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Öğe Acute unilateral myopia induced by add-on aripiprazole: A case report(2016) Bulut, Mahmut; Atli, Abdullah; Kaya, Mehmet Cemal; Demir, Süleyman; İbiloğlu, Aslıhan Okan; Güneş, Mehmet; Yüksel, HarunThe partial agonist aripiprazole is a novel atypical antipsychotic with a relatively safer side effect profile. Acute unilateral myopia is a very rare condition that is commonly associated with drug use. Here, we present a woman diagnosed with obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) who have been treated for two years in our clinic. She was on fluoxetine (Prozac) 80 mg/day when adding aripiprazole (Abilify) 10 mg/day as an augmentation agent has triggered unilateral myopia. After cessation of aripirazole her myopia has disappeared. Psychiatrists should keep in mind that unilateral myopia as a side effect may develop after combining aripiprazole with fluoxetine in patients with OCD and MDD.Öğe Acute Unilateral Myopia Induced by Add-On Aripiprazole: A Case Report(Kure Iletisim Grubu A S, 2016) Gunes, Mehmet; Demir, Suleyman; Bulut, Mahmut; Kaya, Mehmet Cemal; Atli, Abdullah; Ibiloglu, Aslihan Okan; Yuksel, HarunThe partial agonist aripiprazole is a novel atypical antipsychotic with a relatively safer side effect profile. Acute unilateral myopia is a very rare condition that is commonly associated with drug use. Here, we present a woman diagnosed with obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) who have been treated for two years in our clinic. She was on fluoxetine (Prozac) 80 mg/day when adding aripiprazole (Abilify) 10 mg/day as an augmentation agent has triggered unilateral myopia. After cessation of aripirazole her myopia has disappeared. Psychiatrists should keep in mind that unilateral myopia as a side effect may develop after combining aripiprazole with fluoxetine in patients with OCD and MDD.Öğe Altered lipid peroxidation markers are related to post-traumatic stress disorder (PTSD) and not trauma itself in earthquake survivors(Springer Heidelberg, 2016) Atli, Abdullah; Bulut, Mahmut; Bez, Yasin; Kaplan, Ibrahim; Ozdemir, Pinar Guzel; Uysal, Cem; Selcuk, HilalThe traumatic life events, including earthquakes, war, and interpersonal conflicts, cause a cascade of psychological and biological changes known as post-traumatic stress disorder (PTSD). Malondialdehyde (MDA) is a reliable marker of lipid peroxidation, and paraoxonase is a known antioxidant enzyme. The aims of this study were to investigate the relationship between earthquake trauma, PTSD effects on oxidative stress and the levels of serum paraoxonase 1 (PON1) enzyme activity, and levels of serum MDA. The study was carried out on three groups called: the PTSD group, the traumatized with earthquake exercise group, and healthy control group, which contained 32, 31, and 38 individuals, respectively. Serum MDA levels and PON1 enzyme activities from all participants were measured, and the results were compared across all groups. There were no significant differences between the PTSD patients and non-PTSD earthquake survivors in terms of the study variables. The mean PON1 enzyme activity from PTSD patients was significantly lower, while the mean MDA level was significantly higher than that of the healthy control group (p < 0.01 for both measurements). Similarly, earthquake survivors who did not develop PTSD showed higher MDA levels and lower PON1 activity when compared to healthy controls. However, the differences between these groups did not reach a statistically significant level. Increased MDA level and decreased PON1 activity measured in PTSD patients after earthquake and may suggest increased oxidative stress in these patients. The nonsignificant trends that are observed in lipid peroxidation markers of earthquake survivors may indicate higher impact of PTSD development on these markers than trauma itself. For example, PTSD diagnosis seems to add to the effect of trauma on serum MDA levels and PON1 enzyme activity. Thus, serum MDA levels and PON1 enzyme activity may serve as biochemical markers of PTSD diagnosis.