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    Acute toxic effects of methyl alcohol on the rat brain: The protective effects of caffeic acid phenethyl ester
    (Acta Medica Mediterranea, 2014) Çevik M.U.; Varol S.; Yücel Y.; Akil E.; Uzar E.; Kaplan I.; Can Y.U.
    Background: Efficiency of caffeic acid phenethyl ester (CAPE) in reducing free radicals generated by oxidative stress has been previously reported. In the present study, the protective effect of CAPE on methyl alcohol (MeOH) induced oxidative damages on rat brain were presented. Methods: The rats were randomly divided into four groups as follows: Control, methotrexate (MTX) alone, MTX+MeOH, and MTX+MeOH+CAPE (CAPE treatment). All animals except the control group were treated with MTX for 7 days. MTX was diluted in sterile saline and administered (0.3 mg/kg/day) intraperitoneally (ip). At the eighth day, MeOH was administered (3gm/Kg) (ip) in MeOH+MTX and CAPE treatment groups. Four hours after MeOH administration in the CAPE group rats were treated with 10 ?mol/kg CAPE (ip), serum physiologic (i.p.) in MeOH+MTX group. After eight hours, rats were anaesthetized and sacrificed. Malondialdehyde (MDA) levels, paraoxonase-1 (PON-1. activity were measured on the cerebral tissue. Results: MTX+MeOH group compared to the MTX alone group; a statistically significant increase in MDA levels (p= 0.042. were detected. In addition, MTX+MeOH group than MTX MTX alone group in led to a statistically significant decrease in PON-1 activity (p= 0.018.. CAPE treatment, significantly decrease in MDA levels was compared with MeOH+MTX (p= 0.001.. However, CAPE treatment caused an increase on PON-1 activity in MeOH group, which was statistically significant (p= 0.009.. Conclusion: Consequently, it was demonstrated for the first time that CAPE prevents acute MeOH intoxication induced brain injury by reducing the increase in lipid peroxidation, and elevating the decrease in PON-1 activity.
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    Brief psychotic disorder in patients with systemic lupus erythematosus: Case reports
    (1999) Özen Ş.; Özbulut Ö.; Sari Y.; Işikakdo?an A.; Yücel Y.; Başak F.
    Systemic Lupus Erythematosus (SLE) is a chronic and multisystem-involved autoimmune disease. The etiology of SLE still remains unclear. Central nervous system involvement is a common and an important complication of SLE. Neuropsychiatric manifestations consist of the symptoms which are directly related to the vascular lesions and also cognitive and affective disorders. In this report, two cases of SLE with symptoms of brief psychotic disorder were presented and discussed under literature.
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    Demographic and etiologic data and risk factors of young stroke patient
    (Duzce University Medical School, 2012) Acar A.; Uzar E.; Çevik M.U.; Yücel Y.; Cansever S.; Arikanoğlu A.; Ekici F.
    Purpose:Was to evaluate the etiopathogenesis and vascular risk factors in young patients with ischemic stroke. Methods: Fifty-three young patients (age between 17-45 years) with ischemic stroke were analysed retrospectively. The cases were classified according to TOAST classification. In medical history, smoking, alcohol taking, oral contraceptive, abortion history, pregnancy, hypertension, diabetes mellitus, and atherosclerosis has been evaluated. Results: Of the 53 patients, 23 (43.4%) were males and 30 (56.6%) were females. The risk factors described for the etiology of stroke was found to large vessel disease 17 (32.1%), cardioemboli 12 (22.6%), small vessel disease 11 (20.8%), other factors 11 (20.8%) and undetermined factors 3 (5.7%). Conclusions: We believe that may reduce the incidence of stroke in the young patients by determined risk factors and taking the necessary measures, hereby may prevent mortality and disability in the patients who have risk for stroke. © 2012 Düzce Medical Journal.