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    CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND PARAOXONASE-1 192 AND 55 GENE POLYMORPHISMS
    (Taylor & Francis Ltd, 2010) Tekes, S.; Isik, B.; Yildiz, T.; Simsek, S.; Isik, M. R.; Budak, T.
    Chronic obstructive pulmonary disease (COPD) is a leading cause of chronic morbidity and mortality. The oxidative stress is increased in COPD patients. Paraoxonase (PON1) in the lung may have a role to protect from oxidative stress. We have investigated a possible relationship between PON1 55 and PON1 192 gene polymorphisms in COPD patients and control subjects. A Total of 62 inpatients of COPD, 45 non-smokers and 35 smokers without COPD were included in the study The serum levels of PON1 were measured. The PON1 genotypes were determined by PCR amplification of the region containing the polymorphism followed by restriction enzyme digestion. The serum levels of PON1 were significantly low in the COPD patients group (p<0.001). There were no statistical differences between the COPD and control groups for PON1 55 polymorphism. The PON1 192 QQ and QR genotypes occurred with similar frequencies in the COPD and control groups with no significant differences while a significant difference was found between the PON1 192 RR allele frequencies (p<0.05) of all groups. PON1 192 gene polymorphism may be considered associated with COPD. PON1 polymorphisms and low PON1 activity levels might be considered as an independent risk factor for COPD.
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    COMPARISON OF INTERFERON-GAMMA RELEASE ASSAY VERSUS TUBERCULIN SKIN TEST FOR LATENT TUBERCULOSIS SCREENING IN HEMODIALYSIS PATIENTS
    (Taylor & Francis Ltd, 2009) Ates, G.; Ozekinci, T.; Yildiz, T.; Danis, R.
    Early diagnosis and proper treatment of latent tuberculosis infection (LTB1) in patients with end stage renal diseases (ESRD) is critical to reduce increased reactivation risk of LTB1. However; this condition is known to decrease responsiveness to the tubercidin skin test (TST). A new, diagnostic test [QuantiFERON-TB Gold in-tube (QFT-GIT)] has been developed using mycobacterium tuberculosis specific antigens for the identification of LTB1. We aimed to evaluate the two test methods among hemodialysis patients for their diagnostic usefulness. We performed a cross-sectional comparison study on 275 ESRD recruits tested for LTB1 using the TST and QTF-GIT. Valid TST and QFT-GIT results were available for 259 and 246 patients, respectively. Overall, 46.7% of 246 patients were tested positive for the QTF-GIT and 35.5% of 259 were found to be TST positive. The QTF-GIT but not TST results were correlated with the history of tuberculosis: conversely, QTF-GIT and TST results were not associated with contact to tuberculosis. Moreover, QTF-GIT test generated indeterminate results in 10.4% of subjects. The concurrence between the two test methods was poor (67.8%, kappa = 0.34). Inconsistent results, most of which were, tested as TST negative/QTF-GIT positive were observed in 32.2% patients. The present results suggest that the QTF-GIT is more sensitive than TST in the detection of LTB1 among renal dialysis patients. Nevertheless, large longitudinal studies are required for more accurate results.
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    THE TUMOR NECROSIS FACTOR-A-308 G/A POLYMORPHISM AND THE TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND POLYMORPHISMS, IN ASTHMATIC PATIENTS AND HEALTHY SUBJECTS
    (Taylor & Francis Ltd, 2010) Isi, H.; Oral, D.; Yildiz, T.; Ates, G.; Sinir, C.; Ay, O. I.; Turkoz, G.
    Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. Like other atopic diseases, asthma is a complex disorder caused by interactions between multiple genes of small to modest effect and equally important environmental factors. The aim of this study was to determine the TNF-alpha-308 G/A polymorphism and the TRAIL polymorphisms, and their influence on asthma in asthmatic patients and healthy subjects. The study population consists of 51 asthmatic patients (47 female and 4 male) and 72 healthy subjects (62 female and 10 male). The mean age of the asthmatic patients and healthy controls were 45.33+/-14.05, and 41.88+/-17.41 years, respectively. The asthmatic patients and healthy controls were similar with respect to their ages and sex characters. There was statistically a significant difference between the asthmatic patients and control groups in terms of TRAIL Arg141His, G422A (rs6557634) polymorphism (p=0.02). Statistically, there was not any significant difference between the asthmatic patients and control groups for TRAIL Thr209Arg, C626G (rs20575) TRAIL Glu228Ala, A683C (rs20576) and polymorphisms (p=0..57). Also, there was no significant difference between the asthmatic patients and control groups in terms of TNF-alpha-308 G/A polymorphism (p=0.90). In our study, the TRAIL Arg141His G422A (rs6557634) polymorphism was detected for the first time in asthmatic patients, which may influence the susceptibility to the asthma.