Yazar "Yavuz, Izzet" seçeneğine göre listele
Listeleniyor 1 - 20 / 23
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe A c.3037G>A mutation in FBN1 gene causing Marfan syndrome with an atypically severe phenotype.(Inst Investigacion Clinica, 2017) Callea, Michele; Willoughby, Cohn Eric; Camarata-Scalise, Francisco; Giovannoni, Isabelle; Vinciguerra, Agatino; Yavuz, Izzet; Di Stazio, MariateresaMarfan syndrome is a pleiotropic connective tissue disease inherited as an autosomal dominant trait, mostly caused by mutations in the FBN1 gene, which is located on chromosome 15q21.1 and encoding fibrillin 1. We report a case of Marfan syndrome presenting with severe ocular and systemic manifestations, such as cardiac congenital anomalies. The patient underwent a multidisciplinary approach and his clinical diagnosis was associated with a c.3037G > A mutation in the FBN1 gene. Identification of this genetic alteration should instigate a prompt multidisciplinary assessment and monitoring, in order to prevent devastating consequences such as cardiac and ocular phenotype. Molecular modeling of the mutation highlighted the importance of the preservation of the calcium-dependent structure of an epidermal -growth-factor-like domain of fibrillin-1 and consequently the microfibrillar formation process. This report aims to highlight the importance of an early clinical and molecular diagnosis and once more, the importance of the multidisciplinary approach of this genetic entity.Öğe CAN HISTOLOGICAL AND HISTOMORPHOMETRICAL CHANGES BE INDUCED IN RAT MANDIBULAR CONDYLE FOLLOWING OVARIECTOMY AND LONG-TERM EXTREMELY LOW FREQUENCY MAGNETIC FIELD EXPOSURE?(Taylor & Francis Ltd, 2012) Ulku, Sabiha Zelal; Akdag, Mehmet Zulkuf; Yavuz, Izzet; Celik, Mustafa Salih; Ketani, Muzaffer AydinThe quantity and quality of maxillary and mandibular bone have long been a focus of attention for dental clinicians. The mandibular condyle is a major growth site and plays an important role during mandibular growth. The aim of the present study was to evaluate the effects of long-term extremely low frequency magnetic field (ELF-MF) and hormonal changes produced by bilateral ovariectomy on the histologic and histomorphometric structure of rat mandibular condyle. Forty mature female Sprague-Dawley rats were randomly divided into four different groups (n = 10): control (Cnt), ovariectomy (OVX), ELF-MF exposure (ELF-MF), ELF-MF exposure with OVX application (ELF-MF+OVX). All rats were subjected to bilateral ovariectomy except those in Cnt and ELF-MF groups. ELF-MF and ELF-MF+OVX groups were exposed to 1.5 mT ELF-MF during 6 months, 4 h a day After all applications, left condyle of rats were removed to examine histopathologically. Some histopathologic changes were observed, such as irregular appearance in bone marrow cavities in rat condyles of OVX, ELF-MF and ELF-MF+OVX groups. Some disorders in transition from hypertrophic field to ossification layer and irregular appearance in calcification were determined in OVX group. In OVX+ELF-MF and ELF-MF groups, there was significant disruption and latency in calcification and ossification areas. However, no significant differences were found in the thickness of the condylar cartilage layer between groups (P > 0.05). It was suggested that long-term ELF-MF exposure and ELF-MF exposure with ovariectomy application can affect the histologic structure of rats' condyle. Consequently, it was concluded that long-term ELF-MF exposure and ovariectomy application can induce histopathological changes in the structure of the condyle and ELF-MF exposure cannot alter ovariectomy-induced changes.Öğe Clinical and molecular study in a child with X-linked hypohidrotic ectodermal dysplasia(Soc Argentina Pediatria, 2015) Callea, Michele; Yavuz, Izzet; Clarich, Gabriella; Cammarata-Scalisi, FranciscoEctodermal dysplasia encompasses more than 200 clinically distinct entities, which affect at least two structures derived from the ectoderm, including the skin, hair, nails, teeth, sweat glands, and sebaceous glands. X-linked hypohidrotic ectodermal dysplasia is the most common type and is caused by mutation of the EDA gene that encodes Ectodysplasin-A. It occurs in less than 1 in 100 000 individuals and is clinically characterized by hypodontia, hypohidrosis, hypotrichosis, and eye disorders. We present a child evaluated in a multidisciplinary manner with clinical and molecular diagnosis of X-linked hypohidrotic ectodermal dysplasia with type missense mutation c.1133C>T; p.T378M in EDA gene.