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  • Küçük Resim
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    Akut myeloid lösemili hastalarımızda t(8;21) ve inv (16)'nın kantitatif RT-PCR ile araştırılması
    (Akademi Doktorlar Yayınevi, 2005) Ayyıldız, Orhan; Kalkanlı, Sevgi; Batun, Sabri; Işıkdoğan, Abdurrahman; Söker, Murat; Yurt, Murat; Müftüoğlu, Ekrem
    Akut myeloid lösemilerde (AML) kromozomal anomaliteler ile prognoz aras›nda ilişki olduğu gösterilmiştir. Çok say›da farkl› kromozomal anomaliteler aras›nda t(8;21) ve inv(16)'n›n varl›ğ›n›n iyi prognoz göstergesi olduğu kabul edilmektedir. Diğer kromozomal anomaliteler ise kötü prognostik değer olarak kabul edilmekte ve tedavi plan› bunlara göre düzenlenmektedir. Biz de bu amaçla kliniğimizde tan› konulan 19 AML hastas›nda kantitatif reverz transkripsiyon polimeraz zincir reaksiyonu (RT-PCR) metoduyla t(8;21) ve inv(16) anormalliklerini inceledik. Ayr›ca tüm hastalara klasik sitogenetik inceleme yap›ld›. Hastalar›n 9'u erkek,10'u bayand›. Yaş aral›ğ› 19-58’idi. Morfolojik olarak 5'i AML-M1, 8'i AML-M2, 5'i AML-M4, 1'i AML-M5 tipinde idi. Hastalar›n biri 2.indüksiyonda olmak üzere tüm hastalar ilk indüksiyon tedavisiyle remisyona girdi. Sitogenetik incelemede bir hastada t(8;21) saptand› ve RTPCR metoduyla t(8;21) teyid edildi. Diğer hastalarda yap›sal ve say›sal olarak herhangi bir kromozomal düzensizliğe rastlanmad›. Bu çal›şmay› sunmam›zdaki amaç; AML'li olgular›m›zda t(8;21) ve inv(16) anomalitelerini göstermektir.
  • Küçük Resim
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    Antiepileptik tedavi alan hastalarda serum immünglobülin düzeyleri
    (Erciyes Üniversitesi Tıp Fakültesi, 1995) Taşdemir, Nebahat; Batun, Sabri; Tombul, Temel; Sönmez, Mehmet Güler; Yaramış, Ahmet; Haspolat, Yusuf Kenan
    Özet: Epilepsili hastaların hümoral ve hücresel immün sistemlerinde yetersizlik olduğu bilinmektedir. Ayrıca, antiepileptik tedavinin epilepsili hastalarda serum immünglobülin düzeyini düşürdüğü görüsü mevcuttur. Çalışmamızdaki amacımız antiepileptik tedavinin, kronik antiepileptik tedavi alan hastalarda serum Ig düzeylerine etkisini araştırmak, immün sistem bozukluğuna neden olup olmadığına açıklık getirmektir. Kliniğimizde epilepsi nedeniyle takip ve tedavi edilen yaşları 1.5 ve 49 yıl arasında (Ort:18.97) olan, 43 hastanın serum immünglobülin düzeyleri immün difüzyon yöntemiyle çalışıldı. Hastaların 25'i karbamazepin, 9'u valproik asit, 6'sı fenitoin, 8'i fenobarbital ve türevlerini kullanmaktaydı. Yirmi-altı hastada (%60) IgA ve IgM düzeyleri düşük bulundu. Bu olguların 12'sinde IgA (%46), 10'unda IgM (%38,5), 4'ünde IgA ve IgM düşüktü(%15,4). Hastalarda Ig düzeyleri kontrol grubuna göre anlamlı olarak düşüktü (IgA için p<0.001, IgM için p<0.01). Olgular yaş, cins, nöbet tipi ve kullandıkları atiepileptik ilaç cinsine göre analiz edildi. Bu parametrelerle Ig düzeylerinin ilişkisi literatürle karşılaştırılarak tartışıldı.
