Yazar "Canoruc, Naime" seçeneğine göre listele

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    Analysis of inherited thrombophilic mutations and natural anticoagulant deficiency in patients with idiopathic portal hypertension
    (Springer, 2009) Bayan, Kadim; Tuzun, Yekta; Yilmaz, Serif; Canoruc, Naime; Dursun, Mehmet
    Idiopathic portal hypertension (IPH) is characterized by non-cirrhotic presinusoidal intrahepatic portal hypertension. The etiopathogenesis of the disease is poorly understood. Obliteration with microthrombosis of the small portal vein branches may lead to lesions underlying portal hypertension. We aimed to put forward a comprehensive thrombophilic mutation profile in IPH and its probable contribution to pathogenesis. Eleven patients and 12 controls were included. We used the CVD-StripAssay which is based on the reverse-hybridization principle to identify a total of 12 thrombophilic gene mutations: Factor V R506Q, Factor V H1299R, prothrombin G20210A, Factor XIII V34L, beta-Fibrinogen -455 G-A, PAI-1 4G/5G, platelet GPIIIa L33P, MTHFR C677T, MTHFR A1298C, ACE I/D, Apo B R3500Q and Apo E2/E3/E4, respectively. We also evaluated some blood parameters and protein C, protein S, AT-III levels using commercially available assays. IPH patients and controls were similar in respect to gender distribution (P = 1.000). Mean age was 31.2 in patients and 29.1 in controls (P = 0.622). Pica history was present in 54.5% of the patients. Mean protein C and AT-III levels were lower in patients than that of controls (P = 0.002 and 0.001, respectively). Factor XIII V34L, PAI-1, GPIIIa L33P, MTHFR C677T and MTHFR A1298C frequencies of genetic polymorphisms were found to be significantly higher among patients than that of controls. Apolipoprotein E2/E3/E4 analysis showed an inverse relationship with IPH when E2 plus E4 compared with E3. A higher frequency of Beta-Fibrinogen -455G-A mutation was observed in patients, but this difference did not reach a statistical significance. Our data represent the most comprehensive study to date with respect to thrombophilic gene polymorphisms in IPH. The data support a possible pathogenetic role in IPH, at least by some of the prothrombotic mutations. In order to confirm or refuse this proposal, a larger cohort of patients is needed.
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    The Effectiveness of Scoring Systems and Various Biochemical Parameters in Predicting Survival in a Respiratory Intensive Care Unit
    (Turkish Biochem Soc, 2010) Yildiz, Tekin; Gundogus, Baran; Ates, Guengoer; Akyildiz, Levent; Celik, Yusuf; Topcu, Fuesun; Canoruc, Naime
    Aim: The aim of the present study was to compare various clinical and biochemical parameters, Acute Physiological and Chronic Health Evaluation II (APACHE II), and Sequential Organ Failure Assessment (SOFA) for their effectiveness in distinguishing surviving and non-surviving patients who had acute respiratory failure (ARF) while in the Respiratory Intensive Care Unit (RICU). Materials and Methods: A prospective observational clinical study was carried out in the RICU of the Chest Disease Clinic. One hundred and sixteen patients were observed. Laboratory parameters and scoring points for the first 24 hours were recorded. Patients' demographic characteristics, biochemical parameters, length of stay at the RICU, and GCS, APACHE II and SOFA scores were also recorded. The primary outcome of the current study was the mortality rate in the RICU. Results: Mortality rate was determined to be 39.6% (46 patients) of 116 patients, although the predicted mortality rate was 49.7 %. There was a statistically significant difference between surviving and non-surviving patients in terms of SOFA (p=0.004, OR=1.33, CI=1.10-1.61), INR (p = 0.02, OR = 3.95, CI = 1.30-12.07), albumin (p=0.02, OR=2.58, CI=1.17-5.64), and PCO2 levels (p=0.005, OR=1.04, CI=1.01-1.06), respectively. Conclusion: Our results suggest that the mortality rate may be higher when SOFA, INR, albumin and PCO2 abnormalities are seen. Co-morbidities such as non-pulmonary organ dysfunction and metabolic disorders other than respiratory failure may have contributed additionally to increased mortality risk for patients who were admitted to the RICU. These parameters should be taken into account when ARF patients are admitted to the RICU.
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    Electron paramagnetic resonance of some ?-irradiated amino acid derivatives
    (Walter De Gruyter Gmbh, 2006) Zincircioglu, S. Burhanedtin; Canoruc, Naime; Osmanoglu, Semsettin; Baskan, M. Halim; Dicle, I. Yesim; Aydin, Murat
    gamma-Irradiated powders of N-acetyl-L-arginine, N-alpha-carbamyl-L-arginine, N-glycyl-L-leucine and glycyl-L-alanine were investigated at room temperature by electron paramagnetic resonance. The observed species in N-acetyl-L-arginine and Na-carbamyl-L-arginine were attributed to the CH2CHNHCNHNH2 radical, and those in N-glycyl-L-leucine and glycyl-L-alanine powders to (CH3)(2)(CCH2 and CH3CHCOOH radicals.
