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Öğe Analysis of Complications of a Neglected Disease: 13 Years of Experience with Liver Hydatid Cysts in a High-Volume Hospital(Mdpi, 2024) Azizoglu, Mustafa; Aydogdu, Bahattin; Kamci, Tahsin Onat; Arslan, Serkan; Basuguy, Erol; Bilici, Salim; Okur, Mehmet HanifiBackground and Objectives: The aim of this study was to evaluate the clinical presentation, treatment outcomes, and complications associated with hepatic hydatid cysts in a pediatric population. Materials and Methods: This retrospective study analyzed 214 pediatric patients with liver hydatid cysts, focusing on clinical presentation, treatment outcomes, and associated complications. Patients were classified based on treatment modality, including non-operative management with albendazole, PAIR, and surgical intervention. This study compared cyst characteristics, recurrence rates, and complications such as cysto-biliary fistulas. Results: Among the patients, 68% (n = 145) had a single cyst and 86% (n = 184) were found to have isolated liver cysts. No significant statistical difference was observed between Group 1 and Group 2 in terms of age, gender, and basic laboratory values and general characteristics of the cysts, such as the lobe where the cyst was located, involvement of multiple organs, number of cysts, the state of cyst rupture, and recurrence; no statistically significant difference was found between the groups (p > 0.05 for each comparison). Cyst rupture incidence was 6%, and the average incidence of recurrence was 2%, with a surgical recurrence incidence of 3%. A total of 37 patients had a laparotomy, while 7 had laparoscopic surgery. In total, capitonnage was performed in 68 patients, omentopexy in 4, and cystostomy in 6. Consequently, among the treated patients (PAIR + surgery), the incidence of cysto-biliary fistula was 11%, anaphylaxis was 2%, surgical recurrence was 3%, and the incidence of reoperation (Clavien-Dindo >= 3) was 6%. The average follow-up period was 72 months, during which no mortality was observed. Conclusions: We identified key clinical outcomes related to both non-surgical treatments (cyst rupture and recurrence) and surgical groups (cysto-biliary fistulas, anaphylaxis, the need for reoperation, rupture, and recurrence).Öğe Can direct bilirubin-to-lymphocyte ratio predict surgery for pediatric adhesive small bowel obstruction?(Mexican Acad Surgery, 2024) Azizoglu, Mustafa; Arslan, Serkan; Kamci, Tahsin O.; Basuguy, Erol; Aydogdu, Bahattin; Karabel, Muesemma A.; Okur, Mehmet H.Objective: Estimating which patients might require surgical intervention is crucial. Patients with complete bowel obstructions exhibit disrupted enterohepatic cycles of bile and bacteremia due to bacterial translocation. The goal of this study was to develop a prediction index using laboratory inflammatorydatato identifypatients who mayneed surgery. Materials and methods: The patients were divided into two groups based on their management strategy: Non -operative management (Group 1) and surgical management (Group 2). Results: The indirect bilirubin, direct bilirubin, and total bilirubin were significantly higher in Group 2 than in Group 1 (p = 0.001, p < 0.001, and p < 0.001, respectively). The neutrophil-to-lymphocyte ratio (NLR), platelet-to-NLR (PNLR), and direct bilirubin-to-lymphocyte ratio (DBR) were significantly higher in Group 2 compared to Group 1 (p = 0.041, p = 0.020, and p < 0.001, respectively). In group 2, 78% have viable bowels. Resection was performed in 40% of cases, with 12% mortality and a 10 -day average hospital stay. DLR performs the best overall accuracy (72%), demonstrating a well-balanced sensitivity (62%) and specificity (81%). Conclusions: This study suggested that DBR is a more accurate predictive index for surgical intervention in pediatric adhesive small bowel obstruction patients compared to NLR and PNLR, providing valuable guidance for treatment strategies.