Öğe Aripiprozole-Induced Diplopia: A Case Report(Kure Iletisim Grubu A S, 2013) Atli, Abdullah; Selvi, Yavuz; Yildiz, Aydin; Kaya, Mehmet CemalDiplopia is a condition that involves seeing double and impairs quality of life. Acute diplopia can be seen with some general medical drugs and psychotropic drugs. Aripiprazole is a new atypical antipsychotic agent; it has partial agonist activity at D2 and 5-HT1A receptors and antagonist activity at 5-HT2A receptors. This paper reports development of diplopia, a rare adverse effect of psychotropic drugs, in a 24 year old patient with schizophreniform disorder following use of oral aripiprazole. Clinicians should keep in mind that diplopia may occur with aripiprazole treatment.Öğe Assessment of COVID-19 trauma responses. Who has been more traumatized during the pandemic?(Masson Editeur, 2022) Cim, Emine Fusun Akyuz; Kurhan, Faruk; Dinc, Dilem; Atli, AbdullahBackground and Objective. - To evaluate the effect of cognitive and sociodemographic characteristics of healthcare and non-healthcare workers on their traumatic responses to the COVID-19 pandemic. Methods. - Data were collected using an online survey between August-September 2020. The survey included the following scales: Beck Anxiety Inventory (BAI), Anxiety Sensitivity Index (ASI), and Impact of Event Scale-Revised (IES-R). Traumatic responses were categorized into three types: avoidance (IESR_A), intrusion (IES-R_I), and hyperarousal (IES-R_H). Results. - The study included a total of 672 participants, comprised of 399 (59.4%) men, and 273 (40.6%) women with a mean age of 39.25 +/- 933 years. The results indicated that women had higher IES-R_I (r=.5.78, p < 0.001), IES-R_A (r = 4.47, p < 0.001), and IES-R_H (r =.5.20, p < 0.001) scores compared to men. Patients with a history of psychiatric diseases had significantly higher IES-R_I (r = -3.82, p < 0.001), IES-R_A (r = -2.00, p < 0.05), and IES-R_H (r = -4.06, p < 0.001) scores compared to patients with no history of psychiatric diseases. Non-healthcare workers had significantly higher IES-R_A (r = -2.69, p < 0.01) scores compared to healthcare workers. Conclusion. - Female gender and a positive history of psychiatric diseases were found to lead to an increase in the frequency of all three traumatic responses to COVID-19. Contrary to expectation, being a healthcare worker was not found as a factor facilitating trauma response formation in our study. (C) 2022 Elsevier Masson SAS. All rights reserved.Öğe A Case of Skin Picking Disorder of a Patient with a History of Childhood Abuse(Aves, 2016) Okan Ibiloglu, Aslihan; Atli, Abdullah; Kaya, Mehmet Cemal; Demir, Suleyman; Bulut, Mahmut; Sir, AytekinSkin picking (excoriation) disorder is the recurrent excoriation of one's own skin, resulting in noticeable skin damage. People pick their skin for different reasons. For the majority of patients, first skin picking is associated with a history of childhood abuse and personal problems. Subjects who moderately to severely cause injurious self-harm are more likely to have a history of exposure to domestic violence and childhood abuse than those who do not self-harm. At the same time, these conditions could be related to the etiology for majority of other psychiatric disorders. We report herein, a case of a patient with skin picking disorder who had a history of childhood physical and emotional abuse with borderline personality disorder.Öğe A case who had deliberate self-harm by inserting needles to her body for 12 years(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2016) Okan Ibiloglu, Aslihan; Atli, Abdullah; Demir, Suleyman; Sir, AytekinDeliberate self-harm or self-injurious behaviors (SIB) defined as 'the intentional, direct injuring of body tissue without suicidal intent' in addition to this topic has generated mounting interest among mental health professionals, over the past years. Psychiatric disordered patients have the tendency to self-harm repeatedly. We report here, a case that was referred for SIB with deliberately inserted needles in her body, over the last 12 years.