leiden, FII G20210A, MTHFR C677T, MTHFR A1298C and PAI-1 4G/5G gene mutations were assessed by polymerase chain reaction analysis with a light cycler analyzer. An odds ratio of greater than one is considered to increase the risk of SS disease as found in Factor V Leiden, FII G20210A, MTHFR C677T, MTHFR A1298C and PAI-1 4G/5G polymorphism, as follows respectively: 1.13, 1.85, 6.00, 8.14 and 1.45. MTHFR C677T and MTHFR A1298C polymorphism were found significantly higher in SS patients than the control group (P < 0.001), however FV-Leiden, FII G20210A and PAI-1 4G/5G polymorphism showed no significant difference (P > 0.05). The level of plasma total homocysteine (tHcy) was significantly higher in patients with SS than in the control group (P < 0.001). We suggest that the genetic mutations of FV-Leiden, FII G20210A, MTHFR C677T, MTHFR A1298C and PAI-1 4G/5G increase the risk of SS. Also, high plasma tHcy levels may be a risk factor for the development of SS.
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    Antecedents and concomitants of parenting stress in adolescent mothers in foster care
    (Pergamon-Elsevier Science Ltd, 2009) Celik, Yusuf; Celik, Fatma
    [Abstract Not Available]
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    Antiemetics in the ED: a randomized controlled trial comparing 3 common agents
    (W B Saunders Co-Elsevier Inc, 2006) Celik, Yusuf
    [Abstract Not Available]
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    Antioxidant support in composite musculo-adipose-fasciocutaneous flap applications: An experimental study
    (Taylor & Francis Ltd, 2014) Bozkurt, Mehmet; Kapi, Emin; Kulahci, Yalcin; Gedik, Ercan; Ozekinci, Selver; Isik, Fatma Birgul; Celik, Yusuf
    Free radicals are chemicals that play roles in the etio-pathogenesis of ischaemia-reperfusion injury. Various antioxidants have been used in an attempt to mitigate the damage induced by these chemicals. In the present study, the antioxidative effects of grape seed extract (proanthocyanidin), tomato extract (lycopene), and vitamin C (ascorbic acid) on a composite re-established-flow inferior epigastric artery based rectus abdominis muscle-skin flap model on which experimental ischaemia was induced were investigated. The rats have been administered antioxidants for 2 weeks prior to the surgery and for 2 more weeks thereafter. Macroscopic, histopathological, and biochemical analyses were carried out at the decision of the experiment. It was found that flap skin island necrosis was significantly reduced in the proanthocyanidin, lycopene, vitamin C groups (p < 0.001). Statistical analyses showed significant decreases in inflammation, oedema, congestion, and granulation tissue in the proanthocyanidin and lycopene groups compared to the vitamin C and control groups (p < 0.001). When the viability rates of fat and muscle tissues were examined, significant improvements were found in the proanthocyanidin and lycopene groups in comparison to the other groups (p < 0.001). Serum antioxidant capacity measurements revealed significant differences in the lycopene group compared to all other groups (p < 0.001). It is concluded that lycopene and proanthocyanidin are protective antioxidants in rat composite muscle-skin flap ischaemia-reperfusion models.
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    Are maternal and fetal parameters related to perinatal mortality in HELLP syndrome?
    (Springer Heidelberg, 2011) Guzel, Ali Irfan; Kuyumcuoglu, Umur; Celik, Yusuf
    We designed this retrospective study to evaluate the association between maternal and fetal parameters and perinatal mortality in hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. In this retrospective study, 152 pregnancies complicated with HELLP syndrome were evaluated. Risk factors recorded were maternal age, gravidity, gestational age (weeks), systolic and diastolic blood pressure, platelet count, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), fetal weight, and Apgar scores. The association of these factors with perinatal mortality was determined. Statistical analyses were performed using the Chi-square (chi (2)) test with Yates' correction, the Student's t test, logarithmic transformation, and the logistic regression method. Ninety-two (60.52%) patients had mild preeclampsia, 46 (22.2%) had eclampsia, and 14 (15.2%) had severe preeclampsia. The fetal mortality rate was higher in eclamptic and severe preeclamptic patients (P = 0.029). No correlation was found between maternal age, laboratory values (platelet count, ALT, AST, and LDH), or systolic and diastolic blood pressure and fetal morbidity. According to the logistic regression model, fetuses with prematurity, low birth weight, and low Apgar scores (Apgar score 1 a parts per thousand currency sign 3 and Apgar score 5 a parts per thousand currency sign 5) were found to be at significant risk for perinatal mortality (P < 0.001). The odds ratios (95% CI) were 3.0 (2-5), 3.42 (1.82-6.41), 0.62 (0.44-0.86) and 4.66 (2.04-10.63), respectively. Maternal laboratory and clinical parameters were not associated with fetal mortality. Fetal prematurity, low birth weight, and low Apgar scores were significantly associated with fetal mortality. The HELLP syndrome and severe preeclampsia may be life threatening to the mother; therefore, the accepted treatment is expeditious delivery. Our study indicates that prevention of prematurity must be the main priority for the fetus in pregnancies complicated by the HELLP syndrome. This can be efficaciously achieved using glucocorticoid therapy for lung maturity and ensuring that delivery is at an experienced hospital with a multidisciplinary approach including a neonatal intensive care unit.
