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Öğe Correlation of Tumour Markers in Ascitic Fluid and Serum: Are Measurements of Ascitic Tumour Markers a Futile Attempt?(Field House Publishing Llp, 2009) Tuzun, Y.; Celik, Y.; Bayan, K.; Yilmaz, S.; Dursun, M.; Canoruc, F.Correlations between tumour markers in ascitic fluid and serum were investigated to determine whether ascitic fluid analysis had any diagnostic advantage over serum in 91 adults with ascites (55 malign; 36 benign). Serum and ascitic fluid were analysed for carcinoembryonic antigen (CEA), cancer antigen (CA) 125, CA19.9, CA72.4, CA15.3, alpha-fetoprotein (AFP) and cytokeratin-19 fragment (CYFRA). The tumour markers were skewed between the groups so were logarithmically transformed. Correlations between serum and ascitic fluid were tested using Pearson's correlation coefficient. Serum and ascitic fluid levels of CEA, CA125, CYFRA and AFP in the malign group were statistically different and CEA, CA19.9, CA5.3, CYFRA and AFP were statistically different in the benign group. For both groups, all tumour markers were highly correlated in serum and ascitic fluid, with the exception of CYFRA in the malign group. These results indicate that, where malignant ascites is suspected, analysing tumour markers in ascitic fluid does not have any advantage over serum analysis.Öğe Definition of C282Y mutation in a hereditary hemochromatosis family from Turkey(Wiley-Blackwell, 2011) Aydinol, B.; Yilmaz, S.; Genc, S.; Aydinol, M. M.[Abstract Not Available]Öğe Epidemiological trends and seasonal dynamics of tuberculosis in Southeastern Turkey(Wolters Kluwer Medknow Publications, 2023) Taylan, M.; Dogru, S.; Sezgi, C.; Yilmaz, S.Background: Tuberculosis (TB) is an important public health issue. Determining TB trend and seasonal variability provides useful information for designing treatment strategies and control programs. Aim: The present study attempts to investigate the epidemiological trend and the seasonal variations. Materials and Methods: TB data containing 2450 cases were collected over a period of seven years in the province of Diyarbakir in southeast Turkey. Trend function and seasonal variability were investigated by statistical curve fitting, surface fitting, and autoregressive time series analysis. Results: The study revealed a gradually decreasing trend in the number of TB cases over a period of seven years. Total TB incidence had seasonal variations (P = 0.04); there was a greater number of TB cases between April and July, with a peak in June. There were significant monthly seasonal variations with June peaks among females (P < 0.001), in patients in the age groups of 0-15 (P < 0.001) and 36-45 years (P < 0.001), in new cases (P < 0.001) and in the patients with pulmonary TB (P = 0.01). The extra-pulmonary TB cases peak in May (P = 0.01). Pulmonary TB and TB patients in the 36-45 age group had summer peak, while the other groups peaked at spring. Conclusions: Spring and summer peaks detected in total TB cases and in many subgroups indicate that multicenter and comprehensive clinical studies are needed to explain these variations.Öğe Geometrically nonlinear analysis of plane frames with semi-rigid connections accounting for shear deformations(Techno-Press, 2012) Gorgun, H.; Yilmaz, S.The behaviour of beam-to-column connections plays an important role in the analysis and design of steel structures. A computer-based method is presented for nonlinear steel frames with semirigid connections accounting for shear deformations. The analytical procedure employs transcendental stability functions to model the effect of axial force on the stiffness of members. The member stiffness matrix, and the fixed end forces for various loads were found. The nonlinear analysis method is applied for three planar steel structures. The method is readily implemented on a computer using matrix structural analysis techniques and is applicable for the efficient nonlinear analysis of frameworks.Öğe Hereditary thrombophilia screening in recurrent abortus in Turkish females(Wiley-Blackwell, 2011) Aydinol, M. M.; Aydinol, B.; Yilmaz, S.; Genc, S.[Abstract Not Available]Öğe Lack of correlation between CRP and hepatitis B viral load in serum of patients with chronic HBV(W B Saunders Co Ltd, 2007) Gedik, M.; Ozekinci, T.; Ozbek, E.; Atmaca, S.; Yilmaz, S.[Abstract Not Available]Öğe Living obstructive, mixed and central apneas in the same epoch: an interesting OSAS case(Wiley, 2018) Yilmaz, S.; Sen, H. Selimoglu; Kirbas, G.[Abstract Not Available]Öğe Relationship between SP1 polymorphism and osteoporosis in young osteoporotic women(Wiley-Blackwell, 2016) Aydinol, B.; Nas, K.; Yilmaz, S.; Akpolat, V.; Kartal, O.; Genc, S.[Abstract Not Available]Öğe Replacement of hystological findings(Wiley, 2007) Yilmaz, S.; Bayan, K.; Tuezuen, Y.; Dursun, M.; Kaplan, A.; Oezmen, S.; Canoruc, F.Because of limitations in biopsy procedure, several non-invasive tests have been developed for predicting the histological findings in chronic hepatitis. A fibrosis (F) score 1 or above and necroinflammation [histological activity index (HAI)] score 4 or above are required to initiate the treatment in chronic viral hepatitis. Literature includes many studies on hyaluronic acid (HA) as a non-invasive procedure in predicting histological findings but lacks on high-sensitive-C-reactive protein (hsCRP). We evaluated the diagnostic value of HA and hsCRP in patients with chronic viral hepatitis. Ninety-eight subjects (42 chronic viral hepatitis, 28 cirrhosis and 28 healthy controls) were included in the study. Liver biopsies were performed on 42 chronic hepatitis patients and assessed by Ishak scoring system. All sera were stored at -70 degrees C until assay. Many laboratory parameters related to viral hepatitis, HA and hsCRP were studied following the instructions. We tried to determine a cut-off value for HA to represent >= F1 score and that for hsCRP to represent >= 4 HAI score. Hepatitis B virus was the predominant aetiology of chronic hepatitis in our study. Mean HA levels were 113, 754 and 24 ng/ml in patients with chronic hepatitis, cirrhosis and controls, respectively (ANOVA, p < 0.001). A HA level > 64.7 ng/ml had a 100% specificity for diagnosing chronic hepatitis. A value >= 154 ng/ml had a 100% specificity, 100% positive predictive value and 90% negative predictive value for diagnosing liver cirrhosis (Area 1.00; p < 0.0001). A cut-off value of 63 ng/ml for HA had a 100% specificity for diagnosing fibrosis score >= 1 in chronic hepatitis (Area 0.86; p < 0.001). An hsCRP level > 0.56 mg/dl had a 100% specificity and 12% sensitivity for diagnosing chronic hepatitis (Area 0.71; p = 0.002), while cut-off of 0.53 mg/dl had 75% specificity for diagnosing HAI >= 4 in chronic hepatitis (Area 0.32; p = 0.132). This study supported the HA level in predicting fibrosis score >= 1 with a cut-off value of 63 ng/ml. Cut-off of 154 ng/ml had a strong worth for cirrhosis. A cut-off of hsCRP for predicting HAI score >= 4 warrants further evaluation in wider study populations. We concluded that we are a bit closer to the strategy for guiding therapy in patients with chronic hepatitis, without a liver biopsy.
