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Öğe Comparison of inflammatory mediators, cardiac risk factors and functional-structural changes of left ventricle(Blackwell Publishing, 2006) Toprak, G.; Alan, S.; Cevik, K.; Yokus, B.; Celik, Y.[Abstract Not Available]Öğe Comparison of Pelargonium sidoides, Placebo and Antibiotic Treatment of Chronic Endometritis in Dairy Cows: A Field Trial(Medwell Online, 2009) Bademkiran, S.; Kurt, D.; Yokus, B.; Celik, R.We compared the effects of the intrauterine application of an extract of Pelargonium sidoides (EPs 7630) to parenteral antibiotic injection in the treatment of chronic endometritis, which is commonly encountered postpartum in cows. Forty six cows diagnosed with chronic endometritis 21-27 days postpartum were selected and divided into 3 groups. Cows in Group I (n = 16) received a physiological parenteral injection of 10 mL of serum per day for 3 days. Similarly, cows in Group II (n = 15) received 1 mg kg(-1) ceftiofur (Ceftivil (R) parenterally. Those in Group III (n = 15) received an 8 mg (10 mL)/cow intrauterine dose of EPs 7630 (Umca (R)) for 3 days. When examined between the 35th and 41st day, clinical recovery rates were found to be as follows: for Group 1, 1/16 (6.2%); for Group 11, 8/15 (53.3%) and for Group III, 4/15 (26.69%). After this examination, cows whose chronic entrometritis symptoms persisted according to clinical and rectal examination received a further 3 days of the treatment appropriate to their group. Later on various parameters were identified thus, for Groups I-III, respectively: insemination rate 87.5, 66.6 and 93.3%; days to 1st service 103.5, 91.0 and 96.0; 1st service conception rate 28.5, 40.0 and 35.7%; days open 140, 120 and 131 and cows pregnant within 250 DIM 56.25, 80.0 and 66.6%.Öğe Curcumin reduced diabetic nephropathy in a rat model(Funpec-Editora, 2022) Arican, C. D.; Gokdemir, G. S.; Gokdemir, M. T.; Yokus, B.; Tasdemir, E.; Sermet, A.This study aimed to examine the effects of curcumin, a phytochemical antioxidant, on the treatment and care of diabetic nephropathy and to contribute to alternative treatment strategies for diabetes. Male Wistar albino rats (8-10 weeks old) were divided into five groups of seven. Experimental diabetes was induced in all rats except for those in Group 1 (placebo group) by administration of 110 mg/kg nicotinamide, followed by intraperitoneal administration (after 15 min) of 55 mg/kg streptozotocin. Groups 1, 3, 4, and 5 were treated with 0.1 ml normal saline (0.9% NaCl), 150mg/kg/day metformin, 10 mg/kg/day glycazide (diamicron), and 200 mg/kg/day curcumin, respectively. Group 2 did not receive any treatment. Kidney tissues of rats were collected for histopathological examination There were no significant differences in the kidney dimensions of the rats. In the histopathological evaluation of kidney tissues with diabetic nephropathy, glomerular congestion and destruction were observed. Rats treated with curcumin had significantly less kidney damage, based on histopathological analysis, than those treated with the diabetes drugs. We conclude that curcumin has protective effects in kidneys due to its antioxidant properties. It has potential for use, in addition to antidiabetic drugs, for diabetes treatment.Öğe The Effect of Sorghum Grain on Ruminal Fermentation and Some Blood Parameters in Beef Cattle(Medwell Online, 2008) Baran, M. S.; Yokus, B.; Gul, I.; Alp, M.; Sahin, N.In this research, the effect of sorghum in beef cattle mixture feeds as energy source instead of wheat on ruminal fermentation and some blood parameters was investigated. In the experiment, 20 Holstein beef cattle of 1.5 years old, each weighing average 330 kg were used. The trial was done in 2 stages: the first stage was pre-experimental period for 2 weeks and the second stage was the main experimental period for 10 weeks, totally lasting twelve weeks. During the whole experimental period, isocaloric and isonitrogenic 2 diets were used. In control group, mixtures involved 27% wheat, but in experimental group 27% sorghum was used instead of wheat. Dried alfalfa hay was used as roughage. Both rations consisted of 80% concentrated feed and 20% roughage. The differences between the groups for ruminal fermentation parameters; rumen fluid pH, ammonia concentrations, total volatile fatty acids, acetate, propionate, butyrate levels were not significant (p>0.05). In both groups differences, at the beginning and middle of the trial period for blood serum parameters (total protein, glucose, albumin, Ca, Na, P, K, Zn, Cu, Fe, Mg), were not significant, but at the middle and end of the trial, the differences between the groups was significant for blood serum Se levels (p<0.05). Trial results indicated that sorghum grain could be used instead of wheat as an economical energy source in beef cattle rations.