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    Association between adverse perinatal outcomes and amino acid levels measured with nutrient questionnaire in adolescent pregnancies
    (Lippincott Williams & Wilkins, 2016) Guzel, Ali Irfan; Cinar, Mehmet; Erkilinc, Selcuk; Aksoy, Rifat Taner; Yumusak, Omer Hamid; Celik, Fatma; Celik, Yusuf
    Background: To evaluate the maternal serum amino acid levels in first trimester adolescent pregnancies by using a new developed dietary questionnaire. Methods: A group of 169 pregnant women in the first trimester of their pregnancy were asked to complete the dietary questionnaire. Among all the women, 39 were adolescent pregnancies. The results of the questionnaire were evaluated by a nutrient database program (BeBiS software program) designed to evaluate Turkish traditional foods and commercial processed foods. Results: There was no statistically significant difference between the groups in terms of body mass index and educational and socio-economic status. The mean age and gravidity was statistically significantly lower in adolescent pregnancies. The mean isoleucine, leucine, lysine, methionine, phenylalanine, tyrosine, threonine, valine, arginine, and proline levels were statistically significantly lower in adolescent pregnancies. Receiver operating characteristic (ROC) curve analysis showed the cut-off values of these amino acids. Of these amino acids; lower values of histidine, serine, and alanine were associated with lower birth weight, and lower values of histidine and alanine were associated with preterm delivery. Conclusion: To the best of our knowledge, this is the first study evaluating the amino acid levels in adolescent pregnancies. According to this study, some amino acid levels were lower in adolescent pregnancies and associated with adverse perinatal outcomes. Further studies with maternal and perinatal outcomes are needed to demonstrate the effects of these amino acids in such pregnancies. Copyright (C) 2016, the Chinese Medical Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license.
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    Audiological Findings in Acromegaly Patients
    (Mediterranean Soc Otology & Audiology, 2011) Baylan, Muzeyyen Yildirim; Gokalp, Deniz; Celik, Yusuf; Tuzcu, Alpaslan; Meric, Faruk; Topcu, Ismail
    Objective: The aim of this study was to evaluate otologic problems in patients with acromegaly. Materials and Methods: This retrospective study was performed on 26 patients with acromegaly and 27 age-matched healthy controls. Otoscopic examination, pure tone odiometry, tympanometry, otoacoustic emissions, and stapes reflex were performed in all cases. Hearing thresholds of air and bone conduction (AC and BC), middle ear function, cochlear function, tympanic membrane compliance, gradient, peak pressure, and external ear canal volume were researched in patients with acromegaly. Results: The hearing thresholds for all frequencies except Right-AC 4000 frequencies were found to be significantly higher in patients with acromegaly as compared to the control group (p<0.05). Also significant correlation coefficients were calculated among disease duration, hearing thresholds, and tympanometric variables (p<0.05). There was a significant difference in tympanometry results between the two groups in regard to external ear canal volumes of the right and left ears (p <= 0.05). No differences were observed between the two groups in their type of tympanometry, stapes reflex, and otoacoustic emissions (OAE) (p>0.05). Conclusions: We have determined that patients with acromegaly have lower levels of hearing in both bone and air conduction compared with the normal population. This may be ascribed to deformation of hearing physiology related to hypertrophy in the temporal bone.
