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Öğe CHRONIC FATIGUE AND DEPRESSION EXPERIENCED BY SENIOR STUDENTS OF DICLE UNIVERSITY(Carbone Editore, 2014) Aslan, I; Tanriverdi, M. H.; Bucaktepe, Erten P. G.; Celepkolu, T.; Yilmaz, A.Aims: Chronic fatigue syndrome (CFS) is a debilitating disease that presents with a chronic fluctuating course of multi-systemic symptoms. The purpose of this study was to examine chronic fatigue syndrome and depression, experienced by senior students attending Diyarbakir Dicle University, to investigate the factors involved in the development of CFS and depression and to shed light on preventive measures that can be taken to overcome CFS, with the help of the collected data. Methods: The study was conducted in Dicle University Campus between January and April 2012 and 525 students participated in the study. The questionnaire, used for this study, included 22 questions regarding the participants' demographic features, working conditions, habits and activities and a 17-item extracted from the HAM-D scale (Hamilton Depression Rating Scale), and the CFS evaluation criterias of the CDC (Center for Disease Control and Prevention). In order to analyze the data, Student's t-test, Chi-square (Fisher's exact) test, One way Analysis of Variance (ANOVA), Pearson correlation test and logistic regression analysis were used. Results: Of all the students, 2% of them (n=11) were found to suffer from CFS. CFS was found to be more prevalent among females. Minor depressive symptoms were found to occur in 92 students (18%), and 20 students (4%) had major depressive symptoms. Gender, non-relaxing sleep, social life and person's perception of their health status were found to have a relationship with CFS. The CFS cases were found to have a higher HAM-D scale value. Conclusion: The school stress experienced by the students and their social life experiences are influential on depression and on the development of CFS. For this reason, the guidance departments and social support units of universities must be improved, in order to prevent CFS.Öğe Effect of caffeic acid phenethyl ester on oxidant and anti-oxidant status of liver and serum in a rat model with acute methanol intoxication(Springer London Ltd, 2017) Yazgan, U. C.; Elbey, B.; KuAY, S.; Baykal, B.; Keskin, I.; Yilmaz, A.; Sahin, A.Methanol toxicity is one of the major public health problems because it can cause severe morbidity and mortality. Methanol intoxication causes changes in the balance between the production of free radicals and antioxidant capacity. We aimed to investigate the effects of caffeic acid phenethyl ester (CAPE) on the total oxidant status, total antioxidant status (TAS), and oxidative stress index (OSI) parameters of the liver and the serum in a rat model of acute methanol intoxication. Rats were treated with intraperitoneal (i.p.) Methotrexate (MTX) for 7 days. On the 8th day, i.p. Methanol was administered in the methanol, ethanol and CAPE groups. Four hours after methanol treatment, ethanol was injected i.p. in the ethanol group; CAPE (i.p.) in the CAPE group; serum physiologic i.p. in other groups. After 8 hours, rats were killed and the serum and the liver samples were obtained for biochemical analyses. The OSI value was significantly higher in the methanol group compared to the ethanol and CAPE groups. Serum TAS levels of the methanol group were significantly different compared to the control group, but not compared to the MTX group. The amelioration of oxidative stress was greater in the CAPE group compared to the ethanol group but was not statistically significant. This study demonstrates that CAPE treatment ameliorates oxidative stress in the serum and liver in a rat model of acute methanol intoxication.Öğe Evaluation of ecological design strategies in traditional houses in Diyarbakir, Turkey(Elsevier Sci Ltd, 2011) Baran, M.; Yildirim, M.; Yilmaz, A.This study focuses on the ecological design between traditional Diyarbakir houses and their physical environment (topography and climate) and structural environment (building form, spatial organization, material, landscape and planting, and technical infrastructure). The basic principle was to identify the criteria that would use natural energy sources and provide the most benefit to the inhabitants. The influence of different seasons on thermal perception was investigated. The average temperature differences between the outdoor and indoor environment of the houses were 7 degrees C in winter, 6 degrees C in summer and +/-2 degrees C in spring and autumn. Consequently, this paper discusses ecological design solutions used in traditional houses and their applicability to modern buildings and recognizes that architecture should coexist and maintain harmony with nature. (C) 2010 Elsevier Ltd. All rights reserved.Öğe High-field NMR T 2 relaxation mechanism in D2O solutions of albumin(Springer, 2013) Yilmaz, A.; Zengin, B.400 MHz NMR T (2) in D2O solutions of albumin and pure D2O were measured at different temperatures. A relation, based on the chemical exchange between bound HDO and non-exchangeable protein protons, was derived theoretically for the contributions of bound HDO [P (b)(1/T (2b))]. A second relation was also derived theoretically by considering spin-rotation interactions between bound HDO and surrounding protein protons. The P (b)(1/T (2b)) values in albumin solutions were then determined by replacing experimental data into the first relation. The values of the 1/T (2) and P (b)(1/T (2b)) in albumin solutions increase linearly with temperature(T), whereas the 1/T (2) in D2O decreases with T. In addition, the spin-rotation correlation times were calculated from the second relation. The dipolar correlation time of albumin was then reproduced from the spin-rotation correlation times for confirmative purposes. In conclusion, the 1/T (2) in albumin solutions with D2O is caused by spin-rotation interactions.