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Öğe DETERMINATION OF VOLUME OVERLOAD BY BIOELECTRICAL IMPEDANCE ANALYSIS AND NT-PROBNP IN DIABETIC PRE-DIALYSIS PATIENTS(Editura Acad Romane, 2016) Yildirim, Y.; Kara, A. V.; Kilinc, F.; Aydin, F.; Aydin, E.; Yilmaz, Z.; Kadiroglu, A. K.Introduction. Diabetic chronic kidney disease has more fatal clinical progresses and this situation can be related to volume overload, which is seen more commonly in diabetic chronic kidney disease patients than in non-diabetic chronic kidney disease patients. Therefore, we examined the effect of diabetes mellitus on volume overload in newly diagnosed stage 5 chronic kidney disease patients whose volume overloads were not showing signs of improvement from renal replacement therapy. Method. One hundred and five patients (46 diabetic, 59 non-diabetic) with end-stage chronic kidney disease, who had glomerular filtration rate (GFR) under 15 mL/min for at least three months were enrolled in this prospective study. We determined the body volume overload and configuration using a bioimpedance device. NT-proBNP levels were recorded. Results. There was a statistically significant difference between diabetic and non-diabetic groups according to overhydration (OH, p=0.003), extracellular water (ECW, p=0.045), intracellular water (ICW, p<0.001) and OH/ECW (p=0.003). In addition, there was a statistically significant difference between groups in terms of N-terminal Pro-brain Natriuretic Peptide (NT-proBNP levels, p=0.008). Discussion. We compared diabetic and non diabetic end-stage chronic kidney disease patients who were not in renal replacement therapy yet. We found more volume overload and extracellular fluid volume in the diabetic group.Öğe Effects of entecavir, tenofovir and telbivudine treatment on renal functions in chronic hepatitis B patients(Univ Catholique Louvain-Ucl, 2019) Kara, A., V; Yildirim, Y.; Ozcicek, F.; Aldemir, M. N.; Arslan, Y.; Bayan, K.; Celen, M. K.Background and study aims : The aim of this study was to enlighten the controversy about the renal safety of entecavir, tenofovir, and telbivudine treatments in chronic hepatitis B (CHB) patients by comparing these treatments in real-world conditions. Patients and methods: We retrospectively enrolled 104 treatment-naive patients with CHB monoinfection into our study. Patients were treated with entecavir monotherapy (n=38), tenuflivir monotherapy (n=35), or telbivudine monotherapy (n=31). We then compared and statistically analyzed the effects of these drugs on the estimated glomerular filtration rate (eGFR) over a 24-month follow-up period. Results : In the entecavir group, time-dependent change in eGFR was not statistically significant (p = 0.357). There was a statistically significant increase in eGFR in the telbivudine group at 12 months (p < 0.001) and at 24 months (p < 0.001) and, in contrast, a statistically significant decrease in the tenofovir group at 12 months (p < 0.001) and at 24 months (p < 0.001). There was no significant relationship between entecavir and eGFR change (p = 0.763). We found that tenofovir and telbivudine were independent predictors of eGFR change (decrease in eGFR, p < 0.001 and increase in eGFR, p = 0.001, respectively) Conclusions : We recommend close follow-up of renal functions, especially for patients treated with tenofovir. Telbivudine was superior to the other drugs in terms of renal function. We conclude that an individualized therapy program considering treatment efficacy and side effects is the best option for patients.Öğe FATTY ACID, MINERAL AND PROXIMATE COMPOSITIONS OF VARIOUS GENOTYPES AND COMMERCIAL CULTIVARS OF SWEET ALMOND FROM THE SAME ECOLOGICAL CONDITIONS(Corvinus Univ Budapest, 2018) Simsek, M.; Gulsoy, E.; Yavic, A.; Arikan, B.; Yildirim, Y.; Olmez, N.; Erdogmus, B.This study was carried out on the fatty acid, mineral and proximate compositions of ten sweet almond genotypes and two commercial varieties named as Ferragnes and Ferraduel grown in the same ecological conditions known as the Firat riverside region during two consecutive years. In this context, the crude oil (Co), crude protein (Cp), total sugar (Ts), total ash (Ta) and moisture (Mo) contents from the almond genotypes and cultivars ranged from 48.69 to 55.8%, 20.41 to 25.82%, 2.92 to 5.27%, 3.29 to 4.66% and 2.52 to 3.75%, respectively. The genotypes and cultivars showed a varied mineral content as well. Potassium (K) was the main mineral in all genotypes and cultivars, ranging from 679.53 to 986.63 mg100 g(-1) ; phosphorus (P) was the second most abundant mineral, ranging from 584.57 to 697.31 mg100 g(-1) ; followed by magnesium (Mg) and calcium (Ca), ranging from 325.27 to 381.93 mg100 g(-1) , 250.15 to 332.19 mg100 g(-1) , respectively. Of the identified fatty acids, oleic acid (Oa) (69.76-72.02%) was the predominant fatty acid, followed by linoleic acid (La) (18.82-21.62%), palmitic acid (Pa) (5.627.76%), and stearic acid (Sa) (1.20-1.69%). Other fatty acids were present at trace amounts. The unsaturated (Ufa)/saturated fatty acid (Sfa) ratios ranged from 9.29 to 12.12. From the results of the present study, we can conclude that the kernels of almond genotypes and cultivars are being potential sources of valuable oil which might be used for edible and other industrial purposes.Öğe An Investigation of the Effects of the Mean Platelet Volume, Platelet Distribution Width, Platelet/Lymphocyte Ratio, and Platelet Counts on Mortality in Patents with Sepsis who applied to the Emergency Department(Medknow Publications & Media Pvt Ltd, 2018) Orak, M.; Karakoc, Y.; Ustundag, M.; Yildirim, Y.; Celen, M. K.; Guloglu, C.Aim: The aim of this study is to examine the role of the mean platelet volume (MPV), platelet distribution width (PDW), platelet/lymphocyte ratio (PLR), and platelet values for predicting mortality in patients with sepsis. Materials and Methods: This is a retrospective study, involving patients 18 years and above who were diagnosed with sepsis. Blood samples were analyzed for platelets characteristics (counts, MPV, PDW, and PLR). The patients were separated into two groups namely the survivors and deceased. The two groups' MPV, PDW, PLR, and platelet counts which were considered to have an effect on mortality, were compared. Results: Three hundred and thirty patients who were diagnosed with sepsis in our emergency department and complying with the study participation criteria were studied retrospectively. Comparison of the MPV, PDW, PLR, and platelet counts of the deceased and survivors showed that the MPV, PDW, and PLR were higher in the deceased while the platelet counts were higher in the survivors. Conclusion: The low number of platelets in patients with sepsis at the moment of application and the high PDW and PLR values are valuable for predicting a high mortality.Öğe Recessive Complex Brachydactyly, Symphalangism, Zygodactyly and Male Infertility - not a Novel Syndrome but Caused by Linked Mutations in BMPR1B and PDHA2, a New Male Infertility Gene(Nature Publishing Group, 2018) Yildirim, Y.; Ouriachi, T.; Woehlbier, U.; Ouahioune, W.; Balkan, M.; Malik, S.; Tolun, A.[Abstract Not Available]