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    Increased cortisol level in type 1 diabetic patient may lead decreasing of bone mineral density
    (Nature Publishing Group, 2007) Tuzcu, Alpaslan; Bayer, Semir; Arikan, Senay; Gokalp, Deniz; Bahceci, Mithat; Canoruc, Naime
    [Abstract Not Available]
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    A New and Practical Aspartate Aminotransferase Test in Vaginal Washing Fluid for the Detection of Preterm Premature Rupture of Membranes
    (Karger, 2008) Kale, Ebru; Kuyumcuoglu, Umur; Kale, Ahmet; Guezel, Ali Irfan; Canoruc, Naime
    Objectives: To determine whether measurement of aspartate aminotransferase (Ast) and alanine aminotransferase (Alt) levels in vaginal fluid is useful for the diagnosis of preterm premature rupture of membranes (PPROM). Study Design: The PPROM group and normal pregnancy group consisted of 36 and 48 pregnant patients between 26 and 36 weeks' gestation, respectively. Vaginal fluid Ast and Alt levels were measured in both groups. Results: Vaginal fluid Alt level was not statistically significant in the PPROM group as compared with the control group (p = 0.064). Vaginal Ast level was statistically significant in the PPROM (14.4 +/- 17.46 U/l) group as compared with the control group (3.08 +/- 7.8 U/l; p = 0.001). The optimal cutoff value of 3 IU/l for Ast gave a sensitivity level of 91% at a specificity of 83%, with positive and negative predictive values of 80 and 93%, respectively. Conclusion: Ast measurement from vaginal washing fluid appears to be a useful marker for the detection of PPROM. Copyright (C) 2008 S. Karger AG, Basel
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    Plasma resistin and leptin levels in overweight and lean patients with rheumatoid arthritis
    (Tubitak Scientific & Technological Research Council Turkey, 2009) Canoruc, Naime; Kale, Ebru; Turhanoglu, Ayse Dicle; Ozmen, Sehmus; Ogun, Ceyla; Kaplan, Abdurahman
    Aim: Adipocytokines; are now considered important players in the etiopathogenesis of numerous metabolic and inflammatory disorders. However, plasma leptin and resistin levels in rheumatoid arthritis (RA) are still unclear. We aimed to investigate the plasma levels of leptin and resistin in patients with rheumatoid arthritis and to compare them with controls. Materials and Methods: Consecutive 52 patients with RA were compared with 52 control subjects in terms of mean leptin and resistin levels. Results: Patients with RA showed considerably higher plasma levels of leptin (34.3 +/- 27.9 vs. 11.1 +/- 4.1) and resistin (4.8 +/- 0.7 vs. 4.0 +/- 1.3) than healthy controls (P < 0.0001). There was no significant difference regarding age, duration of disease, sex, CRP, and leptin and resistin levels between overweight and lean RA Subjects. Plasma leptin level was significantly correlated with ESR (Erythrocyte Sedimentation Rate) (r = 0.287, P = 0.039) and swollen and tender joint count (r = 0.563, P < 0.0001) but not with resistin in subjects with RA. Measuring the plasma leptin level may be a potential marker of disease activity in RA. Conclusions: Studies including more RA patients might be needed to define the role of leptin and resistin in RA subjects.
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    Ultrastructural evaluation of the effects of cinnamon on the nervus ischiadicus in diabetic rats
    (Riyadh Armed Forces Hospital, 2009) Bahceci, Selen; Aluclu, Mehmet U.; Canoruc, Naime; Bahceci, Mithat; Akkus, Murat; Baran, Sedat; Gokalp, Deniz
    Objective: To investigate the effects of oral cinnamon supplementation on the nervus ischiadicus at the electron microscopical level in rats. Methods: This study was performed between 20042006 in Dicle University School of Medicine, Diyarbakir, Turkey in 15 adult Sprague-Dawley rats. Rats were divided into 3 groups; control (C) (n=5), diabetic without cinnamon (D) (n=5), and diabetic with cinnamon (D-C) (n=5). Diabetes was induced with intraperitoneal alloxan administration. All diabetic rats were treated with human insulin. AN rats were fed with standard pellet chow. The D-C group rats were fed with standard pellet chow plus Cinnamomum cassia at the dose of 400mg/kg. All rats were sacrificed after 3 months and we obtained the nervus ischiadicus of all rats. Contrast stained thin sections evaluated by Jeol-TEM-1010 electron microscope, were not statistically different in both groups and photo samples were obtained. Results: Mean blood glucose, hemoglobin AlC, and lipid profile were not statistically different in both groups. Marked detachment of myelin lamellae at Schmidt-Lanterman clefts, lysis in cristae mitochondrialis and degenerative changes, severe dispersion of organelles in neurolemma, mesoaxon region, and remarkable edema at the endoneurium were found in diabetic rats. On the contrary, mesoaxon, nucleus, nucleolus and myelin sheet were almost of normal appearance at the ultra-structural level in the D-C group. Conclusions: Cinnamon extracts may have beneficial effects on the development of diabetic neuropathy in alloxan induced diabetic rats.