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    Acil ünitesine intihar girişimi nedeniyle başvuran olguların değerlendirilmesi: Şanlıurfa örneklemi
    (Turkish Association for Psychopharmacology, 2014) Atlı, Abdullah; Uysal, Cem; Kaya, Mehmet Cemal; Bulut, Mahmut; Güneş, Mehmet; Karababa, İbrahim Fatih; Bez, Yasin; Beşaltı, Sever; Sır, Aytekin
    Amaç: İntihar, istemli olarak kişinin yaşamına son vermesidir. Dünya Sağlık Örgütüne göre her yıl bir milyondan fazla insan intihar etmektedir ve dünyada yaşanan ölümlerin %2’si intihar nedeniyledir. Ülkemizde 2011 yılı istatistiklerine göre 2677 kişi intihar etmiştir ve kaba intihar hızı %3.62 olarak bulunmuştur. Bu çalışmada amacımız Şanlıurfa ilinde intihar girişimi nedeni ile acil servise başvuran hastaların özelliklerini ortaya koymaktır. Yöntem: Çalışmamız geriye dönük bir çalışma olup, Şanlıurfa ilindeki Balıklıgöl Devlet Hastanesi acil servisine intihar girişimi nedeniyle başvuran bireyler çalışmaya dâhil edildi. Bireylerin tıbbi kayıtlarındaki bazı klinik ve fenomenolojik özellikleri incelenmiştir. Bulgular: 2011 yılı içinde hastane acil servisine 227 kişinin intihar girişimi nedeni ile başvurduğu anlaşılmıştır. Başvuranların 177’si (%78) kadın, 78’i (%22) erkekti. Hastaların %57’si 15-24 yaş aralığındaydı ve %51’i evliydi. En sık intihar şeklinin yüksek doz ilaç alma olduğu tespit edilmiştir. İntihar girişimlerinin yaklaşık yarısının (%49.8) 16-24 saatleri arası gerçekleştirildiği görülmüştür. En sık intihar nedeni ise aile içi sorunlar olarak bildirilmişti (%37.9). Sonuç: Araştırmamızdaki acil servise intihar girişimi nedeni ile yapılan başvuruların yarısından fazlasının evli ve 15-24 yaş aralığında olması bu bölgede aile içi sorunların intihar girişimleri için önemli bir risk etmeni olduğunu düşündürmektedir. En sık intihar nedeni olarak aile içi sorunların bildirilmiş olması bu düşünceyi destekler niteliktedir. İntihar girişimleri açısından depresyon, borderline kişilik özellikleri, fiziksel-cinsel travma, impulsivite gibi psikiyatrik rahatsızlıklarla beraber aile içi sorunlar ve eşler arası geçimsizlik gibi sosyal etmenler önemli yer tutmaktadır. Sonuç olarak; çalışmamızın verileri bir bütün olarak incelendiğinde ve Türkiye’nin diğer bölgelerinde yapılan benzer çalışmalarla karşılaştırıldığında; evli olmak, genç olmak, eğitim düzeyinin düşük olması ve aile içi sorunlar ile intihar girişimleri arasında ilişki bulunmaktadır. Yetkili kurumların bazı önlemler almasının intihar girişimlerini azaltmada etkili olabileceği düşünülmektedir.
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    Acute unilateral myopia induced by add-on aripiprazole: A case report
    (2016) Bulut, Mahmut; Atli, Abdullah; Kaya, Mehmet Cemal; Demir, Süleyman; İbiloğlu, Aslıhan Okan; Güneş, Mehmet; Yüksel, Harun
    The partial agonist aripiprazole is a novel atypical antipsychotic with a relatively safer side effect profile. Acute unilateral myopia is a very rare condition that is commonly associated with drug use. Here, we present a woman diagnosed with obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) who have been treated for two years in our clinic. She was on fluoxetine (Prozac) 80 mg/day when adding aripiprazole (Abilify) 10 mg/day as an augmentation agent has triggered unilateral myopia. After cessation of aripirazole her myopia has disappeared. Psychiatrists should keep in mind that unilateral myopia as a side effect may develop after combining aripiprazole with fluoxetine in patients with OCD and MDD.
