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Protective effects of caffeic acid phenethyl ester on dose-dependent intoxication of rats with paraquat
(Sage Publications Inc, 2015) Silfeler, Ibrahim; Alp, Harun; Ozgur, Tumay; Evlioglu, Osman; Celik, Murat; Er, Metin; Yilmaz, Gulsah
Purpose: Paraquat (PQ; 1,1'dimethyl-bipyridilium 4,4'-dichloride), which is used extensively throughout the world, is highly toxic to humans. We aimed to investigate the protective effects of different doses of caffeic acid phenethyl ester (CAPE) on PQ-intoxicated rats. Materials and methods: A total of 80 rats were divided into the following eight groups, comprising 10 rats in each group: group 1: control; group 2: administered with CAPE (10 mu mol/kg); group 3: administered with 15 mg/kg PQ (PQ 15 group); group 4: administered with 30 mg/kg PQ (PQ30 group); group 5: administered with 45 mg/kg PQ (PQ45 group); group 6: administered with 15 mg/kg PQ CAPE; group 7: administered with 30 mg/kg PQ + CAPE and group 8: administered with 45 mg/kg PQ + CAPE. Both PQ and CAPE were injected intraperitoneally. Pancreatic tissue was examined with both haematoxylin and eosin and immunochemical staining. Results: The ratio of the immunohistochemical staining area to the total pancreatic area of the beta cells revealed that statistically significant differences were observed only between the PQ and PQ + CAPE groups (p < 0.05). Discussion: The evaluation of the data suggests that CAPE can be used to prevent acute effects of PQ intoxication.