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    Öğe
    Ruthenium (II) complexes of thiosemicarbazone: Synthesis, biosensor applications and evaluation as antimicrobial agents
    (Elsevier Science Bv, 2014) Yildirim, Hatice; Guler, Emine; Yavuz, Murat; Ozturk, Nurdan; Yaman, Pelin Kose; Subasi, Elif; Sahin, Elif
    A conformationally rigid half-sandwich organoruthenium (II) complex [(eta(6)-p-cymene)RuClTSCN-S]Cl, (1) and carbonyl complex [Ru(CO)Cl(PPh3)(2)TSCN-S] (2) have been synthesized from the reaction of [{(eta(6)-p-cymene) RuCl}(2)(mu-Cl)(2)] and [Ru(H)(Cl)(CO)(PPh3)(3)] with thiophene-2-carboxaldehyde thiosemicarbazon (TSC) respectively and both novel ruthenium (II) complexes have been characterized by elemental analysis, FT-IR and NMR spectroscopy. The peripheral TSC in the complexes acts as an electrochemical coupling unit providing the ability to carry out electrochemical deposition (ED) and to form an electro-deposited film on a graphite electrode surface. The biosensing applicability of complexes 1 and 2 was investigated by using glucose oxidase (GOx) as a model enzyme. Electrochemical measurements at -0.9 V versus Ag/AgCl electrode by following the ED Ru(II) reduction/oxidation due to from the enzyme activity, in the presence of glucose substrate. The designed biosensor showed a very good linearity for 0.01-0.5 mM glucose. The in vitro antimicrobial activities of complexes 1 and 2 were also investigated against nine bacterial strains and one fungus by the disc diffusion test method. No activity was observed against the Gram-negative strains and fungus, whereas complex 1 showed moderate antibacterial activities against Gram-positive bacterial strains. (C) 2014 Elsevier B.V. All rights reserved.
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    Öğe
    Synthesis, structural characterization, oxygen sensitivity, and antimicrobial activity of ruthenium(II) carbonyl complexes with thiosemicarbazones
    (Taylor & Francis Ltd, 2014) Ozturk, Nurdan; Yaman, Pelin Kose; Yavuz, Murat; Oter, Ozlem; Timur, Suna; Subasi, Elif
    Ru(II) carbonyl complexes were prepared by reacting [Ru(H)(Cl)(CO)(PPh3)(3)] with the respective thiosemicarbazone ligands and the complexes were characterized by UV-vis, FT-IR, and H-1 and P-31 NMR spectroscopy. Oxygen sensitivities and antimicrobial activities of the complexes were determined. [Ru(CO)(PPh3)(2)(eta(3)-O, N-3, S-TSC1)] (1), [Ru(Cl)(CO)(PPh3)(2)(eta(2)-N-3, S-TSC2)] (2), and [Ru(Cl)(CO) (PPh3)2(eta(2)-N-3,S-TSC3)] (3) have been prepared by reacting [Ru(H)(Cl)(CO)(PPh3)(3)] with the respective thiosemicarbazones TSC1 (2-hydroxy-3-methoxybenzaldehyde thiosemicarbazone), TSC2 (3-hydroxybenzaldehyde thiosemicarbazone), and TSC3 (3,4-dihydroxybenzaldehyde thiosemicarbazone) in a 1 : 1 M ratio in toluene and all of the complexes have been characterized by UV-vis, FT-IR, and H-1 and P-31 NMR spectroscopy. The spectroscopic studies showed that TSC1 is coordinated to the central metal as a tridendate ligand coordinating via the azomethine nitrogen (C=N), phenolic oxygen, and sulfur to ruthenium in 1, whereas TSC2 and TSC3 are coordinated to ruthenium as a bidentate ligand through azomethine nitrogen (C=N) and sulfur in 2 and 3. Oxygen sensitivities of 1-3 and [Ru(Cl)(CO)(PPh3)(2)(eta(2)-N-3, S-TSC4)] (4), and antimicrobial activities of 1-3 have been determined.