Browsing by Author "Boğa, Mehmet"
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Amelioration potential of synthetic oxime chemical cores against multiple sclerosis and Alzheimer's diseases: Evaluation in aspects of in silico and in vitro experiments
Yılmaz, Anıl; Koca, Murat; Ercan, Selami; Acar, Özden Özgün; Boğa, Mehmet; Şen, Alaattin; Kurt, Adnan (Elsevier B.V., 2024)Alzheimer disease (AD) and multiple sclerosis (MS) are inflammatory neurological disorders. The main symptom of AD is dementia, and the main symptoms of MS are vertigo, sexual dysfunction, cognitive problems, and fatigue. ... -
Anticholinesterase and antioxidant activities of novel heterocyclic Schiff base derivatives containing an aryl sulfonate moiety
Kamalı, Ayfer; Çakmak, Reşit; Boğa, Mehmet (Wiley-V C H Verlag GMBH, 2022)In this research, nine novel heterocyclic Schiff base derivatives (10-18) bearing an aryl sulfonate moiety were designed, synthesized for the first time, and characterized. Then, their inhibitory effects on acetyl- and ... -
Antioxidant and anticholinesterase potentials of novel 4,6-dimethoxyindole based unsymmetrical azines: Synthesis, molecular modeling, in silico ADME prediction and biological evaluations
Bingül, Murat; Ercan, Selami; Boğa, Mehmet; Bingül, Alev Arslantürk (Taylor and Francis Ltd., 2023)Chemically and biologically important -C = N-N = C- diimine linkage was used to build unsymmetrical azine systems with indole heterocyclic backbone and substituted aromatic carbaldehydes. Ten novel compounds 7a-j were ... -
Chemical and Biological Perspectives of Monoterpene Indole Alkaloids From Rauwolfia species
Boğa, Mehmet; Bingül, Murat; Özkan, Esra Eroğlu; Şahin, Hasan (Elsevier, 2018)The biosynthesis of monoterpene indole alkaloids (MIAs) starts with a geraniol for the terpenoid portion. Secologanin, a secoiridoid glycoside, is derived from 10-hydroxygeraniol, produced in the presence of geraniol ... -
Chemical constituents, cytotoxic, antioxidant and cholinesterases inhibitory activities of Silene Compacta (fischer) extracts
Boğa, Mehmet (Marmara University, 2017)In Turkey, Silene species have been used as infusion in urinary bladder and biliary tract diseases in traditional medicine. Silene species have been also consumed as food in Anatolia and Europe. In this study, the phenolic, ... -
Chemical fingerprints and bioactivities of 12 Anatolian Achillea L. species by LC-MS/ MS with chemometric approach: novel phytonutrients, natural food preservatives and chlorogenic acid sources
Yılmaz, Mustafa Abdullah; Ertaş, Abdulselam; Yener, İsmail; Türkmenoğlu, Fatma Pınar; Ölmez, Özge Tokul; Öztürk, Mehmet; Altun, Muhammed; Çakır, Oğuz; Tarhan, Abbas; Boğa, Mehmet (Turkiye Klinikleri, 2022)The objective of this study was to evaluate the biological activities and chemical fingerprint profiles of the extracts obtained from twelve Achillea L. species (A. lycaonica, A. biebersteinii (syn: A. arabica), A. kotschyi ... -
Comparative analysis of antioxidant, anticholinesterase, and antibacterial activity of microbial chondroitin sulfate and commercial chondroitin sulfate
Ünver, Tuba; Erenler, Ayşe Şebnem; Bingül, Murat; Boğa, Mehmet (Wiley-V C H Verlag Gmbh, 2023)Chondroitin synthesis was performed using the recombinant Escherichia coli(C2987) strain created by transforming the plasmid pETM6-PACF-vgb, which carries the genes responsible for chondroitin synthesis, kfoA, kfoC, kfoF, ... -
Comparative phytochemical and bioactivity studies on two related Scorzonera L. species: A chemotaxonomic contribution
Şahin, Hasan; Demir, Serhat; Boğa, Mehmet; Sarı, Aynur; Makbul, Serdar; Gültepe, Mutlu (Elsevier, 2023)Scorzonera L. (Asteraceae) is considered a taxonomically difficult genus with its more than 160 species. Scorzonera bella (SB) and S. veratrifolia (SV) species have been treated as synonyms since 1975. Recent botanical ... -
Comprehensive analysis of an uninvestigated wild edible medicinal garlic species from Turkey: Allium macrochaetum Boiss. & Hausskn.
