Yazar "Yavuz, M." seçeneğine göre listele

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    Evaluation of antioxidant activity of ethanol extract of Hypericum retusum and its protective effect on protein oxidation
    (Wiley-Blackwell, 2009) Ceken, B.; Kizil, G.; Yavuz, M.; Kizil, M.
    [Abstract Not Available]
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    Öğe
    Gold nanoparticle loaded phytosomal systems: synthesis, characterization and in vitro investigations
    (Royal Soc Chemistry, 2014) Demir, B.; Barlas, F. B.; Guler, E.; Gumus, P. Z.; Can, M.; Yavuz, M.; Coskunol, H.
    Most medicinal and pharmaceutical herbal extracts are poorly soluble in aqueous moieties and have reduced adsorption by living cells. Liposomal encapsulation of those so called phytosomes could be a solution to overcome this problem. Meanwhile, much research shows that metallic nanoparticles such as gold nanoparticles ( AuNPs) exhibit biological activity such as wound healing and antioxidant properties on living cells. Here, we constructed a novel liposomal formulation by encapsulating both Calendula officinalis extract and AuNPs. After the preparation of vesicles using the traditional thin film hydration method within extrusion, the resulting AuNP-phytosomes were characterized by dynamic light scattering size measurements, zeta potential and atomic force microscopy. These vesicles are less than 100 nm in size and have a high encapsulation efficiency for chlorogenic acid and quercetin as the model major molecules of Calendula extract. Furthermore, AuNP-phytosomes exhibited antioxidant and wound healing activity significantly according to the free forms of each encapsulated material and the plain liposome as well as the phytosome form. Moreover, the cellular interactions of the vesicles were monitored using the nano-vesicles prepared by Texas-Red labelled lipids under fluorescence microscopy.
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    PROTECTIVE ACTIVITY OF ETHANOL EXTRACT OF THREE ACHILLEA SPECIES AGAINST LIPID PEROXIDATION, PROTEIN OXIDATION AND DNA DAMAGE IN VITRO
    (Akademiai Kiado Zrt, 2010) Kizil, M.; Kizil, G.; Yavuz, M.; Ceken, B.
    The present study was designed to investigate the protective ability of the ethanol extracts of Achillea aleppica D.C. subsp. aleppica (AA), Achillea aleppica D.C. subsp. zederbaueri (Hayek) Hub.-Mor (AZ) and Achillea biebersteinii A fan. (AB) against the lipid peroxidation, protein oxidation and DNA damage induced by Fenton system. Ethanol extract of Achillea species were evaluated by quantifying the ability of different concentrations of plant extracts to supress Fe2+-induced lipid peroxidation in rat liver homogenates. The inhibition of lipid peroxidation by ethanol extracts of AA, AB and AZ was the result of their scavenging effect on Fe2+/ascorbate generated free radicals. The ability of AA, AZ and AB to prevent oxidative damage to bovine serum albumin (BSA) induced by Fe3+/H2O2 and ascorbic acid was investigated. The ethanol extracts of AA, AB and AZ at different concentrations (50-1000 mu g ml(-1)) efficiently prevented protein oxidation induced by hydroxyl radical as assayed by protein oxidation markers including protein carbonyl formation (PCO). We have also investigated the effect of ethanol extracts of AA, AB and AZ on DNA cleavage induced by UV-photolysis of H2O2 using pBluescript M13+ plasmid DNA. These extracts significantly inhibited DNA damage induced by reactive oxygen species (ROS). Therefore, Achillea aleppica D.C. subsp. aleppica (AA), Achillea aleppica D.C. subsp. zederbaueri (Hayek) Hub.-Mor (AZ) and Achillea biebersteinii Afan. extracts may be useful in the food industry as effective synthetic antioxidants.