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Öğe THE IMPACT OF ANKYLOSING SPONDYLITIS ON FEMALE SEXUAL FUNCTIONS(Wiley-Blackwell, 2014) Bozkurt, M.; Sariyildiz, M. A.; Batmaz, I; Karakoc, M.; Cevik, R.; Bozkurt, Y.; Penbegul, N.[Abstract Not Available]Öğe Relation of asymmetric dimethylarginine and cardiac involvement in systemic sclerosis(Publisaude-Edicoes Medicas Lda, 2014) Dag, Sevin; Budulgan, M.; Dilek, B.; Batmaz, I; Ariturk, Z.; Nas, K.; Cevik, R.Objectives: The heart is a commonly involved organ in systemic sclerosis (SSc) and pulmonary hypertension is a commonly observed complication that is associated with poor prognosis in this disease. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthases. In this study, we aimed to contribute to an early diagnosis of cardiac involvement by evaluating ADMA and tissue Doppler echocardiographic findings in patients with SSc. Methods: 30 SSc patients without clinical cardiac symptoms and 30 controls were included. Plasma ADMA levels were measured and tissue Doppler echocardiography examination was carried out for all participants. Systolic and diastolic functions were assessed; pulmonary arterial systolic pressure and mean pulmonary arterial pressure were measured. Results: The patient and control groups demonstrated a significant difference with regard to right ventricular free wall tissue Doppler late diastolic wave, pulmonary arterial systolic pressure, right ventricular ejection fraction, and right ventricular diastolic dysfunction values. ADMA levels were significantly higher in SSc patients and also in active patients compared to inactive patients. No significant relationship between ADMA and echocardiographic parameters was found. Conclusion: Tissue Doppler echocardiography is capable of revealing impaired right ventricular functions and increased pulmonary arterial systolic pressure before the occurrence of any cardiac clinical symptoms in patients with SSc. Serum ADMA levels were increased in SSc and in patients with active disease.Öğe Serum GDF-15 level in rheumatoid arthritis: relationship with disease activity and subclinical atherosclerosis(Publisaude-Edicoes Medicas Lda, 2017) Tanrikulu, O.; Sariyildiz, M. A.; Batmaz, I; Yazmalar, L.; Polat, N.; Kaplan, I; Cevik, R.Objectives: Growth differentiation factor (GDF)-15 was originally identified as a factor secreted by activa ted macrophages, and plays an important role in cell growth and differentiation. GDF-15 plays an important role in cell growth, signal transduction, and apoptosis regulation. The aim of this study was to evaluate the serum GDF-15 levels and their relationship with di sease- related characteristics in patients with rheumatoid arthritis (RA). Materials and methods: Forty-six patients diagnosed with RA and 36 demographically matched healthy control subjects participated in this study. GDF-15 levels were measured in blood samples from patients and controls. The disease activity score-28 (DAS28) was used to evaluate the disease activity of RA. The quality of life was evaluated using the disease-specific rheumatoid arthritis quality of life (RAQoL) scale. The health assessment questionnaire (HAQ) was used to evaluate the functional status. The degree of joint damage was assessed according to Larsen's method. Atherosclerosis was assessed by a cardiologist with the help of echocardiography according to the carotid intima media thickness (CIMT) method; vascular stiffness was assessed by using the flow mediated dilatation (FMD) method. Results: Serum GDF-15 levels were significantly hi gher in RA patients when compared to the control sub jects (p< 0.05). RA patients were divided into two groups according to the disease activity; while 26 subjects (57%) were in the active group, 20 patients were in the non-active group (43%). Serum GDF-15 levels were significantly higher in the group that was considered to have an active disease. According to Pearson's correlation, serum GDF-15 levels were positively correlated with erythrocyte sedimentation rate (ESR) le vels, morning stiffness, DAS28 score, tender joint count, and CIMT (p<0.05). Conclusion: GDF-15 may play a role in the pathway of disease activity, joint involvement, and atherosclerosis in patients with rheumatoid arthritis.Öğe Sexual dysfunction in male patients with Behget's disease(Publisaude-Edicoes Medicas Lda, 2016) Yildiz, M.; Batmaz, I; Sula, B.; Ucmak, D.; Sariyildiz, M. A.; Daggulli, M.; Turkcu, F.Introduction: The purpose of this study was to evaluate sexual dysfunction in male patients with Behget's Disease in comparison to healthy control subjects. Material and Methods: Seventy-two sexually active male patients with Behcet's Disease and 62 healthy control subjects were included in this study. Patients' demographic and clinical characteristics were noted. Sexual function was assessed by means of the International Index of Erectile Function scoring system. In addition, disease-related quality of life was measured by means of the Nottingham Health Profile, and anxiety and depression levels were assessed by means of the Hospital Anxiety and Depression Scale. Results: Patients with Behget's Disease scored significantly lower in each of the 5 parameters of International Index of Erectile Function (p < 0.001) and significantly higher in Hospital Anxiety and Depression Scale compared to healthy control subjects (p < 0.001). International Index of Erectile Function scores correlated with age, duration of disease and Hospital Anxiety and Depression Scale and Nottingham Health Profile scores in patients with Behcet's Disease (p < 0.05). Conclusion: Sexual function is impaired in male patients. With Behcet's Disease, which might be associated by age, duration of disease, psychological status and quality of life.Öğe SLEEP QUALITY IN PATIENTS WITH PSORIATIC ARTHRITIS(Clinical & Exper Rheumatology, 2014) Gezer, O.; Batmaz, I; Sariyildiz, M. A.; Sula, B.; Ucmak, D.; Bozkurt, M.; Nas, K.[Abstract Not Available]Öğe ULTRASONOGRAPHIC EVALUATION OF FEMORAL CARTILAGE THICKNESS IN PATIENTS WITH PSORIATIC ARTHRITIS(Clinical & Exper Rheumatology, 2014) Batmaz, I; Sariyildiz, M. A.; Can, I; Karkucak, M.; Serdar, O. F.; Yazmalar, L.; Capkin, E.[Abstract Not Available]
