Yazar "Bayhan, G" seçeneğine göre listele

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    Aggressive angiomyxoma of the female pelvis and the labium
    (Wiley-Blackwell, 2003) Yalinkaya, A; Askar, I; Bayhan, G; Kilinc, N; Yayla, M
    [Abstract Not Available]
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    Cis-platinum combination chemotherapy during pregnancy for mucinous cystadenocarcinoma of the ovary.: Case report
    (S O G Canada Inc, 1999) Bayhan, G; Aban, M; Yayla, M; Gül, T; Yaldiz, M; Erden, AC
    [Abstract Not Available]
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    Expression of E-cadherin in squamous cell carcinomas of the cervix with correlations to clinicopathological features
    (I R O G Canada, Inc, 2005) Yaldiz, M; Hakverdi, AU; Bayhan, G; Akkus, Z
    Objective: To evaluate the expression of E-cadherin, a calcium-dependent cell adhesion molecule, in a retrospective analysis of paraffin-embedded tissue specimens of cervical squamous carcinoma and the relationship with histopathological differentiation and lymph node status. Methods: In this study, we investigated by immunohistochemistry E-cadherin expression in ten normal cervical epithelia and 24 cervical invasive squamous carcinomas. Results: Normal cervical squamous epithelium showed strong expression of E-cadherin at the membrane of the cell and intercellular junctions. In 24 tumors immunnostained by E-cadherin antibody, 11 (46%) showed preserved expression and 13 (54%) reduced expression. There was no significant correlation between E-cadherin expression and histological differentiation (p = 0.650, p = 0.294). In the status of lymph node metastasis, reduced expression of E-cadherin was seen in 11/15 (73%) with lymph node metastasis versus 2/9 (22%) without lymph node metastasis. There was a significant inverse correlation between E-cadherin expression and lymph node metastasis (p = 0.032). Conclusion: Reduced E-cadherin expression may be an important factor among a variety of biologic events that occur during the process of metastasis. However, this should be explored by a large scale study.
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    Expressions of p53, proliferating cell nuclear antigen, and Ki-67 in gestational trophoblastic diseases
    (I R O G Canada, Inc, 2002) Uzunlar, AK; Yilmaz, F; Bayhan, G; Akkus, Z
    Objective: This study was done to determine whether the expressions of p53, PCNA. and Ki-67 could differentiate spontaneous abortions with hydropic changes from gestational trophoblastic diseases. Materials and Methods: Twenty partial hydatidiforin moles, 21 complete hydatidiform moles. nine invasive hydatidiform moles. three choriocarcinomas and 19 first trimester hydropic spontaneous abortions were evaluated by means of immunohistochemical methods with antibodies to p53, PCNA. and Ki-67 in this study. Results: The Ki-67, PCNA, and p53 immunoreactivity was significantly higher in the gestational trophoblastic disease group than in the spontaneous abortion group with hydropic changes. None of the three parameters provided reliable discrimination among gestational trophoblastic disease subgroups. Conclusion: Our findings Suggest that expressions of Ki-67, proliferating cell nuclear antigen and p53 can be used to differentiate between spontaneous abortion with hydropic changes and gestational trophoblastic disease when all three markers are used together.
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    Primary gastric choriocarcinoma
    (I R O G Canada, Inc, 2000) Bayhan, G; Yaldiz, M; Yalinkaya, A; Kilinç, N; Gül, T; Erden, AC
    [Abstract Not Available]
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    Serum levels of leptin, insulin-like growth factor-I and insulin-like growth factor binding protein-3 in women with pre-eclampsia, and their relationship to insulin resistance
    (Parthenon Publishing Group, 2004) Kocyigit, Y; Bayhan, G; Atamer, A; Atamer, Y
    The present study was carried out to compare serum levels of leptin, insulin-like growth factor- I (IGF-I), insulin-like growth factor binding protein-3 (IGFBP-3), homeostasis model assessment-(pancreatic beta-cell function) (HOMA-(%B)) and homeostasis model assessment-(tissue insulin sensitivity) (HOMA-(%S)) in women with mild and severe pre-eclampsia and normotensive pregnant women; and to evaluate the possible relationships between these Parameters in the pathogenesis of pre-eclampsia. Seventy-three women were divided into three groups: group A consisted of 20 normotensive pregnant women (NPW); group B consisted of 25 women with mild pre-eclampsia (MPE); and group C consisted of 28 women with severe pre-eclampsia (SPE). Serum level of leptin was measured by enzyme immunoassay using a commercial kit. Serum levels of IGF-I and IGFBP-3 were measured with a two-site immunoradiometric assay. Serum level of insulin was measured by the electrochemiluminescence immunoassay method. HOMA used indices of pancreatic beta-cell function and tissue insulin sensitivity. Differences between groups were compared by one-way analyses of variance and the post hoc Tukey-HSD test fir multiple comparisons; however, when a variable was not normally distributed, the Mann-Whitney U test was used. Associations between variables were tested using Pearson's coefficient of correlation. Birth weight was significantly lower (p < 0.001) in the MPE and SPE groups than in the NPW group. Serum levels of leptin and insulin in women with SPE and MPE were significantly higher (p < 0.001) than in NPW. Serum levels of IGF-I and IGFBP-3 were significantly lower in women with SPE and MPE compared with NPW (p < 0.001). The mean HOMA- (%B) level in women with SPE and MPF was significantly higher than in NPW (p < 0.001), whereas the mean HOMA-(%S) level in women with SPE and MPF was significantly lower than in NPW (p < 0.001). In the SPE group, systolic blood pressure correlated significantly with serum levels of IGF-I and leptin (r = 0.375, p < 0.05 and r = 0.495, p < 0.01, respectively). A negative correlation between, mean HOMA-(%S) level and serum IGFBP-3 level was noted (r =-0.357, p < 0.05). There was a positive correlation between serum level of IGF-I and mean HOMA-(%B) level in mildly pre-eclamptic women (r = 0.541, p < 0.01). We conclude that pre-eclampsia is associated with insulin resistance; and that existing hyperinsulinemia and insulin resistance in women with pre-eclampsia seem not to correlate with leptin and birth weight, but may correlate positively with IGF-I and IGFBP-3. Therefore we think that hyperleptinemia, low IGF-I or IGFBP-3, and insulin resistance may contribute to the pathogenesis of pre-eclampsia.
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    The use of recombinant factor VIIa in a primigravida with Glanzmann's thrombasthenia during delivery
    (Walter De Gruyter Gmbh, 2004) Kale, A; Bayhan, G; Yalinkaya, A; Yayla, M
    Glanzmanns thrombasthenia is an inherited hemorrhagic disorder characterized by a severe reduction in, or absence of, platelet aggregation in response to multiple physiologic agonists due to qualitative or quantitative abnormalities of platelet glycoprotein IIbIIIa. Glanzmanns thrombasthenia is characterized by potentially major mucocutaneous bleeding and prolonged bleeding time. Platelet counts, platelet morphology, prothrombin, and activated thromboplastin times are all within normal ranges in patients with Glanzmanns thrombasthenia. Pregnancy and delivery are rare in Glanzmann thrombasthenia patients and have been associated with immediate postpartum hemorrhage. We describe the peripartum management of a 31-yearold primipara with Glanzmanns thrombasthenia who underwent spontaneous vaginal delivery. Four units of singledonor platelets, two units of packed red blood cells, 36 g/kg recombinant human coagulation Factor VIIa (rFVIIa) were given during peripartum management.