Yazar "Yildirim, I. H." seçeneğine göre listele

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    Effects of lamb sex, parity, and birth type on milk yield, lactation length, and milk components in Zom ewes raised under semi-intensive conditions
    (South African Journal Of Animal Sciences, 2023) Bayril, T.; Akdemir, F.; Baran, M. S.; Orhan, C.; Yildirim, I. H.; Yildiz, A. S.; Celik, R.
    This study aimed to determine the effects of parity, birth type, and lamb sex on milk yield, lactation length, milking period, and milk components in Zom ewes. In this study, which included 83 Zom ewes, it was observed that birth type affected daily and lactation milk yield, and only parity affected lactation length. The effects of the milking period on milk yield and birth type on milk fat content were marked. The effect of lamb sex on protein, solid non-fat, and lactose contents was substantial, but that of parity and birth type were not statistically significant. There was a negative correlation between lamb sex and solid non-fat, protein, lactose, and density and between fat, protein, and lactose. There was a positive correlation between the fat and solid non-fat content, freezing point, and mineral content. In conclusion, the effect of milking period was statistically significant for milk yield and components. Additionally, the effects of lamb sex on solid non-fat, protein, and lactose contents were found to be substantial.
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    Is GDF5 gene promoter polymorphism+104T/C associated with osteoarthritis in the Eastern of Turkey population?
    (C M B Assoc, 2017) Tuluce, Y.; Yildirim, I. H.; Ozkol, H.; EdiZ, L.; Delen, V.
    Osteoarthritis (OA) is the most common form of arthritis. Genetic factors have been shown to play important roles in the etiology of OA. The gene growth differentiation factor 5 (GDF5) has been implicated in skeletal development and joint morphogenesis in human and mice. A functional single nucleotide polymorphism (SNP) +104T/C in the 5'-UTR of GDF5 (rs143383) was reported to be associated with osteoarthritis susceptibility in Han Chinese and Japanese populations. Our objective was to assess whether this SNP was also associated with OA in the Eastern Turkey population. A total of 172 cases including 95 patients with idiopathic OA and 77 control cases were recruited into the study. DNA samples were extracted from peripheral blood lymphocytes of all cases by using salting out method. The +104T/C polymorphism was genotyped by PCR-RFLP method. In terms of genotype comparison there wasn't any correlation between patient and control groups. Frequency of C allele was found to be higher in-patient group than control group and statistical analysis showed a poor correlation in allele frequencies of the +104T/C SNP of GDF5 gene between cases and controls (p< 0.05). Significant correlation between GDF5 and OA has been reported in Asian population, especially T alleles were found in higher frequencies and related to OA. Our study did not confirm this association and also in term of T allele. Interestingly, we found higher frequency of C allele in patient group than control group and our results are compatible with the study carried out in Greek population.
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    Isolation and determination of antimicrobial resistance of Arcobacter species isolated from animal faeces in the Diyarbakir region of Turkey using the 16S rDNA-RFLP method
    (Czech Academy Agricultural Sciences, 2017) Yesilmen, S.; Vural, A.; Erkan, M. E.; Yildirim, I. H.
    In this study, the presence of Arcobacter spp. was investigated in the faeces of cattle, sheep, goats, dogs and cloacal swab samples of chickens using the 16S rDNA-RFLP method. The prevalence of Arcobacter in these species was found to be 13%, 12%, 16%, 4% and 33%, respectively. On the other hand, Arcobacter spp. could not be isolated from rabbit faeces. A total of 78 (13%) Arcobacter spp. isolates were obtained from the 500 faecal samples and 100 cloacal swab samples examined in this study. From these 78 Arcobacter isolates, 24 (30.8%), 20 (25.6%), 11 (14.1%), 8 (10.7%), 4 (5.1%), 3 (3.9%) and 2 (2.6%) were identified by 16S rDNA-RLFP as A. cryaerophilus, A. butz-leri, A. skirrowii, A. cloacae, A. cibarius, A. halophilus, and A. nitrofigilis, respectively. All A. cryaerophilus (n = 24) isolates were found to be resistant to cloxacillin; all A. butzleri (n = 20) and A. skirrowii isolates were found to be resistant to penicillin/novobiocin, cefoperazone, tetracycline and cloxacillin. It was determined in this study that clinically healthy cattle, sheep, goats, dogs and chickens are reservoirs of Arcobacter spp.
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    The prevalence of Familial Mediterranean Fever common gene mutations in patients with simple febrile seizures
    (Verduci Publisher, 2014) Ozen, F.; Kocak, N.; Kelekci, S.; Yildirim, I. H.; Hacimuto, G.; Ozdemir, O.
    BACKGROUND: Febrile seizures (FS) represent the most common form of childhood seizures that occurs in 2-5 % of the children younger than 6 years. There have been many recent reports on the molecular genetic and pathogenesis of FC. It has been recognized that there is significant genetic component for susceptibility of FC with different reported mutation. FEB1, FEB2, FEB4, SCNA1, SCNA2, GABRG2 and IL-1 beta are related to with febrile convulsions (FCs). Interleukin 1 beta (IL-1 beta) is a cytokine that contributes to febrile inflammatory responses. There are conflicting results on increasing this cytokine in serum during FC. AIM: The determine the association between mutations of MEFV gene product pyrine and febrile seizures. PATIENTS AND METHODS: The study was carried out on 104 children that were diagnosed as FS and 96 healthy children. MEFV gene mutations were detected and analyzed with Pyro-Mark Q24. PCR was performed using the Pyro-Mark PCR Kit and pyrosequencing reaction was conducted on instrument instructions. RESULTS: M694V is the most common mutation in our patient group and we found a significant association between MEFV gene mutations and FSs. Of 104 patients, 68 were heterozygotes for any mutation and 10 patients were compound. 17.7% of control group were heterozygotes for any studied mutation. Statistical analyses showed that there was strongly significant statistical difference between results obtained from FS and control group (X = 46.20, p < 0.0001). CONCLUSIONS: MEFV gene mutations, especially M694V mutation, are positively associated with FSs.