  • Küçük Resim
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    Cerebrospinal fluid prostate specific antigen (CSF PSA) in prostate cancer patients with lower spine metastasis
    (2005) Şahin, Hayrettin; Aflay, Uǧur; Batun, Sabri; Bircan, Mehmet Kamuran; 0000-0003-3311-3530
    Aim: In this prospective study, our aim was to investigate the CSF PSA levels and CSF/Serum PSA ratios in patients with prostate cancer with lower spine metastasis. Methods: The study involved patients with prostate cancer (n= 15), benign prostatic hyperplasia (n= 17) and non-prostatic disease (n= 9). Serum and CSF were obtained prior to spinal anesthesia for urological surgery. Total PSA levels in the serum and CSF were measured by electrochemiluminescence immunoassay. The results were tested statistically using the Mann-Whitney U test. Results: The mean serum PSA levels were 20.36 ng/ml in the prostate cancer patients, 5.37 ng/ml in the BPH patients and 0.76 ng/ml non-prostatic disease. The mean CSF PSA levels in groups were 0.127, 0.051 and 0.027 ng/ml, respectively. The mean CSF PSA/serum PSA ratios in groups were 0.007, 0.018 and 0.042, respectively. This result is statistically significant (P< 0.001). Conclusions: Although mean serum PSA and CSF PSA levels in the patients with cancer of the prostate and lower spine metastasis are higher than those in the others, the mean CSF PSA/serum PSA ratio is lower. However, clinical usefulness of CSF PSA value and CSF PSA/ Serum PSA ratio can be limited because CSF PSA values are usually very low, and CSF PSA/Serum PSA ratio of 4 prostate cancer patients are as high as 1 BPH patient.
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    A comprehensive analysis of 12 thrombophilic mutations and related parameters in patients with inflammatory bowel disease
    (Springer, 2006) Yilmaz, Serif; Bayan, Kadim; Tuezuen, Yekta; Batun, Sabri; Altintas, Abdullah
    Background Possible association of inflammatory bowel disease (IBD) with the most common inherited prothrombotic conditions has been the focus of many investigations. Advance in modern molecular biology is expanding the thrombophilia evaluation steadily. We tried to put forward a comprehensive thrombophilic profile in IBD and to see the probable role of this profile in pathogenesis. Methods A total of 60 adults (33 patients and 27 healthy controls) were included. We used the CVD-StripAssay which is based on the reverse-hybridization principle to identify a total of 12 thrombophilic gene mutations: Factor V R506Q, Factor V H1299R, prothrombin G20210A, Factor XIII V34L, beta-Fibrinogen-455 G-A, PAI-1 4G/5G, platelet GPIIIa L33P, MTHFR C677T, MTHFR A1298C, ACE I/D, Apo B R3500Q and Apo E2/E3/E4, respectively. Besides, we evaluated many related blood parameters such as protein C, protein S, AT-III, IL-6, TNF-alpha, Apo-A1, Apo-B100, homocysteine (tHcy) etc. using commercially available assays. Results The frequencies of genetic polymorphisms were found to be statistically insignificant among patients and controls, except for three: Beta-Fibrinogen-455G-A, MTHFR A1298C and ACE-I/D. Two patients with a history of deep venous thrombosis had more than one polymorphism. Patients with MTHFR C677T and MTHFR A1298C gene mutations had a similar mean tHcy levels with controls. Patients with Apolipoprotein B R3500Q and Apolipoprotein E4 gene mutations had similar mean LDL-cholesterol levels. Mean total cholesterol and triglyceride levels were similar in patients and controls of Apo E2, E3, E4 alleles. Conclusion Predominantly, the presence of genetic mutations that predispose to hypercoagulable states does not appear to be in correlation with IBD. There was a statistical difference between the proportions of the mutated allele frequencies of Beta-Fibrinogen-455G-A, MTHFR A1298C and ACE-I/D in IBD.
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    Could platelet aggregation ratio be an indicator for differential diagnosis of transient ischemic attack and cerebral ischemic stroke?