Öğe Çocuk evliliği yapan kadınlarda çift uyumu ve çocukluk çağı ruhsal travması(Türk Psikofarmakoloji Derneği, 2016) Güneş, Mehmet; Selçuk, Hilal; Demir, Süleyman; İbiloğlu, Aslıhan Okan; Bulut, Mahmut; Kaya, Mehmet Cemal; Yılmaz, Ahmet; Atli, Abdullah; Sır, AytekinÖz:Amaç: Çocuk evliliği yapan kadınların işlevselliklerini bozan birçok problemlerle karşılaştıkları bildirilmiştir. Çocuk evliliği yapan kadınların çocukluk çağında daha fazla ruhsal travmaya maruz kalmış olabileceğini ve çift uyumlarının daha fazla bozulmuş olabileceği düşünülmektedir. Bu çalışmada çocuk evliliği yapan kadınlarda çocukluk çağı ruhsal travmasını ve çift uyumunu araştırmayı amaçladık.Yöntem: Çalışmanın örneklemi 2013 yılı Temmuz-Ağustos ayları arasında Dicle Üniversitesi Kadın Doğum ve Hastalıkları Polikliniğine rutin gebelik kontrolü için başvuran gebe kadınlardan seçildi. Çalışma grubu rutin gebelik kontrolü için başvuran 83 gebe arasından çalışma kriterlerini sağlayan 50 çocuk evliliği (18 yaşından önce evlenmiş) yapmış olan gebe kadın seçilerek oluşturuldu. Kontrol grubu ise 18 yaşından sonra evlenmiş 87 gebe kadın arasından çalışma kriterlerini sağlayan sağlıklı 50 gebe kadın seçilerek oluşturuldu. Tüm katılımcılar psikiyatrist tarafından standardize edilmiş görüşme aracı olan SCID kullanılarak değerlendirildi. Araştırmacılar tarafından oluşturulan sosyodemografik veri formu, Çocukluk Çağı Ruhsal Travma Ölçeği (ÇÇRTÖ), Çift Uyum Ölçeği (ÇUÖ) ve Arizona Cinsel Yaşantılar Ölçeği (ACYÖ) uygulandı.Bulgular: Çift uyumu eşler arası birliktelik boyutu (EABB) ve duygulanım ifade boyutu (DİB) alt ölçek puanları çalışma grubunda kontrol grubuna kıyasla istatistiksel olarak anlamlı düzeyde daha düşük bulunmuştur (sırasıyla p=0.015, p=0.003). Çift uyumunu en sık çocukluk çağı ruhsal travması, evlenme yaşı, ilk gebelik yaşı, cinsel istismar ve cinsel şiddete maruz kalma gibi faktörlerin etkilediği bulundu. ÇÇRTÖ'de emosyonel istismar (p=0.04) ve fiziksel ihmal (p=0.035) puanları çalışma grubunda kontrol grubuna kıyasla istatistiksel olarak anlamlı düzeyde daha yüksek bulunmuştur. Ayrıca çalışma grubunda kontrol grubuna kıyasla evliliğin ilk yıllarında fiziksel (p=0.001) ve cinsel şiddete (p=0.007) maruz kalma oranları istatistiksel olarak anlamlı düzeyde daha yüksek bulunmuştur. Cinsel istek, cinsel uyarılma ve ACYÖ toplam puanı çalışma grubunda kontrol grubuna kıyasla istatistiksel olarak anlamlı derecede farklı bulunmuştur (sırasıyla p=0.012, p=0.034, p=0.048).Sonuç: Çalışmamız çocuk evliliği yapanlarda çift uyumu ile çocukluk çağı travması ve cinsel işlevlerin birlikte değerlendirildiği ilk çalışmadır. Çalışmamızda çocuk evliliği yapanların çift uyumunun bozulmuş olduğu ve buna en fazla çocukluk çağı ruhsal travması, erken yaşta evlenme, çocuk yaşta gebe kalma, cinsel istismar ve cinsel şiddete maruz kalmanın neden olduğu belirlenmiştir. Çalışmamızda çocuk evliliği yapanların çocukluk çağında daha fazla emosyonel istismar, fiziksel ihmale / şiddet ve cinsel şiddete maruz kaldıkları tespit edilmiştir. Ayrıca çocuk evliliği yapan kadınların cinsel işlevlerinin önemli oranda bozulduğu tespit edilmiştir.Öğe Comparison of clinical characteristics of patients on whom electroconvulsive therapy was applied as inpatient and outpatient(Turkish Association for Psychopharmacology, 2016) Demir, Süleyman; Bulut, Mahmut; Atli, Abdullah; Güneş, Mehmet; Kaya, Mehmet Cemal; İbiloğlu, Aslıhan Okan; Çatı, Songül; Sır, AytekinObjective: Electroconvulsive therapy (ECT) is an efficient and reliable somatic treatment used to treat severe mental disorders. ECT procedure is generally performed by hospitalizing the patient in our country (Turkey). However, there is no obligation to perform ECT by hospitalization, as ECT may be performed without hospitalizing the patient. Outpatient ECT gradually increases during acute and maintenance treatment. Outpatient ECT provides some advantages, such as reduced disruption in social and professional functionality and decrease in treatment costs. Studies that compare acute outpatient ECT and ECT applied after hospitalization are limited. In the present study, we aimed to review