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Öğe ADSORPTION OF HEAVY METAL IONS BY POPLAR SAWDUST(Editura Acad Romane, 2007) Bulut, Yasemin; Yokus, BeranDecontamination of synthetic Ni(II), Cd(II) and Pb(II) Solutions using poplar sawdust Was investigated. Batch sorption studies have been carried Out to determine the effect of contact time, temperature and initial Concentration of heavy metal ions (HMI) on adsorption. Equilibrium time was found to be around 60 min. Pseudo-first-order, pseudo-second-order and intraparticle diffusion models were used to fit the experimental data. Adsorption isotherms showed that HMI adsorption on sawdust deviated from the Freundlich and Langmuir equations. The Freundlich and Langmuir constants were calculated at different temperatures (25, 45 and 60 degrees C). Thermodynamic parameters, Such as free energy, entropy and enthalpy changes for the adsorption of heavy metal ions have been also Computed and discussed. In addition, the adsorption competition of Ni(II), Cd(II) and Pb(II) ions was determined from the A% values obtained from double and triple mixtures of these ions. Ion exchange is probably one of the major adsorption mechanisms for binding divalent metal ions to poplar sawdust.Öğe Alterations of Hematological Variations in Rats Exposed to Extremely Low Frequency Magnetic Fields (50Hz)(Elsevier Science Inc, 2009) Cakir, Dilek Ulker; Yokus, Beran; Akdag, Mehmet Zulkuf; Sert, Cemil; Mete, NuriyeBackground and Aims. The aim of this study was to evaluate the possible effects of in vivo exposure to extremely low frequency electromagnetic fields (ELF-EMF) on whole blood parameters (hematological parameters) in rats. Methods. Forty eight female Wistar rats, obtained from the Medical Science Application and Research Center, Dicle University, Turkey in 2004 were divided into four separate groups: two exposed groups (0.97 mT, 50 and 100 days, 3 h/day) and two controls (sham). Results. Eosinophil, hemoglobin and MPV levels significantly decreased in rats that were exposed to EMF for 50 days. When the data for rats exposed for 50 days and 100 days were compared, it was found that MPV levels in rats exposed for 100 days were significantly lower. There was no significant difference in total leukocyte, neutrofil, lymphocyte, monocyte, eosinophil and basophil counts, or in erythrocyte, Hct, MCH, MCHC, RDW, PLT and PDW levels between the exposed and sham-exposed groups. ELF-EMF exposure had no effect on body weight. Also, liver weight did not show any significant difference between groups. Conclusions. Our results indicate that the applied ELF-EMF exposure may induce slight but statistically significant alterations in some hematological parameters of rats, within the physiological range. (C) 2009 IMSS. Published by Elsevier Inc.Öğe Assessment of Serum Mineral and Certain Biochemical Variables in Self-Sucking Dairy Cows(Medwell Online, 2008) Bademkiran, Servet; Yokus, Beran; Icen, Hasan; Cakir, Dilek Ulker; Kurt, DoganSelf-sucking, that is, a cow sucking on her own teats is an important and leading cause of economic loss. However, the causes of self-sucking are virtually unknown, although numerous possible influencing factors, such as feeding management, nutrient deficits, genetic factors and housing systems have been suggested. In this study, our main objective was to investigate the possible effects of mineral levels on self-sucking in dairy cows. Biochemical variables of blood serum were also investigated. Cows which self-sucked had significantly lower serum concentrations of Mn, Co, Zn, P, Na, Cl, K and total protein, compared with the control group. Levels of serum cholesterol, HDL-C, LDL-C and ALP activity were significantly increased in the self-sucking group. There were no significant differences in serum levels of Ca, Mg, Cu, Fe, saturated Fe, iron binding capacity, urea, creatinin, uric acid, total bilirubin, amylase, gamaglutmyl transaminase, lactate dehidrogenase, creatin kinase, creatine kinase-MB, alanine transaminase and aspartate transaminase activities between the self-sucking group and the control group. The findings provide novel information about whether macro and micro element deficiency may cause self-sucking in dairy cows. An evaluation of our results supports the hypothesis that energy deficiency is a possible cause of self-sucking. Although the explanation is not clear, it may be related to decreased Co, Mn and P levels, which are important in carbohydrate and energy metabolism.