Kayıran, Serpil Demirci; Özkan, Esra Eroğlu; Kara, Emel Mataracı; Yılmaz, Mustafa Abdullah; Zengin, Gökhan; Boğa, Mehmet (Blackwell Publishing Ltd., 2019)The study was aimed to investigate the phenolic compounds of Allium macrochaetum by LC-MS/MS, as well as the antioxidant, antialzheimer, and antimicrobial activities of the extracts, and determination of the essential oil ... -
A Comprehensive study on a medicinal and edible plant scorzonera incisa DC., discussing the natural limits of phytochemical profiling
Şahin, Hasan; Demir, Serhat; Boğa, Mehmet; Sarı, Aynur; Makbul, Serdar; Coşkunçelebi, Kamil (Wiley, 2023)Leaves of Scorzonera incisa DC. (Asteraceae) are eaten raw against diabetes and headache. Evaluation of medicinal, edible plants using profiling methods has become a common phenomenon. Petroleum ether (PE), ethyl acetate ... -
A comprehensive study on chemical and biological profiles of Algerian Azadirachta indica (A. Juss)
Boukeloua, Ahmed; Leila, Soudani; Bendif, Hamdi; Elkadeem, Ahmed Mustafa; Boğa, Mehmet; Serralheiro, Maria Luísa; Yılmaz, Mustafa Abdullah; Yener, İsmail (Elsevier Ltd, 2024)The study aimed to analyse the chemical and biological composition of Azadirachta indica (A. Juss) (A. indica) leaves. Minerals were quantified using inductively coupled plasma-mass spectrometry (ICP-MS). Phenolic compounds ... -
Cytotoxic and apoptotic effects of Hypericum androsaemum on prostate adenocarcinoma (PC-3) and hepatocellular carcinoma (Hep G2) cell lines with identification of secondary metabolites by LC-HRMS
Bektaş, Nurdan Yazıcı; Ersoy, Ezgi; Boğa, Mehmet; Boran, Tuğçe; Çınar, Ercan; Özhan, Gül; Gören, Ahmet Ceyhan; Özkan, Esra Eroğlu (Scientific Technical Research Council Turkey-TUBITAK, 2021)The study aims to determine the secondary metabolites of Hypericum androsaemum L. extracts by liquid chromatography-high resolution mass spectrometry (LC-HRMS), and investigate the antioxidant and cytotoxic activities of ... -
Design, synthesis and biological evaluation of 1,3-diaryltriazene-substituted sulfonamides as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors
Akocak, Süleyman; Boğa, Mehmet; Lolak, Nabih; Tuneğ, Muhammed; Sanku, Rajesh Kishore Kumar (Turkish Chemical Society, 2019)1,3-diaryltriazenes are one of the most useful and important linkers for many pharmaceutical applications. Therefore, in the current work, a series of 1,3-diaryltriazene sulfonamides 4(a-k) were synthesized by reacting ... -
Determination of cytotoxic, anticholinesterase, antioxidant and antimicrobial activities of some wild mushroom species
Dündar, Abdurrahman; Okumuş, Veysi; Özdemir, Sadin; Çelik, Kadir Serdar; Boğa, Mehmet; Özçağlı, Eren (Informa Healthcare, 2016)In the performed study of methanol extraction of wild edible mushroom species; Agaricus arvensis, Agaricus campestris, Armillaria mellea, Fomes fomentarius, Coprinus micaceus, Coriolus versicolor and Lactarius deliciosus ... -
Di-, and triterpenoids isolation and LC-MS analysis of salvia marashica extracts with bioactivity studies
Aydın, Sibel Kıran; Ertaş, Abdulselam; Boğa, Mehmet; Erol, Ebru; Toraman, Gülbahar O. Alim; Saygı, Tuba Kusman; Halfon, Belkıs; Topçu, Gülaçtı (ACG Publications, 2021)Abstract: In this study, dichloromethane, acetone, and methanol extracts of the aerial parts of the Salvia marashica plant which is an endemic species to Anatolia, were investigated. The total phenolic amounts of ... -
Di-, and Triterpenoids Isolation and LC-MS Analysis of Salvia marashica Extracts with Bioactivity Studies
Boğa, Mehmet; Erol, Ebru; Sayğı, Tuba Kuşman; Aydın, Sibel Kıran; Ertaş, Abdülselam; Toraman, Gülbahar Ö. Alim; Topçu, Gülaçtı (2021)In this study, dichloromethane, acetone, and methanol extracts of the aerial parts of the Salviamarashica plant which is an endemic species to Anatolia, were investigated. The total phenolic amounts of theseextracts were ... -
Diyarbakır ve Batman' da toplanan teucrium multicaule bitkisinin kimyasal ve biyolojik aktivite yönünden incelenmesi
Tanaman, Irmak (Dicle Üniversitesi, Sağlık Bilimleri Enstitüsü, 2022)Amaç: Diyarbakır ve Batman'dan toplanan T. multicaule bitkilerinin kök ve toprak üstü kısımlarının etanol ekstrelerinin toplam fenolik ve toplam flavonoid miktar, antioksidan ve antikolinesteraz aktiviteleri araştırıldı. ... -
Evaluation of acetyl-and butyrylcholinesterase enzyme inhibitory activities and cytotoxic activities of anthraquinone derivatives
Özkök, Funda; Boğa, Mehmet; Tuneğ, Muhammed; Atalay, Vildan Enisoğlu; Onul, Nihal Yılmaz; Asgarova, Kamala (Turkish Chemical Society, 2022)In this study, the enzyme activity of anthraquinone compounds which were synthesized beforehand by our research group was investigated. Molecular docking studies were performed for compounds 1-(4-aminophenylthio)anthrace ... -
Evaluation of the medicinal potential of a traditionally important plant from Turkey: Cerinthe minor L.
Ersoy, Ezgi; Karahan, Selim; Boğa, Mehmet; Çınar, Ercan; İzgi, Sevcan; Kara, Emel Mataracı (Istanbul University Press, 2022)Background and Aims: Cerinthe minor L. has been used for both culinary and medicinal purposes in Turkey. Since the plant has remained uninvestigated pharmacognostically, this study aims to provide data on the phytochemical ... -
Heterocyclic Schiff base derivatives containing pyrazolone moiety: Synthesis, characterization, and in vitro biological studies
Çınar, Ercan; Başaran, Eyüp; Erdoğan, Ömer; Çakmak, Reşit; Boğa, Mehmet; Çevik, Özge (Wiley, 2021)In this study, some pyrazolone-based Schiff base derivatives 2a-e (except 2a)were synthesized for the first time and structurally illuminated by some spec-troscopic techniques (1H,13C NMR, FT-IR) and elemental analysis. ...
