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    EFFECTS OF DIFFERENT DOSES OF DEXAMETHASONE PLUS FLUNIXIN MEGLUMINE ON SURVIVAL RATE IN LETHAL ENDOTOXEMIA
    (De Gruyter Poland Sp Zoo, 2009) Er, A.; Uney, K.; Altan, F.; Cetin, G.; Yazar, E.; Elmas, M.
    Effects of different doses of dexamethasone plus flunixin meglumine on survival rate were investigated in lethal endotoxemia. A total of 60 Balb/C female mice were divided into 4 equal groups. Lethal endotoxemia (80-100%) was induced by lipopolysaccharide injection (Group 1, 1 mg, intraperinoneally). At 4 hours after the lipopolysaccharide injection; low-dose dexamethasone (0.6 mg/kg, SID, 5 days, intramuscularly) + flunixin meglumine (2 mg/kg, SID, 5 days, subcutaneously), normal-dose dexamethasone (2 mg/kg, SID, 5 days, intramuscularly) + flunixin meglumine (2 mg/kg, SID, 5 days, subcutaneously) and high-dose dexamethasone (10 mg/kg, SID, 5 days, intramuscularly) + flunixin meglumine (2 mg/kg, SID, 5 days, subcutaneously) were injected to Group 2, 3 and 4, respectively. After the injections, survival was monitored at 7 days and 13.3%, 13.3%, 33.3% and 73.3% survival rates were observed in Groups 1, 2, 3 and 4, respectively. As results, high-dose dexamethasone plus flunixin meglumine may be the treatment of choice for endotoxaemia in animals.
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    Effects of Tarantula cubensis alcoholic extract and Nerium oleander distillate on experimentally induced colon cancer
    (Ecole Nationale Veterinaire Toulouse, 2019) Er, A.; Ozdemir, O.; Coskun, D.; Dik, B.; Bahcivan, E.; Faki, H. Eser; Yazar, E.
    The aim of this research was to determine the effects of Tarantula cubensis alcoholic extract (TCAE) and Nerium oleander distillation (NOD) on the colon aberrant cryptal foci (ACF) score, serum cytokines [Tumour necrosis factor (TNF)-alpha, interleukin (IL)-2, IL-6, IL-10], prostaglandin E2, and oxidative status parameters (malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase) in an experimentally induced colon cancer model in rats. Male rats (38 in total) were divided into 4 groups: Control group (n = 8), Colon Cancer group (CC, n = 10), CC+TCAE group (n = 10), and CC i NOD group (n = 10). Except for the Control group, the rest of rats received azoxymethane (15 mg/kg, SC) once a week for two weeks to induce colon cancer. TCAE was administered once a week at 0.2 mL/kg (SC) and NOD was administered in water to CC+TCAE and CC+NOD groups for 18 weeks. After blood samples were collected, the rats were euthanized, colons were removed, washed with saline, then fixed with 10% formaldehyde, and stained with 0.2% methylene blue. ACFs were scored by light microscopy. Serum levels of cytokines, prostaglandin E2, and oxidative status parameters were determined with ELISA. ACF score of the CC group was higher than CC+TCAE and CC+NOD groups. The prostaglandin E2 level of the Control group was lower than the CC i TCAE group, while IL-2 and IL-10 levels of the Control group were lower than all other groups. In conclusion, it can be stated that TCAE and NOD applications may be beneficial in the treatment of colon cancer.