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    Acute Unilateral Myopia Induced by Add-On Aripiprazole: A Case Report
    (Kure Iletisim Grubu A S, 2016) Gunes, Mehmet; Demir, Suleyman; Bulut, Mahmut; Kaya, Mehmet Cemal; Atli, Abdullah; Ibiloglu, Aslihan Okan; Yuksel, Harun
    The partial agonist aripiprazole is a novel atypical antipsychotic with a relatively safer side effect profile. Acute unilateral myopia is a very rare condition that is commonly associated with drug use. Here, we present a woman diagnosed with obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) who have been treated for two years in our clinic. She was on fluoxetine (Prozac) 80 mg/day when adding aripiprazole (Abilify) 10 mg/day as an augmentation agent has triggered unilateral myopia. After cessation of aripirazole her myopia has disappeared. Psychiatrists should keep in mind that unilateral myopia as a side effect may develop after combining aripiprazole with fluoxetine in patients with OCD and MDD.
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    Altered lipid peroxidation markers are related to post-traumatic stress disorder (PTSD) and not trauma itself in earthquake survivors
    (Springer Heidelberg, 2016) Atli, Abdullah; Bulut, Mahmut; Bez, Yasin; Kaplan, Ibrahim; Ozdemir, Pinar Guzel; Uysal, Cem; Selcuk, Hilal
    The traumatic life events, including earthquakes, war, and interpersonal conflicts, cause a cascade of psychological and biological changes known as post-traumatic stress disorder (PTSD). Malondialdehyde (MDA) is a reliable marker of lipid peroxidation, and paraoxonase is a known antioxidant enzyme. The aims of this study were to investigate the relationship between earthquake trauma, PTSD effects on oxidative stress and the levels of serum paraoxonase 1 (PON1) enzyme activity, and levels of serum MDA. The study was carried out on three groups called: the PTSD group, the traumatized with earthquake exercise group, and healthy control group, which contained 32, 31, and 38 individuals, respectively. Serum MDA levels and PON1 enzyme activities from all participants were measured, and the results were compared across all groups. There were no significant differences between the PTSD patients and non-PTSD earthquake survivors in terms of the study variables. The mean PON1 enzyme activity from PTSD patients was significantly lower, while the mean MDA level was significantly higher than that of the healthy control group (p < 0.01 for both measurements). Similarly, earthquake survivors who did not develop PTSD showed higher MDA levels and lower PON1 activity when compared to healthy controls. However, the differences between these groups did not reach a statistically significant level. Increased MDA level and decreased PON1 activity measured in PTSD patients after earthquake and may suggest increased oxidative stress in these patients. The nonsignificant trends that are observed in lipid peroxidation markers of earthquake survivors may indicate higher impact of PTSD development on these markers than trauma itself. For example, PTSD diagnosis seems to add to the effect of trauma on serum MDA levels and PON1 enzyme activity. Thus, serum MDA levels and PON1 enzyme activity may serve as biochemical markers of PTSD diagnosis.
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    Anxiety, depression, sexual dysfunction and quality of life in prostate cancer based on stage of the disease
    (Yerkure Tanitim & Yayincilik Hizmetleri A S, 2013) Kaya, Mehmet Cemal; Bez, Yasin; Demir, Aslan; Bulut, Mahmut; Topcuoglu, Volkan; Kuscu, Mehmet Kemal; Turkeri, Niyazi Levent
    Background: Prostate cancer is common in men and in many studies quality of life, mental health problems and sexual dysfunction were examined in this population. However, there are relatively few studies examining the impact of the disease according to the stages. In this study we aimed to compare the levels of anxiety, depression, quality of life and sexual dysfunction of the prostate cancer patients according to their stages. Method: 80 patients with prostate cancer who applied to urology outpatient clinic were enrolled to the study. Patients were divided into three groups according to their stages; localized/organ-confined, local spread and metastatic spread. Short Form 36 (SF-36), Hospital Anxiety and Depression Scale (HAD) and the Arizona Sexual Experience Scale (ASEX) were performed. Results: According to the stage of prostate cancer, physical functioning subscale of quality of life was significantly lower in patients with metastatic prostate cancer than in patients with organ-confined prostate cancer (F=4.53, p=0.014). There were no associations between anxiety and depression scores and the stage of prostate cancer. Sexual desire was better in organ-confined prostate cancer patients compared to metastatic prostate cancer patients (F=5.32, p=0.007). Conclusion: The patients with prostate cancer might have different levels of physical functioning and sexual aversion problems at different stages of the disease. The clinicians should consider these two issues during follow-up of these patients.