    (Karger, 2006) Tatli, Mehmet; Guzel, Aslan; Akyuz, Aytekin; Batun, Sabri
    Background: Platelet aggregation plays an important role in the pathogenesis of thromboembolic cerebrovascular disease. Platelet aggregation ratio (PAR) and its derivates have been used successfully to identify the effectiveness of antiplatelet agents and their optimum dosage in patients suffering from stroke. However, we failed to find any study using PAR as a predictive factor in differential diagnosis of ischemic cerebrovascular diseases. In this study, we aimed to investigate PAR in patients with acute ischemic stroke and transient ischemic attack (TIA), comparing their neuroradiological features, and whether PAR values could be an indicator for differential diagnosis of TIA and cerebral ischemic stroke. Methods: The study consisted of 75 adult patients who were admitted with suspected stroke and 25 control healthy individuals. All patients were diagnosed with acute ischemic stroke or TIA and the diagnoses were confirmed by clinical examination and computed tomography (CT). The stroke group consisted of 45, and the TIA group of 30 consecutive patients. The patients included in this study had noncardioembolic stroke. PAR values were measured on admission in all groups, according to the modified method of Wu and Hoak. The statistical significance of differences was evaluated using one-way ANOVA, the unpaired Student t test and the Bonferroni and Tamhane post hoc tests. Results: Differences in PARs between the control and TIA groups, control and stroke groups and stroke and TIA groups were significant (p < 0.001). Nevertheless, in each group, differences between genders were not statistically significant. Initial CT scan demonstrated early infarction sign in 26 stroke patients (57%); however, in 19 stroke patients, it was not detected. Differences in PARs between TIA and stroke patients, whose initial CT scan findings were negative, were found to be significant. However, differences in PARs between CT negative stroke patients and positive stroke patients were not significant. Conclusion: We believe that the use of PAR values in the assessment of acute ischemic stroke and TIA could open up a new perspective in the management of such patients. In differential diagnosis, PAR values have to combine with neurological examination and CT scan signs. The current test is not able to differentiate vascular occlusive diseases in other organs from vascular occlusive problems in the brain. Further study is needed to determine the sensitivity and specificity of this test in all patients and to confirm the prognostic value in stroke patients. Copyright (c) 2006 S. Karger AG, Basel.
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    Derin ven trombozu olgularında herediter trombofilik risk faktörleri
    (2007) Yurt, Murat; Batun, Sabri; Kaplan, M.Ali; Altıntaş, Abdullah; Çil, Timuçin
    Derin venöz tromboz (DVT) olgularında kalıtsal risk faktörlerinin sıklığı dünyanın çeşitli bölgelerinde değişmektedir. Faktör V Leiden ve protrombin G20210A (PT G20210A) venöz tromboza neden olan en sık genetik defektlerdir. Bu çalışmanın amacı; bölgemizde ki erişkin DVT olgularında FVL ve PT G20210A mutasyon sıklığını araştırmaktır. Eylül 2001 ile ağustos 2006 tarihleri arasında venöz tromboz tanısı konan 52 hastada FVL ve PT G20210A mutasyon varlığı araştırıldı. Venöz trombozlu 52 hastanın 14’ünde FVL mutasyonu (%26.9), 6’sında da PT G20210A mutasyonu (%11) bulundu. Sonuç olarak; Güneydoğu anadolu bölgesinde DVT olgularında normal sağlıklı populasyonla karşılaştırıldığında FVL ve PT G20210A mutasyonları daha sık bulunmuştur.
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    Diffüz Büyük Hücreli LenfomadaFc?RIIa ile Fc?RIIIa Gen Polimorfizminin Tedaviye Cevabı ve Toplam Ömür Süresi Üzerine Etkisi
    (2018) Bilgir, Oktay; Batun, Sabri
    Amaç: Fc?RIIaile Fc?RIIIa gen polimorfizmi bulunan diffüz büyük B hücreli lenfomalı olguların R-CHOP tedavisine yanıtını araştırmak amacıyla çalışma planlandı. Yöntem ve Gereçler: CD20+ diffüz büyük B hücreli lenfoma tanılı 90 hastanın (47 Kadın,43 Erkek) Fc?RIIa ve Fc?RIIIa gen polimorfizmi qPCR ile bakıldı. Hastalara 6 kez R-CHOP tedavisi verildikten sonra tedaviye yanıt ve toplam ömür süreleri değerlendirildi. Bulgular: Fc?RIIa ile Fc?RIIIa gen polimorfizmi bulunan olgularda tedaviye yanıt ve toplam ömür süresinin diğerlerinden istatistiksel olarak farklı olmadığı saptandı. Tartışma ve Sonuç: Diffüz büyük B hücreli lenfomalı hastalarımızda Fc?RIIa ile Fc?RIIIa gen polimorfizminin tedaviye yanıt ve toplam ömür süreleri üzerine etkisi olmadığı görülmüştür.Malign filloid tümörler veya epitelyal tümör içeren filloid tümörler, onkoplastik cerrahi teknikleri ile negatif cerrahi sınırla rezeke edilebilir. Böylece, filloid tümörlerde onkolojik ve kozmetik olarak başarılı sonuçlar elde etmek mümkündür.
