Browsing by Author "Cen, Osman"

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Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways

Varisli, Lokman; Cen, Osman; Vlahopoulos, Spiros (IMMUA, 2020)

Chloroquines are 4-aminoquinoline-based drugs mainly used to treat malaria. At pharmacological concentrations, they have significant effects on tissue homeostasis, targeting diverse signaling pathways in mammalian cells. ...
Dissecting the effects of androgen deprivation therapy on cadherin switching in advanced prostate cancer: A molecular perspective

Varışli, Lokman; Tolan, Veysel; Cen, Jiyan H.; Vlahopoulas, Spiros; Cen, Osman (Tech Science Press, 2022)

Prostate cancer is one of the most often diagnosed malignancies in males and its prevalence is rising in both developed and developing countries. Androgen deprivation therapy has been used as a standard treatment approach ...
A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder

Sarohan, Aziz Rodan; Kızıl, Murat; İnkaya, Ahmet Çağkan; Mahmud, Shokhan; Akram, Muhammad; Cen, Osman (Elsevier Inc., 2021)

The SARS-CoV-2 virus has caused a worldwide COVID-19 pandemic. In less than a year and a half, more than 200 million people have been infected and more than four million have died. Despite some improvement in the treatment ...