Öğe Associations of alveolar bone loss and interleukin-1 levels in one- and two-stage surgical procedures: a randomized prospective trial(Taylor & Francis Ltd, 2017) Yildirim, Tuba Talo; Kaya, Filiz Acun; Yokus, Beran; Colak, Mehmet; Kaya, Eylem Ozdemir; Tekin, Giray; Saribas, EbruObjective: Dental implants have been widely and successfully used in recent years as an alternative treatment for removable and fixed dental prostheses. The aim of this randomized prospective study was to determine the alveolar bone loss rate (ABLR) and IL-1 levels in one- and two-stage surgical procedures.Materials and methods: This study included 40 patients with a single missing tooth in the posterior mandible; dental implants were inserted using a one-stage surgical procedure (Group I) or a two-stage surgical procedure (Group II). All clinical periodontal parameters were recorded; peri-implant crevicular fluid (PICF) samples were collected before loading (T0) and during the third (T1) and sixth (T2) months after loading. ABLR values were evaluated at T0 and T2 by using dental tomography. PICF was analysed after T2 samples were collected. The study was registered through clinicaltrials.gov; identifier NCT03045458.Results: This study found that, the probing pocket depth was found to be significantly higher in Group I than Group II at both T1 and T2 (p<.05). There was no significant difference in other clinical parameters between the groups (p>.05). There was a significant difference between Group I ABLR values at T0 and T2 (p<.05). The PICF IL-1 levels were not significantly different between groups (p>.05).Conclusions: Within the limitations of the short observational period and small sample size of this study, two-stage implant placement shows comparable clinical outcomes to implants placed using a one-stage placement protocol.Öğe Do 100-and 500-?T ELF magnetic fields alter beta-amyloid protein, protein carbonyl and malondialdehyde in rat brains?(Taylor & Francis Inc, 2013) Akdag, Mehmet Zulkuf; Dasdag, Suleyman; Cakir, Dilek Ulker; Yokus, Beran; Kizil, Goksel; Kizil, MuratSeveral studies still state that presently accepted safety standards for extremely low-frequency magnetic fields (ELF-MFs) do not provide adequate protection, and therefore the standards are still open to question. To help resolve this question, the aim of this study was to illuminate the interaction between biomolecules and ELF-MFs by investigating the effect of ELF-MFs on beta-amyloid protein (BAP), protein carbonyl (PC) and malondialdehyde (MDA) in rat brain. For this study, 30 adult male Sprague-Dawley rats were used, which were divided into two experimental groups and a sham exposed group. Rats in two experimental groups were exposed to 100- and 500-mu T ELF-MFs (50 Hz) for 2 h/day for 10 months, which are the generally accepted safety standards for public and occupational exposures. The same procedures were applied to the rats in the sham group, but with the generator turned off. The results of this study showed that neither ELF-MFs used in this study altered BAP level significantly (p > 0.05). However, PC and MDA levels were increased by the exposure to 100- and 500-mu T ELF-MFs (p < 0.0001). In conclusion, both PC and MDA levels were altered by long-term exposure to either 100 or 500 mu T ELF-MF. However, many further and more comprehensive studies will be required to elucidate the interaction mechanisms between ELF-MFs exposure and living organisms.