Öğe Comparative Evaluation of the Effects of Ozone, Diode Laser, and Traditional Cavity Disinfectants on Microleakage(Taylor & Francis Inc, 2014) Gunes, Sifa; Bahsi, Emrullah; Ince, Bayram; Colak, Hakan; Dalli, Mehmet; Yavuz, Izzet; Sahbaz, CaferAim: This study aimed to evaluate the effects on microleakage of the application of ozone gas, laser and traditional cavity disinfection under in vitro conditions. Material and Methods: Ninety third-molar teeth extracted for various reasons were used in this study. All the teeth were prepared with a standard V cavity on the buccal surface. Then the teeth were randomly allocated to one of 6 groups of 15 teeth; Group 1 benzalkonium chloride, Group 2 chlorhexidine gluconate, Group 3 sodium hypochloride, Group 4 diode laser, Group 5 ozone gas, Group 6 control group- no disinfection was applied. Primer was applied to the cavities, then bond and 10-s polymerization. Clearfil AP-X was used in the cavities as a hybrid composite and polymerized for 20 s. The samples then underwent 1000 thermal cycles of 30-s application, in baths at temperatures between 5 +/- 2 degrees C and 55 +/- 2 degrees C. All the samples were stirred in 0.5% basic phuxine solution and the sections taken under stereomicroscope were examined and photographed at 15 x magnification. SEM analysis was made and the obtained results were statistically evaluated with the Kruskal-Wallis test. Results: No significant difference was seen between the groups in respect of the microleakage values of both the occlusal and gingival edges (p < 0.05). Comparison of the microleakage values of the occlusal and gingival edges of the groups determined the least leakage to be in the ozone group (p < 0.05). Conclusion: No statistical significance was determined between the groups. However, the mean least microleakage was found in the ozone group and the highest amount in the control group.Öğe Cone-beam dental computerize tomography for evaluating changes of aging in the dimensions central superior incisor root canals(Medicina Oral S L, 2011) Kaya, Sadullah; Adiguzel, Ozkan; Yavuz, Izzet; Tumen, Emin-Caner; Akkus, ZekiObjectives: Cone-beam dental computerize tomography (CBCT), a noninvasive imaging method, was used to image the pulp-dentin complex. Pulp changes histologically with aging. While many studies have investigated the histological changes in pulp, few studies have focused on the changes in the shape of the root canals. This study evaluated the changes in the root canals with aging of central superior teeth using CBCT. Study Design: The study examined 100 non-carious maxillary central teeth. These teeth were divided into five groups according to the age of the patients: Group A: 15-24, Group B: 25-34, Group C: 35-44, Group D: 45-54 and Group E: 55 years and older. CBCT was used to determine root length, and pulp width at the cervical, apical 1/2, and apical 1/3. Results: On comparing the groups using one-way analysis of variance (ANOVA), the root length did not differ (P > 0.05), while the pulp width at the cervical, apical 1/2, and apical 1/3 differed between the groups (P < 0.001). Conclusions: The pulp length did not change with aging, while the pulp width did change. CBCT can be used to determine the precise root length and width, to prevent iatrogenic exposure of the apex, complementing existing methods. This will improve the prediction of the prognosis of root canal treatment.Öğe Ear nose throat manifestations in hypoidrotic ectodermal dysplasia(Elsevier Ireland Ltd, 2013) Callea, Michele; Teggi, Roberto; Yavuz, Izzet; Tadini, Gianluca; Priolo, Manuela; Crovella, Sergio; Clarich, GabriellaThe ectodermal dysplasias (EDs) are a large and complex group of inherited disorders. In various combinations, they all share anomalies in ectodermal derived structures: hair, teeth, nails and sweat gland function. Clinical overlap is present among EDs. Few causative genes have been identified, to date. Altered gene expression is not limited to the ectoderm but a concomitant effect on developing mesenchymal structures, with modification of ectodermal-mesenchymal signaling, takes place. The two major categories of ED include the hidrotic and hypohidrotic form, the latter more frequent; they differentiate each other for the presence or absence of sweat glands. We report Ear Nose Throat manifestations of ED, linked to the reduction of mucous glands in the nasal fossae with reduced ciliar function, and decrease salivary glands function. Often patients report an increased rate of infections of the upper respiratory tract and of the ear. Nasal obstruction due to the presence of nasal crusting, hearing loss and throat hoarseness are the most represented symptoms. Environmental measures, including a correct air temperature and humidification, is mandatory above all in subjects affected by hypohidrotic form. (C) 2013 Elsevier Ireland Ltd. All rights reserved.