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    Are oxidative stress markers useful to distinguish schizoaffective disorder from schizophrenia and bipolar disorder?
    (Cambridge Univ Press, 2014) Bulbul, Feridun; Virit, Osman; Alpak, Gokay; Unal, Ahmet; Bulut, Mahmut; Kaya, Mehmet Cemal; Altindag, Abdurrahman
    Objective Schizoaffective disorder is a disease with both affective and psychotic symptoms. In this study, we aimed to compare oxidative metabolism markers of schizoaffective disorder, bipolar disorder and schizophrenic patients. Furthermore, we also aimed to investigate whether schizoaffective disorder could be differentiated from schizophrenia and bipolar disorder in terms of oxidative metabolism. Methods Total oxidant status (TOS) and total antioxidant status (TAS) were measured in the blood samples that were collected from schizoaffective patients (n = 30), bipolar disorder patients (n = 30) and schizophrenic patients (n = 30). Oxidative stress index (OSI) was calculated by dividing TOS by TAS. Results TOS and OSI were found to be higher in patients with schizoaffective disorder compared with those in schizophrenia and bipolar disorder patients. TAS was not significantly different between the groups. Conclusion Schizoaffective disorder was found to be different from bipolar disorder and schizophrenia in terms of oxidative parameters. This result may indicate that schizoaffective disorder could differ from bipolar disorder and schizophrenia in terms of biochemical parameters. Increased TOS levels observed in schizoaffective disorder may suggest poor clinical course and may be an indicator of poor prognosis.
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    Bipolar disorder treatment
    (Yerkure Tanitim & Yayincilik Hizmetleri A S, 2013) Sir, Aytekin; Bulut, Mahmut
    [Abstract Not Available]
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    A Case of Skin Picking Disorder of a Patient with a History of Childhood Abuse
    (Aves, 2016) Okan Ibiloglu, Aslihan; Atli, Abdullah; Kaya, Mehmet Cemal; Demir, Suleyman; Bulut, Mahmut; Sir, Aytekin
    Skin picking (excoriation) disorder is the recurrent excoriation of one's own skin, resulting in noticeable skin damage. People pick their skin for different reasons. For the majority of patients, first skin picking is associated with a history of childhood abuse and personal problems. Subjects who moderately to severely cause injurious self-harm are more likely to have a history of exposure to domestic violence and childhood abuse than those who do not self-harm. At the same time, these conditions could be related to the etiology for majority of other psychiatric disorders. We report herein, a case of a patient with skin picking disorder who had a history of childhood physical and emotional abuse with borderline personality disorder.
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    Catatonia associated globe vesicale
    (Yerkure Tanitim & Yayincilik Hizmetleri A S, 2012) Sahin, Sengul; Bulbul, Feridun; Unal, Ahmet; Bulut, Mahmut; Virit, Osman; Altindag, Abdurrahman; Savas, Haluk
    Catatonia is a syndrome that includes catalepsy, waxy flexibility, stupor, negativism, mutism, and echolalia. Side effects such as dehydration, malnutrition, constipation, flexion contractors and rhabdomyolysis may develop due to catatonia. Here, we aimed to report a case of globe vesicale associated with catatonia and the successful treatment of this case with benzodiazepine use and electroconvulsive therapy (ECT) treatment. As a result, the globe vesicale should be considered in patients presenting with catatonia and if present it should be treated urgently.