clinical characteristics of acute ambulatory ECT and ECT applied by hospitalization comprehensively and retrospectively. Methods: Inpatients and outpatients that received ECT in the Psychiatry Clinic of Dicle University between 2011 and 2014 were enrolled in the present study. Patients’ files between aforementioned years were reviewed retrospectively and data including patient age, gender, diagnosis according to DSM system, hospitalization period, whether ECT was applied, number of ECT sessions, and whether ECT was performed as an inpatient or outpatient procedure were recorded. For the patients who were hospitalized multiple times, each hospitalization was regarded as a different patient and data were assessed independently. For the outpatients who received ECT, all separate ECT sessions were added and ECT count was determined. Those who received maintenance ECT sessions were not included in the outpatient ECT group. Patients who received ECT by acute referral as outpatients were included in this group. Results: Between 2011 and 2014, 904 patients were admitted to the Psychiatry Clinic of Dicle University, Faculty of Medicine , of which 138 received ECT treatment. We also included in the study an additional 38 outpatients who received acute ECT. Inpatients of our clinic in application to ECT were rates of 15.3%. There was no statistically significant difference detected between age, number of ECT sessions applied, diagnosis, and gender of admitted inpatients and outpatients (p>0.05). Conclusions: In our study clinical characteristics of inpatients and outpatients subjects who admitted in order to practiced the ECT were determined to be similar. We believe that an efficient treatment method may be presented to the patients by including acute outpatient ECT more frequently in the treatment plan from physiciansÖğe Comparison of Clinical Characteristics of Patients on whom Electroconvulsive Therapy was Applied as Inpatient and Outpatient(2016) Bulut, Mahmut; İbiloğlu, Aslıhan Okan; Çatı, Songül; Atli, Abdullah; Demir, Süleyman; Kaya, Mehmet Cemal; Sır, AytekinObjective: Electroconvulsive therapy (ECT) is an efficient and reliable somatic treatment used to treat severe mental disorders. ECT procedure is generally performed by hospitalizing the patient in our country (Turkey). However, there is no obligation to perform ECT by hospitalization, as ECT may be performed without hospitalizing the patient. Outpatient ECT gradually increases during acute and maintenance treatment. Outpatient ECT provides some advantages, such as reduced disruption in social and professional functionality and decrease in treatment costs. Studies that compare acute outpatient ECT and ECT applied after hospitalization are limited. In the present study, we aimed to review clinical characteristics of acute ambulatory ECT and ECT applied by hospitalization comprehensively and retrospectively.Methods: Inpatients and outpatients that received ECT in the Psychiatry Clinic of Dicle University between 2011 and 2014 were enrolled in the present study. Patients' files between aforementioned years were reviewed retrospectively and data including patient age, gender, diagnosis according to DSM system, hospitalization period, whether ECT was applied, number of ECT sessions, and whether ECT was performed as an inpatient or outpatient procedure were recorded. For the patients who were hospitalized multiple times, each hospitalization was regarded as a different patient and data were assessed independently. For the outpatients who received ECT, all separate ECT sessions were added and ECT count was determined. Those who received maintenance ECT sessions were not included in the outpatient ECT group. Patients who received ECT by acute referral as outpatients were included in this group.Results: Between 2011 and 2014, 904 patients were admitted to the Psychiatry Clinic of Dicle University, Faculty of Medicine , of which 138 received ECT treatment. We also included in the study an additional 38 outpatients who received acute ECT. Inpatients of our clinic in application to ECT were rates of 15.3%. There was no statistically significant difference detected between age, number of ECT sessions applied, diagnosis, and gender of admitted inpatients and outpatients (p>0.05). Conclusions: In our study clinical characteristics of inpatients and outpatients subjects who admitted in order to practiced the ECT were determined to be similar. We believe that an efficient treatment method may be presented to the patients by including acute outpatient ECT more frequently in the treatment plan from physicians.