Öğe Early prognostic markers to predict unsuccessful pregnancy in dairy cattle(Wiley, 2024) Yokus, Beran; Takci, Abdurrahman; Ercan, Nazli; Em, Bernan; Uysal, ErsinThis study aimed to investigate maternal serum levels of some angiogenic factors and certain proteins in dairy cattle for (1) early prediction of unsuccessful fertilization and (2) early detection of possible pregnancy failures (early EM) after positive insemination Serum samples were collected from the same cattle at three distinct time points: 30 days before artificial insemination (B-AI), on the day of artificial insemination (AI), and 30 days after artificial insemination (A-AI). As a result of the pregnancy examination, the cows were divided into two main groups according to whether they were pregnant. The results showed that leucyl/cystinyl aminopeptidase (LNPEP) concentration was significantly decreased B-AI and Secreted frizzled-related proteins (SFRP-3), Vascular Endothelial Growth Factor (VEGF) and LNPEP levels were significantly decreased on day of AI, while PRL level was increased, and these data have prognostic significance as early indicator of the risk of potentially failed pregnancy. Additionally, a significant decrease in LNPEP, SFRP3, and VEGF levels, along with an increase in PRL levels was also observed in A-AI. These results suggest that these biomarkers can be used as a screening test to monitor the course of pregnancy. There were no significant differences in serum levels of Insulin-Like Growth Factor 2 (IGF-2), Tissue inhibitors of metalloproteinases (TIMP-1), angiopoietin (ANG), Endoglin (ENG), Fibroblast growth factor (FGF), Inhibine-A (INH-A) and Transforming growth factors-beta 1 (TGF-beta 1) between the evaluated periods neither unsuccessful nor the successful pregnancy groups. This is the first study reporting that the maternal serum levels of LNPEP, SFRP3, VEGF, and PRL have important roles in pregnancy success and may indicate whether insemination outcome will be successful B-AI and predict the risk of unsuccessful pregnancy after AI in dairy cattle. The increase in such studies will allow the development of more specific, practical, and applicable markers.Öğe Effect of 50-Hz 1-mT magnetic field on the uterus and ovaries of rats (Electron microscopy evaluation)(Int Scientific Information, Inc, 2006) Aksen, Feyzan; Akdag, M. Zulkuf; Ketani, Aydin; Yokus, Beran; Kaya, Abdurrahman; Dasdag, SuleymanBackground: The aim of this study was to investigate the effect of extremely low frequency magnetic fields (ELFMF) on the uterus and ovary of rats. Material/Methods: Forty-eight female Wistar albino rats were divided into two groups, one for 50 and the other for 100 days of exposure. Each group was further divided into two groups, one sham exposed (n=12) and the other the experimental group (n=12). The experimental rats were exposed to 50-Hz 1-mT ELFMF for three hours/day for 50 or 100 days. The sham groups of rats were kept under the same circumstances without applying ELFMF. Electron microscopic examination was performed to evaluate the ovaries and uterus. Results: Ultrastructural dissolution, decrease in cell organelles, cavities in cells, heterochromative appearance, and typical structural loss of the nucleus were observed in germinal epithelial cells of the rat ovaries in the 50-days ELFMF exposure group. Ultrastructural alterations in germinal epithelium and tunica albuginea of ovaries, irregularity in nucleus and nucleolus, increase in lipid vacuoles of cell cytoplasm and reduction in organelles were observed in rat ovaries in the 100-days ELFMF exposure groups. Similar alterations were observed in uterus. Malondialdehyde concentration (MDA) of the ovaries and uterus increased in rats of the two exposure groups (p < 0.001). Conclusions: The results of the study showed that 50 and 100 days of exposure to a 1-mT ELFMF can cause alterations at the cellular level and in MDA concentration.Öğe Effect of 900 MHz Radio Frequency Radiation on Beta Amyloid Protein, Protein Carbonyl, and Malondialdehyde in the Brain(Taylor & Francis Inc, 2012) Dasdag, Suleyman; Akdag, Mehmet Zulkuf; Kizil, Goksel; Kizil, Murat; Cakir, Dilek Ulker; Yokus, BeranRecently, many studies have been carried out in relation to 900 MHz radiofrequency radiation (RF) emitted from a mobile phone on the brain. However, there is little data concerning possible mechanisms between long-term exposure of RF radiation and biomolecules in brain. Therefore, we aimed to investigate long-term effects of 900 MHz radiofrequency radiation on beta amyloid protein, protein carbonyl, and malondialdehyde in the rat brain. The study was carried out on 17 Wistar Albino adult male rats. The rat heads in a carousel were exposed to 900 MHz radiofrequency radiation emitted from a