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    The evaluation of the prevalence of extrahepatic findings in chronic hepatitis-C virus infection
    (Turkiye Klinikleri, 2005) Kadiro?lu A.K.; Göral V.; Şit D.; Çelik M.; Yilmaz M.E.
    Objective: To evaluate the prevalence of clinical and biological extrahepatic findings in HCV infection. Material and Methods: Forty anti-HCV (+) patients and 40 HbsAg (+) patients were evaluated in the study. In the anti-HCV (+) group, 35 of 40 (87.5%) manifested chronic liver disease and 5 of 40 (12.5%) had liver cirrhosis. In the HbsAg (+) group, 33 of 40 (82.5%) were seen to have chronic liver disease and 7 of 40 (17.5%) liver cirrhosis. HCV and HBV infections were confirmed by ELISA and polymerase chain reaction (PCR). Biochemical, hematological and immunological tests were performed for both anti-HCV (+) and HbsAg (+) groups. They were as well evaluated for other clinical presentations, such as rheumatological, dermatological, neurological, and psychiatric symptoms. Results: In the anti-HCV (+) group, the mean age was 49.0 ± 15.7 years, the mean duration of disease was 38.1 ± 51.8 months. In the HbsAg (+) group, they were, respectively, 36.4 ± 13.2 years and 35.3 ± 42.1 months. Extrahepatic clinical presentations in the anti-HCV (+) group versus HbsAg (+) group were as follows: 25% arthralgia and 5% arthritis versus 5% arthralgia (p= 0.031); 10% paresthesia and 12.5% peripheral neuropathy versus 5% paresthesia (p= 0.041); 10% pruritus versus 5% pruritus (p= 0.045); 50% depression and 2.5% anxiety versus 7.5% depression (p= 0.000); 25% ANA (+), 2.5% ASMA (+) and 7.5% [ANA + ASMA + AMA] (+) versus only 5% ANA (+). A positive correlation was found between clinic status and age (r = 0.429, p= 0.006, r= 0.461, p= 0.003), between clinic status and duration of disease (r= 0.516, p= 0.001, r= 0.517, D= 0.001) and between serum albumin and hct levels (r= 0.561, p= 0.000, r= 0.649, p= 0.000) in the anti-HCV (+) and HbsAg (+) groups, respectively. The relative risk values of each of the extrahepatic findings were established in both groups. Conclusion: Extrahepatic findings such as rheumatological, neurological, psychiatric and dermatological clinical presentations, as well as autoantibody positivity, were more frequently observed in the anti-HCV (+) group. It was also observed that the prevalence of extrahepatic findings in this clinical setting was more increased in variable ratio in those with chronic HCV infection rather than in normal individuals. Copyright © 2005 by Türkiye Klinikleri.
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    Öğe
    Horizontal pigmented nail bands during daunorubicin treatment [2]
    (2004) Soker M.; Ayyildiz O.; Işikdo?an A.; Çelik M.
    [No abstract available]
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    Öğe
    Multicentric plasma cell type Castleman disease: A case report
    (2003) Işikdo?an A.; Ayyildiz O.; Yakut M.; Çelik M.; Adresi Y.
    Castleman disease is known as giant lymph node hiperplasia or angiofollicular lymph node hiperplasia. It has two histopathologic type; hyalen vascular type (80%) and plasma cell type (20%). Plasma cell type generally has systemic symtomps and has localized and multisentric type. nineteen year-old male was admitted to our clinic with symptoms of fatigue, chest pain and weight loss. Anemia, hepatosplenomegali and right supraclavicular lymhadenopathy were clinical signs. Hemoglobin: 8 gr/dl, erythrocyte sedimentation rate: 86 mm/h, hypoalbuminemia, and policlonal hypergamaglobulinemia were found. Right mediastinal mass was detected. Abdominal ultrasonography revealed hepatosplenomegali and lymphadenopathy in hilum of spleen. Histopathological evaluation of mediastinal lymph node led the diagnosis of plasma cell type Castleman disease. Here we reported a patient with Castleman disease because, it is very rare disease and important in differantial diagnosis of lymphadenopathy.
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    Öğe
    The role of CA 72-4, a new tumor marker in gastric cancer
    (Turkiye Klinikleri, 2006) Göral V.; Yeşilbağdan H.; Kaplan A.; Şit D.; Çelik M.
    Objective: Gastric cancer is among the most frequent malignancies throughout the world. Many studies are carried out with tumor markers, tumor suppressive genes and oncogenes in the diagnosis of gastric cancers and the prediction of prognosis. The role of CA 72-4, a new tumor marker in the diagnosis of gastric cancer, and the correlation between CA 72-4 and CA 19-9, CA 15-3, CA 125, carcinoembryonic antigen (CEA) were investigated in this study. Material and Methods: CEA, CA 19-9, CA 125, CA 15-3, CA 72-4, erythrocyte sedimentation rate, AST, ALT, albumin and hematocrit values were examined in patients with gastric cancer. Age, sex, clinical manifestations, physical examination findings, localization (proximal/distal) and histological typing of the tumor according to Lauren classification, lymph node involvement, metastasis state, and tumor grade and the patient's performance status were evaluated. Results: Serum CEA, CA 19-9, CA 125, CA 15-3 levels were quite high in our study patients with gastric cancer. All patients whose CA 72-4 level was over 100 U/ml were advanced cases (grade IV). These 4 markers seemed to increase relatively consistently with tumor involvement and tumor grade. Although CA 72-4 is more sensitive, all other tumor markers except for CA 15-3 play an important role in the diagnosis and determining the prognosis in patients with gastric cancer. We determined that the serum CA 72-4 level in the group with cancer was significantly elevated with respect to the control group. This elevation was correlated with tumor expansion and tumor grade. Particularly in patients with liver metastases, CA 72-4 level was higher. Conclusion: We suggest that CA 72-4 level is a valuable parameter in determining the prognosis of gastric cancer and recommend its use as a laboratory test. Copyright © 2006 by Türkiye Klinikleri.