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    Çocuk evliliği yapan kadınlarda çift uyumu ve çocukluk çağı ruhsal travması
    (Türk Psikofarmakoloji Derneği, 2016) Güneş, Mehmet; Selçuk, Hilal; Demir, Süleyman; İbiloğlu, Aslıhan Okan; Bulut, Mahmut; Kaya, Mehmet Cemal; Yılmaz, Ahmet; Atli, Abdullah; Sır, Aytekin
    Öz:Amaç: Çocuk evliliği yapan kadınların işlevselliklerini bozan birçok problemlerle karşılaştıkları bildirilmiştir. Çocuk evliliği yapan kadınların çocukluk çağında daha fazla ruhsal travmaya maruz kalmış olabileceğini ve çift uyumlarının daha fazla bozulmuş olabileceği düşünülmektedir. Bu çalışmada çocuk evliliği yapan kadınlarda çocukluk çağı ruhsal travmasını ve çift uyumunu araştırmayı amaçladık.Yöntem: Çalışmanın örneklemi 2013 yılı Temmuz-Ağustos ayları arasında Dicle Üniversitesi Kadın Doğum ve Hastalıkları Polikliniğine rutin gebelik kontrolü için başvuran gebe kadınlardan seçildi. Çalışma grubu rutin gebelik kontrolü için başvuran 83 gebe arasından çalışma kriterlerini sağlayan 50 çocuk evliliği (18 yaşından önce evlenmiş) yapmış olan gebe kadın seçilerek oluşturuldu. Kontrol grubu ise 18 yaşından sonra evlenmiş 87 gebe kadın arasından çalışma kriterlerini sağlayan sağlıklı 50 gebe kadın seçilerek oluşturuldu. Tüm katılımcılar psikiyatrist tarafından standardize edilmiş görüşme aracı olan SCID kullanılarak değerlendirildi. Araştırmacılar tarafından oluşturulan sosyodemografik veri formu, Çocukluk Çağı Ruhsal Travma Ölçeği (ÇÇRTÖ), Çift Uyum Ölçeği (ÇUÖ) ve Arizona Cinsel Yaşantılar Ölçeği (ACYÖ) uygulandı.Bulgular: Çift uyumu eşler arası birliktelik boyutu (EABB) ve duygulanım ifade boyutu (DİB) alt ölçek puanları çalışma grubunda kontrol grubuna kıyasla istatistiksel olarak anlamlı düzeyde daha düşük bulunmuştur (sırasıyla p=0.015, p=0.003). Çift uyumunu en sık çocukluk çağı ruhsal travması, evlenme yaşı, ilk gebelik yaşı, cinsel istismar ve cinsel şiddete maruz kalma gibi faktörlerin etkilediği bulundu. ÇÇRTÖ'de emosyonel istismar (p=0.04) ve fiziksel ihmal (p=0.035) puanları çalışma grubunda kontrol grubuna kıyasla istatistiksel olarak anlamlı düzeyde daha yüksek bulunmuştur. Ayrıca çalışma grubunda kontrol grubuna kıyasla evliliğin ilk yıllarında fiziksel (p=0.001) ve cinsel şiddete (p=0.007) maruz kalma oranları istatistiksel olarak anlamlı düzeyde daha yüksek bulunmuştur. Cinsel istek, cinsel uyarılma ve ACYÖ toplam puanı çalışma grubunda kontrol grubuna kıyasla istatistiksel olarak anlamlı derecede farklı bulunmuştur (sırasıyla p=0.012, p=0.034, p=0.048).Sonuç: Çalışmamız çocuk evliliği yapanlarda çift uyumu ile çocukluk çağı travması ve cinsel işlevlerin birlikte değerlendirildiği ilk çalışmadır. Çalışmamızda çocuk evliliği yapanların çift uyumunun bozulmuş olduğu ve buna en fazla çocukluk çağı ruhsal travması, erken yaşta evlenme, çocuk yaşta gebe kalma, cinsel istismar ve cinsel şiddete maruz kalmanın neden olduğu belirlenmiştir. Çalışmamızda çocuk evliliği yapanların çocukluk çağında daha fazla emosyonel istismar, fiziksel ihmale / şiddet ve cinsel şiddete maruz kaldıkları tespit edilmiştir. Ayrıca çocuk evliliği yapan kadınların cinsel işlevlerinin önemli oranda bozulduğu tespit edilmiştir.
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    Çocukluk Çağı İstismar Öyküsü Olan Cilt Yolma Bozukluğu Olgusu
    (2016) Bulut, Mahmut; Atlı, Abdullah; Sır, Aytekin; Kaya, Mehmet Cemal; İbiloğlu, Aslıhan Okan; Demir, Süleyman
    Cilt yolma bozukluğu, kişinin kendi cildini tekrarlayıcı biçimde yolarak, belirgincilt hasarının oluşmasıdır. İnsanlar farklı nedenlerle ciltlerini yolmaktadır.Hastaların çoğunda cilt yolmaya başlama ile çocukluk çağı istismaröyküsü ve kişisel sorunlar bağlantılıdır. Orta şiddetten ciddi dereceye kadarkendine zarar veren bireylerde, çocukluk çağı istismarı ve aile içi şiddetemaruz kalma öyküsünün varlığı, kendine zarar vermeyenlere göre,daha muhtemeldir. Bununla beraber, bu durum psikiyatrik bozukluklarınçoğunluğunun etyolojisi ile ilişkili olabilir. Burada borderline (sınır) kişilikbozukluğu ile birlikte çocukluk çağı fiziksel ve duygusal istismar öyküsüolan, bir cilt yolma bozukluğu olgusunu sunacağız.