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    Bacterial colonization due to increased nurse workload in an intensive care unit
    (Elsevier Science Inc, 2015) Aycan, Ilker Onguc; Celen, Mustafa Kemal; Yilmaz, Ayhan; Almaz, Mehmet Selim; Dal, Tuba; Celik, Yusuf; Bolat, Esef
    Introduction: the rates of multiresistant bacteria colonization or infection (MRB+) development in intensive care units are very high. The aim of this study was to determine the possible association between the risk of development of nosocomial infections and increased daily nurse workload due to understaffing in intensive care unit. Methods: we included 168 patients. Intensity of workload and applied procedures to patients were scored with the Project de Recherche en Nursing and the Omega scores, respectively. The criteria used for infections were those defined by the Centers for Disease Control. Results: of the 168 patients, 91 (54.2%) were female and 77 (45.8%) were male patients. The mean age of female and male was 64.9 +/- 6.2 years and 63.1 +/- 11.9 years, respectively. The mean duration of hospitalization in intensive care unit was 18.4 +/- 6.1 days. Multiresistant bacteria were isolated from cultures of 39 (23.2%) patients. The development of MRB+ infection was correlated with length of stay, Omega 1, Omega 2, Omega 3, Total Omega, daily PRN, and Total PRN (p < 0.05). There was no correlation between development of MRB+ infection with gender, age and Apache-II scores (p > 0.05). Conclusion: the risk of nosocomial infection development in an intensive care unit is directly correlated with increased nurse workload, applied intervention, and length of stay. Understaffing in the intensive care unit is an important health problem that especially affects care-needing patients. Nosocomial infection development has laid a heavy burden on the economy of many countries. To control nosocomial infection development in the intensive care unit, nurse workload, staffing level, and working conditions must be arranged. (C) 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.
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    Can elevated prolidase activity predict the duration of ischemic exposure in different types of ischemia?
    (Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2013) Yavuz, Celal; Guclu, Orkut; Demirtas, Sinan; Karahan, Oguz; Yazici, Suleyman; Caliskan, Ahmet; Celik, Yusuf
    Background: This study aims to determine the relationship between serum prolidase activity and ischemia duration in different ischemia types. Methods: Forty male Sprague Dawley rats were divided into five equal groups. The rats were sacrificed and blood samples were obtained to determine the basal serum prolidase levels in group 1 (control group) without any intervention. In groups 2 and 3, the superior mesenteric arteries were clamped with simple laparotomy to induce mesenteric ischemia. In groups 4 and 5, the right common femoral artery was clamped to induce peripheral ischemia and blood samples were taken at 120 and at 360 minutes, respectively. The serum prolidase levels were measured using the samples obtained from each group. Results: The basal prolidase level in rats was found to be 266.8 +/- 20.5 U/L. The serum prolidase levels increased after two-hours of peripheral (404.0 +/- 105.6 U/L) and mesenteric ischemia (317.1 +/- 121.4 U/L). However, the serum prolidase levels decreased after six-hours of peripheral (346.1 +/- 104.9 U/L) and mesenteric ischemia (233.4 +/- 36.6 U/L). Although the serum prolidase levels were elevated in the second hour of mesenteric ischemia, they were lower than the enzyme levels obtained after two-hours of peripheral ischemia (p=0.006). Conclusion: The serum prolidase level may be an important predictive biomarker for identifying the duration of ischemia.
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    Changes in the loading of tibial articular cartilage following medial meniscectomy: a finite element analysis study
    (Springer, 2013) Atmaca, Halil; Kesemenli, Cevdet Cumhur; Memisoglu, Kaya; Ozkan, Arif; Celik, Yusuf
    Depending on the location and extent of the meniscectomy, loading on the tibial articular cartilage alters. The main purpose of the present study was to analyze the loading on the tibial articular cartilage following medial meniscectomy performed in various location and extent, as well as in the healthy knee, via finite element analyses on the solid models. Totally, 11 finite element solid models, including the reference model, were created to investigate the effect of location (anterior, posterior, longitudinal) and extent of meniscectomy (25, 50, 75, and 100 %) on loading of tibial articular cartilage. Maximum equivalent stress of the tibial cartilage was measured 0.86 Megapascal in the reference model and increased approximately by 78 % in 25 % meniscectomy group, 177.9 % in 50 %, 473.8 % in 75 % meniscectomy group, and 752.6 % in total meniscectomy. When only the amount of meniscal tissue removed was considered ignoring the location of meniscectomy, no significant difference was found in the amount of tissue excised between 25 % meniscectomy and 50 % meniscectomy, as well as between 75 % meniscectomy and total meniscectomy. In all meniscectomy models, the loadings on tibial articular cartilage increased. Except total meniscectomy, the highest impact was observed in longitudinal 75 % meniscectomy. During the surgical treatment, the contributions of menisci on load absorption by increasing the tibiofemoral contact area must be considered. In fact, the increase in the rate of loading on tibial articular cartilage depends on according to type and amount of meniscectomy.
