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    Aggressive periodontitis associated with Kindler syndrome in a large Kindler syndrome pedigree
    (Turkish J Pediatrics, 2017) Yildirim, Tuba Talo; Kaya, Filiz Acun; Taskesen, Mustafa; Dundar, Serkan; Bozoglan, Alihan; Tekin, Gulucag Giray; Akdeniz, Sedat
    Kindler syndrome (KS) is a rare genetic disorder. The clinical features include aggressive periodontal disease and severe desquamative gingivitis. Five individuals with KS were assessed by oral examination, radiographic analysis and periodontal measurements. All the patients' indexes were recorded prior to periodontal treatment and at the end of the 1th, 3th, 6th, 9th and 12th month respectively. All the patients had improvement of periodontal status and enhancement in index scores. The affected individuals were previously screened for FERMT1 mutations. KS patients' periodontal disease activity could be taken under control with regular follow-up.
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    Associations of alveolar bone loss and interleukin-1 levels in one- and two-stage surgical procedures: a randomized prospective trial
    (Taylor & Francis Ltd, 2017) Yildirim, Tuba Talo; Kaya, Filiz Acun; Yokus, Beran; Colak, Mehmet; Kaya, Eylem Ozdemir; Tekin, Giray; Saribas, Ebru
    Objective: Dental implants have been widely and successfully used in recent years as an alternative treatment for removable and fixed dental prostheses. The aim of this randomized prospective study was to determine the alveolar bone loss rate (ABLR) and IL-1 levels in one- and two-stage surgical procedures.Materials and methods: This study included 40 patients with a single missing tooth in the posterior mandible; dental implants were inserted using a one-stage surgical procedure (Group I) or a two-stage surgical procedure (Group II). All clinical periodontal parameters were recorded; peri-implant crevicular fluid (PICF) samples were collected before loading (T0) and during the third (T1) and sixth (T2) months after loading. ABLR values were evaluated at T0 and T2 by using dental tomography. PICF was analysed after T2 samples were collected. The study was registered through clinicaltrials.gov; identifier NCT03045458.Results: This study found that, the probing pocket depth was found to be significantly higher in Group I than Group II at both T1 and T2 (p<.05). There was no significant difference in other clinical parameters between the groups (p>.05). There was a significant difference between Group I ABLR values at T0 and T2 (p<.05). The PICF IL-1 levels were not significantly different between groups (p>.05).Conclusions: Within the limitations of the short observational period and small sample size of this study, two-stage implant placement shows comparable clinical outcomes to implants placed using a one-stage placement protocol.
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    The effect of demographic and disease variables on Schneiderian membrane thickness and appearance
    (Elsevier Science Inc, 2017) Yildirim, Tuba Talo; Guncu, Guliz Nigar; Goksuluk, Dincer; Tozum, Melek Didem; Colak, Mehmet; Tozum, Tolga Fikret
    Objectives. The purpose of this study was to evaluate the prevalence of sinus mucosal thickening (MT) and mucosal appearance (MA) in a patient population as detected with cone beam computed tomography (CBCT) and to determine the effects of various disease and demographic factors on MT and MA. Study Design. The retrospective study consisted of CBCT images of 1000 maxillary arches in 500 patients. The arches were divided into 3 groups (atrophic, partially atrophic, and nonatrophic) according to the type of the maxillary dental crest. The CBCT scans were assessed to detect the prevalence of maxillary sinus MT and MA. chi(2) analysis was used to determine the significance of association of periodontal bone loss (PBL), periapical (PA) status, alveolar crest type, age, and gender on sinus MT and MA. Results. MT was significantly associated with PBL (P = .004), PA status (P = .001), and gender (P < .01). MA was significantly associated with PBL (P = .038), PA status (P = .009), and gender (P < .020). There were no significant associations between age or crest type and either MT or MA. Conclusions. Periodontal bone loss, PA lesions, and gender may have an association with MT of the maxillary sinus.