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    The distribution of telomerase activity in patients with helicobacter pylori positive gastritis
    (TÜBİTAK, 2010) Canoruç, Naime; Kale, Ebru; Yılmaz, Şerif; Bayan, Kadim; Dursun, Mehmet; Batun, Sabri; Kaplan, Abdurrahman
    Aim: Helicobacter pylori is considered a class I carcinogen by the World Health Organization. We aimed to determine whether H. pylori has an effect on telomerase activity in patients with H. pylori related non-specific gastritis, atrophy, and intestinal metaplasia. Materials and methods: One hundred and seventy-two adult patients who underwent upper gastroduodenoscopy were enrolled in the study. Three biopsy specimens were taken from the antrum: 1 from the incisura angularis and 2 from the mid-antrum. Biopsy specimens taken from the incisura angularis were evaluated using the urease test for detection of H. pylori. The mid-antrum specimens were sent for histopathology and tissue telomerase activity testing. The histopathologic evaluation was performed based on the updated Sydney system. Quantitative detection of hTERT mRNA was performed with the available method for telomerase activity. Results: Of the 172 patients, 119 were eligible for the study. H. pylori was positive in 68 (57.14%) and negative in 51 (42.85%) of the cases (P > 0.05). Of the 119 patients, 6 had intestinal metaplasia, 27 had glandular atrophy, 62 had neutrophilic activation, and 102 had chronic inflammation. The telomerase activity of the H. pylori positive and negative groups did not show a statistically significant difference in patients with intestinal metaplasia, glandular atrophy, neutrophilic activation, and chronic inflammation (P > 0.05, for each). hTERT activity was higher in H. pylori positive patients who had glandular atrophy and intestinal metaplasia than the negative group. However, the differences were insignificant. Conclusion: We could not find any significant relationship between telomerase activity and H. pylori related non-specific gastritis, atrophy, and intestinal metaplasia. hTERT activity was higher in patients who had glandular atrophy and intestinal metaplasia (early stages of gastric carcinogenesis) in the H. pylori positive group. However, these differences were not significant. H. pylori, which is considered an oncogenic agent, may influence telomerase activity of further stages of carcinogenesis, particularly those after intestinal metaplasia.
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    The Effects of Estradiol Valerate 2 mg and Dienogest 2 mg Combination on Activated Protein C Resistance in Healthy Postmenopausal Women
    (Galenos Yayincilik, 2006) Kafkas, Samet; Kalkan, Nurdan Yidiz; Bolaman, Zahit; Kalkan, Uzeyir; Odabasi, Ali R. Za; Yuksel, Hasan; Batun, Sabri
    Objective: It is aimed that, to investigate the effect of estradiol valerate and dienogest combination, which is used as a hormone replacement therapy (HRT) regimen on hemostatic parameters and activated Protein C resistance in healthy postmenopausal women. Materials and Methods: Fifty seven women received HRT treatment in four month period. The placebo group consisted of 50 women. In the HRT group 10.5% (6/57), and in the placebo group 4% (2/50) were heterozigot of FV Leiden mutation. Hemostatic parameters were investigated in only non-mutation women, to avoid potential effects of FV Leiden mutation on activated Protein C. Results: Although these changes did not reach statistical significance, a comparison of hemostatic parameters for both groups showed that in the study group (receiving 2 mg EV/2 mg DNG) FV and Protein C levels were increased, and FVIII levels were decreased compared to the placebo group. There were also no significant differences in FVII and free Protein S levels. Multiple logistic regression analysis was performed to determine the association of (2 mg EV/2 mg DNG) treatment with FV, FVII, FVIII, Protein C, free Protein S and activated Protein C sensitivity rate. There was no significant effect of these independent variables on activated Protein C sensitivity rate (p>0.05). Discussion: Combination of estradiol valerate and dienogest has no effect on activated Protein C sensitivity ratios. Hormone replacement therapy does not cause acquired activated Protein C resistance (p>0.05).