generator, simulating mobile phones. For the study group (n: 10), rats were exposed to the radiation 2 h per day (7 days a week) for 10 months. For the sham group (n: 7), rats were placed into the carousel and the same procedure was applied except that the generator was turned off. In this study, rats were euthanized after 10 months of exposure and their brains were removed. Beta amyloid protein, protein carbonyl, and malondialdehyde levels were found to be higher in the brain of rats exposed to 900 MHz radiofrequency radiation. However, only the increase of protein carbonyl in the brain of rats exposed to 900 MHz radiofrequency radiation was found to be statistically significant (p < 0.001). In conclusion, 900 MHz radiation emitted from mobile/cellular phones can be an agent to alter some biomolecules such as protein. However, further studies are necessary.Öğe Effect of ovariectomy and female sex hormones administration upon gastric ulceration induced by cold and immobility restraint stress(Saudi Med J, 2007) Kurt, Dogan; Saruhan, Berna G.; Kanay, Zeki; Yokus, Beran; Kanay, Berna E.; Unver, Ozkan; Hatipoglu, SavasObjective: To investigate the protective effects of estrogen and progesterone administrations on gastric mucosal barrier of rats applied ovariectomy, cold and immobility stress. Methods: Seventy female Wistar rats, obtained from Medical Science Application and Research Center, Dicle University, Turkey on the year 2004, were divided into 10 separate groups (n=7). Nothing was applied to the animals of Group 1 (control); bilateral ovariectomy was performed on the animals of the Groups 2, 4, 5, 6, 7, 8, 9, and 10. Groups 5 and 6 was applied 5 mg/kg 17beta-estradiol and groups 7 and 8 was applied 10 mg/kg progesterone for 7 days. The animals in the Groups 9 and 10 were applied 2.5 mg/kg 17beta-estradiol and 5 mg/g progesterone during 7 days. The animals in the groups 3, 4, 6, 8 and 1 were exposed to cold and immobility stress for 4 hours at 4 degrees C. Results: The levels of mucus and phospholipids were decreased in the rats applied ovariectomy and stress as compared to the control groups (p<0.001). The increase determined the mucus and phospholipids levels in estrogen and progesterone administered rats as compared to stress applied group (p<0.001). While the cold and immobility stress causes important damages in gastric mucosa, estrogen and progesterone administrations has protective effects in ovariectomized rats. Conclusion: The estrogen and progesterone administration prevents the stress that caused decrease in the levels of mucus and phospholipids, thus females are more resistant to gastric ulcer rather than males due to their sex hormones.Öğe Effects of Dietary Zeolite on Serum Contents and Feeding Performance in Rats(Friends Science Publ, 2011) Demirel, Ramazan; Yokus, Beran; Demirel, Dilek Senturk; Ketani, M. Aydin; Baran, M. SedatThe objective of the present study was to determine the effects of dietary natural clinoptilolite on serum contents, health status and feeding performance of rats. Adult male Sprague-Dawley rats (n=24) were randomly divided into four groups with three replicates including a control group (without zeolite) and three doses of natural zeolite (2, 4 & 6%) in the diets. All rats were fed the above concentrates during the whole experimental period for 56 days. Blood samples were collected from each animal at the end of the experiment. Dietary clinoptilolite increased in serum albumin, triglyceride and VLDL levels (P < 0.05). However, the differences among treatment groups were not significant for serum minerals (Ca, P, Mg, K, Na, Cl, Fe), urea, Fe binding, LDL, alkaline phosphatase, glucose, uric acid, total Fe, total protein, globulin, cholesterol, HDL cholesterol, creatinin; metabolizable energy and crude protein consumption for 1 g live weight gain of rats (P > 0.05). The results showed that the supplementation of clinoptilolite did not have positive effect on serum concentrations of the investigated parameters apart from albumin, triglyceride and VLDL, but they had no negative effect on the health status of animals. (C) 2011 Friends Science PublishersÖğe Effects of Gallic Acid on Ischemia-Reperfusion Induced Testicular Injury in a Rat Testicular