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    An Analysis on Aerodynamic and Acoustic Changes After Thyroidectomy
    (Int College Of Surgeons, 2016) Yilmaz, Beyhan; Bakir, Salih; Yilmaz, Edip Erdal; Senhul, Engin; Uslukaya, Omer; Gul, Aylin; Ozkurt, Fazil Emre
    The purpose of this study was to investigate the aerodynamic and acoustic changes after thyroidectomy without laryngeal nerve injury by using objective methods. Voice samples of sustained /alpha/ recorded from 44 adults preoperatively and nearly 1 week and 3 months after thyroidectomy were analyzed for mean vocal fundamental frequency (Mean Fo, Hz), maximum fundamental frequency (Max Fo, Hz), minimum fundamental frequency (Min Fo, Hz), jitter, shimmer, glottal to noise excitation ratio (GNE), irregularity, noise, overall severity, S time, Z time, S/Z ratio, and maximum phonation time (MPT). Voice samples were analyzed using the lingWAVES software. The comparisons of preoperative and early and late postoperative acoustic parameters revealed significant differences in Mean F0, Max F0, MPT, and S Time between the early and late postoperative periods. The voice changes after thyroidectomy were not affected by age, sex, or surgical procedure, but they differed between the benign and malignant nature of the tumor. Patients with malignant tumors showed a greater decrease in Mean F0 and Max F0 compared with the patients with benign tumors, and this difference was statistically significant. Voice changes may occur after thyroidectomy even in the patients with no evidence of laryngeal nerve damage, and these changes can be assessed with objective measurement methods. This information should be explained to the patients during the preoperative counseling, and proper informed consent is ethically and legally required for all planned thyroidectomies.
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    Effects of ellagic acid on experimental acute pancreatitis in rats
    (Wiley-Blackwell, 2015) Bozdag, Zubeyir; Yilmaz, Edip Erdal; Yazgan, Umit Can; Kaplan, Ibrahim; Arikanoglu, Zulfu; Ibiloglu, Ibrahim; Atamanalp, Sabri Selcuk
    [Abstract Not Available]
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    Factors affecting mortality in patients with splenic injuries
    (Edizioni Luigi Pozzi, 2018) Uslukaya, Omer; Bozdag, Zubeyir; Gumus, Metehan; Turkoglu, Ahmet; Boyuk, Abdullah; Yilmaz, Edip Erdal; Gunduz, Ercan
    AIM: Mortality in splenic injuries can create medico-legal problems. Though many studies exist regarding splenic injuries, there are not a sufficient number investigating the factors in splenic injuries influencing mortality. In this study, we aimed to investigate the factors affecting mortality in splenic injuries. MATERIALS AND METHODS: All 237 patients with splenic injury between 2005 to 2014 were retrospectively analyzed. The patients were divided into two groups, survivors and non-survivors. Age, gender, mechanism of injury, grade of splenic injury, pulse, respiratory rate, systolic blood pressure, hemoglobin levels, number of transfusions, surgical procedure, ISS, RTS and hospitalization period were recorded. Univariate and multivariate analysis were used to compare survivors and non-survivors. RESULTS: The average age of the patients was 32 and most (82.7%) were male. Mortality was observed in 18 patients (7.6%). Mortality was found significantly lower in patients who had isolated splenic injury (p=0.048). In univariate analyses, decreased RTS (p<0.001), increased number of blood transfusion (p<0.001), decreased hemoglobin level (p=0, 025) and increased ISS (p<0.001) were found significant in non-survivors. In multivariate analysis; number of transfusions, ISS and RTS were found as independent risk factors for mortality. CONCLUSIONS: We found high number of transfusions, high ISS and low RTS as independent risk factors for mortality in patients with splenic injury.
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    A rare reason for acute abdomen: Intraperitoneal liver hydatid cyst rupture
    (Elsevier Science Inc, 2016) Bozdag, Zubeyir; Turkoglu, Ahmet; Yilmaz, Edip Erdal; Gul, Mesut
    [Abstract Not Available]
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    Therapeutic effects of ellagic acid on L-arginin induced acute pancreatitis
    (Acta Cirurgica Brasileira, 2016) Yilmaz, Edip Erdal; Bozdag, Zubeyir; Ibiloglu, Ibrahim; Arikanoglu, Zulfu; Yazgan, Umit Can; Kaplan, Ibrahim; Gumus, Metehan
    PURPOSE: To investigate the therapeutic effects of ellagic acid on L-arginin induced acute pancreatitis in rats. METHODS: Thirty-two were split into four groups. Group 1 (control) rats were performed only laparotomy, no drugs were administered. Group 2 (control+EA) rats were administered 85mg/kg EA orally. Rats were sacrificed by cardiac puncture 24 hours after the administration. Group3 (AP) 24 hours after intraperitoneal L-arginine administration, rats were sacrificed by cardiac puncture. Group 4 (EA)-(AP): 85mg/kg EA was administered orally after the L-arginine administration. 24 hours later, rats were sacrificed by cardiac puncture. Serum TNF-alpha, IL-1 beta, IL-6, total oxidative status (TOS), total antioxidant capacity (TAC), amylase levels were determined in all groups. RESULTS: Group 3 (AP) rats showed significantly raised TOS level as compared to Group1 (control) rats (p<0.001). Following the EA therapy, a decrease in TOS was observed in Group 4 (AP+EA). TAC levels were significantly raised in the Group 4 (AP+EA) compared to the Group 3 (AP) (p=0.003). Group 3 (AP) showed significantly increased TNF-alpha, IL-1 beta and IL-6 serum levels as compared to Group 4 (AP+EA). Histopathological changes were supported our result. CONCLUSION: The healing effects of ellagic acid on inflammatory and oxidative stress were confirmed by histopathological and biochemical evaluations of the pancreatic tissue.