Yazar "Aydogdu, Gulay" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • [ X ]
    Öğe
    The effect of low-dose Cordyceps on ischemia-reperfusion of the in rats
    (Mexican Acad Surgery, 2022) Aydogdu, Bahattin; Basuguy, Erol; Arslan, Serkan; Azizoglu, Mustafa; Ibiloglu, Ibrahim; Kaplan, Ibrahim; Aydogdu, Gulay
    Objective: None of studies have been conducted in terms of demonstrating the same effect with the low dose in cordycepin. In our study, we analyzed the histopathological and biochemical changes of low-dose Cordycepin(c) on a rat model in the kidney. Materials and methods: Twenty-four male Wistar Albino rats were randomly allocated to three groups (n = 8): the sham-control group (Group 1), the renal I/R-untreated (Group 2) group, and the I/R-C-treated (Group 3) group. Cordyceps was administered intraperitoneally at 5 mg/kg twice. Renal histological changes were compared and the relevant parameters of oxidative stress and inflammation were detected. Results: In blood and tissue biochemistry, it was observed that IL-1 Beta, IL 6, TNF alpha, MDA, TOS, and OSI increased in Group 2 and decreased in Group 3. It was determined that TAS values were increased in Group 3, and decreased in Group 2. In the histopathological evaluation, while Group 1 was evaluated as normal, significant kidney damage was detected in Group 2. It was determined that there was a significant decrease in kidney damage in Group 3. Conclusion: These results suggest that low dose Cordycepin was as effective as normal dose on renal ischemic reperfusion and reduction of damage.
  • [ X ]
    Öğe
    Investigation of the prognostic significance of c-kit and c-erb-b2 expression in osteosarcoma, ewing sarcoma, and rhabdomyosarcoma and comparison with clinical parameters
    (Reial Acad Medicina Illes Balears, 2023) Aydogdu, Gulay; Bilgic, Bilge; Kiroglu, Kumru
    Objective: In the present study, the prognostic and treatment-guiding roles of the c-erb-B2 oncoprotein and tyrosine kinase receptor c-kit in osteosarcoma (OS), Ewing sarcoma (ES), and rhabdomyosarcoma (RMS) were evaluated. Materials and methods: With 25 cases from each group, c-kit and c-erb-B2 expression were investigated immunohistochemically in a total of 75 cases. Results: Staining for c-kit was found to be positive in 15 (60%) of the RMS, 11 of the OS (44%), and 11 of the ES cases (44%). C-erbB-2 staining was positive in 7 RMS cases (8%) and negative in all cases of OS and ES.The SISH method was applied to six c-erb-B2 positive RMS cases, and amplification of the HER2 gene (encoding c-erb-B2) was detected in one case. It was determined that c-kit expression in OS was significantly associated with survival (p<0.05) and could be considered as a poor prognostic parameter. In contrast,c-kit expression had no prognostic significance in ES and RMS. In the RMS group, there was no relationship between c-erb-B2 positivity and prognosis. Conclusion: It was concluded that c-kit expression can be used as a poor prognostic parameter for OS and therapy targeting c-kit may be an alternative treatment option.
  • [ X ]
    Öğe
    A novel diagnostic scoring system for pediatric appendicitis based on age and sex- adjusted hematological parameters
    (Acad Nacional Medicina Mexico, 2023) Aydogdu, Bahattin; Azizoglu, Mustafa; Arslan, Serkan; Aydogdu, Gulay; Basuguy, Erol; Salik, Fikret; Okten, Mustafa
    Background: Acute appendicitis diagnosis can sometimes be a real challenge in pediatric patients. Objective: To establish the importance of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and other hematological parameters adjusted for age and sex in the prediction of acute appendicitis, as well as to describe a new scoring system. Material and methods: Medical records of 946 children hospitalized for acute appendicitis were retrospectively analyzed. A scoring system based on NLR, PLR, lymphocyte/monocyte ratio (LMR), and C-reactive protein (CRP) adjusted for age and sex was developed. Results: Patients were divided into group I, with negative examination, and group II, with acute appendiand PCR were higher in group II. The scores ranged from 0 to 8 points; 4.5 was determined to be the best cut-off point for acute appendicitis with the highest area under the curve (0.96), sensitivity (94%), specificity (86%), positive predictive value (97.5%), negative predictive value (65%), accuracy (92.6%) and misclassification rate (7.4%). Conclusion: The proposed scoring system, calculated based on patient age and gender, can be used for unnecessary surgeries to be avoided.