Öğe Decreased Prolidase Activity in Patients with Posttraumatic Stress Disorder(Korean Neuropsychiatric Assoc, 2016) Demir, Suleyman; Bulut, Mahmut; Atli, Abdullah; Kaplan, Ibrahim; Kaya, Mehmet Cemal; Bez, Yasin; Ozdemir, Pinar GuzelObjective Many neurochemical systems have been implicated in the development of Posttraumatic Stress Disorder (PTSD). The prolidase enzyme is a cytosolic exopeptidase that detaches proline or hydroxyproline from the carboxyl terminal position of dipeptides. Prolidase has important biological effects, and to date, its role in the etiology of PTSD has not been studied. In the present study, we aimed to evaluate prolidase activity in patients with PTSD. Methods The study group consisted of patients who were diagnosed with PTSD after the earthquake that occurred in the province of Van in Turkey in 2011 (n=25); the first control group consisted of patients who experienced the earthquake but did not show PTSD symptoms (n=26) and the second control group consisted of patients who have never been exposed to a traumatic event (n=25). Prolidase activities in the patients and the control groups were determined by the ELISA method using commercial kits. Results Prolidase activity in the patient group was significantly lower when compared to the control groups. Prolidase activity was also significantly lower in the traumatized healthy subjects compared to the other healthy group (p<0.01). Conclusion The findings of the present study suggest that the decrease in prolidase activity may have neuroprotective effects in patients with PTSD.Öğe Deneysel şizofreni modelinde vortioksetinin bilişsel fonksiyonlar üzerine etkilerinin araştırılması(Dicle Üniversitesi, Sağlık Bilimleri Enstitüsü, 2021) Atli, Abdullah; Erdinç, MeralAmaç: Bu çalışmada ketaminle oluşturduğumuz deneysel şizofreni modelinde Vortioksetin’in bilişsel fonksiyonlar üzerine etkileri araştırılmıştır. Gereç ve Yöntem: Çalışmada erkek BALB/c fareler 8 gruba (n:6-9) ayrıldı. Kontrol-1 grubuna; 7 gün salin çözeltisi, Ketamin-1 grubuna: 7 gün ketamin, Vortioksetin grubuna 7 gün vortioksetin, Fluoksetin grubuna 7 gün fluoksetin uygulandı. Kontrol-2 grubuna; 14 gün salin çözeltisi, Ketamin-2 grubuna: 0-7 gün ketamin+8-14 gün salin, Ketamin+Vortioksetin grubuna; 0-7. günlerde ketamin + 8-14. günlerde vortioksetin, Ketamin+Fluoksetin grubuna 0-7. günlerde ketamin + 8-14. günlerde fluoksetin uygulandı. Çalışmanın 7. ve 8. günleri ile 14. ve 15. günlerinde açık alan, yeni obje tanıma, pasif sakınma, modifiye artı labirent testi, zorunlu yüzme testi ve hot plate testi yapıldı. Bulgular: Açık alan testinde; ketamin grubunda ortalama hız, mesafe, açık alan periferik frekans değerlerinin anlamlı olarak yükseldiği bulunmuştur. Yeni obje tanıma testinde ketamin grubunda istatistiksel olarak anlamlı bozulma, vortioksetin ve fluoksetinle ketaminle bozulmada düzelme görülmüştür. Pasif sakınma testlerinde geçiş süresi ketamin grubunda anlamlı olarak düşük çıkarken, vortioksetin ve fluoksetinle geçiş sürelerinde yükselme olmuştur. Modifiye artı T testinde geçiş süresi istatistiksel olarak ketamin grubunda anlamlı olarak yüksek bulunmuş; vortioksetinle ketamin grubuna göre anlamlı olarak azalmıştır, fluoksetinle de azalma görülmüş ancak istatistiksel olarak anlamlı bulunmamıştır. Zorunlu yüzme testinde ketamin grubunda anlamlı bir azalma görülmezken, vortioksetin ve fluoksetin gruplarında hareketsiz geçirilen sürelerde azalmalar gözlenmiştir. Hot plate testlerinde grupların reaksiyon süreleri arasında fark tespit edilememiş ancak vortioksetin grubunun kısmen hiperaljeziye neden olduğu görülmüştür. Sonuç: Sonuç olarak; şizofreni benzeri deneysel hayvan modeli çalışmamızda vortioksetinin uzamsal bellek başta olmak üzere bilişsel belirtileri düzeltebileceği gösterilmiştir.