Öğe Effects of Extremely Low Frequency Magnetic Field on Pulp Tissue of Rats(Medwell Online, 2011) Kaya, Sadullah; Celik, M. Salih; Akdag, Mehmet Zulkuf; Adiguzel, Ozkan; Yavuz, Izzet; Nergiz, Yusuf; Ayaz, ErcanThis study aims to investigate the effect of Extremely Low Frequency Magnetic Field (ELF-ME) on dental pulp of ovariectomized rats. About 75 female Wistar-albino rats were randomly divided into 5 groups: cage-control, ovariectomy, ELF-MF exposure, ELF-MF exposure with strontium ranelate treatments and ovariectomy application, ELF-MF exposure with ovariectomy application. All groups except cage-control and ovariectomy groups were exposed to 1.5 mT ELF-MF exposure throughout 6 months, 4 h a day. After all applications, pulp tissues of rat teeth were investigated under light microscope. Between the groups, histological differences in collagen fibrils, fibroblasts, blood vessels and odontoblasts that create the pulp were found. We concluded that osteoporosis affected the odontoblasts and fibroblasts in rat dental pulp, ELF-MF exposure did not resolve the histopathological effect due to osteoporosis but enhanced this pathological effect, strontium ranelate was more efficient to eliminate the effects of osteoporosis than ELF-MF application.Öğe Effects of Extremely Low Frequency Magnetic Fields on Periodontal Tissues and Teeth in Rats(Medwell Online, 2011) Kaya, Filiz Acun; Akdag, Mehmet Zulkuf; Kaya, Can Ayhan; Dasdag, Suleyman; Yavuz, Izzet; Kilinc, Nihal; Dogru, Arzum GulerThe aim of this study is to research the effects of ELF magnetic fields on periodontal tissues and teeth in rats histopathologically. The experiments were performed on 27 male Sprague-Dawley rats, aged 4 months at the beginning of the study, weighing (342.4 +/- 38.89) g and fed with standard pelleted food. The rats were divided into three groups; two experimental and one control (sham). Experimental groups were exposed to 100 and 500 mu T ELF magnetic fields during 10 months, 2 h a day, respectively. Third group was sham that were treated like experimental group except ELF magnetic fields exposure in methacrylate boxes. There was no statistical difference between the experimental groups among all tissues (p>0.05). Alveolar bone, pulp and gingiva there were statistically significant differences among the groups of sham and 1st experimental, sham and 2nd experimental (p<0.05). The statistical difference between the experimental and sham groups in the study makes us to think that ELF magnetic fields may have effects on periodontal tissues and teeth.Öğe Effects of Radiofrequency Radiation by 900 MHz Mobile Phone on Periodontal Tissues and Teeth in Rats(Medwell Online, 2008) Kaya, Filiz Acun; Dasdag, Suleyman; Kaya, Can Ayhan; Akdag, Mehmet Zulkuf; Yavuz, Izzet; Kilinc, Nihal; Kaya, SadullahThe aim of this study, is to research an answer to the question of have mobile phones effects on periodontal tissues and teeth. Twenty eight Wistar Albino adult male rats (4 months) with initial average weight of 267 +/- 15 g were obtained from the Medical Science Application and Research Center, caged individually and fed with standard pelletted food (TAVAS Inc. Adana, TR). They were separated into three groups such as cage control (n = 7), sham exposed (n = 7) and experimental (n = 14) and kept on a 14/10 h light/dark schedule. The rats were confined in a Plexiglas carousel and rat heads in the carousel exposed to 900 MHz microwave exposure emitted from generator. For the study group, rats exposed to the radiation 2 h per day (7 days in a week) for 10 months. Although, there was no statistical difference determined among the groups of experimental and sham groups (p>0.05), there were numerically more individuals effected of RF radiation in the experimental group. In our study is the statistically significant difference among the groups of experimental, sham and control groups in the case of vasodilatation in periodontal ligament and alveolar bone (p<0.05). By the histopathologic evaluation abnormal changes like vasodilatation and focal bleeding areas were determined in periodontal ligament, alveolar bone, gingiva and pulpa among some individuals. These degenerations were in different levels. These findings of our study indicates that there is need to more animal, human being and epidemiologic studies including much more individuals.