Yazar "Şermet, Abdurrahman" seçeneğine göre listele

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    Changes in blood antioxidant status and lipid peroxidation following distance running
    (1998) Atmaca, Mukadder; Koçyiğit, Yüksel; Şermet, Abdurrahman; Diken, Hüda; Kelle, Mustafa
    To examine the effects of increased O2 utilization on blood antioxidant status and lipid peroxidation, ten trained male athletes took part in a 20 km distance race. Venous blood samples were removed before and immediately after completion of the half-marathon. Plasma creatine kinase (CK) activity, an index of muscle damage, increased (p<0.05) after the race but this was not accompanied by changes in thiobarbutiric acid reactive substance (TBARS), which is an index of lipid peroxidation. Plasma cholesterol and uric acid concentrations significantly increased (p<0.01 and p<0.05 respectively) but plasma $alpha$-topocherol, triglyceride, and the total protein levels did not change (p>0.05) after the race. The erythrocyte and leucocyte counts, hematocrit, and hemoglobin levels rose after the race (p<0.05, p<0.001, p<0.05, and p<0.01, respectively). However,the mean corpuscular volume (MCV), and mean corpuscular hemoglobin concentration (MCHC) did not change. Erythrocyte superoxide dismutase (SOD) and catalase activities were unaffected by the exercise but total glutathione (GSH) and reduced GSH decreased (p<0.05) after the race. In the post-race samples, a rise in oxidized glutathione (GSSG) was not statistically significant (p>0.05). The result indicate that, when trained athletes run a comparatively short distance sufficient to cause some degree of muscle damage but insufficient to cause increases in the plasma indices of lipid peroxidation, changes in erythrocyte antioxidant status do occur.
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    Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model
    (Sciendo, 2024) Kaya, Hacer Kayhan; Demirtaş, Berjan; Yokuş, Beran; Kesim, Dilek Aygün; Taşdemir, Ezel; Şermet, Abdurrahman
    Statin treatment may increase the risk of diabetes; there is insufficient data on how statins affect glucose regulation and glycemic control and the effects of statins on liver enzymes related to carbohydrate metabolism have not been fully studied. Therefore, we aimed to compare the effects of the statin derivatives, pravastatin, and rosuvastatin, on carbohydrate metabolism in an experimental diabetic rat model. Female Wistar albino rats were used and diabetes was induced by intraperitoneal injection of streptozotocin. Thereafter, 10 and 20 mg kg(-1 )day(-1) doses of both pravastatin and rosuvastatin were administered by oral gavage to the diabetic rats for 8 weeks. At the end of the experiment, body masses, the levels of fasting blood glucose, serum insulin, insulin resistance (HOMA-IR), liver glycogen, and liver enzymes related to carbohydrate metabolism were measured. Both doses of pravastatin significantly in creased the body mass in diabetic rats, however, rosuvastatin, especially at the dose of 20 mg kg(-1 )day(-1) reduced the body mass signi ficantly. Pravastatin, especially at a dose of 20 mg kg(-1 )day(-1), caused significant increases in liver glycogen synthase and glucose 6-phosphate dehydrogenase levels but significant decreases in the levels of glycogen phosphorylase, lactate dehydrogenase, and glucose-6-phosphatase. Hence, pravastatin partially ameliorated the adverse changes in liver enzymes caused by diabetes and, especially at the dose of 20 mg kg(-1 )day(-1), reduced the fasting blood glucose level and increased the liver glycogen content. However, rosuvastatin, especially at the dose of 20 mg kg(-1 )day(-1), significantly reduced the liver glycogen synthase and pyruvate kinase levels, but increased the glycogen phosphorylase level in diabetic rats. Rosuvastatin, 20 mg kg(-1 )day(-1 )dose, caused significant decreases in the body mass and the liver glycogen content of diabetic rats. It can be concluded that pravastatin, especially at the dose of 20 mg kg(-1 )day(-1) is more effective in ameliorating the negative effects of diabetes by modulating carbohydrate metabolism.
