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Öğe Bilateral basal cell carcinoma symmetrically appearing on lower eyelids: A case report(2003) Askar I.; Kilinc N.; Aytekin S.Basal cell carcinoma is the most common skin malignancy and is found in skin exposed to the sun. It is rarely seen bilaterally in ears, ankles or breasts. There has been no literature about bilateral basal cell carcinoma of lower eyelids symmetrically. A 68-year-old male patient had been suffering from two lesions on his lower eyelids for two years. The first lesion appeared on the right lower eyelid two years ago and got larger. Then the second lesion occurred on the left lower eyelid a year and a half ago. The patient had worked as a farmer for fifteen years. Physical examination revealed ulcerated lesions, with surrounding hyperemia, 12×6 mm in size, on both lower eyelids. Both lesions were excised and repaired with lateral malar flap+mucosal graft. One year later, there no evidence of recurrence, and postoperative scars were functionally and cosmetically acceptable. We present a case of bilateral basal cell carcinoma involving both lower eyelids symmetrically, reviewing the literature.Öğe Clinico-epidemiologic study of cutaneous leishmaniasis in Diyarbakir Turkey(Dermatology Online Journal, 2006) Aytekin S.; Ertem M.; Yadran O.; Aytekin N.Cutaneous leishmaniasis (CL) is a zoonotic disease, endemic and notifiable in southeastern Turkey. We investigated clinical features, individual characteristics, and environmental factors of affected patients, and identified additional patients with CL in Diyarbakir. In 2002 we studied the epidemiology of CL in Dedeköy and Durabeyli towns in Diyarbakir Province. We evaluated patients with any skin lesions. A questionnaire including demographic details was completed by each patient. Clinical details of lesions and other dermatological findings were recorded. We walked around the town and surveyed it for environmental factors. CL was diagnosed in 78 individuals aged 1-85 years (mean age of 20). Although all age groups were affected, the majority of patients were under age 20. The lesions ranged from approximately 0.5 to 20 cm. They were located on the face (46.7%), upper extremity (23.2%), lower extremity (5.1%), and other sites. Different types of lesions were observed such as nodule with crust, nodule with osseous crust, violaceous infiltrative plaque with vegetative nodule, erysipelas-like plaque verrucous annular plaque, and eczema-like plaques. The incidence of CL is increasing in Dicle and Durabeyli towns and the clinical appearance may vary greatly.Öğe The demonstration of changes in bulbar conjunctiva surface epithelium in the psoriatic patients treated with PUVA.(2008) Söker S.; Nergiz Y.; Cakmak S.; Bahçeci S.; Aytekin S.We investigated the effects of disease itself and PUVA treatment on surface epithelium of conjunctiva in psoriatic patients (PP) before PUVA and after PUVA therapy and in 32 healthy volunteers. Squamous metaplasia was detected in PP both before and after PUVA therapy. We concluded that PUVA treatment applied together with preventive measures, would lead to less severe ocular side effects.Öğe Febrile ulceronecrotic Mucha-Habermann disease: A case report and a review of the literature(2005) Aytekin S.; Balci G.; Duzgun O.Y.We report a case of febrile ulceronecrotic Mucha-Habermann disease (FUMHD) in a 27-year-old woman. After 20 days of a mild eruption, extensive polymorphous, papular and ulcerohemorrhagic skin lesions gradually developed, associated with intermittent high temperature, and constitutional symptoms. The initial treatment with acyclovir was not successful, the skin lesions still progressed distally and individual lesions evolved from necrotic papules and bullae to erosions and ulcers. Skin biopsies showed the typical histopathological changes of PLEVA. The patient was treated with systemic prednisolone but dosage was limited in order to avoid sepsis. Despite corticosteroid therapy and supportive therapy, the fulminating course led to death. Including this present case, only 31 cases of FUMHD have been reported in English literature. Our case is the second report from Turkey. © 2005 Dermatology Online Journal.Öğe Giant sebaceous naevus: A case report(1997) Aytekin S.; Yilmaz F.; Harman M.; Aktas M.; Akdeniz S.; Derici M.Sebaceous naevi are circumscribed hamartomatous lesions composed predominantly of sebase glands at birth or early childhood. The esions may be round, oval, or linear, varying in length from about 1 to 10 cm. We described a 19 year-old female with a giant sebaceous naevus measuring 10x17 cm on the scalp, forehead and left cheek.Öğe A new patient with pyoderma gangrenosum, acne, and suppurative hidradenitis (PASH) syndrome: Case report(2013) Aytekin S.; Uçmak D.; Ayhan E.; Fidan V.PAPA syndrome is a autoinflammatory syndrome clinically characterized by pyogenic arthritis, severe acne, and pyoderma gangrenosum caused by mutations in the PSTPIP1 gene. It is a rare autosomal dominant disease of early onset. Pyoderma gangrenosum, acne and hidradenitis suppurative (PASH) syndrome has been recently identified as nonhereditary and characterized by absence of arthritis different from PAPA syndrome. No mutations have been detected to date in patients with PASH syndrome. Only three patients with PASH syndrome were reported. Herein, we report a new patient with PASH syndrome. He had severe disseminated pyoderma gangrenosum and multiple depressed scars resulting from related acne and hidradenitis suppurative but lacked any episodes of pyogenic arthritis. He was successfully treated with systemic corticosteroids. Copyright © 2013 by Türkiye Klinikleri.