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    Anatomical surgical approach to lateral ventricle masses and histopathological findings of the brain
    (Via Medica, 2024) Ünlü, İlker; Alptekin, Mehmet; Tuncer, Mehmet Cudi
    Background: The selection of surgical approach to the lateral ventricular masses includes difficulties due to their deep localisations and close proximity to the vascular and the eloquent brain structures. The most appropriate approach that should be chosen in surgical treatment of lateral ventricular masses is still controversial. In this study, the factors in the choice of surgical approach to the lateral ventricle masses and the results of them were investigated. Materials and methods: In this study, 80 patients who underwent surgery in our clinic due to the lateral ventricular masses were retrospectively analysed between the years 2002 and 2013. All the cases were evaluated in terms of clinical and neuroradiological results pre- and postoperatively. In 24 cases the anterior interhemispheric transcallosal, in 4 cases the posterior interhemispheric transcallosal, in 30 cases the posterior interhemispheric precuneal, in 14 cases the transcortical, and in 8 cases the combined surgical approaches were performed. Results: Gender distribution of the cases were 45 male/35 female, and the mean age of them was 31.7 years (7 month — 73 years). In 64 patients the gross total resection was performed, whereas in 16 patients subtotal resection was performed due to the infiltration of eloquent brain areas. In the histopathological examination 52 neuroepithelial, 8 mixed neuroglial, 3 meningeal, 2 lympho-hematopoietic system, 1 pine blastoma, 1 germ cell, 5 metastatic, and 8 other benign masses were observed. After surgery, additional neurological deficits developed in 9 patients. Mortality was observed in 6 patients postoperatively. The average follow-up time was 13 (1–83) months. Conclusions: The essential factors that affect the results of surgical treatment of lateral ventricular masses are the size of the mass, histopathology, location, extension, and the relationship with the neurovascular structures. The goal of surgery is to provide a histopathological diagnosis, gross total resection, if possible, and to normalise the flow of cerebrospinal fluid by eliminating the mass effect of pressure. © 2024 Via Medica.
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    Effects of Curcumin and Doxorubicin on the Viability of Neuroblastoma Cancer Cell Line
    (2024) Ünlü, İlker; Özdemir, İlhan; Öztürk, Şamil; Tuncer, Mehmet Cudi
    Aim: Neuroblastoma has a very important place among childhood diseases, and despite all the methods used in treatment, it is very difficult to prevent neuroblastoma invasion. The number of studies showing that curcumin, the most active component of turmeric, is not toxic, is increasing day by day. In this study, the anticancer activities of curcumin (Cur), one of the important active compounds, were demonstrated in the Neuroblastoma cancer cell line (Na2B). Method: Neuroblastoma cell line was used in the study. To determine the IC50 doses of Dox and Cur, Na2B cells line were cultivated with an automatic pipette. MTT analysis was performed to analyze cell survival (viability). Inhibition levels in the cells were determined at 24 and 48 hours. Results: While the IC50 of Na2B cell proliferation was approximately 124.5 uM at the 48th hour in Dox-treated cells, the IC50 value of Cur at the 48th hour was found to be 224.6 uM. Conclusion: These results showed that Cur could be an alternative agent in the treatment of neuroblastoma, and its fewer side effects compared to other chemotherapeutic agents such as Dox would increase its preferability.
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    Effects of Curcumin and Doxorubicin on the Viability of Neuroblastoma Cancer Cell Line
    (Merthan TUNAY, 2024) Ünlü, İlker; Özdemir, İlhan; Öztürk, Şamil; Tuncer, M. Cudi
    Aim: Neuroblastoma has a very important place among childhood diseases, and despite all the methods used in treatment, it is very difficult to prevent neuroblastoma invasion. The number of studies showing that curcumin, the most active component of turmeric, is not toxic, is increasing day by day. In this study, the anticancer activities of curcumin (Cur), one of the important active compounds, were demonstrated in the Neuroblastoma cancer cell line (Na2B). Method: Neuroblastoma cell line was used in the study. To determine the IC50 doses of Dox and Cur, Na2B cells line were cultivated with an automatic pipette. MTT analysis was performed to analyze cell survival (viability). Inhibition levels in the cells were determined at 24 and 48 hours. Results: While the IC50 of Na2B cell proliferation was approximately 124.5 uM at the 48th hour in Dox-treated cells, the IC50 value of Cur at the 48th hour was found to be 224.6 uM. Conclusion: These results showed that Cur could be an alternative agent in the treatment of neuroblastoma, and its fewer side effects compared to other chemotherapeutic agents such as Dox would increase its preferability.
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    Honokiol Showed Neuroprotective Effects on Cerebellum in Spinal Cord Injury in Rats
    (Colegio de Farmaceuticos de la Provincia de Buenos Aires, 2024) Ünlü, İlker; Tutal Gürsoy, Görkem; Deveci, Engin
    Spinal cord injury (SCI) is developed by primarily traumatic external causes or secondarily hemorrhage and edema in cord. SCI causes neurological and multiorgan dysfunction. In the present study, effects of honokiol was investigated on cerebellar tissue in experimental SCI model by biochemical and histochemical analysis. Thirty-male Sprague Dawley rats were assigned to three groups. SCI was developed by dropping a steel rod with a diameter of 3 mm and a weight of 10 g was dropped from 10 cm to the spinal cord T7-9 vertebras under anesthesia. Upon SCI, 50 mg/kg honokiol was intraperitoneally introduced to animals for postoperative 7 days. Cerebellar tissue samples were fixed in zinc-formalin and processed for further histochemical analysis. Blood samples were collected for malondialdehyde (MDA), total antioxidant status (TAS) and oxidant status (TOS). Results were statistically analyzed and recorded. MDA and TOS values were higher and TAS values were lower in SCI compared to sham group. Honokiol restored the values close to values of sham group. Histopathological scores were increased in SCI group but honokiol treatment alleviated the pathologies and restored scores in SCI+honokiol group. IL-6 and Bax expression was mainly negative in sham groups. Glial cells, Purkinje cells and granular cells of cerebellum showed negative IL-6 and Bax immune reaction. SCI increased the expression of IL-6 and Bax in basket cells, Purkinje cells, glia cells of the substantia alba, in ganglions layer. After SCI, honokiol administration reduced the immune reaction of IL-6 and Bax in cerebellar cells and substansia alba. SCI caused hypoxia and tissue degeneration and inflammation in cerebellum. Honokiol administration may prevent cell degeneration and apoptosis by balancing cytokine activity to prevent oxidative stress and may be an alternative in cerebellar therapy. © 2024, Colegio de Farmaceuticos de la Provincia de Buenos Aires. All rights reserved.