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    Effect of exercise on blood antioxidant status and erythrocyte lipid peroxidation: Role of dietary supplementation of vitamin E
    (1999) Atmaca, Mukadder; Kelle, Mustafa; Diken, Hüda; Şermet, Abdurrahman; Tümer, Cemil
    We tested the effects of moderate physical exercise on the blood antioxidant capacity and erythrocyte lipid peroxidation in 21 Wistar albino rats. Erythrocyte superoxide dismutase (SOD) activity increased significantly (p<0.05) in control exercised animals (C-Ex), but catalase activity did not change. SOD activity was decreased by dietary supplementation of vitamin E (p<0.05). In vitamin E supplemented group (E-Ex), catalase activity was reduced in comparision to C-Ex group. Total glutathione (total GSH) level was unaffected by the exercise. However, significant reduction was observed in reduced glutathione (GSH), whereas oxidized glutathione (GSSG) increased (p<0.01 and p<0.001, respectively). In E-Ex animals, total GSH and GSH were increased in comparison to C-Ex group. GSH/GSSG ratio decreased abnormally in both exercised groups (p<0.001). Serum cholesterol and uric acid levels increased significantly after exercise (p<0.05). The susceptibility of eryhrocytes to in vitro peroxidation increased in C-Ex and E-Ex animals (p<0.001 and p<0.01, respectively). Elevated malondialdehyde (MDA) concentrtaion in serum attained statistical significance after exercise. However, this elevation was prevented by vitamin E supplementation. Our results indicated that moderate intensive treadmill running exercise was sufficient to result in muscle damage and increases in the susceptibility of erythrocytes to in vitro peroxidation. In addition, dietary supplementation of vitamin E is able to minimize oxidative damage caused by exercise.
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    Effects of cigarette smoking on blood antioxidant status in short-term and long-term smokers
    (2001) Şermet, Abdurrahman; Kelle, Mustafa; Deniz, Basra; Tümer, Cemil; Baylan, Yüksel; Diken, Hüda
    Effects of cigarette smoking on blood antioxidant status in short-term and long-term smokers
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    The effects of vitamin E on gastric ulcers and gastric mucosal barrier in stress induced rats
    (1998) Kurt, Doğan; Canoruç, Fikri; Denli, Orhan; Kanay, Zeki; Şermet, Abdurrahman; Güzel, Cihat
    Effects of vitamin E on gastric ulcers gastric mucosal barrier were investigated in cold + restraint stress (CRS) induced rats. In this study 21 males two month old Swiss Albino Rats were used. Stress treated rats significantly decreased mucus and phospholipid content of gastric mucosa (p<0.01,P<O.Ol). Vitamin E was administered orally in the dose of 100 mg/kg body weight thirty min. before stress. Vitamin E reduced significantly gastric ulceration (p<0.01). Moreover, it significanly protected mucus secretion and phospholipid content of gastric mucosa in rats (p<0.01, p<0.01, respectively). These results indicate that extrinsic application of vitamin E may strengthen gastric mucosal barrier in rats.
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    Evaluation of the serum visfatin eotaxin and fetuin-A levels of patients with type 2 diabetes mellitus
    (MediHealth Academy Yayıncılık, 2022) Kaya, Hacer Kayhan; Şermet, Abdurrahman; Pekkolay, Zafer; Taşdemir, Ezel; Keşim, Dilek Aygün
    Objective: The aim of this study was to determine the serum visfatin, eotaxin and fetuin-A levels in patients with normal BMI and overweight type 2 diabetes mellitus (T2DM). Material and Method: This study perform in 30 T2DM patients and in 20 healthy subjects. Test subjects were divided into four groups as two diabetics and two controls. Diabetics with a body mass index (BMI) of 26.2-29.9 kg/m2 were included in the overweight diabetic group (OD), and those with a body mass index of 20.9-24.9 kg/m2 were included in the normal BMI diabetic group (ND). The volunteers in the control group were also divided into two groups as overweight (OC) and normal BMI (NC). Smoking and alcohol users were not included in the study. In addition, patients with significant diabetic complications such as retinopathy, hypertension, neuropathy, renal failure, and cardiovascular disease were excluded from the study. The serum visfatin eotaxin and fetuin-A levels were measured using the ELISA method. The Mann-Whitney U test was used to compare the data of the groups, while Spearman’s analysis was applied for the correlations. Results: The visfatin levels of the OD and ND were significantly higher compared to those of their control groups (p