Öğe Diagnostic performance of increased prolidase activity in schizophrenia(Elsevier Ireland Ltd, 2016) Gunes, Mehmet; Bulut, Mahmut; Demir, Suleyman; Ibiloglu, Aslihan Okan; Kaya, Mehmet Cemal; Atli, Abdullah; Kaplan, IbrahimWe investigated whether prolidase activity has a diagnostic test value in schizophrenia and assessed the relation between prolidase activity and sociodemographic-clinical characteristics of patients with schizophrenia. Fifty patients with schizophrenia (diagnosed as schizophrenia according to DSM-V criteria) and 50 healthy volunteers were included in this study. Case and control groups had a similar distribution in age, sex, body mass index (BMI), and smoking status. Serum prolidase activity was measured in both groups and was determined to be significantly higher in the patient group (509.706 +/- 41.918) compared to the control group (335.4 +/- 13.6; t = 6.231; p = 0.0001). A cut-off point of 392.65 U/L prolidase was determined for diagnostic measures from the plotted ROC curve. The area under the ROC curve was 1.000, which was significant (p < 0.0001). Higher values were assigned as the disease state. Both positive predictive value (PPV) and negative predictive value (NPV) were 100% at the cut-off point of 392.650 U/L. The prolidase levels of the control group were all below the cut-off point. There were no statistically significant differences between the two groups with regard to age, gender, or BMI (p > 0.05), and no correlation was found between mean prolidase activity and age of onset of the disease, family history, disease duration, number of hospitalizations, subtypes of schizophrenia, PANSS scores or sub scores, CGI-S scores, S-A scale scores, and the antipsychotic treatment (p > 0.05). The results of this study indicate that serum prolidase activity may be a useful diagnostic test for schizophrenia; however, further studies are needed to verify this. (C) 2015 Elsevier Ireland Ltd. All rights reserved.Öğe Dicle Üniversitesi Hastaneleri Sağlık Kurulu'na silah ruhsatı almak için yapılan başvuruların değerlendirilmesi: Retrospektif bir çalışma(T. C. Adalet Bakanlığı Adli Tıp Kurumu, 2014) Uysal, Cem; Atli, Abdullah; Kır, Ziya M.; Bulut, Mahmut; Korkmaz, Mustafa; Güneş, Mehmet; Sivri, Süleyman; Gören, SüleymanAmaç: Toplumumuzda şiddet gün geçtikçe yükselmekte, kişilerin ateşli silah taşımaya karşı olan eğilimleri artmakta ve bireysel silahlanmada hızlı bir artış olduğu bilinmektedir. Bu çalışmada amacımız Dicle Üniversitesi Tıp Fakültesi Hastaneleri Sağlık Kurulu’na silah ruhsatı alımı için başvuran kişilerin sosyodemografik ve klinik özelliklerinin, retrospektif olarak incelenmesidir. Yöntemler: Çalışmamız Ocak 2011–Ocak 2012 tarihleri arasında Dicle Üniversitesi Tıp Fakültesi Hastaneleri Sağlık Kuruluna silah ruhsatı almak için başvuran toplam 146 kişilik (142 erkek ve 4 kadın) evren örnekleminde yapılmıştır. Veriler retrospektif olarak değerlendirilmiştir. Bulgular: Bireylerin sosyodemographic özellikleri değerlendirildiğinde, katılımcıların yaş aralığının 22-83 arasında bulunduğu belirlenmiştir. Silah ruhsatı için başvuru yapan kişilerin en sık yaş dağılımı 22–30 yaş (%43,8, n=64) olarak bulundu. Olgularımızın 7 (%4,8) tanesinin ilköğretim mezunu olduğu, 92 tanesinin (%63) lise mezunu olduğu ve 16 (%11) tanesinin yüksekokul ya da üniversite mezunu olduğu tespit edilmiştir. Sonuç olarak, 130 olguya (%89) silah ruhsatı alma izni verildiği ve 16 (%11) olguya verilmediği anlaşılmaktadır. Sonuç: Silahlanma toplum sağlığını etkileyen bir problemdir. Ülkemizdeki ateşli silahlar ile meydana gelen ölümlü ve yaralamalı olaylar incelendiğinde, yeni yasal ve sosyal düzenlemelerin yapılması gerektiği görülmektedir.