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    Comparison of clinical characteristics of patients on whom electroconvulsive therapy was applied as inpatient and outpatient
    (Turkish Association for Psychopharmacology, 2016) Demir, Süleyman; Bulut, Mahmut; Atli, Abdullah; Güneş, Mehmet; Kaya, Mehmet Cemal; İbiloğlu, Aslıhan Okan; Çatı, Songül; Sır, Aytekin
    Objective: Electroconvulsive therapy (ECT) is an efficient and reliable somatic treatment used to treat severe mental disorders. ECT procedure is generally performed by hospitalizing the patient in our country (Turkey). However, there is no obligation to perform ECT by hospitalization, as ECT may be performed without hospitalizing the patient. Outpatient ECT gradually increases during acute and maintenance treatment. Outpatient ECT provides some advantages, such as reduced disruption in social and professional functionality and decrease in treatment costs. Studies that compare acute outpatient ECT and ECT applied after hospitalization are limited. In the present study, we aimed to review clinical characteristics of acute ambulatory ECT and ECT applied by hospitalization comprehensively and retrospectively. Methods: Inpatients and outpatients that received ECT in the Psychiatry Clinic of Dicle University between 2011 and 2014 were enrolled in the present study. Patients’ files between aforementioned years were reviewed retrospectively and data including patient age, gender, diagnosis according to DSM system, hospitalization period, whether ECT was applied, number of ECT sessions, and whether ECT was performed as an inpatient or outpatient procedure were recorded. For the patients who were hospitalized multiple times, each hospitalization was regarded as a different patient and data were assessed independently. For the outpatients who received ECT, all separate ECT sessions were added and ECT count was determined. Those who received maintenance ECT sessions were not included in the outpatient ECT group. Patients who received ECT by acute referral as outpatients were included in this group. Results: Between 2011 and 2014, 904 patients were admitted to the Psychiatry Clinic of Dicle University, Faculty of Medicine , of which 138 received ECT treatment. We also included in the study an additional 38 outpatients who received acute ECT. Inpatients of our clinic in application to ECT were rates of 15.3%. There was no statistically significant difference detected between age, number of ECT sessions applied, diagnosis, and gender of admitted inpatients and outpatients (p>0.05). Conclusions: In our study clinical characteristics of inpatients and outpatients subjects who admitted in order to practiced the ECT were determined to be similar. We believe that an efficient treatment method may be presented to the patients by including acute outpatient ECT more frequently in the treatment plan from physicians
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    Comparison of Clinical Characteristics of Patients on whom Electroconvulsive Therapy was Applied as Inpatient and Outpatient
    (2016) Bulut, Mahmut; İbiloğlu, Aslıhan Okan; Çatı, Songül; Atli, Abdullah; Demir, Süleyman; Kaya, Mehmet Cemal; Sır, Aytekin
    Objective: Electroconvulsive therapy (ECT) is an efficient and reliable somatic treatment used to treat severe mental disorders. ECT procedure is generally performed by hospitalizing the patient in our country (Turkey). However, there is no obligation to perform ECT by hospitalization, as ECT may be performed without hospitalizing the patient. Outpatient ECT gradually increases during acute and maintenance treatment. Outpatient ECT provides some advantages, such as reduced disruption in social and professional functionality and decrease in treatment costs. Studies that compare acute outpatient ECT and ECT applied after hospitalization are limited. In the present study, we aimed to review clinical characteristics of acute ambulatory ECT and ECT applied by hospitalization comprehensively and retrospectively.Methods: Inpatients and outpatients that received ECT in the Psychiatry Clinic of Dicle University between 2011 and 2014 were enrolled in the present study. Patients' files between aforementioned years were reviewed retrospectively and data including patient age, gender, diagnosis according to DSM system, hospitalization period, whether ECT was applied, number of ECT sessions, and whether ECT was performed as an inpatient or outpatient procedure were recorded. For the patients who were hospitalized multiple times, each hospitalization was regarded as a different patient and data were assessed independently. For the outpatients who received ECT, all separate ECT sessions were added and ECT count was determined. Those who received maintenance ECT sessions were not included in the outpatient ECT group. Patients who received ECT by acute referral as outpatients were included in this group.Results: Between 2011 and 2014, 904 patients were admitted to the Psychiatry Clinic of Dicle University, Faculty of Medicine , of which 138 received ECT treatment. We also included in the study an additional 38 outpatients who received acute ECT. Inpatients of our clinic in application to ECT were rates of 15.3%. There was no statistically significant difference detected between age, number of ECT sessions applied, diagnosis, and gender of admitted inpatients and outpatients (p>0.05). Conclusions: In our study clinical characteristics of inpatients and outpatients subjects who admitted in order to practiced the ECT were determined to be similar. We believe that an efficient treatment method may be presented to the patients by including acute outpatient ECT more frequently in the treatment plan from physicians.
