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Öğe A comparative evaluation of the effects of bevacizumab and 5-fluorouracil on wound healing in rat model(Drunpp-Sarajevo, 2012) Gunay, Ahmet; Atilgan, Serhat; Yesilova, Yavuz; Yaman, Ferhan; Ozgoz, Mehmet; Lacin, NihatPurpose: Our aim is to evaluate the use of combined bevacizumab with 5-Fluorouracil (5-FU) on post-operative scarring survival following experimental skin incision surgery in comparison to the agents alone. Material and methods: Skin incision surgery was performed on 28 female Spraque-Dawley rats. The rats were allocated to one of four treatments: 5-FU combined with Bevacizumab, 5FU alone, bevacizumab alone and phosphate buffered saline (PBS). A single subcutaneous injection was administered immediate postoperatively. Histological staining determined the presence of cutaneous fibrosis and mRNA expression of collagen I and fibronectin in the tissue was quantified. Results: Relative quantity of Colla1 mRNA transcript 5 fold increased in Group 1 (PBS) in comparison to control group. However, Colla1 level in Group 2 (5-FU) and 3 (bevacizumab) is decreased. The lowest level of Colla1 was detected in Group 4 (combination of 5-FU and bevacizumab). On the other hand, relative quantity of Fn1 is slightly elevated in Group 1 (PBS) and decreased in Group 2 (5-FU) and group 3 (bevacizumab) in comparison to control group. The lowest level of Fn 1 was detected in Group 4 (combination of 5-FU and bevacizumab). Conclusions: Bevacizumab in combination with 5-FU resulted in a greater anti-fibrotic effect compared to monotherapy with 5FU or bevacizumab alone, as evidenced by the attenuation in fibronectin and mature collagen I expression and deposition. (P<0.05) The results provide compelling evidence that combined bevacizumab and 5-FU offers superior anti-fibrotic effect over monotherapy. A synergistic effect is suggested to be present.Öğe Effects of caffeic acid phenethyl ester on palatal mucosal defects and tooth extraction sockets(Dove Medical Press Ltd, 2014) Gunay, Ahmet; Arpag, Osman Fatih; Atilgan, Serhat; Yaman, Ferhan; Atalay, Yusuf; Acikan, IzzetAim: The purpose of this study was to evaluate the effects of caffeic acid phenethyl ester (CAPE) on palatal mucosal defects and tooth extraction sockets in an experimental model. Materials and methods: Forty-two male Sprague-Dawley rats with a mean age of 7 weeks and weighing 280-490 g were used in this study. The rats were randomly divided into two groups: group A (the control group, n=21) and group B (the experimental group, n=21). Under anesthesia with ketamine (8 mg/100 g, intraperitoneally), palatal mucosal defects were created and tooth extraction was performed in the rats in groups A and B. Group A received no treatment, whereas group B received CAPE. CAPE was injected daily (10 mu mol/kg, intraperitoneally). The rats were killed on days 7, 14, and 30 after the procedures. Palatal mucosa healing and changes in bone tissue and fibrous tissue were evaluated histopathologically. Result: Pairwise comparisons showed no statistically significant difference between days 7 and 14 in either group (P>0.05). At day 30, bone healing was significantly better in group B (CAPE) than in group A (control) (P<0.05). Fibrinogen levels at day 30 were significantly higher in group A (control) than in group B (CAPE) (P<0.05). Pairwise comparisons showed no statistically significant difference in palatal mucosa healing levels between days 7 and 14 in both groups (P>0.05). Conclusion: In conclusion, the findings of this study suggest that CAPE can significantly improve tooth socket healing.Öğe Effects of Sildenafil on Dental Pulp: Immunohistochemical and Ultrastructural Evaluation(Soc Chilena Anatomia, 2016) Soker, Sevda; Deveci, Engin; Yaman, Ferhan; Atilgan, Serhat; Ipek, Fikret; Uysal, IbrahimSildenafil is a strong peripheral vasodilator and is used to treat cardiovascular and neurosurgery. The purpose of this study was to investigate the immunohistochemical and ultrastructural effects of sildenafil on dental pulp of rats. The study was performed with adult female Wistar-Albino rats. Control group (n=7) were fed on standard laboratory diet until surgery. The study group (n=7) were administered sildenafil orally with orogastric tube 10 mg.kg(-1) once a day for 30 days. Each rat was anesthetized and incisor teeth were removed. This study examined the immunohistochemical and ultrastructural effects of sildenafil on the dental pulp in rats. The relaxation from the vessel, endothelial cell hyperplasia, moderate degeneration of collagen fibers were observed to cause degenerative changes in odontoblast with sildenafil. In the pulp tissue long-term use sildenafil is thought to cause degeneration and new vessel formation.