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    Correlation of mean platelet volume, neutrophil-to-lymphocyte ratio, and disease activity in children with juvenile ıdiopathic arthritis
    (E-Century Publishing Corporation, 2015) Güneş A.; Ece A.; Şen V.; Uluca Ü.; Aktar F.; Tan İ.; Yel S.
    Juvenile idiopathic arthritis (JIA) is a chronic inflammatory arthritis characterized by periods of remission and relapse. Mean platelet volume (MPV) is an indicator of systemic inflammation. In the present study, we aimed to determine the association between mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR), platelet distribution width (PDW) and clinical measures of diseases activity in children with JIA. The study included 115 patients with JIA (64 with active disease and 51 with inactive disease) and 64 age-gender matched healthy control subjects. Routine laboratory methods were used to measure white blood cell count (WBC), platelet count (PLT), neutrophil count, lymphocyte count, hemoglobin (Hb), MPV, PDW, NLR, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) in all subjects of both the patient and control groups. Active disease was associated with significantly increased MPV (8.23 ± 1.16 fl) compared with inactive disease (7.00 ± 1. 08 fl) and control subjects (6.77 ± 1.08 fl) P<0.001, P<0.001, P=NS, respectively). NLR was significantly higher in patients with active (2.11 ± 1.19) and inactive (2.03 ± 1.51) disease relative to the control subjects (1.33 ± 0.66) (P<0.001, P=0.017, respectively). Mean PDW was significantly higher in patients with active disease (17.84 ± 1.06) compared with the control group (17.19 ± 0.93) (P=0.01). Our results suggest that MPV may be a useful marker of disease activity in patients with JIA. Regular treatment may decrease platelet activation in JIA patients. However, NLR was not a predictive marker of disease activity in patients with JIA. © 2015, E-Century Publishing Corporation. All rights reserved.
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    Evaluation of patients hospitalized in pediatric intensive care unit
    (Duzce University Medical School, 2011) Tutanç M.; Arica V.; Başarslan F.; Karcioğlu M.; Yel S.; Kaplan M.; Arica S.
    Objective: The patients hospitalized in Pediatric Intensive Care Unit (PICU) were evaluated for the diagnosis, gender, length of stay, months at which they were hospitalized and discharged. Method: In this study, 698 patients hospitalized and followed-up in the Pediatric Intensive Care Unit of Pediatric Health and Diseases of Dicle University Faculty of Medicine between dates of November 2002 - February 2005 were evaluated. Results: 95 (13.6%) of patients were hospitalized with the diagnosis of pulmonary infection, 84 of those (%12) with sepsis, 70 (10%) with poisoning, 49 (7%) with infection of central nerve system, 44 (6.3%) with status epilepticus, 28 (4%) with hepatic coma, 27 (3.9%) with snakebite, 24 (3.4%) with scorpion bite, 18 (2.6%) with trauma, 17 (2.4%) with intracranial bleeding, 15 (2.1%) with meningococcemia, 12 (1.7%) with drowning, 8 (1.14%) with electric shock, and 7 of patients (1%) with malignancy. While most frequent hospitalization was recorded in January (10.7%) and June (10.4%), the least frequent hospitalization was observed in October (5.7%). Number of female patients was 300 (42.8%), whereas number of male patients was 398 (57.2%). Mean length of stay was 5.3±6.1 days. 363 (51.8%) of patients were transferred to other services after their general condition had been stabilized, 86 (12.3%) of patients were discharged from the intensive care unit, 8 (1.14%) of patients were referred to an advanced center, and 238 (34.4%) of patients died. Conclusion: In this study, it is intended to highlight the fact that the pulmonary infection and thus the respiratory support are the most frequently recorded conditions in the intensive care unit and that preventable diseases such as poisoning in childhood, trauma, drowning, and electric shock take an important place in hospitalization. © 2011 Düzce Medical Journal.
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    The prevalence of malnutrition and obesity in schoolchildren in the Southeast Anatolia Region of Turkey
    (2010) Kara I.H.; Dikici, Bünyamin; Yel S.; Özdemir Ö.