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    Comparison of hysterosalpingography and laparoscopy in the evaluation of infertile women
    (Saudi Med J, 2008) Sakar, Mehmet N.; Gul, Talip; Atay, Ahmet E.; Celik, Yusuf
    Objective: To compare tuboperitoneal factors of infertile women by hysterosalpingography (HSG) and laparoscopy. Methods: In this cohort study, 82 infertile cases were evaluated retrospectively by laparoscopy, 3 months subsequent to HSG in the Department of Gynecology and Obstetrics, Medical School of Dicle University, Diyarbakir, Turkey, between March 2004 and April 2006. The findings of HSG and laparoscopy were compared. Results: Out of the 82 infertile women, pathological findings were observed in 45.1% by HSG, and 54.9% had no pathological finding. On laparoscopic evaluation, however, pathological findings were observed in 65.85%, and 34.15% had no pathological findings. The pathological findings were detected by laparoscopy in 20 of the 45(44.4%) patients who had no pathological findings by HSG, and no pathological findings were detected by laparoscopy in 3 of the 37 (8.1%) patients who had pathological findings by HSG. Laparoscopy revealed no pathological findings in 6 of the 35 patients who had tubal pathology by HSG. The sensitivity of HSG was 63%, specificity was 89.3%, and the positive predictive value was 92%, with a 55% predictive value, and the accuracy ratio was 72%. Conclusion: Laparoscopy is a superior method for the research of tubal and pelvic pathologies in the evaluation of infertility. However, HSG is a more economical and elementary method suitable for evaluation of endometrial and tubal pathologies, and laparoscopy is an appropriate method for examining the external part of tubae, fimbriae, the relation of tuba and ovary, endometriosis, adhesions, tuberculosis, and other pathologies. Therefore, these 2 methods are not alternative, but complementary.
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    Comparison of the risk factors for adverse perinatal outcomes in adolescent age pregnancies and advanced age pregnancies
    (Studio K, 2012) Kuyumcuoglu, Umur; Guzel, Ali Irfan; Celik, Yusuf
    Objectives: To evaluate clinical outcomes of pregnancies in adolescent, advanced and reproductive women maternal age. Materials and methods: A total of 187 pregnant women were included into the study 51 (27.27%) were adolescent pregnancies, mean age 17.7 +/- 3.3 years (range, 14-18 years), 40 (21.29 %) advanced maternal age pregnancies, mean age 41.4 +/- 2.6 years (range, 39-50 years) and 96 (51.33 %), healthy controls, mean age 28.8 +/- 4.3 years (range, 19-37 years). The majority of the adolescent pregnant women were nulliparous, while all of the advanced age pregnant women were multiparous (mean gravidity 4.5 +/- 2.4; range, 6-12). Mean gravidity of the control group was 3.6 +/- 1.7 (range, 1-12). Results: There was statistically significant difference among the groups regarding demographic characteristics. According to the Bonferroni method, there was statistically significant difference among the three groups. Adverse fetal features were statistically different among the groups and the odd ratios were higher in the advanced maternal age group. The odds ratios (95% Cl) for lower Apgar scores (Apgar score 1 and 5) and low birth weight in adolescent maternal age and advanced maternal age group were as follows: 1.88 (127 - 2.78) vs. 2.46 (1.55 - 3.85), 2.17 (1.18 - 4.00) vs. 4.79 (3.02 - 6.69) and 1.39 (1.14 - 1.68) vs. 3.06 (1.59 - 5.88), respectively Gestational age at birth showed minimal risk for adolescent age group but no risk was noted in the advanced age group. Conclusions: The present study showed that pregnancies in adolescent maternal age, advanced maternal age and reproductive maternal age are different from each other in terms of clinical characteristics. According to this study advanced maternal age pregnancies are more risky and more likely to have adverse fetal outcome.
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    Conjunctival-limbal autograft, amniotic membrane transplantation, and Intraoperative mitomycin C for primary pterygium
    (Humana Press Inc, 2007) Keklikci, Ugur; Celik, Yusuf; Cakmak, Sevin Soker; Unlu, M. Kaan; Bilek, Bagdagul
    We evaluated and compared the safety and efficacy of the conjunctival-limbal autograft, amniotic membrane transplantation, and intraoperative application of mitomycin C in 94 patients undergoing primary pterygium surgery and concluded that conjunctival-limbal autografting and amniotic membrane methods were more effective and safer than intraoperative mitomycin C.
