Browsing by Author "Karahan, Selim"
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Dermal absorption and toxicity of alpha amanitin in mice
Kaya, Ertugrul; Surmen, Mustafa Gani; Yaykasli, Kursat Oguz; Karahan, Selim; Oktay, Murat; Turan, Hakan; Colakoglu, Serdar (Informa Healthcare, 2014)The fungus Amanita phalloides is known to contain two main groups of toxins: amanitins and phallotoxins. The amanitins group effectively blocks the RNA polymerase II enzyme found in eukaryotic cells. As alpha amanitin has ... -
Efavirenz'in anksiyojenik ve depresyon benzeri etkilerinde monoaminerjik, gabaerjik ve nitrerjik sinir iletim sistemlerinin rolü
Karahan, Selim (Dicle Üniversitesi, Sağlık Bilimleri Enstitüsü, 2019)Amaç: Efavirenz (EFV), HIV-1 tedavisinde sıklıkla kullanılan bir ilaçtır. EFV ile tedavinin ilk haftalarında birçok nöropsikiyatrik yan etkinin gelişimesi, kullanımını kısıtlayan bir durumdur. Bu çalışmada, akut EFV ... -
Evaluation of the medicinal potential of a traditionally important plant from Turkey: Cerinthe minor L.
Ersoy, Ezgi; Karahan, Selim; Boğa, Mehmet; Çınar, Ercan; İzgi, Sevcan; Kara, Emel Mataracı (Istanbul University Press, 2022)Background and Aims: Cerinthe minor L. has been used for both culinary and medicinal purposes in Turkey. Since the plant has remained uninvestigated pharmacognostically, this study aims to provide data on the phytochemical ... -
Gene expression profiles for apoptotic and necrotic pathways during Amanita phalloides intoxication in mice
Karahan, Selim; Atli, Zehra; Kaya, Ertugrul; Ozdemir, Feride; Boga, Mehmet; Izgi, Sevcan (Istanbul Univ, Fac Pharmacy, 2022)Background and Aims: Amanita phalloides is the deadliest toxic mushroom in the world and causes death from acute liver failure. alpha-amanitin (alpha-AMA), the most potent toxin, inhibits RNA polymerase II in hepatocytes, ... -
Lidokainin streptozotosin ile indüklenen alzheimer hastalığının deneysel modeli üzerindeki etkisi
Tamam, Yusuf; Yokuş, Beran; Tamam, Cüneyt; Yüceer, Hande; Karahan, Selim; Em, Bernan; Tamam, Şerife Banu; Tüzün, Erdem (Türk Nöropsikiyatri Derneği, 2023)Amaç: Alzheimer hastalığı (AH), serebral korteks ve hipokampusta amiloid plakların birikmesinden kaynaklanan nörodejeneratif bir hastalıktır. Bu çalışmada, streptozotosin (STZ) ile indüklenen sıçan AH modelinde lokal ... -
Phytochemical analysis of essential oils and the extracts of an ethnomedicinal plant, Teucrium multicaule collected from two different locations with focus on their important biological activities
Ersoy, Ezgi; Tanaman, Irmak; Özkan, Esra Eroğlu; Karahan, Selim; Şahin, Hasan; Çınar, Ercan; Cantürk, Yeter Yeşil; Kara, Emel Mataracı; Zengin, Gökhan; Boğa, Mehmet (Elsevier, 2023)Teucrium species have been among the most commonly used traditional medicinal plants and they are known to have extensive therapeutic applications. The main focus of this study, Teucrium multicaule is also renowned for ... -
The Therapeutic potential of ethnomedicinally important Anatolian thyme species: A Phytochemical and biological assessment
Özkan, Esra Eroğlu; Ersoy, Ezgi; Cantürk, Yeter Yeşil; Kara, Emel Mataracı; Çınar, Ercan; Şahin, Hasan; Karahan, Selim; Sancaktepe, Kübra Karaca; Yılmaz, Mustafa Abdullah; Boğa, Mehmet (Frontiers, 09.06.2022)Thyme has been used for various therapeutic purposes in many different cultures, which makes it one of the most riveting medicinal plants throughout history. From its beneficial effects on the respiratory tract or the ... -
Towards a better understanding of commonly used medicinal plants from Turkiye: Detailed phytochemical screening and biological activity studies of two Teucrium L. species with in vitro and in silico approach
Ersoy, Ezgi; Süvari, Goncagül; Ercan, Selami; Özkan, Esra Eroğlu; Karahan, Selim; Tuncay, Evin Aygün; Boğa, Mehmet (Elsevier Ireland Ltd., 2023)Ethnopharmacological relevance: Since ancient times, Teucrium L. species have been among the most commonly used traditional medicinal plants mainly in the Mediterranean region. From tackling gastrointestinal problems to ... -
Yüksek Saflıkta Beta Amanitin Üretimi
Yaykaşlı, Kürşat Oğuz; Sarıtaş, Ayhan; Bayram, Recep; Kaya, Ertuğrul; Karahan, Selim; Yaykaşlı, Emine (2012)Amaç: Beta amanitin nadiren bilimsel araştırmalarda kullanılmakta ve kullanımı gün geçtikçe artmaktadır. Piyasada bu ürün %90 saflıkta ticari olarak satılmaktadır. Bu araştırmada yüksek saflıkta beta amanitin üretme yöntemi ...