Öğe Effects of toothache on the educational and social status of children(Univ Indonesia, 2019) Dogan, Mehmet S.; Aras, Ahmet; Atas, Osman; Karaali, Abdullah E.; Gunay, Ayse; Akbaba, Haluk M.; Yavuz, IzzetBackground: Untreated tooth cavities and the resulting toothaches have significant effects on children's social and psychological development. The aim of this study was to evaluate the impact of toothache on children's educational and social activities. Methods: For this retrospective study, we issued a 15-question survey to the parents of 515 children between ages of 5-16 years in Diyarbakir, Turkey. The chi-square test was used to test the strength of the relationship between two variables (p = 0.05). Results: 318 (61.7%) parents reported having difficulty in feeding their children, 94 (18.3%) left a game due to toothache, 173 (33.6%) had school absences, 167 (32.4%) avoided laughing, and 439 (85.2%) parents felt that dental problems influenced their child's success in school. Conclusions: Tooth pain has a negative impact on school and the social lives of children. Families need education about this issue, and health policies should be developed to address this problem.Öğe ELF Electromagnetic Field and Strontium Ranilate Influences on the Trace Element Content of Rat Teeth(Medwell Online, 2009) Kaya, Sadullah; Akdag, Mehmet Zulkuf; Yavuz, Izzet; Celik, Mustafa Salih; Adiguzel, Oezkan; Tumen, Emin Caner; Kaya, Filiz AcunExposure to Extremely Low Frequency (ELF) Electromagnetic Field (EMF) emanating from the generation, distribution and utilization of electricity. The major debate in recent years has focused on the possibility that exposure to EMF may result some health consequences such as differentiation on bone constitute. In this study, the effect of ELF-EMFs and strontium ranelate on teeth constitute amount of mineral were investigated in rats. Seventy-five four month old adult female Sprague-Dawley rats were randomly divided into 5 different groups (n = 15). After all applications, some mineral levels such as: Ca, Mg and Zn in rat teeths were determined with Atomic Absorbtion Spectrophotometry (AAS) and the phosphorus content of teeth was determined by Ultraviolet Spectrophotometer (UVS). It was determined that the levels of Ca and P were not statistically different in comparison to Cg-Cnt and between groups (p>0.05). However, it was observed that the levels of Zn significantly alterations between some groups (p<0.05). The levels of Mg in ELF-EMF+OVX, ELF-EMF and OVX groups decreased significantly in comparison to Cg-Cnt group (p<0.05). As a result, it can be suggested that mineral amount of rat teeth can change after ovariectomy and ELF-EMF exposure, also strontium ranelate treatments can't increase mineral amount of teeth.Öğe An evaluation of clinical, radiological and three-dimensional dental tomography findings in ectodermal dysplasia cases(Medicina Oral S L, 2015) Dogan, Mehmet-Sinan; Callea, Michele; Yavuz, Izzet; Aksoy, Orhan; Clarich, Gabriella; Gunay, Ayse; Gunay, AhmetBackground: This study aimed to review the results related to head and jaw disorders in cases of ectodermal dysplasia. The evaluation of ectodermal dysplasia cases was made by clincal examination and examination of the jaw and facial areas radiologically and on cone-beam 3-dimensional dental tomography (CBCT) images. Material and Methods: In the 36 cases evaluated in the study, typical clinical findings of pure hypohidrotic ectodermal displasia (HED) were seen, such as missing teeth, dry skin, hair and nail disorders. CBCT images were obtained from 12 of the 36 cases, aged 1.5-45 years, and orthodontic analyses were made on these images. Results: The clinical and radiological evaluations determined, hypodontia or oligodontia, breathing problems, sweating problems, a history of fever, sparse hair, saddle nose, skin peeling, hypopigmentation, hyperpigmentation, finger and nail deformities, conical teeth anomalies, abnormal tooth root formation, tooth resorption in the root, gingivitis, history of epilepsy, absent lachrymal canals and vision problems in the cases which included to the study. Conclusions: Ectodermal dysplasia cases have a particular place in dentistry and require a professional, multi-disciplinary approach in respect of the chewing function, orthognathic problems, growth, oral and dental health. It has been understood that with data obtained from modern technologies such as three-dimensional dental tomography and the treatments applied, the quality of life of these cases can be improved.Öğe Hypohidrotic ectodermal dysplasia: A case report(Quintessence Publishing Co Inc, 2008) Yavuz, Izzet; Kiralp, Suha; Baskan, ZelalEctodermal dysplasias represent a large and complex group of diseases comprising more than 170 clinical conditions. They are caused by impaired development of the ectodermal appendages and characterized by a primary defect in at least one of the following tissues: nails, hair, sweat glands, or teeth. Ectodermal dysplasia has emotional consequences for affected individuals at early ages. This case report outlines a possible routine approach to restoring function and esthetics and aiding in the social interaction for a 9-year-old girl diagnosed with hypohidrotic ectodermal dysplasia at about 7 years of age.