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Öğe Daunorubicin induced blue-gray hyperpigmentation: A case report(2005) Ayyildiz O.; Şit D.; Söker M.; Kadiro?lu A.K.; Yeşilba?dan A.H.Daunorubicin is used widely in the treatment of acute myeloblastic leukemia (AML). Daunorubicin has some toxicity which limit the usage of drug. Blue-gray pigmentation is an uncommon side effect of daunorubicin. It is one of the side effect which might disturb patient for a long time cosmetically. We report here a hyperpigmentation case with acute myelomonocytic leukemia who is still on the treatment.Öğe Differential diagnosis of Churg Strauss syndrome: Two cases reports(2007) Altintaş A.; Çil T.; Ayyildiz O.; Şit D.; Müftüoğlu E.Churg-Strauss syndrome (CSS) is characterized by necrotising, eosinophilic-rich granulomatous inflammation of small and medium vessels. Differantial diagnosis with Hypereosinophilic syndrome is crucial. Herein, we presented two patients with eosinophilia and eosinophilia related organ damage and emphasize the clinical properties and differential diagnosis of CSS and Hypereosinophilic syndrome; which has many similarities.Öğe The evaluation of the prevalence of extrahepatic findings in chronic hepatitis-C virus infection(Turkiye Klinikleri, 2005) Kadiro?lu A.K.; Göral V.; Şit D.; Çelik M.; Yilmaz M.E.Objective: To evaluate the prevalence of clinical and biological extrahepatic findings in HCV infection. Material and Methods: Forty anti-HCV (+) patients and 40 HbsAg (+) patients were evaluated in the study. In the anti-HCV (+) group, 35 of 40 (87.5%) manifested chronic liver disease and 5 of 40 (12.5%) had liver cirrhosis. In the HbsAg (+) group, 33 of 40 (82.5%) were seen to have chronic liver disease and 7 of 40 (17.5%) liver cirrhosis. HCV and HBV infections were confirmed by ELISA and polymerase chain reaction (PCR). Biochemical, hematological and immunological tests were performed for both anti-HCV (+) and HbsAg (+) groups. They were as well evaluated for other clinical presentations, such as rheumatological, dermatological, neurological, and psychiatric symptoms. Results: In the anti-HCV (+) group, the mean age was 49.0 ± 15.7 years, the mean duration of disease was 38.1 ± 51.8 months. In the HbsAg (+) group, they were, respectively, 36.4 ± 13.2 years and 35.3 ± 42.1 months. Extrahepatic clinical presentations in the anti-HCV (+) group versus HbsAg (+) group were as follows: 25% arthralgia and 5% arthritis versus 5% arthralgia (p= 0.031); 10% paresthesia and 12.5% peripheral neuropathy versus 5% paresthesia (p= 0.041); 10% pruritus versus 5% pruritus (p= 0.045); 50% depression and 2.5% anxiety versus 7.5% depression (p= 0.000); 25% ANA (+), 2.5% ASMA (+) and 7.5% [ANA + ASMA + AMA] (+) versus only 5% ANA (+). A positive correlation was found between clinic status and age (r = 0.429, p= 0.006, r= 0.461, p= 0.003), between clinic status and duration of disease (r= 0.516, p= 0.001, r= 0.517, D= 0.001) and between serum albumin and hct levels (r= 0.561, p= 0.000, r= 0.649, p= 0.000) in the anti-HCV (+) and HbsAg (+) groups, respectively. The relative risk values of each of the extrahepatic findings were established in both groups. Conclusion: Extrahepatic findings such as rheumatological, neurological, psychiatric and dermatological clinical presentations, as well as autoantibody positivity, were more frequently observed in the anti-HCV (+) group. It was also observed that the prevalence of extrahepatic findings in this clinical setting was more increased in variable ratio in those with chronic HCV infection rather than in normal individuals. Copyright © 2005 by Türkiye Klinikleri.Öğe Multiple atrial thrombus in a splenectomized patient with thalassemia major(2005) Kidir V.; Balakan O.; Süner A.; Şit D.; Ayyildiz O.Many previously undescribed complications develop in the patients with thalassemia major due to improving survival. One of these complications is thromboembolic conditions. Hypercoagulability is known clearly especially in splenectomized thalassemia patients. The most common site of thrombosis is brain in the patients with thalassemia major. Intracardiac thrombosis is infrequent. We discussed a splenectomized patient with thalassemia major who has an increasing effort dyspnea and right atrial multiple thrombus last 2 years.