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Öğe Cefuroxime Axetil Related DRESS (drug reaction with eosinophilia and systemic symptoms) Syndrome(Modestum Ltd, 2016) Yildirim, Yasar; Kara, A. Veysel; Yilmaz, Zulfikar; Yildirim, Resit; Yilmaz, Sureyya; Kadiroglu, A. Kemal; Yilmaz, M. EminDRESS (Drug reaction with eosinophilia and systemic symptoms) syndrome is a rare, potentially life-threatening, drug induced hypersensitivity reaction manifested by fever, rash, eosinophilia, lymphadenopathy, and organ involvement especially liver and kidney. The disease is characterized by a long latency period (at least two weeks) between the drug exposure and disease onset. The most commonly reported drugs associated with DRESS syndrome in the literature are allopurinol, and anticonvulsants. We describe a patient presented with eosinophilia, fever, diffuse maculopapular rash, hepatomegaly, and multiple intra-abdominal lymphadenopathies just ten days after initiation of cefuroxime axetil. In our case, we aim to announce the first case report of cefuroxime axetil related DRESS syndrome, and also speculate on the possible association between cephalosporin and DRESS syndrome.Öğe The effects of nebivolol on serum levels of malonyldialdehyde and paraoxonase in patients with end stage renal disease(Oxford Univ Press, 2007) Sit, Dede; Kayabasi, Hasan; Kadiroglu, Ali Kemal; Yilmaz, Zulfikar; Yilmaz, M. Emin[Abstract Not Available]Öğe Evaluation of obstetrical patients with disseminated intravascular coagulopathy - tertiary center experience(Taylor & Francis Ltd, 2016) Basaranoglu, Serdar; Evsen, Mehmet Siddik; Agacayak, Elif; Tunc, Senem Yaman; Yilmaz, Zulfikar; Yildirim, Yasar; Deregozu, AvSequiObjective: The purpose of the present study is twofold: (a) to investigate the etiology of disseminated intravascular coagulopathy (DIC) caused by obstetrical conditions and (b) to present parameters that can be used in predicting DIC-related mortality in obstetrical patients. Material and method: Obstetrical patients who had a delivery at or were referred (after delivery) to Obstetrics and Gynecology Clinic of Dicle University between July 2006 and December 2013 were retrospectively analyzed in this study. Those patients diagnosed with DIC were included in the study. Results: Fifty-six obstetrical patients carrying the diagnosis of DIC were included in this study. The overall mortality rate was 25% among these patients. More specifically, the mortality rate was 10.7% among patients with a DIC score <= 5 and 40.7% among those with a DIC score >5. Multiple logistic regression analysis resulted in the finding that international normalized ratio (INR) and urea were among those factors affecting mortality in obstetrical DIC [OR: 8.44 (CI: 1.9-36.8), OR: 1.05 (CI: 1.0-1.1), respectively]. Conclusion: DIC is a syndrome that might be caused by obstetrical conditions. It is associated with high mortality and morbidity rates. In obstetrical DIC, urea is the most important factor affecting mortality. In addition, we are of the opinion that DIC score might guide mortality predictions as a determinant of prognosis.Öğe Left ventricular global longitudinal strain can detect subclinical left ventricular systolic dysfunction in adult patients with primary nephrotic syndrome(Springer, 2023) Cap, Nese Kanbal; Aydin, Emre; Kadiroglu, Ali Kemal; Ozbek, Mehmet; Yildirim, Yasar; Yilmaz, Zulfikar; Aydin, Fatma YilmazIt has been shown that there is an increased risk of cardiovascular events such as heart failure and death in nephrotic syndrome. Left ventricle global longitudinal strain (LVGLS) is a more sensitive measure of assessing myocardial dysfunction and is more reproducible than left ventricle ejection fraction (LVEF%). LVGLS can detectsubclinical deterioration in the left ventricle early. In this study, we aimed to investigate LVGLS in Primary Nephrotic Syndrome (PNS) patients with normal LVEF%. Patients with histopathologically confirmed PNS were evaluated for this prospective single-center study. Patients with similar age and gender characteristics without nephrotic syndrome were included as the control group. LVGLS measurements were performed by 2D speckle tracking echocardiography. A total of 171 patients, 57 with PNS and 114 in the control group, were included in the study. The mean age was 38 +/- 12 years in the study population, and 95(56%) of the patients were women. LVEF% was 60.2 +/- 4.2 in the PNS group and 61.1 +/- 3.2 in the control group, and there was no significant difference between the two groups (p=0.111). LVGLS was found to be significantly lower in the PNS group (-19.3 +/- 2.3% vs.-20.8 +/- 1.5 %, p<0.001). A significant relationship was observed between PNS and LVGLS in the multivariable linear regression analysis (beta= 4.428, CI 95% =0.57?1.48, p<0.001). A significant relationship was observed between PNS and LVGLS, and LVGLS was found to be lower in PNS patients. In patients with PNS, subclinical left ventricular systolic dysfunction may be detected in the early period by measuring LVGLS.