Öğe In Vitro Comparison of Three Dimensional Cone Beamed Dental Tomography with Intraoral Radiography in Detection of Dental Root Factures(Univ Indonesia, Fac Dentistry, 2019) Akleyin, Ebru; Yavuz, IzzetThe precise diagnosis of dental root fractures in clinical practice is quite difficultObjective: Accurate diagnosis of dental root fractures in clinical practice is quite challenging. Here, we aimed to compare results of three-dimensional cone beam computed tomography (CBCT) and conventional intraoral radiography images for diagnosing dental root fractures. Methods: Fifty maxillary central teeth with healthy roots were included in this experiment. Ten teeth were subjected to a single blow in a laboratory to produce cracks, whereas horizontal root fractures with varying degrees of gaps between the fractured segments were created in 40 teeth. The teeth were divided into five equal groups: teeth with crack; teeth with root fractures without gaps; and teeth with root fractures with 0.2-, 0.4-, and 0.6-mm gaps between the fractured segments. CBCT and conventional intraoral radiography images were evaluated by 30 dentists. The mean diagnostic accuracy for detection of root fracture and the positive predictive value were calculated forboth diagnostic modalities. Results: The mean diagnostic accuracy with the use of CBCT images was significantly better than that with the use of traditional intraoral radiography images. Conclusion: CBCT allows for more detailed characterization of root fractures and cracks than traditional intraoral radiography.Öğe Influences of extremely low frequency magnetic fields on mineral and trace elements content of rat teeth(Academic Journals, 2008) Yavuz, Izzet; Akdag, M. Zulkuf; Dasdag, Suleyman; Ulku, Sabiha Zelal; Akkus, ZekiExposure to extremely low frequency magnetic fields (ELF-MF) emanating from the generation, distribution, and utilization of electricity is widespread. The major debate in recent years has focused on the possibility that exposure to ELF-MF may result in adverse health consequences. The present study was carried out to investigate the effects of ELF-MF on the mineral content in rat teeth. 27 male Sprague-Dawley rats were divided into three groups: two experimental (each, n=10), one control sham (n=7). After ELF-MF and sham exposure, some mineral levels (Ca, Mg, Zn, and P) were determined with Atomic Absorbtion Spectrophotometry (AAS). It was determined that Ca levels increased in the two experimental groups as compared to the sham group (p<.05). The levels of Ca, Mg, Zn, and P in second experimental group rats were also higher than sham group (p<.05). The results demonstrate that ELF-MF can have significant effects on teeth mineral content. Future observations and epidemiological studies of ELF-MF effects should be accompanied by laboratory experiments to evaluate oral and dental effects.Öğe Isotretinoin embryopathy. An entity that can be avoided(Soc Argentina Pediatria, 2018) Cammarata-Scalisi, Francisco; Nieves, Dairelis; Avendano, Andrea; Lacruz-Rengel, Maria A.; Alviarez, Karelys; Davila, Francys; Yavuz, IzzetIsotretinoin is the most effective drug in the treatment of severe recalcitrant nodulocystic acne. However, treatment with this drug is associated with adverse effects, the most severe being teratogenesis. It has been estimated that 40% of pregnancies exposed to isotretinoin present spontaneous abortion and 35% develop embryopathy. We present the case of a newborn with a history of prenatal exposure to isotretinoin, a clinical entity that can be avoided, with severe congenital defects in the central nervous system and important facial dysmorphisms, with unfavorable clinical course.