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    Comparison of OCT findings of schizophrenia patients using FGA, Clozapine, and SGA other than Clozapine
    (Univ Sao Paulo, Ins Psiquiatria, 2020) Orum, Mehmet Hamdi; Bulut, Mahmut; Karadağ, Ayşe Sevgi; Dumlupınar, Ebru; Kalenderoğlu, Aysun
    Objective: The effect of antipsychotic (AP) drugs on optical coherence tomography (OCT) findings in schizophrenia has not yet been fully elucidated. In this study, we aimed to investigate the effects of APs (the first generation antipsychotic group [FGAG], the second generation antipsychotic group [SGAG], the clozapine group [CG]) on OCT findings in schizophrenia. Methods: The thickness of the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and choroidal thickness were measured using a spectral OCT device. Results: No significant difference was found between FGAG, SGAG, CG (p > 0.05) while there was a significant difference between the control group and the patients group in terms of RNFL, GCL, and IPL (p < 0.05). A significant difference between SGAG and CG, FGAG (p < 0.05); between control group and FGAG (p < 0.05) were found in terms of choroidal thickness. Conclusion: These findings suggested the deterioration of the metabolic parameters due to the SGA use. Thinner choroidal layer thickness in the CG compared to the SGAG and control group was thought to be related to the patients using clozapine had a resistance to the treatment
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    Customary practices, domestic violence, and psychosomatic pain among adolescent mothers in Turkey
    (World Health Organization, 2018) Bez, Yasin; Uysal, Cem; Bulut, Mahmut; Kaya, Mehmet; Görük, Neval; Demir, Süleyman; Sır, Aytekin
    Background: Adolescent motherhood is present in many societies worldwide, including Turkey. Aims: We aimed to determine the demographical and cultural characteristics of adolescent mothers, lifetime domestic violence and history of miscarriage, and whether they suffer from any kind of medically unexplained (psychosomatic) pain in a study in south-eastern Turkey. Methods: We included 501 mothers in this case–control study. The study group comprised 228 mothers who gave their first deliveries at or before 19 years of age, and the control group consisted of 273 mothers who first delivered after 19 years of age. The case–control study was conducted between February and April 2013 in Diyarbakir, Turkey. Results: Adolescent mothers marry more frequently with their relatives. They have a higher prevalence of culture-bound customary applications such as bride price. They are less likely to be asked for their consent to marry and tend to have more children. They are more frequently victims of domestic violence and more often report medically unexplained psychosomatic pain. Conclusions: Adolescent motherhood is still a public health problem that seems to be related to certain culture-bound customary practices, continuing domestic violence across generations, increased number of children, and more prevalent psychosomatic pain.
