Browsing by Author "Topcu, Gulacti"
Now showing items 1-6 of 6
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Anticholinesterase and Antioxidant Activities of Natural Abietane Diterpenoids with Molecular Docking Studies
Topcu, Gulacti; Akdemir, Atilla; Kolak, Ufuk; Ozturk, Mehmet; Boga, Mehmet; Bahadori, Fatemeh; Cakmar, Seda Damla Hatipoglu (Bentham Science Publ Ltd, 2020)Background: Alzheimer's Disease (AD) is one of the most prevalent causes of dementia in the world, and no drugs available that can provide a complete cure. Cholinergic neurons of the cerebral cortex of AD patients are lost ... -
Antioxidant and Anticholinesterase Activities of Some Dialkylamino Substituted 3-Hydroxyflavone Derivatives
Culhaoglu, Burcu; Capan, Asli; Boga, Mehmet; Ozturk, Mehmet; Ozturk, Turan; Topcu, Gulacti (Bentham Science Publ Ltd, 2017)Background: Flavones, are a class of naturally occuring polyphenolic compounds which have 2-phenylchromen-4-one structure. Various studies showed that flavones have several pharmacological activities such as antioxidant, ... -
Antioxidant, anticholinesterase, and antimicrobial activities and fatty acid constituents of Achillea cappadocica Hausskn. et Bornm.
Ertas, Abdulselam; Boga, Mehmet; Hasimi, Nesrin; Yesil, Yeter; Goren, Ahmet Ceyhan; Topcu, Gulacti; Kolak, Ufuk (Tubitak Scientific & Technological Research Council Turkey, 2014)This study was the first fatty acid analysis and biological activity report on an endemic Achillea species, Achillea cappadocica Hausskn. et Bornm. The major compounds in the fatty acid were identified as oleic (34.7%), ... -
Bioguided Isolation of Secondary Metabolites fromSalvia cerino-pruinosa Rech. f. var. cerino-pruinosa
Kolak, Ufuk; Ertas, Abdulselam; Firat, Mehmet; Cakirca, Hatice; Topcu, Gulacti; Yener, Ismail; Akdeniz, Mehmet (2021)In the current study, the ethanol extracts prepared from the aerial parts and roots of an endemicspecies, Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa were fractionated on silica gel columns and testedfor determination ... -
Inhibition of Amyloid Aggregation Using Optimized Nano-Encapsulated Formulations of Plant Extracts with High Metal Chelator Activities
Kazdal, Fatma; Bahadori, Fatemeh; Celik, Burak; Ertas, Abdulselam; Topcu, Gulacti (Bentham Science Publ Ltd, 2020)Background: The role of Fe+2, Cu+2 and Zn+2 in facilitating aggregation of Amyloid beta (A beta) and consequently, the progression of Alzheimer's disease (AD) is well established. Objective: Development of non-toxic metal ... -
Novel Terpenoids with Potential Anti-Alzheimer Activity from Nepeta obtusicrena
Yilmaz, Anil; Boga, Mehmet; Topcu, Gulacti (Acg Publications, 2016)Dichloromethane extract of Nepeta obtusicrena Boiss. Et Kotschy Ex Hedge afforded two novel terpenoids, a diterpenoid and a triterpenoid in addition to two known triterpenoids, oleanolic acid and ursolic acid. Purification ...
