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    Chromosomal abnormalities in non-obstructive azoospermic men prior to employment of assisted reproduction in Southeast Turkey
    (Japan International Cultural Exchange Foundation, 2015) Balkan M.; Atar M.; Kemal Hatipo?lu N.; Nuri Bodakçi M.; Çakmakçi S.; Yildiz I.; Siddik Evsen M.
    Objective: The causes of male infertility are heterogeneous but more than 50% of cases have a genetic defect. Chromosomal abnormalities that affect on gametogenesis are one of the principle genetic factors in male infertility. The aim of this study is to determine the frequency and type of chromosomal abnormalities in non-obstructive azoospermic men with severe male factor infertility to give appropriate genetic counseling before assisted reproduction techniques. Materials and Methods: A total of 114 azoospermic infertile males were studied for the cytogenetic evaluation prior to use of assisted reproduction techniques. A detailed history was taken for each man. Karyotyping was performed on peripheral blood lymphocytes according to standard methods. Results: The overall incidence of chromosomal abnormalities was about 22.8% (26/114), including the sex chromosome abnormality 19.3% and the autosomal chromosome abnormality 3.5%. Twenty one of 22 patients with sex chromosome abnormality had classic Klinefelter karyotype. There were 2 mosaic cases involving X and Y chromosomes. Of the four cases with autosomal chromosome anomalies, three cases had balanced reciprocal translocations and one case with inversion. FSH, LH and testosterone levels showed significant increase in azoospermic patients with abnormal karyotype when compared with the normal karyotype (P < 0.05). Conclusions: Our findings are generally in accordance with those from other surveys and confirm that the XXY aneuploidy is the most frequent chromosomal abnormality in azoospermic individuals. The occurrence of chromosomal anomalies among infertile males suggests the need for genetic screening and proper genetic counselling before initiation of assisted reproduction treatment. © 2015 Japan Health Sciences University.
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    The possible association of polymorphisms in MTHFR, MTRR, and MTHFD1 genes with male infertility
    (2013) Balkan M.; Atar M.; Erdal M.E.; Yildiz I.; Hatipoğlu N.K.; Bodakç M.N.; Ay O.I.
    Objective: The aim of this study was to investigate the association of the methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), and methylenetetrahydrofolate dehydrogenase (MTHFD1) polymorphisms in idiopathic infertile men and fertile men. Materials and Methods: Case-control study comprising a total of 233 individuals including 108 idiopathic infertile men with nonobstructive azoospermia and 125 fertile men as control. MTHFR C677T, A1298C; MTRR A66G; and MTHFD1 G1958A polymorphisms were studied by Real-Time PCR System. The results were analyzed statistically and a P value <. 05 was considered significant. The Chi square test was used to analyze the genotype distributions of polymorphisms. Results: Single-marker analysis revealed that none of the four polymorphisms was significantly associated with nonobstructive azoospermia. All groups were tested for Hardy-Weinberg equilibrium and the deviation from the Hardy-Weinberg equilibrium takes place for MTHFR C677T (P < 0.05) a combination of controls and infertile group. We also performed a multifactor dimensionality reduction (MDR) analysis to investigate any potential epistatic interactions among the four polymorphisms and male infertility. We found a synergistic interaction between some polymorphisms (P < 0.05). Conclusion: Our findings therefore suggest no individual but interactive association between four prominent folate metabolism pathway markers and male infertility among population in the Southeast Turkey. © 2013 Japan International Cultural Exchange Foundation & Japan Health Sciences University.
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    The protective effect of ellagic acid against renal ischemia-reperfusion injury in male rats
    (Veteriner Fakultesi Dergisi, 2012) Bozkurt Y.; Firat U.; Atar M.; Sancaktutar, Ahmet Ali; Pembegul N.; Soylemez H.; Yuksel H.
    The aim of this study was to evaluate the possible protective effect of ellagic acid (EA) on rats following renal ischemia-reperfusion (I/R) injury. Twenty-four Wistar rats were divided into three groups. Sham group underwent laparotomy then waited for 45 min without ischemia. I/R group were subjected to left renal ischemia for 45 minutes followed by 60 min of reperfusion. I/R+EA group were subjected to the same renal ischemia/reperfusion as the I/R group, were also given 85 mg/kg EA perorally 30 min prior to the ischemia. Malondialdehyde (MDA), total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were determined on the blood samples and kidney tissues. Histopathological analyses were conducted on the kidney tissues. I/R damage significantly increased serum MDA levels in the I/R group when compared with Sham group. Serum TAC level was significantly lower in I/R group than I/R+EA group. A significantly increase on OSI levels and decrease on TAC levels was found in the kidneys in I/R group. In I/R + EA group, EA reversed the negative effects of I/R injury. EA pretreatment was effective in decreasing tubular necrosis score. In conclusion; EA pretreatment ameliorated the oxidative damage and histopathological changes occurring following renal I/R injury.
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    Tubularized incised plate repair in circumcised adults
    (2013) Hatipoglu N.K.; Bodakci M.N.; Soylemez H.; Sancaktutar, Ahmet Ali; Atar M.; Penbegul N.; Cakmakci S.
    Aim In this study, the experience of tubularized incised plate repair in circumcised adults in terms of functional, cosmetic, and satisfactory results is reported. Methods Tubularized incised plate repair urethroplasty (TIPU) was performed to 27 circumcised adult patients between 2008- 2010; 19 (70.4%) had distal penile hypospadias and eight (29.6%) had midshaft hypospadias. All patients were operated by a single surgeon and were asked to fill out a questionnaire to asses functional and cosmetic results of the surgery. Results The mean age of patients was 22.0 years. All patients were controlled in urology office seven days after the removal of urethral catheter. They were controlled in the 3rd, 6th, and 12th month after the operation and they filled out the questionnaire in the 6th month after the operation in the TIP. The mean follow up was 13 months. Three (11.1%) patients had meatus stenosis and two (7.4%) urethral fistula as a complication. Twenty-four (88.8%) patients reported that they were satisfied about penile length, 26 (96.2%) about the appearance of the meatus, 25 (92.5%) about the appearance of the glans penis, 22 (81.4%) about the appearance of the foreskin, 23 (85.1%) about the straightness of the penis with erection, and 24 (88.8%) about the overall appearance of the penis. All patients were satisfied about the urinary flow and seven (100%) patients who were sexually active reported that they were satisfied with vaginal penetration and sexual satisfaction. Conclusion Tubularized incised plate repair technique reveals good functional and cosmetic results even in adults who were circumcised.