Öğe The Effects of Age and Gender on Some Biochemical Serum Parameters in Zom Sheep Raised in the Vicinity of Karacadag(Israel Veterinary Medical Assoc, 2015) Durak, M. H.; Erkan, R. E. C.; Celik, R.; Yokus, B.; Kurt, D.; Gurgoze, S.A hundred and seventy three clinically healthy Zom sheep aged 1-6 years and grazed on grassland under similar conditions in six villages of the Karacadag and Ovabag towns of the central, Bismil and Cinar districts of Diyarbakir province. The effect of gender in the evaluation for serum glucose, gamma similar to glutamyltransferase, and alkaline phosphatase were observed for Zom sheep. The effect of age on the assessment made by taking into consideration the serum cholesterol, direct bilirubin, very low-density lipoprotein, alkaline phosphatase, gamma similar to glutamyltransferase and direct bilirubin and high-density lipoprotein were also observed. In conclusion the age and gender of the Zom sheep needs to be taken into consideration in order to ensure an accurate clinical diagnosis and prognosis.Öğe Effects of seasonal and physiological variations on the serum chemistry, vitamins and thyroid hormone concentrations in sheep(Wiley, 2006) Yokus, B.; Cakir, D. U.; Kanay, Z.; Gulten, T.; Uysal, E.The aim of this study was to investigate the possible effects of the reproductive status and seasonal variations on the serum chemistry and vitamin status and their relationships with the thyroid hormones in Sakiz-Awassi crossbreed sheep. The sheep (n = 34) were divided into two groups. The first group (n = 22) was mated; the second group (n = 12) was not mated. Their serum samples were collected four times a year at the each season and under reproductive status. The periods are 1, early pregnancy (October); 2, late pregnancy (January); 3, lactation (April); and 4, dry season (July). The results of this study indicated that (1) total protein (TP), globulin, cholesterol, creatinine, uric acid and T4/T3 vary with reproductive status but not seasonal variations; (2) alanine aminotransferase, T4, fT4 concentrations in serum vary only with reproductive status; (3) the urea, creatine kinase, lactate dehydrogenase, alkaline phosphatase, aspartate aminotransferase, amylase, albumin, triglyceride, VLDL, Vit A-E, T3 and fT3 concentration could vary with both reproductive status and seasonal variations; (4) the glucose, gamma-glutamyl transpeptidase, folate concentrations were altered neither season of the year nor the reproductive status; (5) a single reference interval for folate, gamma-glutamyl transpeptidase (GGT), glucose, TP, globulin, cholesterol, creatinine, uric acid and T4/T3 can be used for both mated and non-mated sheep because of no differences were found due to the reproductive status. Taking the results together suggests that reproductive status and seasonal variations have to be taken into consideration for a correct interpretation of the serum chemistry values of sheep. Nutritional supplements are required for sheep during certain periods to avoid a decline of their performance, which would then represent consequent economic, loses.Öğe The Effects of Sorghum Grain on Live Weight Gain, Feed Conversion Ratios and Digestibility of Nutrients in Beef Cattle(Medwell Online, 2008) Baran, M. S.; Demirel, R.; Yokus, B.; Kocabagli, N.In this research, the effect of sorghum in beef cattle mixture feeds as energy source instead of wheat on live weight gain, feed conversion ratio and digestibility of nutrients were investigated. In the experiment, 20 Holstein male beef cattle of 1.5 years old and each weighing average 330 kg were used as animal material. The trial was done in two stages: the first stage was pre-experimental period for 2 weeks and the second stage was the main experimental period for 10 weeks, totally lasting 12 weeks. During the whole experimental period, isocaloric and isonitrogenic 2 diets were used. In control group, feed mixtures involved 27% wheat, but in experimental group, 27% sorghum was used instead of wheat. Dried alfalfa hay was used as roughage. Both rations consisted of 80% concentrated feed and 20% roughage. The differences between the control and treatment groups, in terms of live weight gains, feed intakes, daily live weight gains, feed conversion ratios and digestibility of nutrients, during 84 days of feeding period were not significant (p>0.05). Trial results indicated that sorghum grain could be used instead of wheat as an economical energy source in beef cattle rations.