Hypoglycemic potential of 4,6-dimethoxyindole-7- and -2-thiosemicarbazone derivatives
Yükleniyor...
Dosyalar
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Dicle University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The hybrid molecules, derived from biologically active compounds, have been an open target for the medical researchers due to the possible enhanced biological properties. Hybridization of biologically active compounds for the determination of new possible candidates for drug development has been an attractive idea and allow to detect new successful compounds for drug discovery. With respect to this idea, previously synthesized dimethoxyindole based thiosemicarbazones have been chosen as hybrid molecules derived from indole backbone and thiosemicarbazides which have heavily been used for biological studies and evaluated for inhibition of α-amylase and α-glucosidase to exhibit the hypoglycemic potential. The targeted molecules were found to be potent candidates for α-glucosidase enzyme inhibition compared to the standard. The inhibition potential for α-amylase was not comparable with the acarbose with the studied concentration, however, it was determined that the targeted compounds could be selective candidates for glucosidase enzyme inhibition and the future studies were directed for the identification new compounds for this purpose.
Açıklama
Anahtar Kelimeler
Dimethoxyindole, Thiosemicarbazone, α-amylase, α-glucosidase
Kaynak
Socrates 8th International Health, Engineering And Applied Sciences Congress
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Bingül, M. ve Şahin, H. (2023). Hypoglycemic potential of 4,6-dimethoxyindole-7- and -2-thiosemicarbazone derivatives. Socrates 8th International Health, Engineering And Applied Sciences Congress, 28-30 September 2023. (pp. 69-73). Diyarbakır: Dicle University.