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    Continuing Diagnostic and Therapeutic Challenges in Gallbladder Polyps
    (Southeastern Surgical Congress, 2013) Arikanoglu, Zulfu; Taskesen, Fatih; Aliosmanoglu, Ibrahim; Gul, Mesut; Gumus, Hatice; Celik, Yusuf; Tas, Ilhan
    [Abstract Not Available]
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    Diagnostic value of screening tests in subgroups of women with recurrent pregnancy loss
    (Taylor & Francis Ltd, 2015) Guzel, Ali Irfan; Erkilinc, Selcuk; Ozer, Irfan; Celik, Yusuf; Yilmaz, Nafiye; Doganay, Melike
    Objective: To evaluate the diagnostic value of screening laboratory tests in women who had recurrent pregnancy loss (RPL). Methods: A total of 252 women with RPL managed in our tertiary referral research and education hospital were included in the study. Risk factors recorded involved age, gravidity, parity, number of prior live births, number of pregnancy losses, and thrombophlia tests. The cases were divided into three different groups and each group was analyzed separately. Results: There was no statistically significant difference between the first and second groups in terms of clinical and laboratory parameters (p>0.05). In the third group, there was a statistically significant difference among cases in terms of parity, gravidity, number of pregnancy losses, serum AT III levels, APCR, and age of the women. According to the logistic regression model, odds ratios (95% CI) were 6.116 (3.797-9.852), 5.665 (2.657-12.079), 4.763 (3.099-7.321), 4.729 (3.080-7.260), 2.820 (1.836-4.333), and 1.911 (1.232-2.965), respectively. Conclusions: We do not recommend the screening of all women with RPL, but in women with high parity and those who had prior live birth pregnancies, increased AT III, and APCR may be diagnostic markers for subsequent pregnancy loss.
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    Dietary antioxidant levels in hyperemesis gravidarum: A case control study
    (Via Medica, 2011) Celik, Fatma; Irfan, Guzel Ali; Kuyumcuoglu, Umur; Celik, Yusuf
    Objectives: Dietary antioxidant intake decreases the risk of many diseases. Hyperemesis gravidarum (HG) is the most common eating disorder during pregnancy Therefore, the authors conducted this prospective and case control study to evaluate dietary antioxidant levels of women with HG and compare with healthy pregnant women. Material and Methods: This prospective case control study was conducted at a government hospital in the southeastern region of Turkey from February 2010 to May 2010. A total of 100 pregnant women were included into the study Dietary antioxidant levels (DAL) were measured according to the new 92-item antioxidant nutrient questionnaire developed by Satia et al (1). 50 women with HG and 50 healthy pregnant women were evaluated. Statistical analyses were carried out with statistical packages for SPSS 15.0 for Windows (SPSS Inc., Chicago, IL, USA). Results: There were no statistically significant differences between the groups regarding the age of the patients, gestational age, educational status, body height and weight (p >.05). Vitamin E, E equivalent, vitamin C, carotene and vitamin A levels were significantly lower in women with HG (p <.05). The results of logistic regression method for these variables including odds ratio (95 % CI) were as follows: 10.07(1.52-66.51), 7.37(2.66-20.41), 4.26(2.66-20.41), 3.66(2.38-5.63) and 2.75 (1.56-4.85), respectively Conclusion: According to this study vitamin E, E equivalent, vitamin C, carotene and vitamin A levels of women may play a role in the pathogenesis of HG. Therefore, diet recommendations should be given by clinicians before pregnancy
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    Differentiation of Tuberculous Peritonitis from Peritonitis Carcinomatosa without Surgical Intervention
    (Medknow Publications & Media Pvt Ltd, 2011) Kaya, Muhsin; Kaplan, Mehmet A.; Isikdogan, Abdurrahman; Celik, Yusuf
    Background/Aim: Ascites of tuberculous peritonitis (TBP) is an exudative type and may well be misdiagnosed as carcinomatous peritonitis, especially in the elderly. The aim of this study was to identify independent predictors that can differentiate TBP from peritonitis carcinomatosa without surgical intervention. Patients and Methods: This prospective cohort study was performed on 75 subjects in the following groups: TBP (n=27) (TBP group), ovarian cancer complicated with ascites (n=24) (Ov Ca group), and gastric cancer complicated with ascites (n=24) (Ga Ca group). The frequency of clinical symptoms, laboratory parameters, and serum tumor markers levels were compared. Results: In univariate analysis; fever, night sweats, and abdominal pain were significantly more frequent in the TBP group compared to those in the Ov Ca group (P < 0.001, P < 0.001, and P = 0.035, respectively) and the Ga Ca group (P < 0.001, P < 0.001, and P = 0.015, respectively). Serum CA 19-9 and carcino embryonic antigen (CEA) levels were significantly lower in the TBP and Ov Ca group compared to the Ga Ca group (P < 0.001 and P < 0.001, respectively). Elevated serum CA 125 level was found in all patients with TBP and Ov Ca and in 86.6% of patients with Ga Ca. In the multivariate analysis, presence of fever (P < 0.001), night sweats (P < 0.001), age under 40 years (P = 0.008), and normal serum CA 19-9 level (P = 0.044) were independent predictor of diagnosis of TBP. Conclusion: The presence of fever, elevated serum CA 125 level, normal serum CA 19-9, and CEA associated with lymphocyte predominant benign ascites may establish the diagnosis of TBP.