Öğe Measuring Bone Density in Healing Periapical Lesions by Using Cone Beam Computed Tomography: A Clinical Investigation(Elsevier Science Inc, 2012) Kaya, Sadullah; Yavuz, Izzet; Uysal, Ibrahim; Akkus, ZekiIntroduction: Differences in bone density before and after endodontic treatment were examined in teeth with periapical lesions in Hounsfield units (HUs) by using cone beam computed tomography (CBCT). Methods: Sixteen patients requiring endodontic treatment for periapical lesions underwent CBCT scan before and after treatment. Their bone densities were calculated in HUs. The study included 16 lesions measuring 8-10 mm in diameter. HU measurements were taken from an area of 2.25 mm(2) on the CBCT images where the bone density was lowest, before and after treatment. Results: The initial and final measurements were compared statistically by using paired samples statistics at the 5% significance level. Conclusions: The results of this study support the use of CBCT to measure bone density before and after endodontic treatment. (J Endod 2012;38:28-31)Öğe A new method: measurement of microleakage volume using human, dog and bovine permanent teeth(Univ Catolica De Valparaiso, 2006) Yavuz, Izzet; Aydin, Haluk; Ulku, Refik; Kaya, Sadullah; Tumen, CanerThis study investigates the feasibility of a different new approach to determining the microleakage volume associated with dental restorations (Class V cavity restorated with glass ionomer cement + high copper amalgam) and the relative marginal adaptation deficiency of dog, bovine and human permanent teeth in in vitro conditions. Also researched is the appropriateness of using dog and bovine teeth in in vitro studies rather than human teeth. Our method utilizes the molecular adsorption characteristics of methylene blue. Within the framework of this study, 60 permanent teeth (20 human, 20 dogs and 20 bovine) were used. These groups were evaluated statistically, of which indicated no statistically significant differences (p > 0.05). It was also concluded that this preliminary investigation showed that the new microleakage volume measurement method may be a valuable new technique for the in vitro study of microleakage dynamics around dental restorations.Öğe Ophthalmic Manifestations in Patients with Ectodermal Dysplasia Syndromes(Wroclaw Medical Univ, 2014) Keklikci, Ugur; Yavuz, Izzet; Tunik, Selcuk; Ulku, Zelal Baskan; Akdeniz, SedatBackground. Ectodermal dysplasia (ED) is a disorder that results from abnormal formation of at least two of the four major ectodermal derivatives in the developing embryo. The ectoderm of the embryo forms the skin, teeth, hair and nails, sweat glands and part of the eyes. Objectives. The aim of this article is to reveal ophthalmologic symptoms and signs as multidisciplinary, reliable criteria for ectodermal dysplasia. Material and Methods. In this retrospective study, 24 patients with ED were analyzed from the recorded data. Ophthalmological examination of the patients, who had previously received the diagnosis of ED in the dental department, was done. During the examination, ocular symptoms related to tear film, corneal changes, lacrimal duct, periorbital hyperpigmentation, alteration lashes and eyebrows were evaluated. Results. The age ranged between 3-45, and the mean and standard deviation (Mean +/- SD) was 15.8 +/- 7.4 years. The number of males was 13 (54.2%) and females, 11(45.8%). Eighteen patients (75.0%) suffered from ocular complaints related to the ocular surface. In 11 of the patients with ED, there were dry eye symptoms. While the mean age of cases with eye involvement was 17.5, it was 23.1 in cases with dry eye symptoms. Conclusions. In the study, it was observed that, in patients with ED, ocular complaints, particularly dry eye symptoms, may increase as age advances.Öğe A Rare Case of Hutchinson-Gilford Progeria Syndrome with Early Dental Loss without Decay(Univ Indonesia, 2018) Pekdemir, Tugce N.; Ozturk, Duygu; Cetindag, Merve T.; Akleyn, Ebru; Sariyildiz, Cansu O.; Callea, Michele; Yavuz, IzzetHutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal recessive genetic disorder that occurs as a point mutation in the LMNA gene. It is a rare hereditary disorder, with approximately 100 cases reported in the medical literature. These patients and our case show features of aged appearance (pseudosenilism), loss of subcutaneous fat texture, growth retardation, sclerodermatous skin, 'horse riding posture', bird-face appearance, beaked nose, high pitched voice, protruding knees and elbows, underweight, short stature, malformation of the teeth, micrognathia, hypodontia, malocclusion, craniofacial disproportion, atherosclerosis and cardiovascular disorders. Unlike typical findings of HGPS, diffuse alopecia and prominent scalp veins were not observed in our case. Patients with HGPS have an average life span of 13 years, owing to myocardial infarction and congestive heart failure and our case also has atherosclerosis and heart failure. The study reported extra-and intraoral findings in a 24-year-old male patient with HGPS who came to our faculty with complaints about absence of teeth and psychological problems caused by absence of teeth and HGPS findings such as pseudosenilism, growth retardation and short stature. The data described necessary dental examinations and treatments for our patient and have reviewed the literature.