Öğe Epilepsi hastasında topiramatın indüklediği ekolali olgusu(Modestum Publishing Ltd., 2014) Akıl, Eşref; Alp, Rezan; Atli, Abdullah; Acar, Abdullah; Özdemir, H. HasanEkolali başkalarının söylediklerini anlamsız olarak tekrar edilmesi olan sözel bir davranış bozukluğudur. Topiramat birçok epileptik nöbet tipinin tedavisinde kullanılan etkili bir antiepileptik ajandır. Olgumuz 44 yaşında epileptik nöbetleri için 1000mg/gün sodyum valproat kullanan bir epilepsi hastası idi. Son aylarda nöbet sıklığında artma nedeniyle tedavisine yüksek dozda ve hızlı titre edilerek 600mg/gün dozunda topiramat eklendi. Topiramat eklendikten sonra epileptik nöbeti olmadı. Hasta topiramat kullanmaya başladıktan kısa bir süre sonra konfüzyon, dezoryantasyon ve özelikle ekolali içeren konuşma bozukluğu gelişti. Bu nedenle bir epilepsi hastasında topiramatın hızlı titrasyonunun sebep olduğu bir ekolali olgusunu sunduk.Öğe Evaluation of Paraoxonase, Arylesterase and Malondialdehyde Levels in Schizophrenia Patients Taking Typical, Atypical and Combined Antipsychotic Treatment(Korean Coll Neuropsychopharmacology, 2016) Gunes, Mehmet; Camkurt, Mehmet Akif; Bulut, Mahmut; Demir, Suleyman; Ibiloglu, Aslihan Okan; Kaya, Mehmet Cemal; Atli, AbdullahObjective: Human serum paraoxonase (PON1) prevents lipids from peroxidation and functions as an antioxidant mechanism. Malonyldialdehyde (MDA) is the final product of lipid peroxidation and can be used as an indicator of oxidative stress. The aim of this study was to investigate PON1, MDA, and arylesterase (ARY) levels in schizophrenic patients who, are taking typical, atypical, or combined (typical and atypical) antipsychotic drug treatment, with respect to those of healthy controls, Methods: We evaluated 41 patients (11 taking typical antipsychotics, 19 taking atypical antipsychotics, 11 taking combined anti psychotics) and 43 healthy controls. Results: MDA levels were higher in schizophrenic patients taking typical antipsychotics compared with healthy controls (p=0.001). ARY levels were higher in patients taking atypical antipsychotics compared with healthy controls (p=0.005): PON1 activity was similar in all groups. Conclusion: Our results indicate that treatment with typical antipsychotic drugs could be related to increased MDA levels; and antipsychotic medication may increase PON1 levels in schizophrenic patients.Öğe Evaluation of Risk Factors for ADHD and Co-Morbid Psychiatric Disorders Among the Parents of Children With ADHD(Sage Publications Inc, 2019) Ibiloglu, Aslihan Okan; Atli, Abdullah; Bulut, Mahmut; Gunes, Mehmet; Demir, Suleyman; Kaya, Mehmet Cemal; Yuksel, TugbaObjective: The aim of this study is to investigate the presence of ADHD and other psychiatric disorders among parents with at least one child with ADHD relative to parents with children who do not have ADHD. Method: Eighty five parents of children with ADHD with 68 control parents who had healthy children without ADHD were interviewed for participation in present study. Each parent was evaluated for co-existing psychiatric disorders using the Structured Clinical Interview for the DSM IV Axis I Disorders (SCID I). Results: We found that ADHD and co-morbid psychiatric symptoms were increased in the parents of children with ADHD in comparison with the healthy control group. Conclusion: Psychiatric co-morbidity was more common among the parents of patients with inattentive and combined presentations. Adult ADHD is associated with psychiatric co-morbidities including anxiety disorders, mood disorders, and somatoform disorders as well as substantial role impairment.Öğe Evaluation of the effects of anesthetic agents and diagnoses on seizure durations, recovery times and complications in electroconvulsive therapy(Turkish Association for Psychopharmacology, 2014) Tüfek, Adnan; Bulut, Mahmut; Tokgöz, Orhan; Çelik, Feyzi; Yıldırım, Zeynep Baysal; Atli, Abdullah; Kaya, Mehmet Cemal; Karaman, HaktanObjective: The aim of this study is to retrospectively evaluate the influence of diagnosis and three different anesthetic agents on seizure durations, hemodynamic parameters, recovery times, and side effects in electroconvulsive therapy (ECT). Method: We have retrospectively evaluated 1342 ECT sessions conducted on 179 patients under general anesthesia at the Psychiatry Department of Dicle University Hospital