Öğe The effect of low-dose Cordyceps on ischemia-reperfusion of the in rats(Mexican Acad Surgery, 2022) Aydogdu, Bahattin; Basuguy, Erol; Arslan, Serkan; Azizoglu, Mustafa; Ibiloglu, Ibrahim; Kaplan, Ibrahim; Aydogdu, GulayObjective: None of studies have been conducted in terms of demonstrating the same effect with the low dose in cordycepin. In our study, we analyzed the histopathological and biochemical changes of low-dose Cordycepin(c) on a rat model in the kidney. Materials and methods: Twenty-four male Wistar Albino rats were randomly allocated to three groups (n = 8): the sham-control group (Group 1), the renal I/R-untreated (Group 2) group, and the I/R-C-treated (Group 3) group. Cordyceps was administered intraperitoneally at 5 mg/kg twice. Renal histological changes were compared and the relevant parameters of oxidative stress and inflammation were detected. Results: In blood and tissue biochemistry, it was observed that IL-1 Beta, IL 6, TNF alpha, MDA, TOS, and OSI increased in Group 2 and decreased in Group 3. It was determined that TAS values were increased in Group 3, and decreased in Group 2. In the histopathological evaluation, while Group 1 was evaluated as normal, significant kidney damage was detected in Group 2. It was determined that there was a significant decrease in kidney damage in Group 3. Conclusion: These results suggest that low dose Cordycepin was as effective as normal dose on renal ischemic reperfusion and reduction of damage.Öğe How does ChatGPT perform on the European Board of Pediatric Surgery examination? A randomized comparative study(Reial Acad Medicina Illes Balears, 2024) Azizoglu, Mustafa; Aydogdu, BahattinPurpose: The purpose of this study was to conduct a detailed comparison of the accuracy and responsiveness of GPT-3.5 and GPT-4 in the realm of pediatric surgery. Specifically, we sought to assess their ability to correctly answer a series of sample questions of European Board of Pediatric Surgery (EBPS) exam. Methods: This study was conducted between 20 May 2023 and 30 May 2023. This study undertook a comparative analysis of two AI language models, GPT-3.5 and GPT-4, in the field of pediatric surgery, particularly in the context of EBPS exam sample questions. Two sets of 105 (total 210) sample questions each, derived from the EBPS sample questions, were collated. Results: In General Pediatric Surgery, GPT-3.5 provided correct answers for 7 questions (46.7%), and GPT-4 had a higher accuracy with 13 correct responses (86.7%) (p=0.020). For Newborn Surgery and Pediatric Urology, GPT-3.5 correctly answered 6 questions (40.0%), and GPT-4, however, correctly answered 12 questions (80.0%) (p= 0.025). In total, GPT-3.5 correctly answered 46 questions out of 105 (43.8%), and GPT-4 showed significantly better performance, correctly answering 80 questions (76.2%) (p<0.001). Given the total responses, when GPT-4 was compared with GPT-3.5, the Odds Ratio was found to be 4.1. This suggests that GPT-4 was 4.1 times more likely to provide a correct answer to the pediatric surgery questions compared to GPT-3.5. Conclusion: This comparative study concludes that GPT-4 significantly outperforms GPT-3.5 in responding to EBPS exam questions.Öğe Laparoscopic versus open splenectomy in children: A comparative study with an extended description of the surgical techniques(Reial Acad Medicina Illes Balears, 2023) Kuzdan, Mehmet Ozgur; Azizoglu, Mustafa; Karaaslan, BirgulObjective: The aim of this study is to compare and present our patients who underwent open splenectomy (OS) and laparoscopic splenectomy (LS).Materials and methods: This research study incorporated patients who underwent splenectomy who were admitted to the Basaksehir cam and Sakura Training and Research Hospital, Department of Pediatric Surgery, between January 2022, and April 2023. The study included a total of 48 patients who underwent splenectomy. The patients were divided into two groups: Group 1 LS (n=21) and Group 2 OS (n=27). Mentioned data were compared between groups.Results: The study included a total of 48 patients. Out of the participants, 66.7% were male. Hematological diseases were observed in 35 patients (72.9%). hematological diseases. The surgical technique employed for splenectomy was laparoscopic in 21 cases (43.8%) and open in 27 cases (56.3%). Age, gender, and Spleen