Öğe Post- pemphigus acanthomata(1998) Aytekin S.; Harman M.; Yilmaz F.; Civas E.; Aktas M.; Derici M.Pemphigus is a group of vesiculobullous disorders in which the blisters usually heal with hyperpigmentation. The appearance of acanthomata at sites of previous blisters has been noted in some cases. We described a 48-year- old patient with pemphigus vulgaris, who was treated with systemic steroids, and who developed acanthomata on the sites of some healed blisters. The acanthomata were seen as verrucous lesions at sites of healed blisters, and were observed in the trunk. Histopathology of lesions showed suprabasal cleft associated with hyperkeratosis, acanthosis, and papillomatosis. Acantholytic cells were seen intraepidermally within the cleft. Acanthomata occurring in patients whose pemphigus is in remission is not uncommon. Since post- pemphigus acanthomata shows histopathologic activity, these cases should be carefully followed-up.Öğe Recombinant interferon alpha-2a in the treatment of classic Kaposi's sarcoma(1996) Arica M.; Arslan A.; Mevlitoglu I.; Aytekin S.; Derici M.Observations. A case of classic Kaposi's Sarcoma (AIDS non related) in a 51-year-old man is presented. He was treated with recombinant interferon alpha-2a (6 million units/day) three times per week intramuscularly for 3 months. All lesions were completely resolved after treatment.Öğe Öğe Syringocystadenoma papilliferum mimicking basal cell carcinoma on the lower eyelid: A case report(2002) Askar I.; Kilinc N.; Aytekin S.Background. Syringocystadenoma papilliferum is an unusual benign tumor most commonly located on the scalp or face, which frequently arises from a nevus sebaceous. Transition of SP to basal cell carcinoma and, rarely, to metastatic adenocarcinoma may occur. Case Report. A 28-year-old female patient had been suffering from a pinkish, painless nodule for 25 years. Physical examination revealed a pinkish, non-tender, painless nodule, 5mm in diameter, on the lower eyelid. The nodular lesion was excised, and the lower eyelid was reconstructed with V-Y advancement flap. Histopathologic examination revealed hyperkeratosis with papillomatosis of epidermis. The dermis showed several cystic invaginations extending downwards from the epidermis. One year later, the postoperative result was cosmetically and functionally acceptable. Conclusion. Syringocystadenoma papilliferum mimicking basal cell carcinoma on the lower eyelid is of interest, since there were scanty skin appendages. Our paper considers the issue of differentiating between SP and BCC, since SP is asymptomatic and may have similar appearance. We believe that SP may be a transitional step from nevus sebaceous to basal cell carcinoma, since molecular studies show PTCH gene in all three lesions, the origins of SP are still debatable, and both SP and BCC can arise in nevus sebaceous of Jadassohn.Öğe Two new cases with Costello syndrome(Dermatology Online Journal, 2013) Aytekin S.; Alyamac G.Costello syndrome (CS) was described in 1977 by Costello who reported two unrelated children with a new syndrome comprising short stature, redundant skin of the neck, palms, soles, and fingers, curly hair, papillomata around the mouth and nares, and mental retardation. Several additional cases have been reported since then. Herein we report two patients with Costello syndrome; one of these patients had associated mesenteric cyst. © 2013 by the article author(s).Öğe Vesiculobullous dermatomyositis with sensory motor neuropathy(Pulse Marketing and Communications LLC, 2013) Ayhan E.; Baykara S.N.; Ozekinci S.; Aytekin S.A 74-year-old man presented with muscle weakness in both legs for a duration of 2 months. Physical examination revealed periorbital edema and erythema, erythema on the neck and chest, erythematous papules on the proximal-distal interphalangeal and metocarpophalangeal joints, crusted plaque lesions on the thighs and around the knees, and bullous and ulcerated lesions in the antecubital and popliteal fossae (Figure 1A and 1B). Some bullous lesions were intact and some were ulcerated. There was severe edema especially in the upper extremities. He had a history of 15-kg weight loss for 4 months. Laboratory findings were remarkable for a white blood cell count of 16.0 K/UL (4.60–10.20 K/UL), a C-reactive protein of 6.93 mg/dL (0–0.5 mg/dL), an erythrocyte sedimentation rate of 50 mm/h (8–15 mm/h), an aspartate aminotransferase level of 213 U/L (10–40 U/L), a lactate dehydrogenase of 447 U/L (<225 U/L), and a creatine kinase level of 1733 U/L (29–200 U/L). Results from antinuclear antibody at 1:320 titers and anti-smooth muscle antibody were positive. Results from anti-SS A/SS B antibodies, anti Jo-1 antibody, U1-snRNP antibody, and anti-ds DNA antibody tests were negative. A skin biopsy specimen obtained from the right antecubital fossa showed minimal orthokeratosis and subepidermal detachments. There was marked edema in the dermis and lymphocyte infiltration around the skin appendages (Figure 2). Direct immunofluorescence studies demonstrated scattered staining for C3 and IgM at the basal membrane zone. Results for IgG, IgA, and fibrin staining were negative. Muscle biopsy from left deltoid muscle was performed and some muscle fibers were demonstrated to be atrophied. There was remarkable difference between muscle fiber diameters. With Masson staining, there was increased connective tissue and no inflammation. Electromyography (EMG) showed a myogenic pattern. Nerve conduction studies showed tibial, median, ulnar, peroneal motor neuropathy, and median, ulnar, and sural sensory neuropathy. Based on these findings, diagnosis of vesiculo-bullous dermatomyositis (DM) was made. Further investigation of esophagogastroduodenoscopy with biopsy revealed ulcerated lesions on antrum and corpus and these were assessed as Helicobacter pylori– negative atrophic chronic gastritis. No pathologic findings were described on chest, abdomen, and pelvic tomography. Levels of tumor markers were within normal ranges. Overall, no sign of malignancy was detected. Methyl prednisolone treatment of 1 mg/kg/d was started; however, new bullous lesions erupted while the original lesions were healing. © 2013 Pulse Marketing & Communications, LLC.