Öğe THE IMPACT OF PHYSICAL AND PSYCHOLOGICAL COMORBID CONDITIONS ON THE QUALITY OF LIFE OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION: A MULTI-CENTER, CROSS-SECTIONAL OBSERVATIONAL STUDY FROM TURKEY(Baywood Publ Co Inc, 2013) Sertoz, O. Onen; Aydemir, O.; Gulpek, D.; Elbi, H.; Ozenli, Y.; Yilmaz, A.; Ozan, E.Objective: Acute myocardial infarction (MI) has significant and detrimental effects on the lifestyles of the patients. It has been shown that quality of life (QoL) in patients with MI is impaired in every aspect. This study aims to evaluate the impact of depression and physical comorbidity on QoL in Turkish patients with acute first MI. Method: This multi-center cross-sectional study was carried out in 15 centers with 998 patients hospitalized for acute first MI. For detection of depression, Beck Depression Inventory (BDI) was used. For evaluation of QoL, World Health Organization Quality of Life Questionnaire (WHOQOL) was applied. Results: The mean age of the patients was 57.5 +/- 10.1 years and 79.2 % (n = 792) of the patients were men. Patients with comorbid depression (BDI >= 10) and comorbid medical conditions, and female patients had significantly lower scores in every domain of WHOQOL. In the regression analysis model, female gender, low education, comorbid medical conditions, especially comorbid hypertension, and BDI score were found to have a significant effect on the domains of WHOQOL. Conclusions: Female patients are more prone to impairment in quality of life after myocardial infarction. Both comorbid medical conditions and depression have a significant impact on the impairment of QoL in Turkish patients with acute MI. In order to improve the subjective wellbeing of post MI patients, both psychiatric and physical comorbidities must be detected and managed even in the short term.Öğe Intraocular pressure during micturition in benign prostatic hyperplasia(Verduci Publisher, 2015) Sahin, A.; Yilmaz, A.; Yildirim, A.[Abstract Not Available]Öğe NMR Proton Spin-Lattice Relaxation Mechanism in D2O Solutions of Albumin Determined at 400 MHz(Springer, 2014) Yilmaz, A.; Zengin, B.; Ulak, F. SadanT-1 values in pure D2O and D2O solutions of human serum albumin (HSA) were measured versus temperature. A formula was derived based on H-H interactions between the surface HDO and non-exchangeable protein protons. The formula was used to evaluate the average distance of the interactions (rav). The effective correlation times were then derived by replacing the experimental data in the formula. Short correlation times obtained for the solution with low HSA (0.02 g albumin for one ml of D2O) decreased from 53 to 29 ps, while longer times increased from 1.19 to 2.22 ns. They are of the order of a fraction of a nanosecond for the solution with high HSA (0.08 g albumin per one ml of D2O). The perfect consistency between the derived theory and experimental data indicates that the high-field 1/T-1 in D2O solutions of albumin is caused by dipolar interactions between the surface HDO and non-exchangeable protein protons. It also suggests that the effective correlation time of the surface HDO is of the order of the mean lifetime of short-lived surface water.Öğe Oxidative stress in rats during exposure to cigarette smoke and after smoking cessation(Wiley-Blackwell, 2016) Donder, A.; Balahoroglu, R.; Huyut, Z.; Yildirim, S.; Dulger, H.; Ilhan, F.; Yilmaz, A.[Abstract Not Available]Öğe Proton NMR Relaxation in Albumin Solution Doped with Mn(II)(Springer Wien, 2009) Yilmaz, A.; Koylu, M. Z.; Uysal, E.The aim of this study is to obtain further information about the source of proton relaxation in the Mn(II)-human serum albumin complex. For this purpose, proton relaxation rates in albumin solutions 1/T(1) and 1/T(2) were measured versus increasing amounts of manganese [Mn(t)]. The fractions of manganese bound to albumin [Mn(b)] and free manganese [Mn(f)] were then determined from proton relaxation rate enhancement data. Paramagnetic contributions of bound manganese to the observed relaxation rates (1/T(1p)*)(b) and (1/T(2p)*)(b) were also determined. Finally, the (1/T(2p)*)(b)/(1/T(1p)*)(b) ratio was used in a derived equation to estimate an effective correlation time tau. Mean tau value of the complex was found to be in the order of 3 ns, while the hydration number of bound manganese q was estimated to be about 4. The 1/tau was found to be the sum of the inverse values of rotational correlation time 1/tau(r), mean residence time of water in hydration spheres of the complex 1/tau(m), and longitudinal electronic relaxation time of manganese 1/tau(s) in the complex. In conclusion, the relaxation mechanism in albumin solutions containing Mn(II) can be interpreted through dipolar and scalar interactions modulated by tau(r), tau(m) and tau(s). This analysis enables one to get reasonable figures for the tau(r) and q of Mn(II) in albumin solution.Öğe Successful Management of Intracranial Bleeding in a Patient With Factor X Deficiency by a Prothrombin Complex Concentrates(Wiley-Blackwell, 2016) Soker, M.; Uzel, H. V.; Soker, S.; Ceviz, A.; Yilmaz, A.[Abstract Not Available]