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    Effects of Local and Systemic Zoledronic Acid Application on Titanium Implant Osseointegration: An Experimental Study Conducted on Two Surface Types
    (Lippincott Williams & Wilkins, 2017) Dundar, Serkan; Yaman, Ferhan; Gecor, Orhan; Cakmak, Omer; Kirtay, Mustafa; Yildirim, Tuba Talo; Karaman, Tahir
    The aim of this study was to evaluate the effects of local and systemic zoledronic acid (ZA) applications on titaniumoksit ceramic blasted (TiO-CB)- and sandblasted large acid-grit (SLA)-surfaced titanium implant osseointegration. Twelve New Zealand White rabbits were used in the study, divided into 6 groups: the TiO-CB (TiO-CB-CNT) (n = 2) and SLA (SLA-CNT) (n = 2) control groups in which TiO-CB- and SLA-surfaced titanium implants were surgically inserted into rabbit tibias but no treatment was applied; the TiO-CB (TiO-CB-LZA) (n = 2) and SLA (SLA-LZA) (n = 2) local ZA groups in which 1 mL of normal saline solution containing 2 mg of ZA was injected into sockets and after this the implants were integrated; and the TiO-CB (TiO-CB-SZA) (n = 2) and SLA (SLA-SZA) (n = 2) systemic ZA groups in which a single infusion of 0.1 mg/kg of ZA was administered during surgical implant insertion. Following a period of osseointegration, bone implant contact (BIC) was recorded as a proportion of the total implant surface length in direct contact with the bone. Results of this study indicate that BIC was greater in the systemic ZA application groups than in the local ZA application groups, and BIC was greater in the local ZA groups than in the controls. Statistically significant differences in BIC were not detected between the TiO-CB- and SLA-surfaced implants in all the groups. Furthermore, this study did not reveal significant differences between the 2 types of surfaces due to similar average roughness values. Overall, systemic ZA application was found to be more effective in increasing BIC than local ZA application based on the results obtained by testing 2 implant surfaces.
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    The effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitis
    (Istanbul Univ Press, Istanbul Univ Rectorate, 2019) Yildirim, Tuba Talo; Ozan, Gonca; Dundar, Serkan; Bozoglan, Alihan; Karaman, Tahir; Dildes, Neval; Kaya, Can Ayhan
    Purpose The aim of this study is to evalute the anti-inflammatory effects of morus migra on experimentally-induced periodontitis in rats. Materials and Methods Twenty-four Wistar-albino rats were randomly divided into three groups: control group (C, n=8), experimental periodontitis (PER, n=8), experimental periodontitis and treated with Morus nigra (MN+PER, n=8) (50 mg/kg per day for 21 days). After 21 days, the rats were sacrificed, and alveolar bones were evaluated histopathologically and histometrically analyzed to obtain level of alveolar bone loss. The detection of RANKL and OPG were immunohistochemically performed. Serum and tissue levels of MMP-8 and MMP-13 were also analyzed. Results Morus nigra treatment decreased tissue MMP-8 and MMP-13 levels and there were significant differences in the case of tissue levels of MMP-8 and MMP-13 between groups PER and MN+PER (p=0.035, p=0.041). There were no significant differences among all the groups serum levels of MMP-8 and MMP-13 (p=0.067, p=0.082). In the histometric evaluation, alveolar bone loss was greater in the PER group compared to C and MN groups (p=0.035). Immuno-histochemical staining of RANKL activities were found significantly lower (p=0.037) and OPG activities were found significantly higher in MN+PER group when compared to PER group (p=0.021). Conclusion The present study reveals that systemic administration of Morus nigra significantly inhibited the regional alveolar bone resorption and contributes to periodontal healing in the rat experimental-periodontitis models.
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    Evaluation of the behavior and health anxiety levels the patients applying to the periodontology clinic during the COVID-19 pandemic
    (Kerman Univ Medical Sciences, 2023) Altindal, Dicle; Kaya, Filiz Acun; Yildirim, Tuba Talo; Uysal, Ersin; Duger, Nurullah
    Objective: The aim of this study was to evaluate the anxiety levels of orthodontic patients during the 1-year period in the ongoing pandemic. Methods: The study included patients between the ages of 12 and 30 years and who were continuing their fixed orthodontic treatment at Ad & imath;yaman University, Faculty of Dentistry, Department of Orthodontics and filled out the State-Trait Anxiety Inventory. A total of 266 patients filled out the questionnaire at their first clinical visit between June 8 and July 8, 2020 (T0) and 176 of 190 patients (response rate: 92.63%) that were still under treatment filled out the questionnaire for a second time between June 15 and July 16, 2021 (T1). Results: In the total population, there was a significant decrease in the State-Trait Anxiety Inventory-S score (P < .05), while there was no significant change in the State-Trait Anxiety Inventory-T score (P > .05). Anxiety scores were significantly higher in women and individuals aged over 18 years at T0 (P < .05), whereas only the anxiety scores of individuals aged over 18 years were significantly higher in T1 than in individuals aged below 18 years (P < .05). The State-Trait Anxiety Inventory-S score showed a significant decrease at T1 compared to T0 for female patients (36.02 +/- 11.32 vs. 38.82 +/- 9.84) and patients aged under 18 years (34.26 +/- 9.54 vs. 36.85 +/- 9.26) (P < .05). Conclusion: The state anxiety levels of orthodontic patients decreased during the 1-year period of the pandemic, while there was no significant change in their trait anxiety levels.