size were found to be similar between the groups (p>0.05). Regarding cholelithiasis, the laparoscopic group had a higher prevalence of 86% (n=12) compared to 31% (n=5) in the open group (p=0.003). Similarly, the rate of cholecystectomy was higher in the laparoscopic group (60%, n=12) compared to the open group (22%, n=6) (p=0.008). The distribution of diseases showed a significant difference between the two groups (p<0.001).Conclusions: Compared to open surgery, laparoscopic splenectomy is a feasible method in terms of performing both surgeries together if the patient has gallbladder stones simultaneouslyÖğe A novel diagnostic scoring system for pediatric appendicitis based on age and sex- adjusted hematological parameters(Acad Nacional Medicina Mexico, 2023) Aydogdu, Bahattin; Azizoglu, Mustafa; Arslan, Serkan; Aydogdu, Gulay; Basuguy, Erol; Salik, Fikret; Okten, MustafaBackground: Acute appendicitis diagnosis can sometimes be a real challenge in pediatric patients. Objective: To establish the importance of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and other hematological parameters adjusted for age and sex in the prediction of acute appendicitis, as well as to describe a new scoring system. Material and methods: Medical records of 946 children hospitalized for acute appendicitis were retrospectively analyzed. A scoring system based on NLR, PLR, lymphocyte/monocyte ratio (LMR), and C-reactive protein (CRP) adjusted for age and sex was developed. Results: Patients were divided into group I, with negative examination, and group II, with acute appendiand PCR were higher in group II. The scores ranged from 0 to 8 points; 4.5 was determined to be the best cut-off point for acute appendicitis with the highest area under the curve (0.96), sensitivity (94%), specificity (86%), positive predictive value (97.5%), negative predictive value (65%), accuracy (92.6%) and misclassification rate (7.4%). Conclusion: The proposed scoring system, calculated based on patient age and gender, can be used for unnecessary surgeries to be avoided.Öğe The performance of the inflammatory indexes in predicting double J catheter insertion necessity among children and adult patients with ureteral stone(Reial Acad Medicina Illes Balears, 2023) Azizoglu, Mustafa; Sagir, SuleymanObjective: The present study was designed to examine the differences in NLR, PLR, and PNLR between two distinct patient groups, further examining their utility as diagnostic markers.Materials and methods: Patients were then separated into two categories: Group 1 (those not require DJ catheter insertion) and Group 2 (those needed DJ catheter insertion). Factors such as patient age, gender, symptoms, diagnosis, hematological parameters, and some indexes (NLR, PLR, and PNLR) were thoroughly assessed.Results: The research study featured 150 participants, split into two groups of 80 (Group 1) and 70 (Group 2) individuals. Despite average age differences, the distribution of ages was statistically significant. Group 1 had more children, while Group 2 contained more adults. Gender distribution between groups was not significantly different. Group 2 had larger mean stone sizes than Group 1. Stone location showed no significant variation between the groups. WBC and NEU were higher in Group 2, while LYM was higher in Group 1. There was no significant difference in MONO, PLT, and urea levels, but CRE level was higher in Group 2. NLR, PLR, and PNLR were also significantly higher in Group 2. Cut-off values for NLR, PLR, and PNLR had moderate to good predictive abilities. There was a positive correlation between stone size and PNLR index.Conclusions: Our study demonstrates the predictive utility of hematological parameters (NLR, PLR, PNLR) in determining the need for DJ catheter placement in ureteral stone patients.