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    Factor V Leiden and G20210A prothrombin mutations in patients with recurrent pregnancy loss: data from the southeast of Turkey
    (Springer, 2007) Altintas, Abdullah; Pasa, Semir; Akdeniz, Nurten; Cil, Timucin; Yurt, Murat; Ayyildiz, Orhan; Batun, Sabri
    Factor V Leiden (FV-Leiden) and prothrombin gene mutations (FII G20210A) are well-established independent risk factors for thrombosis. In the recent years, many studies have suggested that these mutations are associated with an increased risk of recurrent pregnancy loss (RPL). We aimed to investigate the prevalence of these molecular defects in subjects with a history of early RPL. One hundred and fourteen women with three or more consecutive unexplained first-trimester miscarriages were compared to 185 parous women with uncomplicated pregnancies from the same ethnic origin. The presence of FV-Leiden and FII G20210A mutations was assessed by polymerase chain reaction analysis. Overall, 11 out of the 114 women with early RPL (9.6%) had either FV-Leiden or FII G20210A mutation, as compared with 16 out of the 185 women with normal pregnancies (8.6%; p=0.756). The prevalence of FV-Leiden mutation was 7.9% (9/114) in patient group, compared with 7% (13/185) in control group (p=0.780). One hundred and two patients were primary and 12 were secondary aborters. All FV-Leiden positive cases were primary aborters (8.8%; 9/102, p=0.584). Concerning the FII G20210A, two out of 114 (1.7%) were first-trimester RPL (primary aborters) and three out of 185 (1.6%) controls were carriers of the FII G20210A mutation (1.7 vs 1.6%, p=0.931). The results obtained from patients with first-trimester RPL and the control group have no statistical significant differences in the prevalence of FV-Leiden and FII G20210A mutations. These results suggest that mutations have no role in etiology of first-trimester recurrent abortions.
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    Factor V Leiden G1691A, prothrombin G20210A, and MTHFR C677T mutations in Turkish inflammatory bowel disease patients
    (H G E Update Medical Publishing S A, 2007) Yasa, Mehmet Hadi; Bolaman, Zahit; Yukselen, Vahit; Kadikoylu, Gurhan; Karaoglu, Ali Onder; Batun, Sabri
    Background/Aims: Patients with inflammatory bowel disease (IBD) have an increased risk for thromboembolic complications. We investigated the incidence of factor V Leiden G1691A, methylene tetrahydrofolate reductase (MTHFR) C677T, and prothrombin G20210A mutation in 27 Turkish IBD patients with no history of thromboembolic disease. Methodology: Twenty-seven patients, 22 with ulcerative colitis (UC) and 5 with Crohn's disease (CD), and 47 healthy were included to the study. The DNAs were obtained from peripheral blood by using pure polymerase chain kit. Then, factor V Leiden G1691A, which active protein C resistance positive, prothrombin G20210A and MTHFR C677T mutations were investigated in DNA by using LightCycler-Factor V Leiden G1691A mutation, Prothrombin G20210A and MTHFR C677T estimate kits. Results: The heterozygote factor V Leiden G1691A mutation was detected in 3 (11.1%) patients with IBD and 2 (4.3%) controls (p > 0.05). The homozygote factor V Leiden G1691A mutation was not estimated among patients and controls. Heterozygote prothrombin G20210A mutation was detected in 2 (7.4%) patients with IBD and in 0 (0%) controls (p>0.05). There was no homozygote prothrombin G20210A mutation in IBD and controls. Heterozygote MTHFR C677T mutation was 10 of 27 (37%) patients with IBD while 15 of 47 (32%) controls (p>0.05). Homozygote MTHFR C677T mutation was detected in 4 patients (14.9%) with IBD and 3 (6.3%) controls (p>0.05). Conclusions: Our study did not reveal any association between IBD and the most common hereditary thrombophilic factors and these mutations interfere with neither disease manifestations nor the thrombotic complications.
