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Öğe COMPARISON OF VARIOUS RADIATION THERAPY TECHNIQUES IN BREAST CANCER WHERE TARGET VOLUME INCLUDES MAMMARIA INTERNA REGION(Elsevier Science Inc, 2009) Dogan, Mehmet Hakan; Zincircioglu, Seyit Burhanedtin; Zorlu, FarukIn breast cancer radiotherapy, the internal mammary lymphatic chain is treated in the target volume in a group of patients with high-risk criteria. Because of the variability of the anatomic region and structures in the irradiation field, there are a number of different techniques in breast radiotherapy. While irradiating the target volume, we also consider minimizing the dose to critical structures such as heart, lung, and contralateral breast tissue. In this study, we evaluated the dose distribution of different radiotherapy techniques in patients with left-sided breast cancer who had breast-conserving surgery. A three-dimensional computerized planning system (3DCPS) was used for each patient to compare wide-field, oblique photon-electron, and perpendicular photon-electron techniques in terms of dose homogeneities in the target volume; the doses received by the contralateral breast, heart, and lung; and the coverage of the internal mammary chain. Data from 3DCPS were controlled by the Rando-phantom and thermoluminescence dosimetry. Critical structures were irradiated with acceptable dose percentages in addition to the internal mammary chain with both wide-field and photon-electron techniques. We detected more frequent hot spots in the oblique photon-electron technique than in the other techniques, and this situation necessitated changing the junctions. The wide-field technique was easy to perform and exposed less radiation dose to the heart than photon-electron techniques. In conclusion, we suggest the use of the wide-field technique in breast irradiation when the internal mammary area is in the target volume. (C) 2009 American Association of Medical Dosimetrists.Öğe Does Short Term Usage of Fresh Pomegranate Juice (FPJ) Protect Cochlear Hair Cells after Cisplatin-Based Chemo-Irradiation?(Aves, 2014) Akdag, Mehmet; Dasdag, Suleyman; Alabalik, Ulas; Yilmaz, Beyhan; Altas, Sevcan; Zincircioglu, Seyit Burhanedtin; Gul, AylinOBJECTIVE: The aim of this study was to investigate the protective effect of short-term usage of fresh pomegranate juice (FPJ) on ototoxicity after cisplatin-based chemo-irradiation. MATERIALS and METHODS: The study was carried out on 56 adult Wistar Albino rats, which were divided into 8 groups (n: 7 for each group). The first group was accepted as the sham control group. However, rats in the seven experimental groups were treated with FPJ; cisplatin; irradiation; irradiation plus FPJ; cisplatin plus FPJ; both cisplatin and irradiation; and combined use of cisplatin, irradiation, and FPJ, respectively. Ototoxicity was evaluated by Distortion Product Otoacoustic Emissions (DPOA), histopathology, and paracochlear protein carbonyl content. RESULTS: The results of the study showed that cisplatin, irradiation, and both cisplatin and irradiation treatments affected hair cells dramatically. However, the results of cisplatin plus FPJ and combined use of cisplatin, irradiation, and FPJ indicated that FPJ plays an important role in protecting hair cells in the inner ear. Additionally, the findings of signal-noise ratio and protein carbonyl values also supported the results stated above. CONCLUSION: Fresh pomegranate juice treatment can be a supportive agent to reduce hair cell injury in the inner ear of patient treated by cisplatin, radiotherapy, or cisplatin-based chemo-irradiation. However, more performance is necessary for further studies, especially on long-term treatment with FPJ.Öğe The efficacy of oral glutamine in prevention of acute radiotherapy-induced esophagitis in patients with lung cancer(Termedia Publishing House Ltd, 2013) Tutanc, Oznur Donmez; Aydogan, Akin; Akkucuk, Seckin; Sunbul, Ahmet Taner; Zincircioglu, Seyit Burhanedtin; Alpagat, Gulistan; Erden, Ersin SukruAim of the study: This study explores the efficacy of oral glutamine in the prevention of acute radiotherapy-induced esophagitis in patients with lung cancer who are treated with thoracic radiotherapy. Material and methods: This study was planned as a retrospective randomized experimental study. Forty-six patients with lung cancer, who were treated and kept under control between January 2008 and January 2010, were included in the study by the Department of Radiation Oncology, Faculty of Medicine, Dicle University. The patients were divided into two groups. The first group (n = 21) was given prophylactic oral powder glutamine (daily 30 g), while the second group (n = 25) was not given oral glutamine. Results: There were 21 patients in Group 1 (45.7%) and 25 patients in Group 2 (54.3%). No significant statistical difference was observed between the two groups in terms of age, gender, stage, histopathological type, treatment choice, received radiation doses, esophagus length in RI field, or location of the tumor (p > 0.05). A significant statistical difference was observed between the glutamine-supplemented group (first group) and the glutamine:free group (second group) according to the grade of esophagitis (p < 0.0001). Conclusions: In our retrospective randomized experimental study, we determined that the severity of acute radiotherapy-induced esophagitis might be decreased with oral glutamine in patients with lung Cancer who were treated with thoracic radiotherapy.