Öğe Platelet-rich Plasma as an Adjuvant Therapy to Crystallized Phenol in the Treatment of Pediatric Pilonidal Sinus Disease: A Prospective Randomized Controlled Trial(W B Saunders Co-Elsevier Inc, 2025) Azizoglu, Mustafa; Klyuev, Sergey; Kamci, Tahsin Onat; Okur, Mehmet HanifiObjective: This study aims to evaluate the safety and efficacy of platelet-rich plasma (PRP) as an adjuvant to crystallized phenol (CP) in treating pediatric pilonidal sinus disease (PSD). Methods: A single-center randomized controlled trial was conducted at Istanbul Esenyurt Hospital. Eighty-seven patients aged 0-18 were randomly assigned to two groups: the CP group (n = 42) and the CP + PRP group (n = 45). Upon arrival at the clinic, patients began a regimen of manual shaving and, if necessary, laser epilation every 6-8 weeks. For those with pilonidal abscesses, incision, drainage, and antibiotics were given. The treatment area was sterilized and numbed with local anesthesia. Hair removal and curettage were performed, followed by the application of crystallized phenol. In CP + PRP group, PRP injections were also administered. The procedure concluded with wound dressing and thorough disinfection. The study was registered https://clinicaltrials.gov/ (NCT06324656). Results: The CP + PRP group demonstrated significantly shorter healing times (19.4 +/- 7.88 days) compared to the CP group (30.7 +/- 12.9 days) (p < 0.001). The cosmetic score was higher in the CP + PRP group (7.42 +/- 1.61) than in the CP group (6.11 +/- 1.88, p = 0.001). CP + PRP group had lower VAS scores at measured all-time points after applications (p < 0.05 for each). Complications were comparable between the groups, with no significant differences in bleeding, infections, or skin burns (p > 0.05 for each comparison). No difference was found between groups in terms of total complication rate (p = 0.398). The success rate was higher in CP + PRP group (98%; n = 44) compared to CP group (86%; n = 36) (p = 0.039). Recurrence rates were lower in CP + PRP group (2%; n = 1) than CP group (14%; n = 6) (p = 0.039). Conclusion: The autologous PRP injection in pediatric PSD is safe. The addition of PRP to CP treatment for pediatric PSD significantly improves healing time, cosmetic outcomes, and overall success rates without increasing complication rates. This combined approach offers a promising alternative for effective and efficient treatment of PSD in children. Type of the study: Randomized controlled trial. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.Öğe Protective effects of passiflora incarnata on ovarian ischemia/reperfusion damage in rats with ovarian torsion(Turkish Assoc Trauma Emergency Surgery, 2023) Arslan, Serkan; Asir, Firat; Ozkorkmaz, Ebru Gokalp; Azizoglu, Mustafa; Basuguy, Erol; Okur, Mehmet Hanifi; Otcu, Serap Mutlu OzcelikBACKGROUND: This study aimed to investigate whether Passiflora Incarnata (PI) has a protective effect against ischemia-reperfusion (IR)-induced oxidative and inflammatory ovarian damage. METHODS: The effects of PI on ovarian ischemia-reper fusion injury were investigated in female Wistar albino rats. The animals were randomly divided into three groups: Group 1 (sham), Group 2 (IR), and Group 3 (IR+PI). RESULTS: The mean levels of Malondialdehyde (MDA), Myeloperoxidase (MPO), and Total Oxidant Status (TOS) were higher in the IR group (p=0.025, p<0.001, and p=0.016, respectively). The Total Antioxidant Status (TAS) levels were lower in the IR group (p=0.005). Immunostaining revealed significant differences across the groups for Tumor necrosis factor-alpha (TNF-alpha): 13.84%, 49.51%, and 22.51% for Groups 1, 2, and 3, respectively (p<0.01). Bax: 10.53%, 46.74%, and 26.46% for Groups 1, 2, and 3, respectively (p<0.01). Annexin V: 12.24%, 44.86%, and 23.28% for Groups 1, 2, and 3, respectively (p<0.01). The mean scores for hemorrhage, inflammation, follicular degeneration, and congestion showed significant variations among the groups, all registering p<0.001. CONCLUSION: Passiflora Incarnata exhibited antioxidant, anti-inflammatory, and anti-apoptotic properties, promoting cell survival, histologically protecting ovarian tissue, and ameliorating IR injury by reducing oxidative stress.Öğe A questionnaire study among nurses: awareness of blood and urine sample collection procedures(Walter De Gruyter Gmbh, 2014) Yuksel, Hatice; Kaplan, Ibrahim; Toprak, Gulten; Evliyaoglu, Osman; Kus, Seyit; Azizoglu, Mustafa; Mete, Nuriye[Abstract Not Available]
