Yazar "Yavuz, Selim" seçeneğine göre listele

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    Öğe
    Patterns of Hydroxyurea Prescription and Use in Routine Clinical Management of Polycythemia Vera: A Multicenter Chart Review Study
    (Galenos Yayincilik, 2020) Buyukasik, Yahya; Ali, Ridvan; Turgut, Mehmet; Saydam, Guray; Yavuz, Selim; Unal, Ali; Ar, Muhlis Cem
    Objective: This study aimed to evaluate real-life data on patterns of hydroxyurea prescription/use in polycythemia vera (PV). Materials and Methods: This retrospective chart review study included PV patients who had received hydroxyurea therapy for at least 2 months after PV diagnosis. Data were collected from 10 representative academic medical centers. Results: Of 657 patients, 50.9% were in the high-risk group (age 60 years and/or history of thromboembolic event). The median duration of hydroxyurea therapy was 43.40 months for all patients; 70.2% of the patients had ongoing hydroxyurea therapy at last followup. Hydroxyurea was discontinued in 22.4% of the patients; the most common reason was death (38.5%). The predicted time until hydroxyurea discontinuation was 187.8 months (standard error: +/- 21.7) for all patients. This duration was shorter in females (140.3 +/- 37.7 vs. 187.8 +/- 29.7) (p=0.08). This trend was also observed in surviving patients aged >= 50 years at hydroxyurea initiation (122.2 +/- 12.4 vs. 187.8 +/- 30.7, p=0.03). Among the patients who were still on hydroxyurea therapy, 40.3% had a hematocrit concentration of >= 45% at their last followup visit, and the rate of patients with at least one elevated blood cell count was 67.8%. Conclusion: Hydroxyurea prescription patterns and treatment aims are frequently not in accordance with the guideline recommendations. Its discontinuation rate is higher in females.
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    Öğe
    Retrospective evaluation of patients treated with dasatinib for philadelphia positive leukemias: Turkish experience of 16 months
    (2009) İlhan, Osman; Altıntaş, Abdullah; Saydam, Güray; Haznedaroğlu, İbrahim C.; Yavuz, Selim; Tombuloğlu, Murat; Gülbaş, Zafer
    Bu retrospektif çalışmada 114 KML hastasında ortalama tedavi süresi 7.94±4.53 aydı. Hastalar arasında hastalık durum dağılımı %78.1 kronik, %7.9 hızlanmış, %14 blastik faz şeklinde idi. Kronik, hızlanmış ve blastik fazlarda son imatinib dozları sırası ile 609.72±171.29, 714.29±106.90 ve 569.23±160.13 idi. Kronik ve hızlanmış fazlarda tam hematolojik cevap sırası ile %66.3 ve %44.4 olarak bulundu. Moleküler cevap RT-PCR’da bcr/abl transcript seviyeleri ile değerlenmişti. Tam moleküler cevap kronik fazda %27.0, hızlanmış fazda %11.1 ve blastik fazda %18.8 idi. Toplam 99 hastanın 77’si (%77.8) hayatta kalmıştı. Kaplan-Meier sağkalım analizinde 99 hastanın 16. ay genel sağkalım değeri %78 idi. Hastaların %69.2’sinde advers olay bildirilmezken, hastalık ilerlemesi ve evre 1-2 miyelosupresyon en sık bildirilmiş olan advers olaylardı. Hastaların çoğu tam hematolojik cevaba sahipti. Buna göre, dasatinib tedavisinin iyi tolere edildiği ve çoğunlukla hafif yan etkilerle birlikte olumlu çıktılar sağladığı söylenebilir.