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Öğe Evaluation of Rivastigmine Therapy with Tc99m HMPAO Brain Perfusion SPECT and MMSE Scores in Alzheimer's Disease(Springer, 2005) Cerci, S. S.; Kaya, H.; Yildiz, M.; Tamam, Y.; Arslan, S.[Abstract Not Available]Öğe Relationship between endothelial dysfunction and prosthetic heart valve thrombosis: a preliminary investigation(Verduci Publisher, 2013) Kaya, H.; Ozkan, M.; Yildiz, M.AIM: The etiopathogenesis of prosthetic heart valve thrombosis (PHVT) is multifactorial. Since the relationship between PHVT and endothelial function is never studied, we aimed to analyze the role of endothelial function in patients with PHVT. PATIENTS AND METHODS: Twenty-two patients with PHVT (14 female, 31.8% with atrial fibrillation, mean age 46.0 +/- 12.2) and 22 controls with prosthetic heart valves (17 female, 36.4% with atrial fibrillation, mean age 45.7 +/- 11.5) were prospectively evaluated. Two groups had similar demographic and echocardiographic characteristics. Endothelial function was evaluated in all patients by the non-invasive measurement of flow mediated dilatation (FMD) of brachial artery. High-resolution ultrasound was used to measure brachial artery diameter at rest, during reactive hyperemia (endothelium-dependent, FMD), and following sublingual administration of nitroglycerin (endothelium-independent, nitroglycerin-mediated vasodilatation, NMD). RESULTS: Functional capacity at presentation determined as mean NYHA functional capacity class was worse in patients with PHVT than in control group (2.1 +/- 0.6 vs. 1.3 +/- 0.6; p < 0.0001). FMD was significantly reduced in patients with PHVT compared with control group (4.01 +/- 1.52 vs. 8.48 +/- 3.37; p < 0.0001). NMD did not differ between two groups (11.77 +/- 2.30 vs. 13.38 +/- 3.50; p = 0.08). FMD level of < 5.65 predicted prosthetic valve thrombosis with an 82% sensitivity and 77% specificity (area under the curve = 0.888, p < 0.0001). CONCLUSIONS: This study demonstrated the endothelial dysfunction in patients with PHVT compared with well-matched control group. In this study, we found that patients with PHVT have endothelial dysfunction which might contribute to the development of thrombosis.Öğe Sexual dysfunction in male patients with Behget's disease(Publisaude-Edicoes Medicas Lda, 2016) Yildiz, M.; Batmaz, I; Sula, B.; Ucmak, D.; Sariyildiz, M. A.; Daggulli, M.; Turkcu, F.Introduction: The purpose of this study was to evaluate sexual dysfunction in male patients with Behget's Disease in comparison to healthy control subjects. Material and Methods: Seventy-two sexually active male patients with Behcet's Disease and 62 healthy control subjects were included in this study. Patients' demographic and clinical characteristics were noted. Sexual function was assessed by means of the International Index of Erectile Function scoring system. In addition, disease-related quality of life was measured by means of the Nottingham Health Profile, and anxiety and depression levels were assessed by means of the Hospital Anxiety and Depression Scale. Results: Patients with Behget's Disease scored significantly lower in each of the 5 parameters of International Index of Erectile Function (p < 0.001) and significantly higher in Hospital Anxiety and Depression Scale compared to healthy control subjects (p < 0.001). International Index of Erectile Function scores correlated with age, duration of disease and Hospital Anxiety and Depression Scale and Nottingham Health Profile scores in patients with Behcet's Disease (p < 0.05). Conclusion: Sexual function is impaired in male patients. With Behcet's Disease, which might be associated by age, duration of disease, psychological status and quality of life.Öğe Ultrasonographic Measurement of the Femoral Cartilage Thickness in Patients with Behcet's Disease(Univ West Indies Faculty Medical Sciences, 2014) Batmaz, I.; Kara, M.; Tiftik, T.; Yildiz, M.; Cevik, R.; Ozcakar, L.Objective: To evaluate femoral cartilage thickness in patients with Behcet's disease (BD) by using ultrasonography. Methods: Thirty-one patients with BD (18 M, 13 F; mean age: 32.87 +/- 8.5 years) and 31 age-, gender- and body mass index-matched healthy subjects were enrolled. Demographic features and medications of the patients were recorded. The femoral cartilage thicknesses of both knees were measured with a 7-12 MHz linear probe while subjects' knees were held in maximum flexion. Three mid-point measurements were taken from both knees: lateral femoral condyle (LFC), intercondylar area (ICA) and medial femoral condyle (MFC). Results: Cartilage measurements of BD patients were significantly thinner at the ICA (p = 0.009) and LFC (p = 0.007) on the left knee, and at the MFC on both sides (both p < 0.05). Left knee cartilage thickness value at MFC (p = 0.005) was decreased in BD patients with arthritis compared to the healthy control group. Conclusion: These preliminary findings of decreased femoral cartilage thickness in BD patients with arthritis should be complemented with future studies. However, the possibility of early knee joint degeneration and eventual osteoarthritis in BD should also be kept in mind.