    Objective: The aim of this study was to determine the frequency of malnutrition, obesity and overweight, calculated by body mass index (BMI), in elementary school children in the Southeast Anatolia Region of Turkey. Method: This research is a cross-sectional epidemiological study and elementary school children with aged 7-16 years were included randomly by layered random sampling method. A total of selected 20 schools and 1912 students filled the questionnaires in Diyarbakir and Mardin City Centers. A questionnaire included questions related to the educational and professional status of parents, siblings, household conditions, children's demographic characteristics and body mass indexes, body weight and heights was applied to each student. Determined BMIs were classified according to the percentile values of Center for Disease Control and Prevention (CDC-US) growth charts and International Obesity Task Force (IOTF). Results: Mean age of 1040 boys (52,3%) and 872 girls (47,7%), totally 1912 students was 10,8±2,4 years and mean BMI was 17,6±2,8 kg/m2. According to CDC classification, 7,2% of male students were categorized as "underweight", 12,3% of them as "overweight", and 3,4% of them as "obese" whereas 5,5% of them were categorized as "overweight" and 0,6% of them as "obese" according to IOTF classification. In female students, 8,4% were categorized as "underweight", 11,1% "overweight", and 3,3% as "obese" according to CDC classification whereas 5,2% were categorized as "overweight" and 1,2% "obese" according to IOTF. The prevalences were not between boys and girls (p>0.05). Conclusion: In school children in the Southeast Anatolia Region, one of the most important health problems was malnutrition; however prevalances of overweight and obesity had also nonignorable levels. © 2010 Düzce Medical Journal.
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    The Role of FLT3-ITD and CCAAT-Enhancer-Binding Protein ? Mutations on Prognosis of Acute Lymphoblastic Leukaemia in Turkish Patients
    (University of the West Indies, 2022) Uluca U.; Söker M.; Ayyıldız M.O.; Yurt M.; Şen V.; Yel S.; Güneş A.
    Background: Acute lymphoblastic leukaemia (ALL) is the most common malignancy in childhood. Although some prognostic factors have been defined to date, the estimation of prognosis is currently not perfect. Previous studies had shown an association of FLT3 with poor prognosis and CCAAT-enhancer-binding protein ? (CEBPA) mutation with the development of acute myeloid leukaemia (AML). Here, we aimed to evaluate the prognostic value of FLT3-ITD and CEBPA mutations in ALL. Methods: Sixty-one patients with ALL were included in the study. The patients were divided into three risk groups according to BFM risk classification. All of the patients were examined for FLT3-ITD mutations and 45 of them for CEBPA mutations. Mutation positive and negative patients were compared in terms of their risk groups, translocations and cell lineage. The clinical courses of the patients were appraised. Results: FLT3-ITD mutation was detected in 3 of the 61 patients, and CEBPA mutations were detected in 11 of the 45 patients. The incidence of established prognostic indicators including BFM risk classification, t(9; 22); BCR-ABL, t(1; 19); E2A-PBX1, t(12; 21); TEL-AML1, t(4; 11); MLL-AF4 were similar between FLT3-ITD and CEBPA positive and negative patients. A patient with an FLT3-ITD mutation was very susceptible to pancytopenia after maintenance treatment and two other patients with FLT3-ITD mutations were more prone to febrile neutropenia. Conclusion: Our results suggested that CEBPA or FLT3-ITD mutations might not be related to ALL prognosis in the sampled Turkish patients. However, FLT3-ITD mutation might have an influence on the response of bone marrow to chemotherapy. © West Indian Medical Journal 2022. This is an article published in open access under a Creative Commons Attribution International licence (CC BY). For more information, please visit https://creativecommons.org/licenses/by/4.0/deed.en_US
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    Smoking initiation in primary school students in Southeast of Turkey: The roles of sociodemographic factors, gender and parental characteristics
    (2010) Kara I.H.; Dikici, Bünyamin; Yel S.
    Aim: The objective of this survey was to determine the socio-demographic and the parental features and the extent of active and passive smoking among primary school children in Diyarbakir Province in Southeast Anatolian Region of Turkey. Material and Methods: This survey is an epidemiological study with cross-sectional design. According to the layered random sampling method, 15 schools were visited and taking into account the age and gender distribution a total number of 1124 students filled the questionnaire. The survey included questions about the parental and the socio-demographic features, the social and economic status of the family, number of brothers and sisters, the housing and living conditions, as well as the smoking status of students. Results: 1124 students, consisting of 630 boys (%56.0) and 494 girls (%44.0) had an average age of 11.1±2.4 yr. A total of 771 (68.6%) students told that there were smoking family members living in their houses (p<0.0001). The number of students with smoking habit was 136 (92 male, 44 female) (%12.2). The number of family members and sleeping rooms were 7.5±2.8, 4.5±2.1 and 2.1±0.9, respectively. The reason behind smoking addiction was generally related with either peers (45 person, 52.3%) or relatives (10 person, %11.6). The rate of smokers among boys is 1.38 times (OR: 1.38, %95 CI: 1.070-1.778) greater than that of girls. Conclusions: The survey results show that smoking among primary school students is becoming prevalent, the rate of passive smoking is increasing, and the number of family members living in the house is generally beyond the shelter capacity. Especially most of the mothers are found to be uneducated. Therefore, more effort should be directed to address the problems of smoking and lack of education which have the utmost importance among these related negative factors. © 2010 Düzce Medical Journal.