Browsing by Author "Kolak, Ufuk"
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Anticholinesterase and Antioxidant Activities of Natural Abietane Diterpenoids with Molecular Docking Studies
Topcu, Gulacti; Akdemir, Atilla; Kolak, Ufuk; Ozturk, Mehmet; Boga, Mehmet; Bahadori, Fatemeh; Cakmar, Seda Damla Hatipoglu (Bentham Science Publ Ltd, 2020)Background: Alzheimer's Disease (AD) is one of the most prevalent causes of dementia in the world, and no drugs available that can provide a complete cure. Cholinergic neurons of the cerebral cortex of AD patients are lost ... -
Antioxidant, anticholinesterase, and antimicrobial activities and fatty acid constituents of Achillea cappadocica Hausskn. et Bornm.
Ertas, Abdulselam; Boga, Mehmet; Hasimi, Nesrin; Yesil, Yeter; Goren, Ahmet Ceyhan; Topcu, Gulacti; Kolak, Ufuk (Tubitak Scientific & Technological Research Council Turkey, 2014)This study was the first fatty acid analysis and biological activity report on an endemic Achillea species, Achillea cappadocica Hausskn. et Bornm. The major compounds in the fatty acid were identified as oleic (34.7%), ... -
Bazı Salvia (Ada Çayı) Türlerinin HPLC-IT-TOF-MS ile Taranması, Sekonder Metabolitlerinin Saflaştırılması ve Antikanser Özelliklerinin Belirlenmesi
Yılmaz, Mustafa Abdullah; Yener, İsmail; Ertaş, Abdulselam; Temel, Hamdi; Topçu, Gülaçtı; Kandemir, Sevgi İrtegün; Kolak, Ufuk (2018)Arazi çalışmaları sonucu toplanan 6 Salvia türünün ön biyolojik aktivite deneylerinde kullanılmak üzere kloroform ve etanol ekstreleri hazırlandı. Bu 12 ekstreden aktif çıkan etanol ekstrelerinden saf madde izolasyonuna ... -
Bioguided isolation of secondary metabolites from Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa
Ertaş, Abdulselam; Çakırca, Hatice; Yener, İsmail; Akdeniz, Mehmet; Fırat, Mehmet; Topçu, Gülaçtı; Kolak, Ufuk (ACG Publications, 2021)Abstract: In the current study, the ethanol extracts prepared from the aerial parts and roots of an endemic species, Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa were fractionated on silica gel columns and tested for ... -
Bioguided Isolation of Secondary Metabolites fromSalvia cerino-pruinosa Rech. f. var. cerino-pruinosa
Kolak, Ufuk; Ertas, Abdulselam; Firat, Mehmet; Cakirca, Hatice; Topcu, Gulacti; Yener, Ismail; Akdeniz, Mehmet (2021)In the current study, the ethanol extracts prepared from the aerial parts and roots of an endemicspecies, Salvia cerino-pruinosa Rech. f. var. cerino-pruinosa were fractionated on silica gel columns and testedfor determination ... -
Biological and chemical comparison of natural and cultivated samples of satureja macrantha C.A.Mey
Akdeniz, Mehmet; Yener, İsmail; Ertaş, Abdulselam; Fırat, Mehmet; Reşitoğlu, Barış; Haşimi, Nesrin; Kandemir, Sevgi İrtegün; Yılmaz, Mustafa Abdullah; Demirköz, Aslı Barla; Kolak, Ufuk; Öksuz, Sevil (ACG Publications, 2021)Abstract: In this study, investigation on the essential oils and ethanol extracts of naturally grown and cultivated Satureja macrantha samples were reported. The essential oil, flavour and terpenoid-steroid-flavonoid ... -
Chemical Composition of The Essential Oils of Three Centaurea Species Growing Wild in Anatolia and Their Anticholinesterase Activities
Ertas, Abdulselam; Goren, Ahmet Ceyhan; Boga, Mehmet; Demirci, Serpil; Kolak, Ufuk (Taylor & Francis Ltd, 2014)This report represents the first study on the chemical composition of essential oil of endemic Centaurea lycopifolia. This report also represents the first study on the anticholinesterase activity of essential oils of C. ... -
Chemical compositions by LC-MS/MS and GC-MS and biological activities of Chenopodium album subsp. album var. microphyllum
Yilmaz, Pelin Koseoglu; Ertas, Abdulselam; Akdeniz, Mehmet; Avci, Mine Kocyigit; Kolak, Ufuk (Elsevier, 2019)Chenopodium species have been used in folk medicine and as vegetable for years. In the present study, the total phenolic and flavonoid contents, biological activities, phenolic constituents and fatty acid profile of ... -
Chemical Constituents and Biological Activities of Cirsium leucopsis, C. sipyleum, and C. eriophorum
Boga, Mehmet; Yilmaz, Pelin Koseoglu; Cebe, Deniz Baris; Fatima, Mashhad; Siddiqui, Bina S.; Kolak, Ufuk (Walter De Gruyter Gmbh, 2014)Two endemic Cirsium species, C. leucopsis DC. and C. sipyleum O. Schwarz, and C. eriophorum (L.) Scop. growing in Turkey were investigated to establish their secondary metabolites, fatty acid compositions, and antioxidant ... -
Essential oil compositions and anticholinesterase activities of two edible plants Tragopogon latifolius var. angustifolius and Lycopsis orientalis
Ertas, Abdulselam; Goren, Ahmet C.; Boga, Mehmet; Yesil, Yeter; Kolak, Ufuk (Taylor & Francis Ltd, 2014)This is the first report in the literature on essential oil compositions of Tragopogon latifolius var. angustifolius and Lycopsis orientalis which were analysed by using GC-FID and GC-MS techniques. The main constituents ... -
