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    Assesment the role of oxidative stress and efficacy of caffeic acid phenethyl ester (CAPE) on neurotoxicity induced by isoniazid and ethambutol in a rat model
    (Verduci Publisher, 2014) Uzar, E.; Varol, S.; Acar, A.; Firat, U.; Basarslan, S. K.; Evliyaoglu, O.; Yucel, Y.
    OBJECTIVE: The aim of this study were to investigate a role of oxidative stress and the therapeutic efficacy of caffeic acid phenethyl ester (CAPE) in the pathogenesis of neurotoxicity induced by isoniazid and etambutol in a rat model. MATERIALS AND METHODS: Male Sprague-Dawley rats were randomly divided into eight experimental groups: control, INH, ETM, INH+ETM, INH+CAPE, ETM+CAPE, INH+ETM+CAPE, and CAPE treatment group, with ten animals in each group. INH and ETM doses were given orally within tap water for 30 days. CAPE was administered into relevant groups intraperitoneally for 30 days. Brain tissue and sciatic nerve were removed for biochemical and histopathological investigation. RESULTS: In the INH, ETM, and INH+ETM groups, malondialdehyde (MDA) and total oxidant status (TOS) levels were significantly higher than those of the control group (p < 0.05). Also, in these groups, brain total antioxidant capacity (TAC) levels, and superoxide dismutase (SOD) and PON-1 activities were decreased compared with the control group (p < 0.05). By a CAPE supplement within INH and ETM groups, there was a significant decrease in MDA and TOS (p < 0.05). In addition to a significant increase in TAC levels, and SOD and PON-1 activities both in brain and sciatic nerve tissues (p < 0.05). CONCLUSIONS: CAPE may protect against INH- and ETM-induced neurotoxicity in rat brain and sciatic nerve.
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    Cerebral venous sinus thrombosis: an analyses of 47 patients
    (Verduci Publisher, 2012) Uzar, E.; Ekici, F.; Acar, A.; Yucel, Y.; Bakir, S.; Tekbas, G.; Oncel, O.
    OBJECTIVE: Cerebral venous sinus thrombosis (CVST) is an extremely rare disease and its early treatment is important for decreasing the morbidity and mortality. In present study, it was investigated to clinical and etiological factors, localization features, treatment, and prognosis of patients with CVST. PATIENTS AND METHODS: The study group included CVST cases who were followed up between January 2008 and June 2010. Demographical, clinical, radiological, etiological and prognostic characteristics of 47 patients with CVST were retrospectively investigated. RESULTS: Presentation complaints of the patients were as follows in order: acute and/or subacute headache (80.8%), impaired consciousness (25.5%), ear complaints (21.3%), paresis (19.1%) and epileptic seizures (14.9%). Chronic daily headache without any signs of neurological deficit was found in 10.6% of cases. Neurologic examinations of 40.4% of the CSVT patients were found to be normal. The most frequently found etiological factors were as follows: MTHFR gene mutation (25.5%), local infections due to chronic otitis complications (21.3%), puerperium (17%), pregnancy (12.8%), lupus anticoagulant positivity (12.8%). The sigmoid sinus was found to be involved in 35 patients (74.5%), the transverse sinus in 29 (61.7%) and superior sagittal sinus in 21 (44.7%). Impaired consciousness (p = 0.046), hemorrhagic infarct (p = 0.017), acute onset (p = 0.026), and presence of hemiparesis (p = 0.019) were found to be associated with increased mortality. CONCLUSIONS: New onset sub-acute or chronic headache may be the only neurologic complaint of CVST patients. Early diagnosis and anticoagulant treatment may decrease mortality and/or morbidity rates related with CVST in these patients.
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    The relationship of the mean platelet volume and C-reactive protein levels with mortality in ischemic stroke patients
    (Verduci Publisher, 2013) Arikanoglu, A.; Yucel, Y.; Acar, A.; Cevik, M. U.; Akil, E.; Varol, S.; Unan, F.
    BACKGROUND AND OBJECTIVES: The relationship of the mean platelet volume (MPV) and C-reactive protein (CRP) values withmortality in patients with ischemic stroke is not clear. Besides, the correlation between CRP and MPV in patients with ischemic stroke has not been adequately studied yet. In the present study, our aim is to investigate the interrelationship of the CRP and MPV parameters together with their influence on mortality in patients with acute ischemic stroke. PATIENTS AND METHODS: Sixty-three patients with acute ischemic stroke have been enrolled in the study. The stroke patients were divided into 2 groups as those who died within the first 10 days and those who survived. The MPV and CRP in both groups have been compared. Also, the MPV obtained from the ischemic stroke patients were compared with the MPV of the healthy volunteers. RESULTS: A statistically significant difference (p = 0.027) was observed between the MPV of the stroke patients (8.6 +/- 1.95 fL) and the control group (7.93 +/- 0.82 fl). The MPV (9.24 +/- 1.98 fL) and CRP (10.8 +/- 7.0 mg/l) of those ischemic stroke patients who died were statistically significantly higher (p < 0.05) than the MPV (8.09 +/- 1.75 fl) and CRP (3.2 +/- 3.5 mg/l) of the patients who survived. There was also a positive correlation between the MPV and CRP of the ischemic stroke patients (r = 0.31, p = 0.029). CONCLUSIONS: The fact that there is a relationship between the MPV and CRP in ischemic stroke patients and that the CRP and MPV are higher in the ischemic stroke patients who died in comparison to those who survived may be an indication of the roles these markers play in the mortality of stroke patients.
