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Öğe Clinical and epidemiological characteristics of hepatocellular carcinoma cases in east and Southeastern region of Turkey: A multicenter retrospective study(Turkiye Klinikleri, 2013) Yalçin K.; Yakut M.; De?ertekin H.; Türkdo?an K.; Harputluo?lu M.; Bahçecio?lu I.H.; Kadayifçi A.Objective: In this multicenter retrospective study, we aimed to investigate the epidemiological and clinical characteristics of patients with hepatocellular cancer (HCC) in the Eastern and Southeastern Anatolian regions of Turkey. Material and Methods: This study included 218 patients from 7 centers-Dicle University (n=96), Yüzüncü Yi{dotless}l University (n=30), İnönü University (n=28), Fi{dotless}rat University (n=24), Gaziantep University (n=20), Atatürk University (n=19), and Harran University (n=1) hospitals. Information about patients was obtained through pre-prepared forms. Diagnosis of HCC was made histologically or with a combination of clinical, radiological, and laboratory findings. Results: The mean age of the patients was 57.67±12.03 with a male-to-female ratio of 5.8:1. Etiologically, 45% of the study group had HBV infection alone, 29% had HDV co-infection, 15% had HCV infection and 10% were idiopathic cases with unknown etiology. Cirrhotic background was present in 94% of the patients and 89% of cases had an advanced stage disease according to the Okuda classification. Alpha-fetoprotein levels were over 300 ng/ml in 81% of the patients. Conclusion: Hepatitis B virus infection followed by hepatitis delta virus infections appeared to be the leading etiological factors for HCC cases in our region. HBsAg carriage continues to be an important risk factor for HCC in Turkey. The fact that most of the HCC cases are in the late stages of disease, makes it necessary to use effective diagnosis and treatment methods with efficient screening and monitoring programs in our country. © 2013 by Türkiye Klinikleri.Öğe Fever due to malaria in neutropenic patient. A rare complication of blood transfusion(2004) Isikdogan A.; Ayyildiz O.; Soker M.; Yakut M.; Muftuoglu E.[No abstract available]Öğe Multicentric plasma cell type Castleman disease: A case report(2003) Işikdo?an A.; Ayyildiz O.; Yakut M.; Çelik M.; Adresi Y.Castleman disease is known as giant lymph node hiperplasia or angiofollicular lymph node hiperplasia. It has two histopathologic type; hyalen vascular type (80%) and plasma cell type (20%). Plasma cell type generally has systemic symtomps and has localized and multisentric type. nineteen year-old male was admitted to our clinic with symptoms of fatigue, chest pain and weight loss. Anemia, hepatosplenomegali and right supraclavicular lymhadenopathy were clinical signs. Hemoglobin: 8 gr/dl, erythrocyte sedimentation rate: 86 mm/h, hypoalbuminemia, and policlonal hypergamaglobulinemia were found. Right mediastinal mass was detected. Abdominal ultrasonography revealed hepatosplenomegali and lymphadenopathy in hilum of spleen. Histopathological evaluation of mediastinal lymph node led the diagnosis of plasma cell type Castleman disease. Here we reported a patient with Castleman disease because, it is very rare disease and important in differantial diagnosis of lymphadenopathy.