Öğe Effects of Sildenafil on Dental Tissue(Medwell Online, 2011) Yaman, Ferhan; Soker, Sevda; Atilgan, Serhat; Erol, Behcet; Alp, Harun; Agacayak, Serkan Kamil; Gunay, AhmetTo investigate the effects of Sildenafil on dental tissue. The study was performed with adult female Wistar-Albino rats. Control group (n = 7) were fed on standard laboratory diet until surgery. The study group (n = 7) were administered Sildenafil orally with orogastric tube 10 mg kg(-1) once a day for 30 days. Each rat was anesthetized and mandibular bone with incisor teeth and soft tissue were removed. Dental pulp, dentin, periodental ligament, periodental soft tissue and bone were examined histologically. Neovascularization on the dental pulp and gingiva were significantly higher in the study group. Sildenafil can be used as a supporting factor in dental tissue healing.Öğe Effects of Systemic Zoledronic Acid Administration on Osseointegration of Hydroxyapatite-Coated and Resorbable Blast Material Surface Implants in Rabbit Models(Quintessence Publishing Co Inc, 2012) Yaman, Ferhan; Agacayak, Serkan; Atilgan, Serhat; Benlidayi, Emre; Ucan, Musa Can; Erol, Behcet; Kaya, BeyzaPurpose: It is unknown whether zoledronic acid (ZA) interferes with initial bone healing at implant sites. The goal of this study was to examine the effects of systemic zoledronic acid administration on osseintegration of hydroxyapatite (HA)-coated and resorbable blast material surface (RBM) implants in rabbit models. Materials and Methods: Twenty-eight male New Zealand rabbits (aged 6 to 12 months) were used in this study. Rabbits were randomly assigned to four groups. In group A, HA-coated implants were placed in the right tibia of seven rabbits. In group B, RBM-surface implants were placed in the right tibia of seven rabbits. In group C, HA-coated implants were placed in seven rabbits with intravenous (IV) administration of ZA. Finally, in group D. ROM-surface implants were placed in seven rabbits with IV administration of ZA. For groups C and D, IV zoledronic acid (0.1 mg/kg) was performed monthly during the entire osseointegration period. All of the rabbits were sacrificed 12 weeks after the implantation, and tibial specimens were harvested. Histomorphometric bone-to-implant contact (BIC) analysis and the data were statistically analyzed. Results: The highest BIC percentage was detected in group D, with a mean value of 56.73% +/- 1.85%, as compared with 45.80% +/- 3.77% in group C, 35.11% +/- 0.76% in group B, and 3114% +/- 1.04% in group A. Conclusions: Histomorphometric analyses showed significant improvement in the osseointegration of implants in the RBM-surface ZA group compared with the HA-coated ZA group. The results of this study suggest that systemic ZA administration may improve osseointegration of titanium implants in bone. INT J ORAL MAXILLOFAC IMPLANTS 2012;27:1443-1447Öğe Evaluation of Mandibular Fractures in Children during Five years' in a Dental School(Drunpp-Sarajevo, 2012) Yaman, Ferhan; Atilgan, Serhat; Erol, Behcet; Ucan, Musa Can; Yilmaz, Utku Nezih; Agacayak, Serkan Kamil; Gunes, NedimMandibular fractures are rarely encountered among the pediatric population, and when they do present, their clinical features differ from those in adults. This retrospective study looked at the age, sex, type and cause of fracture, treatment method and associated injuries and complications in 260 cases of mandibular fracture in children under age 16. Among the most significant findings: Fracture incidence had a 3:5 male:female ratio; 52% of all mandibular fractures involved condyle/subcondyle fractures and 50.7% involved symphysis/parasymphysis fractures; the most common treatment method was intermaxillary fixation; in no cases were severe complications observed during the healing period.