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    The relationship between plasma adipsin, adiponectin, vaspin, visfatin, and leptin levels with glucose metabolism and diabetes parameters
    (2019) Taşdemir, Ezel; Şermet, Abdurrahman
    Introduction: Recently, interesting adipokines have been described that affect glucose metabolism and insulin resistance.However, the relationships between these adipokines and their importance in the pathogenesis of diabetes are contradictory.The aim of the present study was to investigate the relationship between plasma adipsin, adiponectin, vaspin, visfatin,and leptin levels in diabetic rats with liver enzymes related to glucose metabolism and diabetes parameters.Methods: Wistar albino rats were divided into three groups: control, diabetic control, and treatment groups, each with 7 ofthem. One group of diabetic rats was orally treated with 200 mg/kg/day metformin, and the other diabetic group receivedplacebo. After 6 weeks, the animals were sacrificed by cardiac puncture. Glucose, insulin, glycosylated hemoglobin (HbA1c),adipsin, adiponectin, visfatin, vaspin, and leptin levels in blood were measured by enzyme-linked immunosorbent assay(ELISA), and insulin resistance was determined. In liver homogenates, glucose-6-phosphate dehydrogenase (G6PD), glucose-6-phosphatase (G6P-ase), glucokinase, pyruvate kinase (PK), and fructose-1.6-diphosphatase (F1.6DP) activities weremeasured by ELISA.Results: Dietary food intake and water consumption, fasting blood glucose and HbA1c levels, and insulin resistance of diabeticrats were higher than those of the control and treatment groups. Plasma adipsin, adiponectin, vaspin, and leptin levels significantlydecreased, and visfatin level increased in diabetic rats. G6PD, glucokinase, and PK activities decreased, whereas G6P-aseand F1.6DP activities increased in diabetic rats. There were a negative correlation between plasma adipsin and adiponectinlevels and insulin resistance and a positive correlation between visfatin level and insulin resistance in diabetic rats. In addition,adipsin, adiponectin, and leptin levels were positively correlated with each other and with some liver enzymes.Discussion and Conclusion: In the diabetic rat model, body weight, glucose metabolism enzymes, insulin sensitivity, andchanges in plasma adipsin, adiponectin, vaspin, visfatin, and leptin levels indicate that these adipokines play an importantrole in the glucose metabolism, insulin resistance, and pathogenesis of diabetes.
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    Strokta hipotalamus-anterior pituiter aks disfonksiyonu: İV TRH uygulamasına TSH yanıtları
    (Hekimler Yayın Birliği, 1997) Taşdemir, Nebahat; Gülersönmez, Mehmet; Aluçlu, Ufuk; Haspolat, Yusuf Kenan; Şermet, Abdurrahman
    Serebrovasküler hemorajisi ve infarktı olan, tiroid hastalığı bulunmayan 38 hastada, lezyonun hipotalamus-anterior pituiter aksı etkileyip etkilemediğini ortaya koymayı amaçladık. Bunun için sabah, 8.00'de 500 u.gr TRH İV uygulayarak serum tiroid hormonları; T3 (triiodotironin), T4 (tiroksin), ST3 (serbest T3), ST4 (serbest T4) ve TSH (tiroid stimülan hormon) düzeyleri O'ıncı dakikada, TSH hormonları ise 20'nci, 60'ıncı dakikalarda RİA (Radioimmüne Assay) tekniği ile ölçüldü. Sonuçlar 17 ötiroidili kontrol grubu ile karşılaştırıldı. Stroklu hastalarda TRH'ya TSH'a yanıtları değişkendi, düşük yanıt, %28.94 (n=ll) aşırı geç yanıt %5.26 (n=2) ve normal yanıtlar 65.78 (n=25) elde edildi. Normal olan 25 stroklu hasta ve aks disfonksiyonu gösteren 13 olgu grubundaki TSH parametreleri normal kontrol grubu parametreleri ile karşılaştırıldı. Stroklu hasta grubundaki TSH değerlerinin, kontrol grubuna göre önemli derecede düşük olduğu izlendi (sırasıyla p<0.001, p<0.01).