Essential oil contents of Hypericum linarioides , H. helianthemoides, and H. lydium with their biological activities: Importance of Hypericum genus in the cosmeceutical and pharmaceutical industries
Akdeniz, Mehmet; Yener, İsmail; Ertaş, Abdülselam; Dincel, Demet; Fırat, Mehmet; Kocakaya, Şafak Özhan; Yigitkan, Serkan; Türkmenoğlu, Fatma Pınar; Aydın, Fırat; Kolak, Ufuk (Springer, 2023)In the literature, more than 3000 studies have been carried out on species in the Hypericum genus in the last ten years, especially for H. perforatum. The importance of Hypericum species in traditional medicine and modern ... -
Essential oil, aroma, and fatty acid profiles of five endemic Salvia taxa from Turkey with chemometric analysis
Ertaş, Abdulselam; Akdeniz, Mehmet; Yener, İsmail; Öztürk, Mehmet; Ölmez, Özge Tokul; Fırat, Mehmet; Kolak, Ufuk (Wiley-V C H Verlag GMBH, 2022)The essential oil, aroma, and fatty acid compositions of Salvia cerino-pruinosa var. cerino-pruinosa, S. cerino-pruinosa var. elazigensis, S. pseudeuphratica, S. rosifolia, and S. kurdica collected in 2015, 2016, and 2017 ... -
Evaluation of Antioxidant, Cholinesterase Inhibitory and Antimicrobial Properties of Mentha longifolia subsp noeana and Its Secondary Metabolites
Ertas, Abdulselam; Goeren, Ahmet C.; Hasimi, Nesrin; Tolan, Veysel; Kolak, Ufuk (Acg Publications, 2015)The aim of the present study was to determine the chemical structures of the isolated compounds, the essential oil and fatty acid compositions of Mentha longifolia subsp. noeana with their biological activities. Ursolic ... -
A GC-MS method validation for quantitative investigation of some chemical markers inSalvia hypargeiaFisch. & CA Mey. of Turkey: Enzyme inhibitory potential of ferruginol
Bakir, Derya; Akdeniz, Mehmet; Ertas, Abdulselam; Yilmaz, Mustafa A.; Yener, Ismail; Firat, Mehmet; Kolak, Ufuk (Wiley, 2020)In the present study, a GC-MS method used for quantitative screening of 26 compounds (sclareolide, sclareol, ferruginol, cryptanol, 6,7-dehydroroyleanone, suginal, 9,10-dihydro-7,8-dimethyl-2-(1-methylethyl) phenanthren-3-ol, ... -
In vitro biological activities and fatty acid profiles of Pistacia terebinthus fruits and Pistacia khinjuk seeds
Hacibekiroglu, Isil; Yilmaz, Pelin Koseoglu; Hasimi, Nesrin; Kilinc, Ersin; Tolan, Veysel; Kolak, Ufuk (Taylor & Francis Ltd, 2015)This study reports in vitro anticholinesterase, antioxidant and antimicrobial effects of the n-hexane, dichloromethane, ethanol and ethanol-water extracts prepared from Pistacia terebinthus L. fruits and Pistacia khinjuk ... -
Investigation of cytotoxic and apoptotic effects of 63 compounds obtained from Salvia species: Promising anticancer agents
Kandemir, Sevgi İrtegün; Fidan, Hilal Saruhan; Yener, İsmail; Mete, Nuriye; Ertaş, Abdulselam; Topçu, Gülaçtı; Kolak, Ufuk (Wiley, 2022)Since ancient time, Salvia L. species have been commonly used to treat colds, bronchitis, tuberculosis, heart diseases, and menstrual and digestive disorders in traditional medicine all around the world. They have been ... -
Isolation of secondary metabolites of two endemic species: Salvia rosifolia Sm. and Salvia cerino-pruinosa Rech. f. var. elazigensis (Lamiaceae)
Yarış, Esra; Adsız, Leyla Balur; Yener, İsmail; Tuncay, Eyyüp; Yılmaz, Mustafa Abdullah; Akdeniz, Mehmet; Kaplaner, Erhan; Fırat, Mehmet; Ertaş, Abdulselam; Kolak, Ufuk (Springer, 2021)In the present study, activity-guided isolation and structural elucidation of antioxidant secondary metabolites of ethanol extracts prepared from the root and aerial parts of Salvia rosifolia and Salvia cerino-pruinosa ... -
LC-MS/MS and GC-MS analyses of three endemic Astragalus species from Anatolia towards their total phenolicflavonoid contents and biological activities
Özden, Tuğba Yılmaz; Haşimi, Nesrin; Boğa, Mehmet; Yılmaz, Mustafa Abdullah; Kolak, Ufuk; Kayıran, Serpil Demirci; Temel, Hamdi (2017)Bu çalışmada, Anadolu'da yetişen üç endemik Astragalus türünün kimyasal içeriği ile bazı biyolojik aktivitelerinin belirlenmesi hedeflenmiştir. Astragalus leporinus var. hirsutus, Astragalus distinctissimus ve Astragalus ... -
Method validation of 15 phytochemicals inHypericum lysimachioidesvar.spathulatumby LC-MS/MS, and fatty acid, essential oil, and aroma profiles with biological activities
Akdeniz, Mehmet; Yilmaz, Mustafa Abdullah; Ertas, Abdulselam; Yener, Ismail; Firat, Mehmet; Aydin, Firat; Kolak, Ufuk (Springer, 2020)The aim of the present study was to develop and validate a LC-MS/MS method for quantification of 15 phytochemicals inHypericumspecies. The developed method was fully validated in terms of repeatability (inter-day and ...