Öğe The gastrocnemius muscle hematoma arising from warfarin use: The importance of genotype analysis in hematomas of atypical localization(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2012) Atilgan, Zuhal Ariturk; Tekbas, Ebru Onturk; Atilgan, Serhat; Yazici, Selma; Yavuz, CelalWarfarin is an effective anticoagulant which is used for the prevention of arterial and venous thrombosis. Currently, this type of oral anticoagulant drugs are often used with various indications and rarely leads life-threatening bleeding. Although bleeding into the gastrocnemius muscle, is usually associated with trauma, it may very rarely result from warfarin overdose. In this article, we report a-41-year-old female case with hematoma in the gastrocnemius muscle due to low doses (i.e. 1.25 mg) of warfarin every other. day.Öğe Long-term effects of antihypertensive medications on bone mineral density in men older than 55 years(Dove Medical Press Ltd, 2014) Agacayak, Kamil Serkan; Guven, Sedat; Koparal, Mahmut; Gunes, Nedim; Atalay, Yusuf; Atilgan, SerhatIntroduction: In this study, we investigated the effects of long-term antihypertensive treatment with calcium channel blockers or beta blockers on the bone mineral density of maxilla, as determined by cone-beam computed tomography (CBCT). Material and methods: This retrospective study was conducted on CBCT images of men older than 55 years who had received different dental indications. Data were grouped into three categories according to the antihypertensive medication history of the patients: group A included patients who had been taking beta-blocker treatment for more than 5 years, group B included patients who had been taking calcium channel blocker treatment for more than 5 years, and the control group included patients who had never used any hypertensive medications before. Results: Statistically significant differences were observed between the beta blocker and calcium channel blocker groups. Conclusion: In hypertension treatment, beta blockers may be preferred to calcium channel blockers in patients at high risk for osteoporosis and bone resorption. Keywords: bone mineral density, CBCT, beta blockers, calcium channelÖğe Mandibular fractures: a comparative analysis between young and adult patients in the southeast region of Turkey(Univ Sao Paulo Fac Odontologia Bauru, 2010) Atilgan, Serhat; Erol, Behcet; Yaman, Ferhan; Yilmaz, Nezih; Ucan, Musa CanObjective: The purpose of this study was to review and compare the differences between mandibular fractures in young and adult patients. Material and Methods: Patients treated at the Oral and Maxillofacial Department of Dicle University during a five-year period between 2000 and 2005 were retrospectively evaluated with respect to age groups, gender, etiology, localization and type of fractures, treatment methods and complications. Result: 532 patients were included in the study, 370 (70%) males and 162 (30%) females, with a total of 744 mandibular fractures. The mean age of young patients was 10, with a male-female ratio of 2:1. The mean age of adult patients was 28, with a male-female ratio of 3: 1. The most common causes of injury were falls (65%) in young patients and traffic accidents (38%) in adults. The most common fracture sites were the symphysis (35%) and condyle (36%) in young patients, and the symphysis in adults (36%). Mandibular fractures were generally treated by arch bar and maxillomandibular fixation in both young (67%) and adult (39%) patients, and 43% of the adult patients were treated by open reduction and internal fixation. Conclusion: There was a similar gender, monthly and type of treatment distribution in both young and adult patients in the southeast region of Turkey. However, there were differences regarding age, etiology and fracture site. These findings between young and adult patients are broadly similar to those from other studies. Analysis of small differences may be an important factor in assessing educational and socioeconomic environments.