between 1 September 2009 and 30 June 2012. The relationship between the indications for ECT and the choice of anesthetic agent, number of ECT sessions, motor and EEG seizure durations, recovery times from anesthesia, hemodynamic changes and complications were analysed. Results: The mean age of the 179 patients included in the study was 36.7±7.3 years. In terms of sex, 50.8% (n=91) were male and 49.2% (n=88) were female. The most commonly used anesthetic agent was propofol (73.2%). Among the patients, 50.8% was diagnosed with major depression, 28.5% had bipolar disorder and 12.8% was diagnosed with schizophrenia. A total of 179 (13.3%) out of the 1342 ECT sessions were considered as failed. In 92.2% of the failed ECTs, the anesthetic agent was propofol. No statistically significant relationship was observed between the diagnosis forming the basis for the ECT and the motor and EEG seizure times, beginning of spontaneous breathing, eye opening, time until response to verbal stimuli, changes in hemodynamic parameters and complications. The seizure and recovery times were significantly shorter in the propofol group compared to the ketamine and etomidate groups (p<0.05). The EEG seizure durations were longer in the etomidate group in comparison to the propofol and ketamine groups (p<0.001 and p<0.05, respectively). Conclusion: The diagnoses leading to the ECT have no influence on the motor and EEG seizure times, beginning of spontaneous breathing, eye opening, times of response to verbal stimuli, hemodynamic parameters or complications. However, the anesthetic agents used influence all of these parameters.Öğe Family History in Patients with Bipolar Disorder(Aves, 2016) Ozdemir, Osman; Coskun, Salih; Aktan Mutlu, Elif; Ozdemir, Pinar Guzel; Atli, Abdullah; Yilmaz, Ekrem; Keskin, SiddikIntroduction: In this study, we aimed to better understand the genetic transmission of bipolar disorder by examining the family history of patients. Methods: Sixty-three patients with bipolar disorder and their families were included. The final sample comprised 156 bipolar patients and their family members. An inclusion criterion was the presence of bipolar disorder history in the family. The diagnosis of other family members was confirmed by analyzing their files, hospital records, and by calling them to the hospital. Results: Sixty-five patients were women (41.6%) and 91 were men (58.3%) (ratio of men/women: 1.40). When analyzing the results in terms of the transition of disease from the mother's or father's side, similar results were obtained: 25 patients were from the mother's side and 25 patients were from the father's side in 63 cases. Conclusion: The results of our study support the fact that a significant relationship exists between the degree of kinship and the heritability of bipolar disorder and, furthermore, that the effect of the maternal and paternal sides is similar on the transmission of genetic susceptibility.Öğe Infection risk in psychiatric patients: a catatonic case report(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2014) Atli, Abdullah; Bulut, Mahmut; Kaya, Mehmet Cemal; Cati, Songul; Bez, YasinCatatonia is occurring in some psychiatric disorders such as schizophrenia, bipolar disorder and depression. Catatonia is presented with catalepsy, catatonic excitation, negativism, mutism, posturing, stereotypic movements, mannerism, grimas, echolalia, and echopraksia. Hospital bacterial infections generally occur in patients whom longterm hospitalized and immune system weakened. Patients with psychiatric disorders, - especially immobilized and hospitalized ones-, patients who resist to drug-food intake, lack of self-care may have predisposition to infections. In case of a worsening in the clinical state of the patients with catatonia, which is a severe psychiatric condition, clinicians should keep in mind organic pathologies like sepsis. Herein we reported a case of sepsis, which was diagnosed as bipolar mood disorder depressive episode with catatonic features and had been hospitalized in our clinic for 67 days and resisted to food and drug intake.