Öğe Lack of any Impact of Histopathology Type on Prognosis in Patients with Early-Stage Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix(Asian Pacific Organization Cancer Prevention, 2014) Teke, Fatma; Yoney, Adnan; Teke, Memik; Inal, Ali; Urakci, Zuhat; Eren, Bekir; Zincircioglu, Seyit BurhanedtinBackground: The aim of this study was to evaluate the prognosis of patients with stage IA-IIB cervical carcinoma and to investigate a possible correlation of histology with prognosis. Materials and Methods: Two hundred fifty one patients with adenocarcinoma and squamous cell carcinoma (SCC) histology for FIGO (International Federation of Gynecology and Obstetrics) stage IA-IIB uterine cervical carcinomas at the Radiation Oncology Clinic of GH Okmeydani Training and Research Hospital between January 1996 and December 2006 were selected, analyzed retrospectively and evaluated in terms of general characteristics and survival. Disease-free survival (DFS) and overall survival (OS) was calculated using the Kaplan-Meier method and differences were compared with the log-rank test. Multivariate analysis using a Cox-proportional hazards model was used to adjust for prognostic factors and to estimate hazard ratio (HR) with 95% confidence interval (CI). Results: There was no differences between the two tumour types in age, stage, pelvic nodal metastasis, parametrial invasion, surgical margin status, DSI, LVSI, maximal tumor diameter, grade, and treatment modalities. 5-year OS and DFS were 73% and 77%, versus 64% and 69%, for SCC and adenocarcinoma, respectively (p>0.05). Multivariate analysis revealed independent prognostic factors including pelvic nodal metastasis and resection margin status for OS (p=0.008, p=0.002, respectively). Conclusions: Prognosis of FIGO stage IA-IIB cervical cancer patients was found to be the same for those with adenocarcinoma and SCC.Öğe Oral ketamine administration for radiation therapy in children.(Scientific Publishers India, 2017) Dogan, Erdal; Guzel, Abdulmenap; Zincircioglu, Seyit Burhanedtin; Arslan, Mehmet Serif; Celik, Feyzi; Yildirim, Mehmet Besir; Yildirim, Zeynep BaysalBackground: Radiotherapy is a reliable and effective treatment for various malignancies and can be used for both curative and palliative/prophylactic ends. In order to achieve accuracy, reliability and success in the implementation of radiotherapy, it is imperative that patients adapt to the treatment and remain motionless. Material and methods: In this study, the records of anesthetic agents utilized in 26 patients aged 2-10 being treated by external beam radiotherapy were examined. Results: Radiotherapy under anesthesia was implemented in a total of 56 sessions conducted on 26 patients. During the radiotherapy applications, only 10 (17%) sessions required the use of an extra dose of ketamine. The radiotherapy session duration was 6.3 +/- 2.4 minutes. (The anesthesia start time was 20.5 +/- 4.6.) Additionally, the patients' recovery time from anesthesia was found to be 68.6 +/- 6.2. 61.5% of the patients were administered prophylactic cranial radiotherapy due to acute lymphoblastic leukaemia (ALL). Before and after the procedure, hemodynamic and respiratory parameters were found to be stable. Conclusion: Since a combination of oral ketamine and midazolam provides effective sedation and comfort and can be administrated easily, we believe that it can be safely used in radiotherapy procedures on children.Öğe Protective Role of Vitamin C on Sperm Characteristics and Testicular Damage in Rats Exposed to Radiation(Kafkas Univ, Veteriner Fakultesi Dergisi, 2014) Tas, Muzaffer; Cirit, Umut; Ozkan, Oktay; Denli, Muzaffer; Zincircioglu, Seyit Burhanedtin; Seker, Ugur; Ozmen, Mehmet FeritThe aim of this study was to investigate the protective effects of vitamin C on sperm characteristics and testes in male rats exposed gamma radiation (2 Gy). A total of 21 adult male wistar albino rats (8 weeks of age, weighing 180-220 g) were divided into three groups. Control, radiotherapy (received scrotal.-radiation of 2 Gy as a single dose) and radiotherapy + vitamin C treated rats (during the 55 days after irradiation, 500 mg vitamin C/500 ml water daily orally). Testes samples from all groups were taken at day 55 post-irradiation and epididymal sperm characteristics, all-genital organs weights and testes histology were evaluated. Radiotherapy decreased significantly the sperm motility, concentration, left testes and epididymis weights, Johnsen's biopsy score and seminiferous tubular diameter but it increased the sperm head defects as compared to the Control group (P<0.05). The administration of vitamin C only reduced the harmful effects of radiotherapy on the seminiferous tubular diameter (P<0.05). It has been concluded that the radiotherapy may cause alteration in the genital organ weights, spermatologic and hystologic parameters in rats and administration of vitamin C may be slightly beneficial for seminiferous tubular diameter following testicular irradiation during the radiotherapy.Öğe Research on different techniques in breast cancer radiotherapy(Termedia Publishing House Ltd, 2013) Dogan, Mehmet Hakan; Zincircioglu, Seyit Burhanedtin; Aydinol, MahmutIn breast cancer radiotherapy, the internal mammary lymphatic chain is treated in the target volume in a group of patients with high risk criteria. There are a number of different techniques in breast radiotherapy because of the variability of the anatomic region, structures and risk criteria in the irradiation field. When irradiating the target volume we also consider homogeneity of dose distribution and minimizing the dose to critical structures such as the heart and lung. In this study, we have evaluated the dose distribution of different radiotherapy techniques in twelve patients with left breast cancer who had breast conserving surgery or mastectomy. A two-dimensional computerized planning system (2-DCPS) was used for each patient to compare wide-field, oblique photon-electron, perpendicular photon-electron and oblique-electron techniques in terms of dose homogeneities in the target volume, the doses received by the heart and lung, and the coverage of the internal mammary chain. Critical structures were irradiated with acceptable dose percentages besides the internal mammary chain with both wide-field, photon-electron and oblique-electron techniques. The wide-field technique was easy to perform and exposed the heart to a smaller radiation dose than photon-electron techniques. The oblique electron techniques provide a minimal radiation dose to critical structures. In oblique electron techniques, if the internal mammary chain was not covered in the target volume, the heart dose was minimized. In conclusion, we suggest using oblique-electron techniques in breast irradiation where the internal mammary is in the target volume.
