Yazar "Yukselen V." seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • [ X ]
    Öğe
    The effects of flutamide on lipid profile, insulin sensitivity, hirsutism and gonadotrophins in women with polycystic ovary syndrome
    (1999) Bahceci M.; Tuzcu A.; Dursun M.; Ertem M.; Yukselen V.
    In this study, we evaluated metabolic changes and the effects of flutamide in 22 women with PCOS. Flutamide was administered for a 6-month period in a dose of 750 mg/day. The basal and after treatment body mass index, waist: hip ratio, blood glucose, insulin, lipids, Ferriman-Gallwey scoring (FGS), gonadotrophins, testosterone, trasaminazed and glucose: insulin (G:I) ratio were measured. For comparison, ANOVA was used. The sixth month mean FGS was significantly lower than the basal values (18.5±7.4 and 12.5±4.5, P<0.01). The mean basal G:I ratio was 3.31±1.12 and 6.21±2.53 at the sixth month. The sixth month G:I ratio was significantly higher (P<0.001). The total and LDL-cholesterol were decreased by flutamide (from 144±23 to 123±23 and from 88±32 to 60±25 mg/dl respectively. P<0.02 and P<0.01), whereas, the HDL-cholesterol level was increased with flutamide (from 44.8±3.9 to 46.5±3.2 mg/dl and P<0.001). LH (from 14.7±6.7 to 8.4±3 mlU/ml), LH/FSH ratio (from 3.4±1.7 to 1.9±0.6), total testosterone (from 0.87±0.29 to 0.61±0.18 ng/ml) and free testosterone (from 4.29±1.18 to 2.14±0.9 pg/ml) were decreased by flutamide (P<0.05). Thus, we reached three conclusions: 1-Flutamide may improve insulin insensitivity. 2-In PCOS, flutamide decreases total and LDL-cholesterol, and increases HDL-cholesterol. 3-Flutamide may improve the LH/FSH ratio and induce a decrease in testosterone.
  • [ X ]
    Öğe
    Portal colopathy findings in patients with liver cirrhosis
    (1999) Goral V.; Kizilay E.; Yukselen V.; Dursun M.; Aras N.; Canoruc F.; Buyukbayram H.
    Portal hypertension diffusely affects the gastrointestinal (GI) tract. Portal colopathy is a new clinical entity with liver cirrhosis but the frequency and profile of distinct colonic mucosal lesions (portal colopathy) and rectal varices has been little studied in patients with liver cirrhosis. In this study, colonoscopic findings, upper GI endoscopy, portal system colored Doppler ultrasonographic results and the degree of liver dysfunction were prospectively investigated among 25 haemodynamically stable patients with postviral cirrhosis without a history of bleeding. We found the incidence of esophageal varices to be 96%, congestive gastropathy 20% and portal colopathy excluding anorectal varices and hemorrhoids 92% in our patients. Portal colopathic lesions were occasionally localized in the rectosigmoid area, ascending colon, anal canal and transverse colon. The degree of esophageal varices was associated with congestive colopathy but not with anorectal varices and hemorrhoids. While congestive gastropathy had no significant relationship with esophageal varices, congestive colopathy was present in all patients with congestive gastropathy. However, no association was evident between these lesions and the degree of disease severity. Additional studies are required not only to determine the frequency of this entity, but also to understand the pathophysiology of these lesions. Since the colonic lesions, although usually asymptomatic and clinically insignificant, are a potential source of acute or chronic lower GI bleeding, further investigation is needed to reduce the risk of bleeding and offer alternative treatment models.
  • [ X ]
    Öğe
    Risk of Helicobacter pylori infection in newborn babies of Helicobacter pylori-positive pregnant women
    (1998) Dursun M.; Goral V.; Simsek H.; Yukselen V.; Hascelik G.; Canoru F.
    Helicobacter pylori (H.pylori) is one of the rare organisms that can maintain its life in acidic condition of stomach. A number of studies indicate that it is closely inked to mainly duodenal ulcer as well as peptic ulcer, non-ulcer dyspepsy, gastric cancer and MALT lymphoma. The aim of our study was to determine whether newborn infants of H.pylori-positive mothers are at risk of H.pylori infection A total of 48 mother and their newborn babies were included in the study. Soon after the birth, blood specimens were taken from both mothers and babies. Anti-H.pylori IgG was examined from the blood of the mothers by ELISA. The blood of babies of mothers with anti- H.pylori IgG-positive was investigated for both anti-H.pylori IgG and anti- H.pylori IgA. In 36 (75.0%) of 48 women included in the study, anti-H.pylori IgG antibody was found as positive. In addition, anti-H.pylori IgG was determined to be positive in 32 (89.0%) of 36 babies whose mothers were positive for anti-H.pylori IgG. These 32 babies whose anti-H.pylori IgG was positive were examined for anti-H.pylori IgA. In 3 babies (9.4%), it was found to be positive (p<0.01). In conclusion, owing to IgG's feature of being able to transmit through the placenta, it is clear that the presence of anti- H.pylori IgG in the serum of babies whose mothers are positive for anti- H.pylori IgG antibody cannot be an indicator of H.pylori infection. Determination of anti-H.pylori IgA antibody as positive is important and statistically significant (p<0.01). According to the results of this study, it can be said that at least the possibility of vertical transmission may exist.