Öğe Melanotic neuroectodermal tumor of infancy(Int Scientific Information, Inc, 2011) Atilgan, Serhat; Erol, Behcet; Yaman, Ferhan; Yilmaz, Utku Nezih; Can, CevatBackground: Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, distinctive neoplasm of neural crest origin, primarily containing melanin, and affecting the maxilla of infants during the first year of life. The tumor is benign but may grow very rapidly and invade the bone marrow. Very rare examples of malignant transformation have also been reported. Treatment consists of surgical removal, somewhat more aggressive than the typical conservative removal. Case Report: A 4-month-old male was admitted to our clinic after the parents noted a rapidly growing swelling in the anterior maxilla 3 weeks previously and difficulty in oral feeding and weight loss due to malnutrition. Conclusions: This tumor is an uncommon benign tumor of neural crest origin occurring in infants. The lesion exhibits a good response to surgical excision, with few recurrences, although long-term follow-up is advised because of the possibility, albeit rare, of malignant change.Öğe Microbiologic and histologic assessment of intentional bacterial contamination of bone grafts(W B Saunders Co-Elsevier Inc, 2007) Yaman, Ferhan; Uenlue, Guelten; Atilgan, Serhat; Celik, Yusuf; Oezekinci, Tuncer; Yaldiz, MehmetPurpose: The purpose of this study was to investigate methods of removing pathogenic microorganisms from bone grafts that have been contaminated during surgery. Materials and Methods: Femora were removed from Sprague-Dawley rats and were divided into sections and contaminated in solutions of the bacteria Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Contaminated bone specimens in each group were immersed in various solutions for specified periods so their antibacterial effects could be evaluated. After these procedures were performed, bone specimens were cultured in nutrient media. Bone structure was evaluated, and the appropriate decontamination method was selected. Results: Solutions such as povidone-iodine, neomycin, cephazolin sodium, and rifamycin were found to be effective decontaminants. These solutions did not damage the bone structure. Among these solutions, only rifamycin was effective against all bacteria used in this study to contaminate bone grafts. Conclusions: Rifamycin seems to be the most suitable agent for the elimination of contamination introduced into bone grafts during surgery. (c) 2007 American Association of Oral and Maxillofacial Surgeons.Öğe Myiasis Caused by Musca domestica Larvae in a Child: A Case Study(Medwell Online, 2011) Ucan, Musa Can; Erol, Behcet; Balacan, Fatma; Atilgan, Serhat; Yaman, Ferhan; Arslanoglu, Zeki; Agacayak, Serkan KamilThe term myiasis is the infestation of tissue by the larvae of flies. This parasitic infestation is well documented in the skin, especially among animals and people in tropical and subtropical zones. Among the sites of infestation, the human mouth is a common site mainly in tropical countries and is associated with inadequate public and personal hygiene. Due to its destructive potential, appropriate treatment is necessary. This study describes oral myiasis in an 8 years old boy who lives relatively warmer area of his country. The myiasis occurred in the anterior upper jaw associated with palatal area of left incisor and lateral tooth. Pathologic soft tissue sockets were observed in the palatal area at the level of the both deciduous incisor and lateral along the deep periodontal tissues.Öğe The relationship between high incidence of deep neck infection and toothbrushing frequency(Academic Journals, 2012) Bakir, Salih; Gunay, Ahmet; Tanriverdi, Halis; Gun, Ramazan; Atilgan, Serhat; Palanci, Yilmaz; Ozbay, MusaThis study aimed to investigate and compare the frequency of toothbrushing and dental health status between deep neck space infection (DNSI) patients with dental origin and healthy population. 