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    Hereditary Thrombophilic Factors in Stroke Due to Cerebral Infarct
    (Elsevier Science Inc, 2009) Bolaman, Zahit; Ozkul, Ayca; Kiylioglu, Nefati; Kadikoylu, Gurhan; Erturk, Ahmet; Batun, Sabri; Akyol, Ali
    Background: The stroke is the third most common cause of all deaths. In new Studies, the importance of hereditary thrombophilic factors on stroke is emphasized. The aim of this study is to determine the role of hereditary thrombophilic factors including factor V Leiden A1691G (FVL), prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T gene mutations in patients with stroke because of cerebral infarct. Methods: Twenty-four patients with stroke and 53 controls with risk factor for stroke were enrolled. Polymerase chain reaction was used to detect these mutations. Results: Heterozygote FVL mutation in 2 (8.3%) patients and MTHFR mutation in 10 (41.7%) patients were detected. In the control group, there were 2 (3.9%) patients with heterozygote FVL mutation and 15 (28.3%) patients with MTHR mutation. Both FVL and MTHFR gene Mutations were detected in I patient and 2 controls, respectively. Prothrombin gene mutation was not found in 2 groups. There were not statistically significant differences for all 3 mutation,; in-between 2 groups (P > 0.05). Odds ratios were 0.431 (0.074 2.504, 95% CI) for FVL mutation and 0.553 (0.221 1.381, 95% CI) for MTHFR mutation, respectively. Conclusion: Although our study group was small, hereditary thrombophilic factors might not be risk factors for stroke because of cerebral infarct.
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    İnsüline bağımlı ve insüline bağımsız diabetes mellitus'ta anormal serum immunoglobulin yoğunlukları
    (1996) Batun, Sabri; Taşkapan, Çağatay; Mete, Nuriye; Işık, Fatma Birgül; Mete, Mahmut
    insuline bağımlı diabetes mellitus (IDDM)'lu hastaların % 49'unda, insûline bağımsız diabetes mellitus (NIDDM)'lu hastaların % 52'sinde anormal serum IgA yoğunlukları görüldü. Anormal IgG yoğunlukları ise daha düşük orandaydı (IDDM'ta % 10.2, NIDDM'ta % 12.3). IgA ve IgG'nin tersine, IgM yoğunlukları toplam diyabetiklerin % 43.3ünde kontrollere göre daha düşük bullundu. IgA'nın fruktozamin HbAlc, ve albumin ile korelasyon gösterdiği saptandı. Sonuç olarak IgA konsantrasyonlarının glisemik kontrol ile ilişkili oduğu ve glisemik kontrolün bozuk olduğu hastalarda diğer immunglobulinlerde de anormal yoğunlukların olduğu görüldü.
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    Is procalcitonin valuable in the differential diagnosis of testicular torsion and epididymo-orchitis
    (Saudi Med J, 2010) Yamis, Sait; Gedik, Abdullah; Sahin, Hayrettin; Batun, Sabri; Nergiz, Yusuf; Bircan, Kamuran
    Objectives: To evaluate the efficacy of procalcitonin (PCT) in the differential diagnosis of testicular torsion and epididymo-orchitis. Methods: This experimental study was performed in the research laboratory of Dicle University, School of Medicine, Diyarbakir, Turkey between March and June 2008. The study included 24 male rats randomized equally in 3 groups: sham, epididymo-orchids, and torsion groups. Blood samples were obtained from all rats at the beginning of the study. After torsion and infection occurred in the testes, new blood samples were obtained for PCT measurement. Then, all the right testes of the rats were excised for histopathological evaluation. The Wilcoxon signed test was used for statistical evaluation. Results: Pre- and post PCT levels were statically compared, and PCT levels were significantly higher in the epididymo-orchitis group. Conclusion: Procalcitonin could be an easy, fast, and safe marker for use in the differential diagnosis of testicular torsion and epididymo-orchitis.