Torsion Model(Sci Printers & Publ Inc, 2021) Sogutcu, Nilgun; Yokus, BeranOBJECTIVE: Testicular torsion is a common urological complication mostly affecting adolescents and young men. In this study we investigated biochemical and immunohistochemical effects of gallic acid on the damage induced by testicular torsion-detorsion. STUDY DESIGN: Forty male rats were divided into 4 groups of 10 animals each: control, torsion, torsion/detorsion, and torsion/detorsion + gallic acid. Testicles were removed from the scrotum, and 2.5-hour ischemia was applied to the left testis by twisting the spermatic cord 720 degrees clockwise. Then 3-hour reperfusion was allowed for detorsion. Gallic acid 20 mg/kg was orally administered to the torsion/detorsion + gallic acid group before reperfusion. Biochemical parameters of testicular tissue (MDA, SOD, CAT, and GSH levels) were measured. Testicular tissues were immune-stained with caspase-3 and TNF-alpha antibody. RESULTS: MDA levels in the torsion/detorsion + gallic acid group were close to those in the control group; however, it was higher in the torsion/detorsion group as compared to the control group. Compared to control group, SOD, CAT, and GSH activities were significantly increased in the torsion/detorsion + gallic acid group. However, those values were decreased in the torsion-detorsion group. Spermatogenic cells and interstitial cells showed positive caspase-3 expression in the torsion and torsion-detorsion groups; however, expression level was decreased in the torsion/detorsion + gallic acid group. TNF-alpha expression was observed in degenerated spermatogonia, Leydig cells, and macrophages in the torsion and torsion-detorsion groups. In the torsion/detorsion + gallic acid group, TNF-alpha expression was observed in some interstitial region rather than in cells of seminiferous tubules. CONCLUSION: Gallic acid treatment could be an alternative therapy in testicular ischemia-reperfusion injury to decrease inflammation, germ cell degeneration, and apoptosis.Öğe Effects of Lycopene and Vitamine E Administration Over Gastric Mucosal Damage Induced by Aflatoxin B1(Medwell Online, 2009) Kurt, Dogan; Saruhan, Berna Guney; Yokus, Beran; Cakir, Dilek UlkerIn the present study, we aimed to determine, the changes induced by Aflatoxin B-1 (AFB(1)) administration on rat gastric mucosal barrier and gastric mucins alongside revealing the protective effects of lycopene and Vit E. Thirty-five Wistar-Albino male rats weighing 180-220 g, were divided into 7 groups as to include 5 rats in each group: control, lycopene (10 mg/kg/day lycopene for 15 days (Lycopene 10% FS), AFB(1) (single dose of 2.5 mg AFB(1) kg(-1) on the 12th day of the study), Lycopene + AFB(1) (10 mg lycopene/kg/day for 15 days and single dose of 2.5 mg AFB(1) kg(-1) on the 12th day of the study) and Vitamin E + AFB(1) (10 mg/kg/day Vitamin E for 15 days and single dose 2.5 mg AFB(1) kg(-1) on 12th day). Following the sacrifice of study subjects on the 15th day, gastric mucus and phospholipid levels were determined and their stomachs were examined histopathologically. Examination of mucus and phospholipid levels revealed a significant reduction in group 3-5, in which AFB(1) has been applied (respectively, p<0.001, p<0.001). When lycopene and vitamine E groups are compared with the AFB(1) group, a significant elevation was detected in mucus and phospholipid levels (respectively, p<0.001, p<0.001). Whereas, histopathological examination of gastric mucosas of the aflatoxin group showed degenerative changes, gastric mucosas of the control group and the remaining study groups were normal. Histochemically, while neutral mucins were predominant in general structure of stomach, mixed and sialomucins were observed, as well. Particularly acid mucins with suplhate and periodate reactive acid mucins were found to be more predominant in the aflatoxin group compared to control and other groups. Histochemical features of mucins were observed to be consistent with specific functions of the different regions of stomach. Lycopene and vitamine E administrations were found to be protective against the damage induced by aflatoxin on gastric mucosa.