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    Decreased Prolidase Activity in Patients with Posttraumatic Stress Disorder
    (Korean Neuropsychiatric Assoc, 2016) Demir, Suleyman; Bulut, Mahmut; Atli, Abdullah; Kaplan, Ibrahim; Kaya, Mehmet Cemal; Bez, Yasin; Ozdemir, Pinar Guzel
    Objective Many neurochemical systems have been implicated in the development of Posttraumatic Stress Disorder (PTSD). The prolidase enzyme is a cytosolic exopeptidase that detaches proline or hydroxyproline from the carboxyl terminal position of dipeptides. Prolidase has important biological effects, and to date, its role in the etiology of PTSD has not been studied. In the present study, we aimed to evaluate prolidase activity in patients with PTSD. Methods The study group consisted of patients who were diagnosed with PTSD after the earthquake that occurred in the province of Van in Turkey in 2011 (n=25); the first control group consisted of patients who experienced the earthquake but did not show PTSD symptoms (n=26) and the second control group consisted of patients who have never been exposed to a traumatic event (n=25). Prolidase activities in the patients and the control groups were determined by the ELISA method using commercial kits. Results Prolidase activity in the patient group was significantly lower when compared to the control groups. Prolidase activity was also significantly lower in the traumatized healthy subjects compared to the other healthy group (p<0.01). Conclusion The findings of the present study suggest that the decrease in prolidase activity may have neuroprotective effects in patients with PTSD.
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    Decreased Serum Sulphydryl Levels as a Sign of Increased Oxidative Stress in Generalized Anxiety Disorder
    (Korean Neuropsychiatric Assoc, 2013) Kaya, Mehmet Cemal; Bez, Yasin; Karababa, Ibrahim Fatih; Emhan, Ali; Aksoy, Nurten; Bulut, Mahmut; Gunes, Mehmet
    Objective In recent years, many published studies have focused on the relationship between oxidative stress and psychiatric disorders. However, studies in generalized anxiety disorder (GAD) are few despite relatively high prevalence rates. In an attempt to fill this gap in the literature we aimed to measure serum levels of free sulphydryl, an important member of antioxidant defense mechanisms, of the patients with GAD. Methods A total of 35 (23 female, 12 male) GAD patients without any other co-morbid medical or psychiatric disorder and 35 (23 female, 12 male) healthy controls have been included in the study. Disease severity of the patients were quantified by using the Hamilton Anxiety Rating Scale (HAM-A). Serum free sulphydryl group levels of patients and healthy controls were measured in an appropriate way. Results Mean level of serum sulphydryl groups was significantly lower in the patient group. There was a negative correlation between their level and the disease duration. However, they did not show any significant correlation with the disease severity. Conclusion Decreased serum sulphydryl level observed in pure GAD patients suggests an increased oxidative stress in these patients. Well designed future researches are needed to replicate our findings and to test the implications of the present study.
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    Development and verification of problematic cryptocurrency trading scale
    (Aves Yayıncılık, 2021) Menteş, Nurettin; Yolbaş, İlyas; Bulut, Mahmut
    Aim: Cryptocurrency trading is similar to problematic gambling behavior, with its high-risk factors and its methods of use. In this sense, it can become addictive. The aim of this study is to develop a valid and reliable scale to measure Problematic Cryptocurrency Trading among individuals who trade cryptocurrency. Method: First, the theoretical framework of the study was discussed to lay a basis for the motives of this study. Then, with the help of the DSM-5 diagnostic criteria and internet addiction scales, a 16-item scale was designed. The study was carried out on 2 different sample groups. The results were reported under the titles Study 1 and Study 2. The sample size of Study 1 was 1314. The data were collected through TrueFeedBack BlackStar, a survey platform that provides survey participation by awarding its participants with cryptocurrency. For this data set, item analyses, the t-test, reliability analysis, and the explanatory factor analysis were performed for 27% of the lower and upper groups. The Kaiser–Meyer–Olkin (KMO) test and Bartlett’s test of sphericity to determine the suitability for the factor analysis, the principal component analysis for factorization, and the promax method for factor rotations were used. The SPSS Statistics 22 software package was used for the analyses. The sample size of Study 2 was 353. The data were collected from people known to be trading cryptocurrencies. The confirmatory factor analysis was performed for the model, the factor structure of which was determined in Study 1. For the goodness of fit of the model, root mean square error of approximation (RMSEA), incremental fit index (IFI), goodness of fit index (GFI), and chi-Square Test (χ2 ) goodness of fit criteria were used. The Amos 23 software package was used for the data analysis. Results: As a result of the exploratory factor analysis, a two-factor structure was obtained. For the total scores of the scale, Cronbach’s alpha reliability value was found to be 0.913, and for the subfactors, Cronbach’s alpha values were found to be 0.897 and 0.866. The factor loadings of items varied between 0.786 and 0.597 for the first sub-factor and between 0.869 and 0.683 for the second sub-factor. The confirmatory factor analysis confirmed the two-factor structure of the scale, and the goodness of fit criteria were found to be at acceptable levels. Conclusion: It was determined that the Problematic Cryptocurrency Trading Scale is a valid and reliable scale.
