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    Effects of eradication on proteinuria: a prospective study
    (Springer Wien, 2012) Aydogan, Timucin; Ulas, Turgay; Selcoki, Yusuf; Alkan, Rabia; Yilmaz, Omer Caglar; Yalcin, Kadir Serkan; Inan, Osman
    Background Helicobacter pylori ( H. pylori) is one of the most common bacterial infections, seen in humans worldwide and its possible relationship to different diseases is a focus of attention nowadays. The aim of this study was to analyse the effects of eradication on proteinuria. Ninety-nine patients suffering from dyspeptic complaints were recruited in this prospective study. The patients were divided into two groups according to the presence of infection. Thus, a total of 67 positive and 32 negative patients were studied. The positive patients' group was divided into two groups according to response to eradication treatment. A total of three groups were formed, viz; group 1 comprises of patients who are positive and responds positively to eradication therapy, group 2 comprises of patients who are positive and responds negatively to eradication therapy and group 3 is the control group and comprises of patients that are negative. Urine samples to obtain the protein/creatinine ratio were collected initially and at the end of the study from all patients. Mean difference levels (pre- and post-treatment difference) of urine protein/creatinine ratio was 0.055 +/- 0.13 in group 1. The ratio was -aEuro parts per thousand 0.0007 +/- 0.0067 in group 2 and -aEuro parts per thousand 0.0022 +/- 0.008 in group 3. A statistically significant difference was found in group 1 compared to the other groups in terms of mean difference levels of protein/creatinine ratios (p < 0.001). As a result of our study, treatment of eradication significantly reduced the proteinuria within the normal limits.