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    Karaciğer sirozunda lipid ve lipoprotein değişiklikleri
    (2003) Dursun, Mehmet; Canoruç, Fikri; Tuzcu, Alpaslan; Batun, Sabri; Yılmaz, Şerif; Canoruç, Naime; Karagöz, Ahmet
    Amaç: Kronik Karaciğer (KC) hastalıklarında meydana gelen hepatosellüler hasar lipid ve lipoprotein metabolizmasında önemli değişikliklere yol açmaktadır. Çalışmamızda viral hepatitlere bağlı gelişen KC sirozu vakalarında lipid ve lipoprotein düzeylerindeki değişiklikleri araştırdık. Materyel ve Metod: Çalışmaya 50 KC sirozu vakası ve kontrol gurubu olarak 50 sağlıklı birey alındı. Hastaların 7'si Child ; A, 23'ü Child B ve 20'si Child C safhasında idiler. Hasta ve kontrol gurubunda kolesterol (K), trigliserid (TG), yük-sek-yoğunluklu lipoprotein (HDL), düşük-yoğunluklu lipoprotein (LDL), Çok-düşük-yoğunluklu lipoprotein (VLDL) ve lipoprotein (a) [Lp(a)] düzeyleri çalışıldı. Bulgular: Hasta grubunda lipid düzeylerinin istatistiksel olarak anlamlı düzeyde düşük olduğu gözlendi {hasta ve kontrol grubu lipid düzeyleri sırasıyla: K (81-175mg/dL), trigliserit (73-162 mg/dL), LDL (41-99 mg/dL), HDL (25-45 mg/dL), VLDL (16-31 mg/dL) and Lp(a) (11-17 mg/dL)} [K, TG, HDL, LDL, VLDL'de (pO.OOOl) ve Lp(a)'da (p<0.01)]. Ortalama K düzeyi Child A'da 92.7 mg/dL, Child B'de 90 mg/dL, Child C'de 65.0 mg/dL olarak saptandı. Kolesterol açısından Child-A ve B grubuyla C grubu arasında istatistiksel fark saptandı (p<0.05). Sonuç: Sonuç olarak karaciğer sirozunda K, TG, LDL, HDL, VLDL ve Lp(a) düzeylerinde kontrol grubuna göre istatistiksel olarak anlamlı azalmaların olduğu görülmüş olup ,Child A'dan C'ye doğru gidildikçe lipid düzeylerindeki azalmanın en belirgin olarak kolesterolde olduğu gözlenmiştir.
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    Neurologic and biochemical findings and CD4/CD8 ratio in people occupationally exposed to RF and microwave
    (1992) Daşsağ, S.; Balcı, K.; Çelik, Mustafa Salih; Batun, Sabri; Kaplan, Abdurrahman; Bolaman, Zahit; Tekeş, Selahattin; Akdaǧ, Zülküf; 0000-0003-1211-9677
    In this study, we investigated the biological effects of RF (Radio Frequency) and microwave in terms of neurological and biochemical findings, and CD4/CD8 ratio in people that work at broadcasting and television transmitter stations. The study was carried out on 26 people from 20 to 49 years of age, occupationally exposed to nonionizing radiation. First we gave out a questionnaire consisting of 12 questions to everybody under investigation. Secondly, we determined the levels of ALT, AST, LDH, ALP, CK, phosphorus, total protein, albumin cholesterol, uric acid, urea, creatinin, Na, K, and NSE (Neuron Specific Enolase), and also CD4/CD8, albumin/globulin ratios and percentage of serum proteins. The results obtained in this study were statistically compared to a control group.
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    Prevalence of antineutrophil cytoplasmic antibody positivity in patients with Hodgkin's and non-Hodgkin lymphoma: a single center experience
    (Springer Japan Kk, 2009) Cil, Timucin; Altintas, Abdullah; Isikdogan, Abdurrahman; Batun, Sabri
    Hematological malignancies are associated with the release of different autoantibodies and rheumatological manifestations. Systemic vasculitides are rare in hematological malignancies, and antineutrophil cytoplasmic antibodies (ANCA) have not been described sufficiently in hematological malignancies. In this present prospective study, we examined the prevalence of ANCA and related disease in Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) patients in the southeast region of Turkey. We examined 119 patients with previously or newly diagnosed NHL and 60 patients with HL for the presence of ANCA and related autoimmune diseases between December 2002 and February 2007. ANCA positivity was detected in only 8 patients (4.4%); and all of these ANCA positivities were detected in patients in the HL group (13.3%); p-ANCA positivity was detected in 6 patients (3.3%); and c-ANCA positivity was detected in 2 patients (1.1%). There was statistically significant difference between patients with HL and NHL in terms of p-ANCA (p = 0.001) but none in c-ANCA (p = 0.111) positivity. None of the ANCA positive patients had vasculitides or rheumatic manifestations. In addition, we did not detect any ANCA positivity in the NHL group. In conclusion, ANCA positivities were detected only in HL patients; but we did not detect the association between ANCA positivities and rheumatic manifestations or vasculitis and also the different treatment responses in HL patients.