Öğe A rare cause of anemia in a patient with end stage renal disease: Pulmonary hemorrhagic syndrome: Case report(Turkiye Klinikleri, 2007) Şit D.; Kadiroğlu A.K.; Kayabaşi H.; Büyükbayram H.; Yilmaz M.E.; Işikoğlu B.The association of pulmonary hemorrhagic syndrome and end stage renal disease is a rare condition. Severe anemia that occurred suddenly in a 27 years old male patient who was undergoing chronic HD program was investigated. Platelet count was normal but bleeding time was prolonged. Pulmonary hemorrhagic syndrome was considered secondary to platelet dysfunction. The diagnosis was confirmed by pulmonary biopsy. The patient was successfully treated with conservative approach. Copyright © 2007 by Türkiye Klinikleri.Öğe Retrospective evaluation of brucellosis cases inhabiting in Mus province(2006) Şit D.; Kadiroğlu A.K.; Kayabaşi H.; Hoşoğlu S.The aim of this study was to evaluate the brucellosis patients inhabiting in Mus province, in Eastern Anatolia of Turkey, retrospectively. The mean age of the patients (n: 87) was 38.1±12.4 years, and 45% of them were female. The transmission route was the consumption of unpasteurized fresh cheese (in 85%), and unboiled milk (in 45%). The most common symptoms were recorded as chills (89%), fever (87%), and arthralgia (81%). Splenomegaly (71%) and hepatomegaly (63%) were the predominant physical examination signs. Diagnosis was made based on the clinical features and positive Rose-Bengal test result (93%), however, blood cultures could not be performed due to insufficient laboratory equipment. In 92% of the patients at least one complication has been detected indicating delayed admission to the hospital, while the most common complications were sacroileitis (79%) and spondylitis (44%). Streptomycin+doxycyclin, streptomycin+doxycyclin+ ciprofloxacin, and streptomycin+doxycyclin+ rifampicin combination therapies were used in 62%, 24% and 14% of the patients, respectively, for six weeks, resulting with complete cure.Öğe The role of CA 72-4, a new tumor marker in gastric cancer(Turkiye Klinikleri, 2006) Göral V.; Yeşilbağdan H.; Kaplan A.; Şit D.; Çelik M.Objective: Gastric cancer is among the most frequent malignancies throughout the world. Many studies are carried out with tumor markers, tumor suppressive genes and oncogenes in the diagnosis of gastric cancers and the prediction of prognosis. The role of CA 72-4, a new tumor marker in the diagnosis of gastric cancer, and the correlation between CA 72-4 and CA 19-9, CA 15-3, CA 125, carcinoembryonic antigen (CEA) were investigated in this study. Material and Methods: CEA, CA 19-9, CA 125, CA 15-3, CA 72-4, erythrocyte sedimentation rate, AST, ALT, albumin and hematocrit values were examined in patients with gastric cancer. Age, sex, clinical manifestations, physical examination findings, localization (proximal/distal) and histological typing of the tumor according to Lauren classification, lymph node involvement, metastasis state, and tumor grade and the patient's performance status were evaluated. Results: Serum CEA, CA 19-9, CA 125, CA 15-3 levels were quite high in our study patients with gastric cancer. All patients whose CA 72-4 level was over 100 U/ml were advanced cases (grade IV). These 4 markers seemed to increase relatively consistently with tumor involvement and tumor grade. Although CA 72-4 is more sensitive, all other tumor markers except for CA 15-3 play an important role in the diagnosis and determining the prognosis in patients with gastric cancer. We determined that the serum CA 72-4 level in the group with cancer was significantly elevated with respect to the control group. This elevation was correlated with tumor expansion and tumor grade. Particularly in patients with liver metastases, CA 72-4 level was higher. Conclusion: We suggest that CA 72-4 level is a valuable parameter in determining the prognosis of gastric cancer and recommend its use as a laboratory test. Copyright © 2006 by Türkiye Klinikleri.