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    Öğe
    Diagnostic performance of increased prolidase activity in schizophrenia
    (Elsevier Ireland Ltd, 2016) Gunes, Mehmet; Bulut, Mahmut; Demir, Suleyman; Ibiloglu, Aslihan Okan; Kaya, Mehmet Cemal; Atli, Abdullah; Kaplan, Ibrahim
    We investigated whether prolidase activity has a diagnostic test value in schizophrenia and assessed the relation between prolidase activity and sociodemographic-clinical characteristics of patients with schizophrenia. Fifty patients with schizophrenia (diagnosed as schizophrenia according to DSM-V criteria) and 50 healthy volunteers were included in this study. Case and control groups had a similar distribution in age, sex, body mass index (BMI), and smoking status. Serum prolidase activity was measured in both groups and was determined to be significantly higher in the patient group (509.706 +/- 41.918) compared to the control group (335.4 +/- 13.6; t = 6.231; p = 0.0001). A cut-off point of 392.65 U/L prolidase was determined for diagnostic measures from the plotted ROC curve. The area under the ROC curve was 1.000, which was significant (p < 0.0001). Higher values were assigned as the disease state. Both positive predictive value (PPV) and negative predictive value (NPV) were 100% at the cut-off point of 392.650 U/L. The prolidase levels of the control group were all below the cut-off point. There were no statistically significant differences between the two groups with regard to age, gender, or BMI (p > 0.05), and no correlation was found between mean prolidase activity and age of onset of the disease, family history, disease duration, number of hospitalizations, subtypes of schizophrenia, PANSS scores or sub scores, CGI-S scores, S-A scale scores, and the antipsychotic treatment (p > 0.05). The results of this study indicate that serum prolidase activity may be a useful diagnostic test for schizophrenia; however, further studies are needed to verify this. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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    Öğe
    Dicle Üniversitesi hastaneleri özürlü kuruluna başvuran olguların incelenmesi
    (T. C. Adalet Bakanlığı Adli Tıp Kurumu, 2013) Uysal, Cem; Bulut, Mahmut; Kaya, Mehmet Cemal; Güneş, Mehmet; Bez, Yasin; Zeren, Cem; Taş, Cuma; Uyar, Betül; Karaaslan, Bekir; Gören, Süleyman
    Amaç: Dünya Sağlık Örgütü (DSÖ) gelişmiş ülkelerde nüfusun %10unu, gelişmekte olan ül- kelerde ise %12sini özürlü bi- reylerin oluşturduğunu kabul etmektedir. Türkiye İstatistik Kurumu (TUİK)nun yapmış ol- duğu 2002 Türkiye Özürlüler Araştırması sonuçlarına göre ülkemizde özürlü olan nüfu- sun toplam nüfus içindeki ora- nı %12,29 idi. Bu çalışmamız da özürlülerle ilgili ülkemiz verile- rine katkıda bulunmak amacıyla yapılmıştır. Yöntemler: Hastanemiz özürlü kuruluna 2011 yılı Ocak - Aralık aylarında başvuran 1805 vakaya ait dosya- lar geriye dönük olarak değer- lendirilmiştir. Bulgular: 1805 vakanın %45,4 ü (820 kişi) kadın %54,6 sı (985 kişi) ise erkekti. En fazla başvuru 228 (%12,6) vaka ile Mart ayında gerçekleşmişti. %50den daha az özrü olduğuna karar verilen 1173 (%65) vaka varken, kalan 541 (%30) vakanın özrünün %50 ve üzerinde olduğu tespit edil- miştir. Verilen özür oranlarının süreleri incelendiği zaman; Tüm başvurular içerisinde 873 olgu- nun (%48,4) sürekli özre sahip olduğu görülmüştür. Sonuç: Özürlülüğe yol açan etmenler minimuma indirilmelidir. Alına- cak tedbirler sadece büyükşe- hir kent merkezinde değil diğer küçük yerleşim bölgelerinde de uygulanmalıdır.