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    SENSITIVITY AND SPECIFICITY OF TERMINAL LATENCY INDEX AND RESIDUAL LATENCY IN THE DIAGNOSIS OF CARPAL TUNNEL SYNDROME
    (Wiley-Blackwell, 2011) Uzar, E.; Tamam, Y.; Acar, A.; Yucel, Y.; Palanci, Y.; Cansever, S.; Cevik, M. U.
    [Abstract Not Available]
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    Sensitivity and specificity of terminal latency index and residual latency in the diagnosis of carpal tunnel syndrome
    (Verduci Publisher, 2011) Uzar, E.; Tamam, Y.; Acar, A.; Yucel, Y.; Palanci, Y.; Cansever, S.; Cevik, M. Ugur
    Objectives: Traditionally, nerve conduction study (NCS) are used to diagnose carpal tunnel syndrome (CTS). However, no NCS has the sufficient sensitivity or specificity values to diagnose CTS by itself. Median terminal latency index (mTLI) and median residual latency (mRL) are parameters that calculated to identify abnormalities in distal segments of the median motor nerve. There are few studies on mTLI and mRL in the diagnosis of CTS. The objective of this study was to examine the sensitivity and specificity of mTLI and mRL together with NCS in the diagnosis of CTS. Patients and Methods and Results: The diagnostic sensitivity of mTLI and mRL were calculated and compared with the conventional NCS. Sensitivity values of electrophysiological findings were as follows: median distal sensory latency (mDSL) 91.5%, fourth finger median-ulnar sensory (M4-U4) latency difference 91.5%, mTLI 90.1%, median sensory nerve conduction velocity (mSNCV) 87.4%, and median motor distal latency (mMDL) 68.6%. Specificity values of electrophysiological findings in those with carpal tunnel syndrome were mSNCV 98.6%, mMNCV (median motor nerve conduction velocity) 98.6%, median motor wrist muscle action potential amplitude 98.6%, median sensory nerve action potential amplitude 97.4%, mSDL 97.3% and M4-U4 (fourtm finger median-ulnar sensory peak latency difference) latency difference 97.3%. In all CTS patients with long mMDL values, mTLI was found to be lower, however in 22 CTS patients (22.6%) with normal mMDL, mTLI was also found to be lower. Compared with mMDL, the sensitivity of mTLI in the diagnosis of CTS was found to be higher but its specificity was lower. No differences were found in the sensitivity and specificity of mRL and mMDL. The electrophysiological findings with the highest sensitivity and specificity in diagnosing CTS among conventional NCS were mSDL, M4-U4 peak latency difference and mSNCV. Conclusions: It was concluded that mTLI and mSDL can complete each other in the detection of abnormalities of sensory and motor fibres in the diagnosis of CTS.
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    Serum cytokine and pro-brain natriuretic peptide (BNP) levels in patients with migraine
    (Verduci Publisher, 2011) Uzar, E.; Evliyaoglu, O.; Yucel, Y.; Cevik, M. Ugur; Acar, A.; Guzel, I.; Islamoglu, Y.
    Objective: Although migraine has been related with an increased risk for ischemic stroke and cardiovascular events, there is insufficient data for role of pro-brain natriuretic peptide (pro-BNP) in migraine. In present case-control study, serum levels of pro-inflammatory (TNF-alpha, IL-1 beta and IL-6) and anti-inflammatory cytokines (IL-2, and IL-10) of migraine patients were investigated to determine the role of cytokines and pro-BNP in migraine. Patients and Methods: Sixty-four consecutive newly diagnosed migraine patients and 34 healthy controls were enrolled. Serum TNF-alpha, IL1 beta, IL-2, IL-6, IL-10 and pro-BNP levels were measured by using a chemiluminescence assay. Results: Migraine patients had significantly higher concentrations of IL-1 beta and IL-6 compared with the healthy controls (for IL-1 beta; 5.73 +/- 1.44 vs. 4.90 +/- 1.40 pg/mL, respectively, p = 0.006; for IL-6; 3.1 +/- 1.44 vs. 2.40 +/- 0.22 pg/mL, respectively, p = 0.007). The mean IL-10 levels were found to be significantly lower in migraine patients (3.38 +/- 2.93 pg/mL) than controls (6.76 +/- 1.48 pg/mL) (p = 0.007). There were no differences in TNF-alpha (27.2 +/- 48.1 vs. 15.4 +/- 0.7) and IL-2 (1017 +/- 661 vs. 1153 +/- 228) levels between patients with migraine and healthy controls. Migraine patients had higher concentrations of pro-BNP compared with healthy controls (27.0 +/- 28.0 versus 13.2 +/- 8.6, p = 0.006). Conclusions: Migraine patients have higher serum IL-1 beta and IL-6 levels, and lower IL-10 levels than healthy subjects. These findings support that cytokines may be related to neurogenic inflammation in the pathogenesis of migraine. Also, increased pro-BNP may indicate to preclinical cardiac involvement in patients with migraine.