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  • Küçük Resim
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    Evaluation of Hedera species as herbal medicine raw materials
    (Taylor and Francis Ltd., 2024) Gökkaya, İçim; Yazıcı, Nurdan; Seyhan, Gökçe; Çakır, Oğuz; Yılmaz, Mustafa Abdullah; Barut, Burak; Renda, Gülin
    This study aimed to evaluate the potential of Hedera colchica as an alternative to Hedera helix species for the treatment of mild inflammatory conditions of the upper respiratory tract and chronic inflammatory bronchial diseases. The H. colchica extract with the highest saponin content (C3S; 468.19 ± 16.01 mg HE/g dry weight) and the extract with the highest total phenol content (C1F; 108.60 ± 5.61 mg GAE/g dry weight). Chemical analysis and standardisation of the extract with the highest selective COX-2 inhibitory effect was performed using the LC-MS/MS technique. It was determined that the substances found in the highest ratio in the C1F extract were quinic acid (45.909 µg/g extract) and hesperidin (37.077 µg/g extract). As a result, secondary metabolites, in addition to saponins, found in Hedera species may also contribute to the extract’s effectiveness, more potent extracts can be obtained compared to the total extract-containing preparations available in the market.
  • Küçük Resim
    Öğe
    Phytochemical analysis and assessment of antioxidant and enzyme inhibitory activity of alchemilla pseudocartalinica Juz.
    (Wiley-V C H Verlag Gmbh, 2024) Uzunkaya, Çağla; Gökkaya, İçim; Akkaya, Didem; Soral, Michal; Seyhan, Gökçe; Barut, Burak; Yılmaz, Mustafa Abdullah
    This study aimed to evaluate and compare the antioxidant capacity and enzyme inhibitory activity of extracts, sub-extracts, and fractions prepared from the aerial parts and roots of A. pseudocartalinica. The phytochemical content of the active extracts was also analyzed. According to the results, ellagic acid (38.42 mg/g) was the major compound in the aerial part methanol extract and catechin (185.30 mg/g) in the root methanol extract. The DPPH inhibition activity of all fractions was monitored, with the most active one (Fr B) reaching an IC50 value of (4.92 +/- 0.59 mu g/mL). All the fractions prepared from the aerial parts' water sub-extract showed higher a-glucosidase inhibitory activity than the positive control acarbose. In the tyrosinase assay, Fr B (58.81 +/- 7.50 mu g/mL) exhibited the highest inhibitory actions among all fractions. The structure of the major substances of the most active fraction were elucidated as quercetin 7-O-beta-glucopyranosyl-3-O-beta-glucuronopyranoside- (1), and alpha-[(2-formyl-5-hydroxymethyl)pyrrol-1-yl]aspartic acid (2).