Öğe P53 gene exon 4 RFLP polymorphism and relation with severity of disease in patients with coronary artery disease(Blackwell Publishing, 2006) Cakir, D. U.; Yokus, B.; Tekes, S.; Iltimur, K.; Mete, N.; Uysal, E.[Abstract Not Available]Öğe Prepartum and postpartum serum paraoxonase activity in dairy cattle and their associations with dystocia(Blackwell Publishing, 2006) Yokus, B.; Bademkiran, S.; Cakir, D. U.[Abstract Not Available]Öğe The role of nitric oxide synthase (eNOS) gene polymorphism in coronary artery diseases and relation with severity of disease(Blackwell Publishing, 2006) Tekes, S.; Cakir, D. U.; Yokus, B.; Mete, N.; Iltimur, K.[Abstract Not Available]Öğe Serum myeloperoxidase levels in predicting the severity of stroke and mortality in acute ischemic stroke patients(Verduci Publisher, 2015) Tay, A.; Tamam, Y.; Yokus, B.; Ustundag, M.; Orak, M.OBJECTIVE: The aim of this study was to examine the level of myeloperoxidase (MPO) measured before specific treatment in patients presenting to the Emergency Department with acute ischemic stroke and its correlation to mortality and the severity of the stroke. PATIENTS AND METHODS: The study was carried out on 55 patients with a confirmed diagnosis of ischemic stroke, and on 44 healthy control group. Before specific intervention, serum samples were taken to measure levels of MPO. The medical records, demographic, clinical, laboratory and neuro-imaging data were noted. The National Institutes of Health Stroke Scale was used to determine the severity of the stroke. RESULTS: A total of 55 patients, of whom 32 (58.2%) were male, who had presented within 24 hours of the onset of symptoms of acute ischemic stroke were included in the study. Fifteen of these patients (27.2%), of whom five were women, died. There was a statistically significant difference in the serum MPO levels of patients who survived and those who died. When the patients were grouped as high or normal in terms of plasma MPO levels, a significant correlation was found between MPO level, cortical + subcortical stroke location and strokes with a lesion diameter of more than 4 cm. In the high MPO group, Troponin T and CRP levels were significantly higher than those of the normal MPO group. CONCLUSIONS: The level of myeloperoxidase in the serum of acute ischemic stroke patients rises and there is a correlation between myeloperoxidase level and prognosis.Öğe Total antioxidant capacity, total oxidant status and oxidative stress index in the men exposed to 1.5 T static magnetic field(General Physiol and Biophysics, 2007) Sirmatel, Oe.; Sert, C.; Sirmatel, E.; Selek, S.; Yokus, B.The aim of this study was to investigate the effects of a high-strength magnetic field produced by a magnetic resonance imaging (MRI) apparatus on oxidative stress. The effects of a 1.5 T static magnetic field on the total antioxidant capacity (TAC), total oxidant status (TOS) and oxidative stress index (OSI) in male subjects were investigated. In this study, 33 male volunteers were exposed to a 1.5 T static magnetic field for a short time and the TAC, TOS and OSI of each subject were determined. Magnetic field exposure was provided using a magnetic resonance apparatus; radiofrequency was not applied. Blood samples were taken from subjects and TAC, TOS and OSI values were measured using the methods of Erel. TAC showed a significant increase in post-exposures compared to pre-exposures to the magnetic field (p < 0.05). OSI and TOS showed a significant decrease in post-exposures compared to pre-exposures to a 1.5 T magnetic field (for each of two, p < 0.0 1). The 1.5 T static magnetic field used in the MRI apparatus did not yield a negative effect; on the contrary, it produced the positive effect of decreasing oxidative stress in men following short-term exposure.Öğe Total antioxidant response and oxidative stress index and relation with severity of disease in coronary artery disease(Blackwell Publishing, 2006) Mete, N.; Cakir, D. U.; Yokus, B.; Iltimur, K.[Abstract Not Available]
