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    Effect of 900-, 1800-, and 2100-MHz radiofrequency radiation on DNA and oxidative stress in brain
    (Taylor & Francis Inc, 2019) Alkis, Mehmet Esref; Bilgin, Hakki Murat; Akpolat, Veysi; Dasdag, Suleyman; Yegin, Korkut; Yavas, Mehmet Cihan; Akdag, Mehmet Zulkuf
    Ubiquitous and ever increasing use of mobile phones led to the growing concern about the effects of radiofrequency radiation (RFR) emitted by cell phones on biological systems. The aim of this study is to explore whether long-term RFR exposure at different frequencies affects DNA damage and oxidant-antioxidant parameters in the blood and brain tissue of rats. 28 male Sprague Dawley rats were randomly divided into four equal groups (n = 7). They were identified as Group 1: sham-control, Group 2: 900 MHz, Group 3: 1800 MHz, and Group 4: 2100 MHz. Experimental groups of rats were exposed to RFR 2 h/day for 6 months. The sham-control group of rats was subjected to the same experimental condition but generator was turned off. Specific absorption rates (SARs) at brain with 1 g average were calculated as 0.0845 W/kg, 0.04563 W/kg, and 0.03957, at 900 MHz, 1800 MHz, and 2100 MHz, respectively. Additionally, malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), total antioxidant status (TAS), and total oxidant status (TOS) analyses were conducted in the brain tissue samples. Results of the study showed that DNA damage and oxidative stress indicators were found higher in the RFR exposure groups than in the sham-control group. In conclusion, 900-, 1800-, and 2100-MHz RFR emitted from mobile phones may cause oxidative damage, induce increase in lipid peroxidation, and increase oxidative DNA damage formation in the frontal lobe of the rat brain tissues. Furthermore, 2100-MHz RFR may cause formation of DNA single-strand breaks.
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    Effect of electromagnetic fields and antioxidants on the trace element content of rat teeth
    (Dove Medical Press Ltd, 2017) Dogan, Mehmet Sinan; Yavas, Mehmet Cihan; Yavuz, Yasemin; Erdogan, Sait; Yener, Ismail; Simsek, Ibrahim; Akkus, Zeki
    The purpose of this study was to examine the possible effect of extremely low-frequency electromagnetic fields (ELF-EMFs), from a high-voltage source, on rat teeth in terms of changes in trace elements (TEs) and the effect of antioxidants (melatonin [MLT] and Ganoderma lucidum [GL]) in counteracting these effects. We used adult male Wistar albino rats with a mean weight of 250-300 g and divided the rats into eight groups. The groups were subjected to an ELF- EMF that was applied with a high- voltage line for 8 hours/day for 26 days (Groups I, II, and III) or 52 days (Groups V, VI, and VII). Groups IV and VIII were the 26- and 52- day control/sham groups, respectively. Groups II and VI were treated with GL, and Groups III and VII were treated with MLT. MLT and GL were administered daily based on the weight of the animals and appropriate standards. At the end of the study, the rats were euthanized, and their anterior teeth were extracted. The teeth were preserved in pure water before evaluating the major TEs. At the end of the study, TE concentrations (in mg/kg) were assessed in the control and test groups. Compared with Group V, statistically significant differences in the concentrations of zinc (Zn) and strontium (Sr) were found for Group VII (ELF- EMF + MLT) (P< 0.05). Therefore, ELF- EMF exposure can change the content of certain TEs in teeth and, after administering MLT and GL, the values of some of the TEs return to normal.
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    An Investigation of the Effect of Antioxidant on Biochemical Parameters in ELF-EMF Exposure
    (Bayrakol Medical Publisher, 2020) Yavas, Mehmet Cihan; Akdag, Mehmet Zulkuf; Celik, Mustafa Salih; Gorgul, Ozkan
    Aim: The purpose of our study was to investigate the effect of electromagnetic fields originating from high voltage lines and antioxidant on serum biochemical values of Wistar albino male rats. Material and Methods: A total of 48 rats were included in the study and 3 groups were formed in two different time periods (26/52 days) as follows: Group 1- High voltage (HV), Group 2- HV+Ganoderma lucidum (GL), Group 3- Control. The magnetic field and the electric field were measured. Ganoderma was administered at a dosage of 20 mg/kg/day as a gavage. Results: In the implementation that took 26 days, no significant difference was found between groups in terms of AST, ALT, Ca, amylase, glucose ve creatine values (P>0.05), and a significant difference was found between groups in terms of urea variable (P<0.01). In the implementation that took 52 days, no statistically significant difference was found between groups in terms of AST, ALT, Ca, amylase, glucose, creatine and urea values (P>0.05). Discussion: It is seen that extremely low - frequency electromagnetic fields generated by high voltage lines may cause changes in serum biochemistry values and the use of some antioxidant (ganoderma) products may be beneficial.
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