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Öğe Ağır gastrointestinal sistem kanaması siklofosfamidle tedavi edilen Henoch- Schönlein purpuralı iki çocuk olgu(2013) Yavuz, Sevgi; Uluca, Ünal; Karabel, Duran; Ece, Aydın; Tan, İlhanHenoch-Schönlein purpurası (HSP) çeşitli sistemleri tutan ve farklı klinik seyirler gösteren bir vaskülittir. Purpura tarzında döküntü, karın ağrısı, artrit, böbrek tutulumu ileortaya çıkabilmektedir. Nadiren, deri, gastrointestinal sis tem (GİS) ve böbrek tutulumu ağır seyretmekte ve erken veya geç dönemde çeşitli komplikasyonlara yol açabil mektedir. Bu yazıda yüksek doz intravenöz steroid teda- visine yanıt vermeyen tekrarlayan GİS kanaması intrave-nöz siklofosfamid ile başarılı bir şekilde tedavi edilen ağırGİS tutulumlu iki HSP’li çocuk olgunun sunulması amaç- landı. Hastalarımızdan birinde GİS tutulumuna ilaveten deri grefti gerektirecek kadar ağır nekrotik cilt tutulumu,diğerinde ise nefrotik proteinüri ile seyreden böbrek tu tulumu mevcuttu. HSP’li çocuklarda yüksek doz steroide yanıt alınamayan ağır GİS tutulumunda intravenöz siklofosfamid yararlı olabilir.Öğe Ağır gastrointestinal sistem kanaması siklofosfamidle tedavi edilen HenochSchönlein purpuralı iki çocuk olgu(Dicle Üniversitesi Tıp Fakültesi, 2013) Ece, Aydın; Yavuz, Sevgi; Tan, İlhan; Uluca, Ünal; Karabel, DuranHenoch-Schönlein purpurası (HSP) çeşitli sistemleri tutan ve farklı klinik seyirler gösteren bir vaskülittir. Purpura tarzında döküntü, karın ağrısı, artrit, böbrek tutulumu ile ortaya çıkabilmektedir. Nadiren, deri, gastrointestinal sistem (GİS) ve böbrek tutulumu ağır seyretmekte ve erken veya geç dönemde çeşitli komplikasyonlara yol açabilmektedir. Bu yazıda yüksek doz intravenöz steroid tedavisine yanıt vermeyen tekrarlayan GİS kanaması intravenöz siklofosfamid ile başarılı bir şekilde tedavi edilen ağır GİS tutulumlu iki HSP’li çocuk olgunun sunulması amaçlandı. Hastalarımızdan birinde GİS tutulumuna ilaveten deri grefti gerektirecek kadar ağır nekrotik cilt tutulumu, diğerinde ise nefrotik proteinüri ile seyreden böbrek tutulumu mevcuttu. HSP’li çocuklarda yüksek doz steroide yanıt alınamayan ağır GİS tutulumunda intravenöz siklofosfamid yararlı olabilirÖğe THE EDUCATION OF PEDIATRIC ENDOUROLOGY: THE STATUS OF TURKISH UROLOGY RESIDENTS(Mary Ann Liebert, Inc, 2012) Sancaktutar, Ahmet Ali; Yildirim, Kadir; Bodakci, Mehmet Nuri; Yavuz, Sevgi; Hatipoglu, Namik Kemal; Soylemez, Haluk; Penbegül, Necmettin[Abstract Not Available]Öğe Mean platelet volume as an indicator of disease activity in juvenile SLE(Springer London Ltd, 2014) Yavuz, Sevgi; Ece, AydinThe aim of the study was to assess mean platelet volume (MPV) in children with systemic lupus erythematosus (SLE) at the active and inactive stages. Twenty children with SLE and 30 age- and gender-matched controls were enrolled. Demographic data, SLE disease activity index (SLEDAI), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), MPV, complement 3 (C3), complement 4 (C4), urine protein (Up), and urine creatinine (Ucr) values upon reactivation and remission phases were recorded. MPV was statistically higher in patients than in controls and significantly increased in active phase compared to inactive phase (p = 0.001). A MPV level of 8.4 fL was determined as predictive cutoff value of activation of SLE (sensitivity 75 %, specificity 90 %). MPV was positively correlated with SLEDAI (p = 0.01, r = 0.55), ESR (p = 0.01, r = 0.45), CRP (p = 0.04, r = 0.24), and Up/Ucr (p = 0.01, r = 0.45) and negatively correlated with C3 (p = 0.02, r = -0.36), albumin (p = 0.01, r = -0.63), and Hb (p = 0.01, r = -0.48). There was not any significant association between MPV and the histological classification of lupus nephritis (p = 0.65). MPV might be used as an early indicator of reactivation in children with SLE. MPV seemed to be more accurate than ESR, CRP, and C3 for monitoring the disease activity in SLE.Öğe Nutcracker syndrome complicating with renal abscess(Pakistan Medical Assoc, 2016) Yavuz, Sevgi; Ece, Aydin; Corapli, Mahmut; Ilter, Cigdem; Guven, RufatThe nutcracker syndrome refers to compression of left renal vein between the superior mesenteric artery and aorta. Renal abscess consists of purulent and necrotic material localised to the renal parenchyma. These two entities are extremely rare and their coincidence has not previously been described in literature. Here, we report a case of a 10-year-old girl who developed left renal abscess probably due to nutcracker syndrome.Öğe A Rare Vasculitis of Childhood, Takayasu Arteritis(Modestum Ltd, 2013) Ece, Aydin; Sen, Velat; Yavuz, Sevgi; Gunes, Ali; Uluca, Unal; Sahin, CahitTakayasu arteritis is a potentially life threatening vasculitis that characterized by granulomatous inflammation of large vessels including aorta, its major branches and pulmonary arteries. True incidence of TA is not known in children, since TA is very rare; however, incidence of TA has been estimated as 0.8-2.6 per million children. Making a diagnosis is more difficult in childhood compared with adults due to non-specific clinical findings. The diagnosis of TA is done based on clinical criteria, laboratory investigations support and radiologic images confirm the diagnosis. Corticosteroids with other immunosuppressive drugs are used for treatment and biological agents are given to resistant cases. In this report, it was aimed to draw attention to a potentially fatal disease that frequently diagnostic delays and therapeutic difficulties occur. We, herein reported signs, symptoms, imaging methods and treatment modalities of two children, a 12 year-old male and a 13 year-old female patients, that presented with non-specific initial symptoms and diagnosed as TA with clinical findings and radiological imagesÖğe Reply to the letter "Mean platelet volume as a surrogate marker of inflammation in systemic lupus erythematosus"(Springer, 2014) Ece, Aydın; Yavuz, Sevgi[Özet Yok]