Öğe Evaluation of testosterone levels in men with metabolic syndrome(Turkish Soc Cardiology, 2005) Iltumur, Kenan; Karabulut, Aziz; Toprak, Gulten; Yokus, Beran; Toprak, NizamettinObjectives: Low plasma levels of testosterone in men are associated with increased risk for atherosclerosis. In this study, we assessed plasma testosterone levels in patients with metabolic syndrome (MS) and its relationship with MS parameters. Study design: The study consisted of 36 men (mean age 50.2 +/- 7.2 years) with a diagnosis of MS according to the NCEP (National Cholesterol Education Program) criteria. An age-matched control group comprising 39 healthy volunteers (mean age 48.3 +/- 8.1 years) was also included. Plasma testosterone levels were determined by electro-chemiluminescence immunoassay on the Roche Elecsys 2010 analyzer. Fasting blood samples were analyzed for glucose and insulin levels, and lipid profiles (total cholesterol, triglyceride, LDL, and HDL). In addition, HOMA (Homeostasis Model Assessment) index was calculated. Results: The mean plasma testosterone level was significantly lower in the patient group (3.6 +/- 0.8 vs 4.8 +/- 1.9 ng/ml, p=0.001). There was a significant correlation between the levels of testosterone and HDL cholesterol (r=0.25, p<0.05). Testosterone levels were inversely correlated with the following: body mass index (r=-0.41, p<0.001), waist circumference (r=-0.40, p<0.001), HOMA index (r=-0.31, p=0.008), insulin (r=-0.28, p<0.05), glucose (r=-0.29, p<0.05), triglyceride (r=-0.28, p<0.05), and very low density lipoprotein (r=-0.28, p<0.05). Multivariate analysis identified only body mass index as an independent correlate of testosterone (beta=-0.36, p=0.038). Conclusion: Our results show that plasma testosterone levels are significantly decreased in MS. This may be of clinical importance for the assessment of cardiovascular risks in male patients with MS.Öğe Extremely low frequency magnetic fields cause oxidative DNA damage in rats(Taylor & Francis Ltd, 2008) Yokus, Beran; Akdag, M. Zulkuf; Dasdag, Suleyman; Cakir, Dilek Ulker; Kizil, MuratPurpose: To detect the genotoxic effects of extremely low frequency (ELF) -magnetic fields (MF) on oxidative DNA base modifications [8-hydroxyguanine (8-OH-Gua), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) and 4,6-diamino-5-formamidopyrimidine (FapyAde)] in rat leucocytes, measured following exposure to ELF-MF. Materials and methods: After exposure to ELF-MF (50Hz, 100 and 500 mu T, for 2 hours/day during 10 months), DNA was extracted, and measurement of DNA lesions was achieved by gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS). Results: Levels of FapyAde, FapyGua and 8OHdG in DNA were increased by both 100 mu T and 500 mu T ELF-MF as compared to a cage-control and a sham group; however, statistical significance was observed only in the group exposed to 100 mu T. Conclusion: This is the first study to report that ELF-MF exposure generates oxidatively induced DNA base modifications which are mutagenic in mammalian cells, such as FapyGua, FapyAde and 8-OH-Gua, invivo. This may explain previous studies showing DNA damage and genomic instability. These findings support the hypothesis that chronic exposure to 50-Hz MF may be potentially genotoxic. However, the intensity of ELF-MF has an important influence on the extent of DNA damage.Öğe Fructose-derived glycation and immune function: Effects on antigen binding in human IgG and lymphocytes(Elsevier Science Inc, 2025) Akay, Feryal; Inceoren, Nesrin; Nas, Cemal; Yokus, Beran; Kizil, Goksel; Kizil, MuratDiabetes Mellitus (DM), one of the oldest known metabolic disorders, dates back to 3000 BC and continues to have a profound impact on health and the economy. Nutrition plays a critical role in managing diabetes and enhancing overall quality of life. It is also vital for immune system function, as well as in the prevention and treatment of aging-related diseases. A key factor contributing to the global rise in obesity is the excessive consumption of fructose/glucose (corn) syrup, which leads to various metabolic complications. Uncontrolled intake of carbohydrates, particularly sugars like fructose, triggers the Maillard Reaction, a chemical process that occurs between sugars and proteins, resulting in advanced glycation end-products (AGEs). This process is accelerated in diabetic patients due to hyperglycemia, leading to increased glycation of plasma proteins such as immunoglobulins, which play an essential role in the immune system. Studies show that individuals with Diabetes Mellitus experience a higher susceptibility to infections due to increased viral entry, impaired immune responses, reduced viral clearance, and dysregulated inflammatory cytokine production. In this study, human IgG proteins were glycated in vitro using fructose, simulating the damaging effects seen in diabetic conditions. A mixture containing antioxidants like glutathione, oleuropein, and selenium was prepared and incubated with the glycated IgG to assess its protective properties. Lymphocyte cells from healthy volunteers were also treated with fructose and subjected to similar experiments. Results demonstrated that fructose significantly compromises immune function by damaging key proteins, but the antioxidant mixture effectively mitigates this damage, offering a protective mechanism against glycation in the immune system.Öğe Identification of interleukin 2, 6, and 8 levels around miniscrews during orthodontic tooth movement(Oxford Univ Press, 2012) Hamamci, Nihal; Kaya, Filiz Acun; Uysal, Ersin; Yokus, BeranThe aim of this study was to identify the levels of interleukin (IL)-2, IL-6, and IL-8 around miniscrews used for anchorage during canine distalization. Sixteen patients (eight males and eight females; mean age, 16.6 +/- 2.4 years) who were treated with bilateral upper first premolar extractions were included in the study. Thirty-two maxillary miniscrew implants were placed bilaterally in the alveolar bone between the maxillary second premolars and first molars as anchorage units for maxillary canine distalization. Three groups were constructed. The treatment, miniscrew, and control groups consisted of upper canines, miniscrew implants, and upper second premolars, respectively. Peri-miniscrew implant crevicular fluid and gingival crevicular fluid (GCF) were obtained at baseline (T1) and at 1 (T2), 24 (T3), and 48 (T4) hours, 7 (T5) and 21 (T6) days, and 3 months (T7) after force application. Paired sample t-tests were used to determine within-group changes and Dunnett's t and Tukey's honestly significant difference tests for between-group multiple comparisons. During the 3 month period, IL-2 levels significantly increased (P < 0.01) but only in the treatment group after 24 hours. IL-6 levels were unchanged at all times points in the three groups. IL-8 levels increased significantly at 1 (P < 0.05), 24 (P < 0.01), and 48 (P < 0.01) hours in the treatment group and at 24 (P < 0.05) and 48 (P < 0.01) hours in the miniscrew group. It appears that miniscrews can be used for anchorage in orthodontics when correct physiological forces are applied.Öğe Identification of tumor necrosis factor- ? levels around miniscrews during canine distalization(Korean Assoc Orthodontists, 2011) Kaya, Filiz Acun; Hamamci, Nihal; Uysal, Ersin; Yokus, BeranObjective: The aim of this study was to measure tumor necrosis factor- alpha (TNF- alpha) levels around miniscrews used for anchorage during a 3-month period of canine distalization. Methods: Sixteen patients (8 boys, 8 girls; mean age, 16.6 +/- 2.4 years) whose upper first premolars were extracted for orthodontic treatment were included in this study. Miniscrews were used as an anchorage unit in canine distalization. Thirty-two (32) miniscrew implants were placed bilaterally in the alveolar bone between the maxillary second premolars and first molars. The treatment, miniscrew, and control groups comprised upper canines, miniscrew implants, and upper first premolars, respectively. Peri-miniscrew implant crevicular fluid and gingival crevicular fluid were obtained before applying force and at 1, 24, and 48 hours, and at 7 and 21 days, and 3 months after applying force. Results: During the 3-month period, the TNF- alpha levels increased significantly at 24 hours only in the treatment group (p < 0.01). In the miniscrew and control groups, there were no statistically significant changes. No significant differences were observed between groups. Conclusions: Miniscrews can be conveniently used for anchorage in