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    Screening for Celiac disease in Hodgkin and non-Hodgkin lymphoma patients
    (Aves, 2009) Cil, Timucin; Altintas, Abdullah; Isikdogan, Abdurrahman; Pasa, Semir; Bayan, Kadim; Batun, Sabri; Buyukbayram, Huseyin
    Background/aims: Celiac disease is an abnormal T cell-mediated immune response against dietary gluten in genetically predisposed individuals. The aim of our prospective study was to evaluate the frequency of Celiac disease in patients with lymphoma and to determine the usefulness of the anti-gliadin and anti-endomysial antibodies (EMA) for diagnosis of Celiac disease in this patient group. Methods: We studied 119 patients with previously or newly diagnosed non-Hodgkin's lymphoma and 60 patients with Hodgkin's lymphoma who presented at the hematology and medical oncology divisions of Dicle University Hospital in Turkey between December 2002 and January 2006. Serological screening for Celiac disease was performed in all patients by searching for serum anti-gliadin immanoglobulin A and immunoglobulin G, and EMA immunoglobulin A and immunoglobulin G. Results: In the Hodgkin's lymphoma group, anti-gliadin immunoglobulin A teas detected in 9 (15%) patients (3 male, 6 female), and anti-gliadin immunoglobulin G teas detected in 21 (35%) patients (15 male, 6 female). In the non-Hodgkin's lymphoma group, anti-gliadin immunoglobulin A teas detected in 6 (5%) patients (2 M male 4 female), and anti-gliadin immunoglobulin G was detected in 30 (25.2%) patients (18 male, 12 female). EMA immunoglobulin A and immunoglobulin G were not detected in the Hodgkin's lymphoma and non-Hodgkin's lymphoma groups. Conclusions: Our report is the first to describe the frequency of Celiac disease in patients with lymphoma in the southeast region of Turkey. In our study, there teas no evidence that Celiac disease is a pre-malignant condition for lymphoma. Serological screening for Celiac disease in lymphoma patients does not seem to be necessary.
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    Sıçanlarda etanol ve stresle oluşturulan gastrik mukozal tahribatın E-vitamini ile değişimi
    (1995) Kaplan, Abdurrahman; Yazanel, Orhan; Canoruç, Fikri; Erdinç, Levent; Batun, Sabri
    Çeşitli doku hasarından sorumlu olan serbest ok¬sijen radikalleri ve bu radikallerin elimine edilmesinde kullanılan antioksidan maddelerden E vitamininin et¬kileri bu deneysel çalışmada incelenmiştir. Toplam 34 sıçdn 4 gruba ayrılarak (kontrol grubu, stres grubu, stres+Etanol grubu ve stres+Etanol+E vitamini grubu) mide dokularında serbest oksijen radikallerinin bir me-taboliti olan Malondialdehit (MDA) düzeyleri "thiobar-bitürik asit metodu" ile ölçüldü. MDA düzeyleri stres ve stres+etanol gruplarında kontrol grubuna göre yüksek bulundu(p<0.01). E vitamini verilen stres+Etanol gru¬bunda ise, MDA düzeyleri kontrol düzeylerine yakın bulundu (p>0.05). Sonuç olarak E vitamini lipid perok-sidasyonunu azalttığı, dolayısı ile mokozal tahribata engel olduğu görüldü.
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    Thrombophilias and arteriovenous fistula dysfunction in maintenance hemodialysis
    (Springer, 2009) Danis, Ramazan; Ozmen, Sehmus; Akin, Davut; Batun, Sabri; Kahvecioglu, Serdar; Altintas, Abdullah; Yilmaz, Mehmet E.
    Most episodes of fistula thrombosis are consequences of underlying physioanatomic abnormalities. However, some dialysis access thrombosis develops independent from any obvious anatomic cause. We aimed to clarify the role of thrombophilias in primary and secondary AVF failure. One hundred eighty nine arteriovenous fistulas in 116 adults on maintenance hemodialysis were analyzed. All subjects were evaluated for many thrombotic factors. Fistula information was obtained both from the patients' self reports, and from their medical records. Twenty-seven AVFs in 18 cases (14.3%) had pAVFF. The percentage of subjects with a BMI < 20 kg/m(2) was significantly lower than no-pAVFF group (P = 0.03). ATIII levels and albumin values were significantly lower in patients with sAVFF compared to those with no sAVFF. Other parameters were similar. There was no statistically significant difference between pAFFF versus No-pAFFF and sAFFF versus No-sAFFF groups with respect to all mutant alleles count. Routine extended analyses of all thrombophillic factors are not recommended in AVFF.