64 participants were included in this study in the form of two groups. The first group consisted of 34 DNSI patients with dental onset, and the second group consisted of 30 participants (control group). Study was carried out in two separate categories: the frequency of toothbrushing and assessment of dental health status. Toothbrushing frequency was evaluated with a questionnaire. Dental health status was assessed for periodontal and dental disease by periodontist according to the some widely used indicators; Decayed Missing Filled Teeth (DMFT) scores, Plaque Index score, Gingival Index score and Sulcus Bleeding Index score. Present study showed that the majority had brushed their teeth occasionally. In DNSI group, the percentage of never toothbrushing was very high and regular toothbrushing rate was so low. DNI group has higher scores than the control group and this indicates poor oral hygiene. Our results showed that, oral health was impaired and regular toothbrushing seems to have been neglected in DNSI group. In our opinion, this negligence is a very important contributory factor towards the more occurrence of deep neck abscess.Öğe The relationship between high incidence of deep neck infection and toothbrushing frequency(Academic Journals, 2012) Bakir, Salih; Gunay, Ahmet; Tanriverdi, Halis; Gun, Ramazan; Atilgan, Serhat; Palanci, Yilmaz; Ozbay, MusaThis study aimed to investigate and compare the frequency of toothbrushing and dental health status between Deep neck space infection (DNSI) patients with dental origin and healthy population. 64 participants were included in this study in the form of two groups. The first group consisted of 34 DNSI patients with dental onset, and the second group consisted of 30 participants (control group). Study was carried out in two separate categories: the frequency of toothbrushing and assessment of dental health status. Toothbrushing frequency was evaluated with a questionnaire. Dental health status was assessed for periodontal and dental disease by periodontist according to the some widely used indicators; DMFT scores, Plaque Index score, Gingival Index score and Sulcus Bleeding Index score. Present study showed that the majority had brushed their teeth occasionally. In DNSI group, the percentage of never toothbrushing was very high and regular toothbrushing rate was so low. DNI group has higher scores than the control group and this indicates poor oral hygiene. Our results showed that, oral health was impaired and regular toothbrushing seems to have been neglected in DNSI group. In our opinion, this negligence is a very important contributory factor towards the more occurrence of deep neck abscess.Öğe Systemic and local zoledronic acid treatment with hydroxyapatite bone graft: A histological and histomorphometric experimental study(Spandidos Publ Ltd, 2016) Gunes, Nedim; Dundar, Serkan; Saybak, Arif; Artas, Gokhan; Acikan, Izzet; Ozercan, I. Hanifi; Atilgan, SerhatIn this study, the aim was to compare the relative efficacy of systemic and local zoledronic acid (ZA) on a hydroxyapatite (HA) bone graft in a rat critical-size calvarial bone defect. In total, 84 female rats were divided into four groups: Empty control (EC) group with no treatment applied; HA group, in which only HA bone graft material was used in the calvarium; and HA plus local ZA (HA+LZA) and HA plus systemic ZA (HA+SZA) groups, in which animals received ZA locally or systemically, respectively, with HA bone graft material in the calvarium. A 5-mm standardised critical-size calvarial bone defect was created with a standard trephine drill and the respective treatment was applied. Rats were sacrificed 7, 14 and 28 days later. The numbers of osteoclasts and osteoblasts, and degree of bone formation were evaluated histopathologically and histomorphometrically. Statistically significant differences were detected between the HA, HA+LZA and HA+SZA groups and the EC group for new bone formation (P<0.05). Osteoblast numbers in the HA+LZA and HA+SZA groups were significantly higher compared with those in the EC and HA groups (P<0.05). No statistically significant difference was detected between the HA+LZA and HA+SZA groups in new bone formation or osteoblast number (P>0.05). Bone formation was significantly higher in the HA group than in the EC group (P<0.05). The numbers of osteoclasts in the HA+LZA and HA+SZA groups were significantly higher than those in the groups EC and HA (P<0.05); however, there was no significant difference between groups HA+LZA and HA+SZA (P>0.05). Within the limitations of this study, systemic or local administration of ZA enhanced new bone formation with a HA bone graft in a rat critical-size calvarial defect model.