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    EFFECTIVENESS OF MEDIA MEDIATED INFORMATION AND AWARENESS PROJECT OF HEPATITIS B ON DIAGNOSIS, MONITORING AND TREATMENT OF HEPATITIS B
    (Carbone Editore, 2013) Dal, Tuba; Celen, Mustafa Kemal; Ulas, Sevilay; Celik, Yusuf
    Background: Incidence of hepatitis B is 8-12% in Southeastern Anatolia Region of Turkey. In Diyarbakir, Batman, Siirt, Mardin, which are residential areas with a population of 2.2 million, 95000-144000 persons are suffering from this infectious disease. We aimed to increase the awareness of the public about Hepatitis B through the media, to monitor the impact of this disease on patients, and to determine prevention and treatment strategy. Methods: In four cities, 12 television programs lasting about 60-90 minutes, have been broadcasted 60 days apart between 01.01.2010-31.12.2011. At the same time, in a local newspaper, which was read in the whole region, a corner of hepatitis B formed and different topics, opinions, problems, and wrong treatment methods were discussed in, one day a week. Results: Admission of Diyarbakir patients to Dicle University Hospital was increased by 19% and Batman patients was increased by 23%. A significant difference (p < 0.028) was observed in the number of patients admitted to the infectious diseases clinic for hepatitis B. between the years 2009-2011. Conclusion: Continuous media programs, especially in areas with low levels of socioeconomic status will be effective in diagnosis of new cases, monitoring and treatment, preventing of disease, and preventing of the spread.
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    The Effectiveness of Scoring Systems and Various Biochemical Parameters in Predicting Survival in a Respiratory Intensive Care Unit
    (Turkish Biochem Soc, 2010) Yildiz, Tekin; Gundogus, Baran; Ates, Guengoer; Akyildiz, Levent; Celik, Yusuf; Topcu, Fuesun; Canoruc, Naime
    Aim: The aim of the present study was to compare various clinical and biochemical parameters, Acute Physiological and Chronic Health Evaluation II (APACHE II), and Sequential Organ Failure Assessment (SOFA) for their effectiveness in distinguishing surviving and non-surviving patients who had acute respiratory failure (ARF) while in the Respiratory Intensive Care Unit (RICU). Materials and Methods: A prospective observational clinical study was carried out in the RICU of the Chest Disease Clinic. One hundred and sixteen patients were observed. Laboratory parameters and scoring points for the first 24 hours were recorded. Patients' demographic characteristics, biochemical parameters, length of stay at the RICU, and GCS, APACHE II and SOFA scores were also recorded. The primary outcome of the current study was the mortality rate in the RICU. Results: Mortality rate was determined to be 39.6% (46 patients) of 116 patients, although the predicted mortality rate was 49.7 %. There was a statistically significant difference between surviving and non-surviving patients in terms of SOFA (p=0.004, OR=1.33, CI=1.10-1.61), INR (p = 0.02, OR = 3.95, CI = 1.30-12.07), albumin (p=0.02, OR=2.58, CI=1.17-5.64), and PCO2 levels (p=0.005, OR=1.04, CI=1.01-1.06), respectively. Conclusion: Our results suggest that the mortality rate may be higher when SOFA, INR, albumin and PCO2 abnormalities are seen. Co-morbidities such as non-pulmonary organ dysfunction and metabolic disorders other than respiratory failure may have contributed additionally to increased mortality risk for patients who were admitted to the RICU. These parameters should be taken into account when ARF patients are admitted to the RICU.
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