orthodontics. (Korean J Orthod 2011;41(1):36-41)Öğe The Impact of Dietary Encapsulated Fennel Seed (Foeniculum vulgare Mill.) Essential Oil Inclusion Levels on Performance, Serum Hormone Profiles, and Expression of Reproductive Axis-Related Genes in the Early and Late Laying Phases of Hens(Wiley, 2025) Ipcak, Hasan Huseyin; Denli, Muzaffer; Yokus, Beran; Bademkiran, ServetFennel seed (Foeniculum vulgare Mill.) essential oil (FEO), which is rich in the phytoestrogenic compound trans-anethole, interacts with oestrogen receptors and influences molecular targets within cells and hormonal responses. This study examined the effect of dietary encapsulated FEO inclusion levels on performance, reproductive hormone profiles, and gene expression in laying hens during the early and late phases. The study was conducted in two independent trials, each involving 210 Atak-S laying hens that were randomly distributed into 3 experimental groups, each having 10 replicates with 7 hens. The dietary treatments included a basal diet without FEO (Control) and a basal diet supplemented with 175 (FEO175) or 350 mg (FEO350) of encapsulated FEO/kg for 12 weeks. The results showed that FEO350 treatment improved egg production, egg mass, and feed conversion ratio during both early and late phases (p < 0.05). Moreover, increasing FEO inclusion levels enhanced oestradiol, follicle-stimulating hormone, luteinizing hormone and progesterone concentrations in both early and late laying hens, reaching peak levels at FEO350 (p < 0.05). FEO supplementation upregulated the expression of oestrogen receptor 2 (ESR2) and follicle-stimulating hormone receptor (FSHR) (p < 0.05). Furthermore, FEO350 increased prolactin receptor (PRLR) expression during the early phase but decreased it during the late laying phase (p < 0.05). Positive correlations were observed between egg production and FSHR, ESR2 and steroidogenic acute regulatory protein (STAR) expression, with a negative correlation for PRLR (p < 0.05). In conclusion, 350 mg FEO/kg was found to be the most effective level for enhancing layer performance.Öğe POLYMORPHISM OF P53 GENE EXON 4 IN PATIENTS WITH CORONARY ARTERY DISEASE(John Wiley & Sons Inc, 2009) Tekes, Selahaddin; Cakir, Dilek; Yokus, Beran; Iltumur, Kenan; Simsek, Selda[Abstract Not Available]Öğe Protective Role of Lycopene on Aflatoxin B1 Induced Changes Sperm Characteristics and Testicular Damages in Rats(Kafkas Univ, Veteriner Fakultesi Dergisi, 2010) Tas, Muzaffer; Saruhan, Berna Gueney; Kurt, Dogan; Yokus, Beran; Denli, MuzafferThe aim of this study was to investigate if lycopene could diminish the adverse effects of aflatoxin B-1 (AFB(1)) on sperm characteristics, the testes, epididymis and oxidative stress in rats. A total of 28 adult male Wistar-Albino rats (8 weeks old weighing 180-220 g) were divided into four groups; Controls, lycopene treated rats (10 mg/kg BW, daily by gavage), AFB(1) treated rats (2.5 mg/kg BW, single dose intra peritonal) and lycopene (10 mg/kg BW, daily by gavage) + AFB(1) (2.5 mg/kg BW, single dose intra peritonal) treated rats. Traits of reproductive organs (testes and sperm characteristics, testicular histological findings and the testicular tissue oxidative status) were determined after 15 days of treatment. The sperm motility was significantly decreased while the rate of total abnormal sperms was significantly increased in rats treated with AFB(1) alone compared to their levels in controls (P<0.001). The level of testes malondialdehyde (MDA) in rats treated with AFB(1) was significantly higher than its level in controls (P<0.001). Treatment with AFB(1) significantly decreased testes diameter and seminifer epithelium thickness (P<0.0001) when compared with the others. Similarly, the thickness of the germinative cell layer at seminifer tubul (ST) in rats treated with AFB(1) was significantly smaller than controls. Treatment with lycopene significantly increased sperm motility (P<0.001) and alleviated the many negative effects of AFB(1) on sperm characteristic and testicular damage in rats. In conclusion our results showed that consumption of 10 mg of lycopene/BW given by gavage protected the rats to the toxicity of AFB(1) when it is administrated as a single dose intraperitoneally.
